Related Articles Romo1 Inhibition Induces TRAIL-Mediated Apoptosis in Colorectal Cancer. Cancers (Basel). 2020 Aug 20;12(9): Authors: Jo MJ, Kim BG, Park SH, Kim HJ, Jeong S, Kim BR, Kim JL, Na YJ, Jeong YA, Yun HK, Kim DY, Han J, Heo JY, Yoo YD, Lee DH, Oh SC Abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to behave as an attractive anti-cancer agent in various cancers. Despite its promise TRAIL has limitations...
Sun Aug 23, 2020 13:18
Related Articles Synthetic Notch-Receptor-Mediated Transmission of a Transient Signal into Permanent Information via CRISPR/Cas9-Based Genome Editing. Cells. 2020 Aug 20;9(9): Authors: Sgodda M, Alfken S, Schambach A, Eggenschwiler R, Fidzinski P, Hummel M, Cantz T Abstract Synthetic receptor biology and genome editing are emerging techniques, both of which are currently beginning to be used in preclinical and clinical applications. We...
Sun Aug 23, 2020 13:18
Related Articles Clonal Hematopoiesis of Indeterminate Potential: A Multidisciplinary Challenge in Personalized Hematology. J Pers Med. 2020 Aug 20;10(3): Authors: Hoermann G, Greiner G, Griesmacher A, Valent P Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related condition that represents a potential pre-phase of hematologic neoplasm. Next-generation sequencing (NGS) is used to detect and monitor clonal...
Sun Aug 23, 2020 13:18
Related Articles Immune Checkpoint Inhibitors versus VEGF Targeted Therapy as Second Line Regimen in Advanced Hepatocellular Carcinoma (HCC): A Retrospective Study. J Clin Med. 2020 Aug 19;9(9): Authors: Saeed A, Hildebrand H, Park R, Al-Jumayli M, Abbasi S, Melancon T, Saeed A, Al-Rajabi R, Kasi A, Baranda J, Williamson S, Sun W Abstract Several targeted agents including multi-tyrosine kinase inhibitors (mTKIs) and immunotherapy (IO) agents...
Sun Aug 23, 2020 13:18
Related Articles Organotypic Co-Cultures as a Novel 3D Model for Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2020 Aug 18;12(8): Authors: Engelmann L, Thierauf J, Koerich Laureano N, Stark HJ, Prigge ES, Horn D, Freier K, Grabe N, Rong C, Federspil P, Zaoui K, Plinkert PK, Rotter N, von Knebel Doeberitz M, Hess J, Affolter A Abstract Background: Head and neck squamous cell carcinomas (HNSCC) are phenotypically and molecularly...
Sun Aug 23, 2020 13:18
Related Articles IDH1 Targeting as a New Potential Option for Intrahepatic Cholangiocarcinoma Treatment-Current State and Future Perspectives. Molecules. 2020 Aug 18;25(16): Authors: Crispo F, Pietrafesa M, Condelli V, Maddalena F, Bruno G, Piscazzi A, Sgambato A, Esposito F, Landriscina M Abstract Cholangiocarcinoma is a primary malignancy of the biliary tract characterized by late and unspecific symptoms, unfavorable prognosis, and few...
Sun Aug 23, 2020 13:18
Related Articles C-Reactive Protein (CRP) Levels in Immune Checkpoint Inhibitor Response and Progression in Advanced Non-Small Cell Lung Cancer: A Bi-Center Study. Cancers (Basel). 2020 Aug 17;12(8): Authors: Riedl JM, Barth DA, Brueckl WM, Zeitler G, Foris V, Mollnar S, Stotz M, Rossmann CH, Terbuch A, Balic M, Niedrist T, Bertsch T, Stoeger H, Pichler M, Olschewski H, Absenger G, Ficker JH, Gerger A, Posch F Abstract BACKGROUND: Biomarkers...
