Related Articles Assays for Validating Histone Acetyltransferase Inhibitors. J Vis Exp. 2020 Aug 06;(162): Authors: Waddell AR, Liao D Abstract Lysine acetyltransferases (KATs) catalyze acetylation of lysine residues on histones and other proteins to regulate chromatin dynamics and gene expression. KATs, such as CBP/p300, are under intense investigation as therapeutic targets due to their critical role in tumorigenesis of diverse cancers....
Tue Aug 25, 2020 13:26
Related Articles Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers. J Vis Exp. 2020 Aug 10;(162): Authors: Vedadghavami A, Mehta S, Bajpayee AG Abstract Several negatively charged tissues in the body, like cartilage, present a barrier to the targeted drug delivery due to their high density of negatively charged aggrecans and, therefore, require improved targeting methods to increase their therapeutic...
Tue Aug 25, 2020 13:26
Related Articles A Telemetric, Gravimetric Platform for Real-Time Physiological Phenotyping of Plant-Environment Interactions. J Vis Exp. 2020 Aug 05;(162): Authors: Dalal A, Shenhar I, Bourstein R, Mayo A, Grunwald Y, Averbuch N, Attia Z, Wallach R, Moshelion M Abstract Food security for the growing global population is a major concern. The data provided by genomic tools far exceeds the supply of phenotypic data, creating a knowledge gap....
Tue Aug 25, 2020 13:26
Related Articles A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons. J Vis Exp. 2020 Aug 06;(162): Authors: Bagheri A, Razavipour SF, Wahlestedt C, Mowla SJ, Faghihi MA Abstract Neurite outgrowth assay and neurotoxicity assessment are two major studies that can be performed using the presented method herein. This protocol provides reliable analysis of neuronal morphology together with...
Tue Aug 25, 2020 13:26
Related Articles Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions. J Vis Exp. 2020 Aug 05;(162): Authors: Yarrington KD, Sánchez Peña A, Limoli DH Abstract Polymicrobial communities are ubiquitous in nature, yet studying their interactions at the single-cell level is difficult. Thus, a microscopy-based method has been developed for observing interspecies interactions between two bacterial pathogens. The use of this...
Tue Aug 25, 2020 13:26
Related Articles 3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects. J Vis Exp. 2020 Aug 04;(162): Authors: Capucha T, Shilo D, Blanc O, Turgeman S, Emodi O, Rachmiel A Abstract We are in the midst of the 3D era in most aspects of life, and especially in medicine. The surgical discipline is one of the major players in the medical field using the constantly developing 3D planning and printing capabilities....
Tue Aug 25, 2020 13:26
Related Articles Using Tg(Vtg1:mcherry) Zebrafish Embryos to Test the Estrogenic Effects of Endocrine Disrupting Compounds. J Vis Exp. 2020 Aug 08;(162): Authors: Csenki Z, Horváth Á, Bock I, Garai E, Kerekes F, Vásárhelyi E, Kovács B, Urbányi B, Mueller F, Bakos K Abstract There are many endocrine disrupting compounds (EDC) in the environment, especially estrogenic substances. The detection of these substances is difficult due to their...
Tue Aug 25, 2020 13:26
Related Articles Perfusion and Inflation of the Mouse Lung for Tumor Histology. J Vis Exp. 2020 Aug 06;(162): Authors: Davenport ML, Sherrill TP, Blackwell TS, Edmonds MD Abstract The ability to evaluate lung histology is critical for the fields of lung cancer research and cancer metastasis. It is equally important to perform necropsies rapidly and efficiently from studies without sacrificing the quality of the tissues procured. The goal...
Tue Aug 25, 2020 13:26
Related Articles Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow. J Vis Exp. 2020 Aug 07;(162): Authors: Xie X, Chamoli M, Bhaumik D, Sivapatham R, Angeli S, Andersen JK, Lithgow GJ, Schilling B Abstract We and others have shown that the aging process results in a proteome-wide accumulation of insoluble proteins. Knocking down genes encoding the insoluble...
