Publication date: Available online 22 August 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Kioko Ishiwara-Niembro, Miguel Angel Pérez-Rodríguez, Fernando Alfonso Navarro-Cervantes, Jaime Abraham Jiménez-Pérez
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Publication date: Available online 21 August 2020Source: American Journal of OtolaryngologyAuthor(s): Alyssa M. Civantos, Antonio Bertelli, Antonio Gonçalves, Emily Getzen, Changgee Chang, Qi Long, Karthik Rajasekaran
Publication date: Available online 20 August 2020Source: American Journal of OtolaryngologyAuthor(s): Daniel A. Benito, Luke Pasick, Collin F. Mulcahy, Karthik Rajasekaran, Hosai Todd-Hesham, Arjun S. Joshi, Joseph F. Goodman, Punam Thakkar
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AbstractXenobiotic metabolizing enzymes and other proteins, including odorant-binding proteins located in the nasal epithelium and mucus, participate in a series of processes modulating the concentration of odorants in the environment of olfactory receptors and finely impact odor perception. These enzymes and transporters are thought to participate in odorant degradation or transport. Odorant biotransformation results in (i) changes in the odorant quantity up to their clearance and the termination...
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Conditions: Thyroid Neoplasia; Well-Differentiated Thyroid Cancer; Medullary Thyroid Cancer; Lymph Node MetastasesInterventions: Device: Laser ablation; Device: Cryoablation; Device: Radiofrequency ablationSponsor: Instituto do Cancer do Estado de São PauloNot yet recruiting
Conditions: NSCLC; Esophageal Squamous Cell Carcinoma; Thymic Epithelial TumorIntervention: Sponsor: Shanghai Cancer Hospital, ChinaRecruiting
Conditions: Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8; Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8; Localized Gastroesophageal Junction Adenocarcinoma; Locally Advanced Gastroesophageal Junction Adenocarcinoma; Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8; Pathologic Stage...
Condition: Nasopharyngeal CarcinomaInterventions: Drug: Gemcitabine combined with cisplatin induction chemotherapy; Drug: concurrent chemoradiotherapy with gemcitabineSponsor: Fifth Affiliated Hospital, Sun Yat-Sen UniversityRecruiting
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Simvastatin induces adverse effects on proliferation and mineralization of human primary osteoblasts
Frequently statins were administered to reduce the LDL-concentration in circulating blood. Especially simvastatin (SV) is an often prescribed statin. Pleiotropic effects of these drugs were reported. Thus, the...
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Abstract Background We evaluated the clinical applications of the reconstruction of postoperative defects of the oral cavity using contralateral submental artery flaps. Methods A retrospective study of 18 patients with postoperative intraoral cancer defects reconstructed with contralateral submental artery perforator flaps between October 2018 and October 2019 in our department was conducted. The defect area, flap size, and complications were evaluated. Results All patients were diagnosed...
Abstract Purpose The risk of developing head and neck squamous cell carcinoma (HNSCC) in patients with graft versus host disease (GVHD) after bone marrow transplant (BMT) is well established but large series reporting outcomes are sparse. Methods Retrospective, single institution, study of patients with GVHD and HNSCC after BMT, between January 1, 1968, and June 30, 2016. Results In total, 25 patients were studied, of which 21 (84%) were male and 4 (16%) were female. Mean age for...
Abstract Background It has been reported that the polyadenylate‐binding protein‐interacting protein 1 (PAIP1) pathway is closely connected with the progression of some malignant tumors. Here we examined the potential functional mechanism of PAIP1 in tongue squamous cell carcinoma (TSCC). Methods PAIP1 was knocked down in TSCC cell lines and proliferation and apoptosis in vitro analyzed. The molecular features of TSCC were determined using quantitative proteome and succinylome analyses....
Abstract Background Early detection of a recurrent disease remains essential during follow‐up to improve outcome and reduce morbidity. The purpose of this study was to evaluate the adequacy of panendoscopy after radiotherapy for recurrent laryngeal carcinoma. Methods In this retrospective analysis, 623 patients were included. Clinical and radiological examinations were compared to pathohistological results of panendoscopy and clinical outcome. Results In the first 6 months after therapy,...
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Zusammenfassung Die chirurgische Resektion stellt die wesentliche Säule zur Behandlung der adenoidzystischen Karzinome (ACC) der Speicheldrüsen dar. Hinsichtlich einer zusätzlichen Strahlentherapie gibt es in Bezug auf den Zeitpunkt und die Art der Therapie unterschiedliche Ansätze. In dieser Studie werden das Gesamtüberleben und das rezidivfreie Überleben zweier am Universitätsklinikum Essen behandelter Patienten mit ACC der Speicheldrüsen verglichen, die (A) entweder unmittelbar...
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Related Articles Translation, cross-cultural adaptation, and validation of the sino-nasal outcome test (snot)-22 for Finnish patients. Eur Arch Otorhinolaryngol. 2020 Aug 20;: Authors: Koskinen A, Hammarén-Malmi S, Myller J, Mäkelä M, Penttilä E, Pessi T, Puhakka T, Raappana A, Taulu R, Toppila-Salmi S, Virkkula P, Hytönen M Abstract PURPOSE: The Sino-Nasal Outcome Test-22 (SNOT-22) is the most commonly used disease-specific quality of life...
Related Articles Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2020 Aug 20;: Authors: Weiss BG, Anczykowski MZ, Küffer S, Spiegel JL, Bertlich M, Canis M, Ihler F, Kitz J, Jakob M Abstract PURPOSE: p16 overexpression was considered as surrogate marker to identify human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma...
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LaryngorhinootologieDOI: 10.1055/a-1170-8426© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Ergebnisse der Nasenmuschelverkleinerung bei alten und sehr alten Patienten mit chronischer Rhinitis
LaryngorhinootologieDOI: 10.1055/a-1226-6960 Hintergrund Die Symptomatik der chronischen Rhinitis in der alten und sehr alten Bevölkerung kann aus der isolierten Schleimhauthyperplasie der unteren Nasenmuscheln resultieren. Als eine zielführende Therapie kommt eine Muschelplastik in Betracht. Bedenken bestehen hinsichtlich des oftmals reduzierten Allgemeinzustands, der häufig erhöhten Neigung zur Epistaxis, vor allem bei der Verwendung von Antikoagulanzien, und der Komorbiditäten wie der...
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Thyroid, Ahead of Print.
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We retrospectively analyzed data from records of 48 patients (48 eyes) treated with gamma-knife (n = 18) or Ruthenium-106 brachytherapy (n = 30) for uveal melanoma, in our Ocular Oncology Unit between December 2013 and September 2019, with the aim to evaluate treatment outcomes, and incidence and risk factors for secondary glaucoma. Patients demographics and tumor characteristics at diagnosis were recorded. Follow-up data were collected regarding local tumor control, treatment complications, enucleation...
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