Sun Aug 23, 2020 13:18
Related Articles Time to Next Treatment as a Meaningful Endpoint for Trials of Primary Cutaneous Lymphoma. Cancers (Basel). 2020 Aug 17;12(8): Authors: Campbell BA, Scarisbrick JJ, Kim YH, Wilcox RA, McCormack C, Prince HM Abstract Time to next treatment (TTNT) is an emerging endpoint in clinical studies of primary cutaneous T-cell lymphomas (CTCL), with utility as a surrogate marker for the "duration of clinical benefit". TTNT provides...
Sun Aug 23, 2020 13:18
Related Articles Estimated Intakes of Nutrients and Polyphenols in Participants Completing the MaPLE Randomised Controlled Trial and Its Relevance for the Future Development of Dietary Guidelines for the Older Subjects. Nutrients. 2020 Aug 15;12(8): Authors: Martini D, Bernardi S, Del Bo' C, Hidalgo Liberona N, Zamora-Ros R, Tucci M, Cherubini A, Porrini M, Gargari G, González-Domínguez R, Peron G, Kirkup B, Kroon PA, Andres-Lacueva C, Guglielmetti S, Riso...
Sun Aug 23, 2020 13:18
Related Articles Multi-Parametric Deep Learning Model for Prediction of Overall Survival after Postoperative Concurrent Chemoradiotherapy in Glioblastoma Patients. Cancers (Basel). 2020 Aug 14;12(8): Authors: Yoon HG, Cheon W, Jeong SW, Kim HS, Kim K, Nam H, Han Y, Lim DH Abstract This study aimed to investigate the performance of a deep learning-based survival-prediction model, which predicts the overall survival (OS) time of glioblastoma...
Sun Aug 23, 2020 13:18
Related Articles Finding a Jill for JAK: Assessing Past, Present, and Future JAK Inhibitor Combination Approaches in Myelofibrosis. Cancers (Basel). 2020 Aug 14;12(8): Authors: Kuykendall AT, Horvat NP, Pandey G, Komrokji R, Reuther GW Abstract Myelofibrosis (MF) is a myeloproliferative neoplasm hallmarked by the upregulation of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway with associated extramedullary...
Sun Aug 23, 2020 13:18
Related Articles The Clinical Significance of RAS, PIK3CA, and PTEN Mutations in Non-Small Cell Lung Cancer Using Cell-Free DNA. J Clin Med. 2020 Aug 14;9(8): Authors: Chang WJ, Sung JS, Lee SY, Kang EJ, Kwon NJ, Kim HM, Shin SW, Choi JY, Choi YJ, Kim JW, Park KH, Kim YH Abstract Mutations in the EGFR gene downstream signaling pathways may cause receptor-independent pathway activation, making tumors unresponsive to EGFR inhibitors. However,...
Sun Aug 23, 2020 13:18
Related Articles Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population. Int J Environ Res Public Health. 2020 Aug 13;17(16): Authors: Noreen Z, Loffredo CA, Bhatti A, Simhadri JJ, Nunlee-Bland G, Nnanabu T, John P, Khan JS, Ghosh S Abstract The epidemic of type 2 diabetes mellitus (T2DM) is an important global health concern. Our earlier epidemiological investigation in Pakistan...
Sun Aug 23, 2020 13:18
From Patient Engagement to Precision Oncology: Leveraging Informatics to Advance Cancer Care. Yearb Med Inform. 2020 Aug;29(1):235-242 Authors: Griffin AC, Topaloglu U, Davis S, Chung AE Abstract OBJECTIVES: Conduct a survey of the literature for advancements in cancer informatics over the last three years in three specific areas where there has been unprecedented growth: 1) digital health; 2) machine learning; and 3) precision oncology....
Sat Aug 22, 2020 13:22
Effect of virtual reality therapy in reducing pain and anxiety for cancer related medical procedures: A systematic narrative review. J Pain Symptom Manage. 2020 Aug 18;: Authors: Chow H, Hon J, Chua W, Chuan A Abstract CONTEXT: Virtual reality (VR) has emerged as a novel form of non-pharmacological analgesia therapy. We wished to review the use of VR to treat pain and anxiety in cancer related medical procedures and chemotherapy. ...