Tue Aug 25, 2020 13:26
Related Articles Ovarian Cancer Metastasis to the Larynx: A Case Report and Review of the Literature. Case Rep Surg. 2020;2020:1543129 Authors: Purcell C, Al Afif A, Bullock M, Corsten M Abstract Laryngeal secondary malignancies are rare, and most spread locoregionally from hypopharyngeal or thyroid primaries. Metastasis of ovarian carcinoma to the larynx is extremely rare. A 65-year-old woman with a history of high grade serous ovarian carcinoma...
Tue Aug 25, 2020 17:26
Related Articles Droplet applicator module for reproducible and controlled endoscopic laryngeal adductor reflex stimulation. Biomicrofluidics. 2020 Jul;14(4):044112 Authors: Fast JF, Westermann KA, Laves MH, Jungheim M, Ptok M, Ortmaier T, Kahrs LA Abstract This work presents a droplet applicator module to generate stable droplets with different muzzle energies for the reproducible endoscopic stimulation of the laryngeal adductor reflex (LAR)....
Tue Aug 25, 2020 17:26
Related Articles Laryngeal Papillomatosis in Adults: Assessment for Ten Years at the ENT Department of the National University Hospital of Fann (Dakar, Senegal). Int J Otolaryngol. 2020;2020:2782396 Authors: Ndour N, Maiga S, Houra A, Deguenonvo REA, Ndiaye C, Pilor N, Mbaye A, Sall AC, Diouf MS, Ndiaye IC Abstract Objectives: The aim of this study was to describe the epidemiological, diagnostic, and therapeutic aspects of adult laryngeal papillomatosis...
Tue Aug 25, 2020 17:26
Related Articles Multidimensional penalized splines for incidence and mortality-trend analyses and validation of national cancer-incidence estimates. Int J Epidemiol. 2020 Aug 24;: Authors: Uhry Z, Chatignoux E, Dantony E, Colonna M, Roche L, Fauvernier M, Defossez G, Leguyader-Peyrou S, Monnereau A, Grosclaude P, Bossard N, Remontet L Abstract BACKGROUND: Cancer-incidence and mortality-trend analyses require appropriate statistical modelling....
Tue Aug 25, 2020 17:26
Related Articles Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration. Br J Cancer. 2020 Aug 24;: Authors: Di Credico G, Polesel J, Dal Maso L, Pauli F, Torelli N, Luce D, Radoï L, Matsuo K, Serraino D, Brennan P, Holcatova I, Ahrens W, Lagiou P, Canova C, Richiardi L, Healy CM, Kjaerheim K, Conway DI, Macfarlane GJ, Thomson P, Agudo A, Znaor A, Franceschi S, Herrero R, Toporcov TN, Moyses RA, Muscat J, Negri E, Vilensky...
Tue Aug 25, 2020 17:26
Related Articles Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer Patients. Int J Biol Sci. 2020;16(13):2464-2476 Authors: Huang X, He C, Hua X, Kan A, Sun S, Wang J, Li S Abstract In 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused infections worldwide. However, the correlation between the immune infiltration and coronavirus disease 2019 (COVID-19) susceptibility or severity...
Tue Aug 25, 2020 17:26
Related Articles The nonsurgical management of early stage (T1/2 N0 M0) laryngeal cancer: A population analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Jul;130(1):18-24 Authors: Lee KC, Chuang SK Abstract BACKGROUND: The purpose of this study was to evaluate the patterns of care and survival in the nonsurgical management of early-stage (T1/2 N0 M0) laryngeal cancer. STUDY DESIGN: This was a retrospective cohort study using...