Sat Aug 22, 2020 13:22
Related Articles [Artificial intelligence : What do urologists need to know?] Urologe A. 2020 Aug 21;: Authors: Schreiber A, Hahn H, Wenzel M, Loch T Abstract In the past 10 years, the methods of artificial intelligence (AI) have experienced breakthroughs that have opened up a multitude of new fields of application for information technology. AI is particularly strong in those areas where patterns have to be recognized and conclusions and...
Sat Aug 22, 2020 13:22
Related Articles Why natural killer cells in triple negative breast cancer? World J Clin Oncol. 2020 Jul 24;11(7):464-476 Authors: Abdel-Latif M, Youness RA Abstract The triple-negative subtype of breast cancer (TNBC) has the bleakest prognosis, owing to its lack of either hormone receptor as well as human epidermal growth factor receptor 2. Henceforth, immunotherapy has emerged as the front-runner for TNBC treatment, which avoids potentially...
Sat Aug 22, 2020 13:22
Related Articles Endocrine Therapy Plus Anti-HER2 Therapy as Adjuvant Systemic Therapy for Luminal HER2-Positive Breast Cancer: An Analysis of the National Cancer Database. Breast Cancer (Auckl). 2020;14:1178223420945694 Authors: Nahleh ZA, Elimimian EB, Elson LC, Hobbs B, Wei W, Blake CN Abstract Background: Guidelines regarding the usage of adjuvant systemic therapy in patients with small human epidermal growth factor receptor 2 (HER2)-positive...
Sat Aug 22, 2020 13:22
Related Articles Decreased level of peripheral CD8+CD28+ T cells is associated with lymph node metastasis in patients with breast cancer. Future Oncol. 2020 Aug 21;: Authors: Li Y, Qian T, Zhao H, Zhang Z, Ming Y, Qiao G, Liu J Abstract Background: Lymph node metastasis (LNM) is an independent risk factor for prognosis in patients with early breast cancer (EBC). Here we explored whether peripheral lymphocyte subtypes could be used as surrogate...
Sat Aug 22, 2020 13:22
Related Articles [Radiation intestinal injury in the era of precision radiotherapy]. Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Aug 25;23(8):734-736 Authors: Cao XP Abstract Radiation-induced intestinal injury is caused by radiotherapy of pelvic malignant tumors. The main symptoms include persistent blood in stool, tenesmus, perianal pain, and severe intestinal perforation. Compared to conventional radiotherapy, precision radiotherapy (PT)...
Sat Aug 22, 2020 13:22
Related Articles Gastric Cancer: Where Are We Heading? Dig Dis. 2020;38(4):280-285 Authors: Petryszyn P, Chapelle N, Matysiak-Budnik T Abstract BACKGROUND: Despite its decreasing incidence, gastric cancer (GC) remains one of the leading cancers in the world and an important global healthcare problem due to its overall high prevalence and high mortality rate. SUMMARY: GC is a consequence of Helicobacter pylori infection in 90% of cases,...
Sat Aug 22, 2020 13:22
Related Articles UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs. Cancer Biol Ther. 2019;20(10):1304-1313 Authors: Habicht J, Mooneyham A, Shetty M, Zhang X, Shridhar V, Winterhoff B, Zhang Y, Cepela J, Starr T, Lou E, Bazzaro M Abstract UNC-45A is an ubiquitously expressed protein highly conserved throughout evolution. Most of what we currently know about UNC-45A pertains to its role...
Sat Aug 22, 2020 13:22
Related Articles Reagent-Free and Rapid Assessment of T Cell Activation State Using Diffraction Phase Microscopy and Deep Learning. Anal Chem. 2019 03 05;91(5):3405-3411 Authors: Karandikar SH, Zhang C, Meiyappan A, Barman I, Finck C, Srivastava PK, Pandey R Abstract CD8+ T cells constitute an essential compartment of the adaptive immune system. During immune responses, naı̈ve T cells become functional, as they are primed with their cognate...
Sat Aug 22, 2020 13:22
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/08/21PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Aug 21, 2020 21:28
Related Articles HER2 genomic heterogeneity is a frequent event in gastroesophageal adenocarcinoma and correlates with tumor morphology. Pathol Res Pract. 2020 Sep;216(9):153090 Authors: Machado-Neves R, Vale J, Eloy C, Polónia A Abstract AIM: To characterize a cohort of gastro-esophageal adenocarcinomas (GEA) evaluated for HER2 gene amplification using bright field in situ hybridization (ISH) following the 2016 guidelines for GEA and correlating...
Sun Aug 23, 2020 13:23
Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice. Pharmacol Res. 2020 Aug 18;:105123 Authors: Wang J, Iannarelli R, Pucciarelli S, Laudadio E, Galeazzi R, Giangrossi M, Falconi M, Cui L, Navia AM, Buccioni M, Marucci G, Tomassoni D, Serini L, Sut S, Maggi F, Dall'Acqua S, Marchini C, Amici A Abstract Breast cancer (BC) is...
Sat Aug 22, 2020 13:00
The pharmaceutical stability of trastuzumab after short-term storage at room temperature assessed by analytical techniques and tumour imaging by microSPECT/CT. Int J Pharm. 2020 Aug 18;:119786 Authors: Chan C, Seki JT, Kwong R, Reilly RM Abstract We report the pharmaceutical stability of trastuzumab stored for a short time (12 h) at room temperature (RT; 20-25 oC) compared to trastuzumab stored at 2-8 oC. The physicochemical properties were...
Sat Aug 22, 2020 13:00
Related Articles Phase III, Randomized Study of Dual Human Epidermal Growth Factor Receptor 2 (HER2) Blockade With Lapatinib Plus Trastuzumab in Combination With an Aromatase Inhibitor in Postmenopausal Women With HER2-Positive, Hormone Receptor-Positive Metastatic Breast Cancer: Updated Results of ALTERNATIVE. J Clin Oncol. 2020 Aug 21;:JCO2001894 Authors: Johnston SRD, Hegg R, Im SA, Park IH, Burdaeva O, Kurteva G, Press MF, Tjulandin S, Iwata H, Simon SD,...
Sat Aug 22, 2020 13:00
Related Articles Association of an anaplastic lymphoma kinase pathway signature with cell de-differentiation, neoadjuvant chemotherapy response, and recurrence risk in breast cancer. Cancer Commun (Lond). 2020 Aug 21;: Authors: Liu D, Wu Y Abstract BACKGROUND: Aberrant activation of anaplastic lymphoma kinase (ALK) signaling has been found to be involved in the tumorigenesis of multiple types of cancer. The aim of this study was to determine...
Sat Aug 22, 2020 13:00
Related Articles Phase I study of 99mTc-ADAPT6, a scaffold protein-based probe for visualization of HER2 expression in breast cancer. J Nucl Med. 2020 Aug 17;: Authors: Bragina O, von Witting E, Garousi J, Zelchan R, Sandström M, Medvedeva A, Orlova A, Doroshenko A, Vorobyeva A, Lindbo S, Borin J, Tarabanovskaya N, Sorensen J, Hober S, Chernov V, Tolmachev V Abstract Radionuclide molecular imaging of human epidermal growth factor (HER2) expression...
Sat Aug 22, 2020 00:50
Related Articles Clinical outcomes of patients with breast cancer relapsing after (neo)adjuvant trastuzumab and receiving trastuzumab rechallenge or lapatinib-based therapy: a multicentre retrospective cohort study. ESMO Open. 2020 Aug;5(4): Authors: Blondeaux E, Ferreira AR, Poggio F, Puglisi F, Bighin C, Sottotetti F, Montemurro F, Poletto E, Lai A, Sini V, Minuti G, Mura S, Fontana A, Fregatti P, Cardinali B, Lambertini M, Del Mastro L Abstract ...