Tue Aug 25, 2020 17:26
Related Articles Factors Associated with Failure of Botulinum Toxin Injection in Adductor Spasmodic Dysphonia. Ann Otol Rhinol Laryngol. 2020 Oct;129(10):996-1002 Authors: Zhao K, Guillaud M, Hu A Abstract OBJECTIVE: Electromyography (EMG) Guided botulinum toxin (BTX) injection is considered first-line treatment for adductor spasmodic dysphonia (SD). Failure rate can range between 6% and 29%. Study objective was to determine which factors were...
Tue Aug 25, 2020 17:26
Related Articles Tracheal Tugging. J Pediatr. 2020 03;218:255 Authors: Otani A, Iio K, Ihara T PMID: 31812293 [PubMed - indexed for MEDLINE]
Tue Aug 25, 2020 17:26
Related Articles Vocal cord function during recurrent laryngeal nerve injury assessed by accelerometry and EMG. Laryngoscope. 2020 04;130(4):1090-1096 Authors: Dahle GO, Setså EJ, Svendsen ØS, Stangeland L, Heimdal JH, Henriksen B, Husby P, Brauckhoff K Abstract OBJECTIVE: Gradual impairment of nerve conduction is expected to be tightly associated with simultaneous gradual loss of vocal cord contractility, related to the fact that injured axons...
Tue Aug 25, 2020 17:26
Related Articles The rising rate of nonsmokers among laryngeal carcinoma patients: Are we facing a new disease? Laryngoscope. 2020 03;130(3):E108-E115 Authors: Shoffel-Havakuk H, O'Dell K, Johns MM, Reder L, Popova M, Halperin D, Feldberg E, Lahav Y Abstract OBJECTIVES/HYPOTHESIS: Laryngeal squamous cell carcinoma (SCC) is strongly associated with tobacco smoking. With the rising awareness of tobacco's adverse health effects, we have witnessed...
Tue Aug 25, 2020 17:26
Related Articles Trans-thyroid cartilage recording for neural monitoring of the recurrent laryngeal nerve in thyroid surgery. Laryngoscope. 2020 04;130(4):E280-E283 Authors: Chiang FY, Wu CW, Chang PY, Wu SH, Chen HY, Lin YC, Huang TY, Zesendavaa E, Lu IC PMID: 31077388 [PubMed - indexed for MEDLINE]
Tue Aug 25, 2020 17:26
Related Articles Voice dissatisfaction in individuals with a disorder of sex development. Clin Endocrinol (Oxf). 2019 07;91(1):219-227 Authors: Nygren U, Södersten M, Thyen U, Köhler B, Nordenskjöld A, dsd-LIFE Group Abstract OBJECTIVE: Changes of sex hormone levels in disorders of sex development (DSD) can affect the body, including the vocal folds, during and after foetal development. The voice is a gender characteristic that may also be...
Tue Aug 25, 2020 17:26
Related Articles Drivers of In-Hospital Costs Following Endoscopic Transphenoidal Pituitary Surgery. Laryngoscope. 2020 Aug 24;: Authors: Parasher AK, Lerner DK, Glicksman JT, Miranda SP, Dimentberg R, Ebesutani D, Kohanski M, Lee JYK, Storm PB, O'Malley BW, Palmer JN, Grady MS, Adappa ND Abstract OBJECTIVE: To characterize the patient and clinical factors that determine variability in hospital costs following endoscopic transphenoidal pituitary...
Tue Aug 25, 2020 16:49
Related Articles Comparing the results of duraplasty using amniotic membrane versus pericranium as dural graft; concerning CSF leakage and pseudomeningocele. Br J Neurosurg. 2020 Feb;34(1):51-54 Authors: Tahami SA, Afshar-Fereydonian N, Kazemi F, Taheri M Abstract Purpose: In many brain surgeries, dura cannot be primarily repaired and it is necessary to use a graft. Appropriate repair of dura plays a major role in preventing CSF leakage and...
Tue Aug 25, 2020 16:49
Related Articles Regulatory and Safety Considerations in Deploying a Locally Fabricated, Reusable Face Shield in a Hospital Responding to the COVID-19 Pandemic. Med (N Y). 2020 Jun 19;: Authors: Mostaghimi A, Antonini MJ, Plana D, Anderson PD, Beller B, Boyer EW, Fannin A, Freake J, Oakley R, Sinha MS, Smith L, Van C, Yang H, Sorger PK, LeBoeuf NR, Yu SH Abstract Background: Due to supply chain disruption, the COVID-19 pandemic has caused severe...
Tue Aug 25, 2020 14:50
Related Articles Coronavirus Disease 2019's (COVID-19's) Silver Lining-Through the Eyes of Radiation Oncology Fellows. Adv Radiat Oncol. 2020 Jul 23;: Authors: Pilar A, Gravel SB, Croke J, Soliman H, Chung P, Wong RKS Abstract Purpose: The coronavirus disease 2019 (COVID-19) pandemic has propelled health care workers to the front lines against the pandemic. In addition to anxiety related to infection risks, trainees have the additional burden...
Tue Aug 25, 2020 14:50
Related Articles Sarcoma Care Practice in India During COVID Pandemic: A Nationwide Survey. Indian J Orthop. 2020 Jul 31;:1-8 Authors: Gulia A, Tiwari A, Arora RS, Gupta S, Raja A Abstract Background: Amidst the COVID-19 pandemic, management of cancer has been one of the most intensely debated topics across the globe. We conducted an online survey to determine the consistency/or the lack of it, in the management of sarcoma patients between centres...
Tue Aug 25, 2020 14:50
Related Articles Electrochemotherapy in the treatment of cutaneous malignancy: Outcomes and subgroup analysis from the cumulative results from the pan-European International Network for Sharing Practice in Electrochemotherapy database for 2482 lesions in 987 patients (2008-2019). Eur J Cancer. 2020 Aug 21;138:30-40 Authors: Clover AJP, de Terlizzi F, Bertino G, Curatolo P, Odili J, Campana LG, Kunte C, Muir T, Brizio M, Sersa G, Pritchard Jones R, Moir G, Orlando...
Tue Aug 25, 2020 14:50
Related Articles Anti-EGFR therapies in nasopharyngeal carcinoma. Biomed Pharmacother. 2020 Aug 21;131:110649 Authors: Chen X, Liang R, Zhu X Abstract Nasopharyngeal carcinoma (NPC) is a common malignant tumor in Southern China and South-East Asia. Regardless of initiative high response to radiotherapy, parts of patients still have relapses and metastases. It is reported that epidermal growth factor receptor (EGFR) is highly expressed in most...
Tue Aug 25, 2020 14:50
Related Articles Number of nodal metastases and the American Joint Committee on cancer staging of head and neck cutaneous squamous cell carcinoma: A multicenter study. Oral Oncol. 2020 Aug 21;111:104855 Authors: Ebrahimi A, Gupta R, Luk P, Low TH, McDowell L, Magarey MJR, Smith PN, Perriman DM, Schulte KM, Veness M, Porceddu SV, Clark JR Abstract OBJECTIVES: We aimed to determine if the number of nodal metastases is an independent predictor...
Tue Aug 25, 2020 14:50
Related Articles What is an estimand & how does it relate to quantifying the effect of treatment on patient-reported quality of life outcomes in clinical trials? J Patient Rep Outcomes. 2020 Aug 24;4(1):68 Authors: Lawrance R, Degtyarev E, Griffiths P, Trask P, Lau H, D'Alessio D, Griebsch I, Wallenstein G, Cocks K, Rufibach K Abstract BACKGROUND: Published in 2019, a new addendum to the ICH E9 guideline presents the estimand framework as...
Tue Aug 25, 2020 13:19
Related Articles Embolotherapy for Hepatic Oncology: Current Perspectives and Future Directions. Dig Dis Interv. 2020 Jun;4(2):134-147 Authors: Bajwa R, Madoff DC, Kishore SA PMID: 32832829 [PubMed - as supplied by publisher]
Tue Aug 25, 2020 13:19
Related Articles Microarray Normalization Revisited for Reproducible Breast Cancer Biomarkers. Biomed Res Int. 2020;2020:1363827 Authors: Kenn M, Cacsire Castillo-Tong D, Singer CF, Cibena M, Kölbl H, Schreiner W Abstract Precision medicine for breast cancer relies on biomarkers to select therapies. However, the reliability of biomarkers drawn from gene expression arrays has been questioned and calls for reassessment, in particular for large...
Tue Aug 25, 2020 13:19
Related Articles Biosimilars as a Future, Promising Solution for Financial Toxicity: A Review with Emphasis on Bevacizumab. Cureus. 2020 Jul 20;12(7):e9300 Authors: Saleem T, Qurashi H, Jamali M, Chan Gomez J, Kanderi T Abstract A biosimilar is a biochemical product like another already approved biologic agent, known as the reference agent. To be endorsed by the Food and Drug Administration (FDA), biosimilars must demonstrate that they are as...
Tue Aug 25, 2020 13:19
Related Articles Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture. Transl Vis Sci Technol. 2020 Jun;9(7):39 Authors: Aughton K, Shahidipour H, Djirackor L, Coupland SE, Kalirai H Abstract Purpose: Uveal melanoma (UM) typically spreads to the liver, where it is incurable, as there are limited therapeutic interventions available. This study aimed to standardize laboratory methods for generating three-dimensional...
Tue Aug 25, 2020 13:19
Related Articles PARP inhibitors and epithelial ovarian cancer: Molecular mechanisms, clinical development and future prospective. Oncol Lett. 2020 Oct;20(4):90 Authors: Loizzi V, Ranieri G, Laforgia M, Gadaleta CD, Gargano G, Kardhashi A, De Liso M, Naglieri E, Del Vecchio V, Cicinelli E, Cormio G Abstract Epithelial ovarian cancer (EOC) has a poor prognosis. Since the introduction of paclitaxel as antineoplastic agent >20 years ago, only...
Tue Aug 25, 2020 13:19
Related Articles High-dose carbon-ion based radiotherapy of primary and recurrent sacrococcygeal chordomas: long-term clinical results of a single particle therapy center. Radiat Oncol. 2020 Aug 24;15(1):206 Authors: Bostel T, Mattke M, Nicolay NH, Welzel T, Wollschläger D, Akbaba S, Mayer A, Sprave T, Debus J, Uhl M Abstract BACKGROUND: This study aimed to analyze the oncological long-term results and late toxicity of carbon ion-based radiotherapy...
Tue Aug 25, 2020 13:19
Related Articles Features of alternative splicing in stomach adenocarcinoma and their clinical implication: a research based on massive sequencing data. BMC Genomics. 2020 Aug 24;21(1):580 Authors: Zhang Y, Ma S, Niu Q, Han Y, Liu X, Jiang J, Chen S, Lin H Abstract BACKGROUND: Alternative splicing (AS) offers a main mechanism to form protein polymorphism. A growing body of evidence indicates the correlation between splicing disorders and carcinoma....
Tue Aug 25, 2020 13:19
Related Articles Targeted Therapy- and Chemotherapy-Associated Skin Toxicities: Systematic Review and Meta-Analysis. Oncol Nurs Forum. 2020 Sep 01;47(5):E149-E160 Authors: Ding J, Farah MH, Nayfeh T, Malandris K, Manolopoulos A, Ginex PK, Hasan B, Dunnack H, Abd-Rabu R, Rajjoub M, Prokop L, Morgan RL, Murad MH Abstract PROBLEM IDENTIFICATION: Preventing and managing skin toxicities can minimize treatment disruptions and improve well-being. This...
Tue Aug 25, 2020 13:19
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