Sat Aug 22, 2020 00:50
Related Articles Alterations in sympathetic and parasympathetic brain networks in obstructive sleep apnea. Sleep Med. 2020 Jun 04;73:135-142 Authors: Lin WC, Hsu TW, Lu CH, Chen HL Abstract OBJECTIVE/BACKGROUND: Obstructive sleep apnea (OSA) patients experience hypoxia and, potentially, autonomic impairments stemming from neural damage. In this study, the executive control networks (ECNs), salience networks (SNs), and default mode networks (DMNs)...
Sun Aug 23, 2020 16:53
Related Articles Cerebrovascular reactivity in young and old patients with obstructive sleep apnea. Sleep Med. 2020 May 11;73:125-129 Authors: Li N, Liu Y, Zhao Y, Wu X, Tong J, Hua Y Abstract OBJECTIVE: Impaired cerebrovascular reactivity (CVR) in patients with obstructive sleep apnea syndrome (OSAS) increases the risk of ischemic stroke. CVR also decreases with age in normal individuals. However, it is unclear whether OSAS affects CVR differently...
Sun Aug 23, 2020 16:53
Related Articles Enhanced Recovery and Surgical Optimization Protocol for Minimally Invasive Gynecologic Surgery: An AAGL White Paper. J Minim Invasive Gynecol. 2020 Aug 19;: Authors: Stone R, Carey E, Fader AN, Fitzgerald J, Hammons L, Nensi A, Park AJ, Ricci S, Rosenfield R, Scheib S, Weston E Abstract This is the first Enhanced Recovery After Surgery (ERAS) guideline dedicated to standardizing and optimizing perioperative care for women undergoing...
Sun Aug 23, 2020 16:53
Related Articles Effects of nasal high flow on sympathovagal balance, sleep, and sleep-related breathing in patients with precapillary pulmonary hypertension. Sleep Breath. 2020 Aug 22;: Authors: Spiesshoefer J, Bannwitz B, Mohr M, Herkenrath S, Randerath W, Sciarrone P, Thiedemann C, Schneider H, Braun AT, Emdin M, Passino C, Dreher M, Boentert M, Giannoni A Abstract BACKGROUND: In precapillary pulmonary hypertension (PH), nasal high flow therapy...
Sun Aug 23, 2020 14:06
Related Articles Sleep Outcomes in Neonates with Pierre robin sequence Undergoing External Mandibular Distraction: A Longitudinal Analysis. Plast Reconstr Surg. 2020 Aug 19;: Authors: Ehsan Z, Weaver KN, Pan BS, Huang G, Hossain MM, Simakajornboon N Abstract BACKGROUND: Pierre robin sequence (PRS) is a common cause of upper airway obstruction in newborns. Airway obstruction is often worse during sleep, leading to severe obstructive sleep apnea...
Sun Aug 23, 2020 14:06
Related Articles G-Protein-Coupled Receptor (GPCR) Signaling in the Carotid Body: Roles in Hypoxia and Cardiovascular and Respiratory Disease. Int J Mol Sci. 2020 Aug 20;21(17): Authors: Aldossary HS, Alzahrani AA, Nathanael D, Alhuthail EA, Ray CJ, Batis N, Kumar P, Coney AM, Holmes AP Abstract The carotid body (CB) is an important organ located at the carotid bifurcation that constantly monitors the blood supplying the brain. During hypoxia,...
Sun Aug 23, 2020 14:06
Related Articles Comparison of Findings between Clinical Examinations and Drug-Induced Sleep Endoscopy in Patients with Obstructive Sleep Apnea Syndrome. Int J Environ Res Public Health. 2020 Aug 19;17(17): Authors: Lin HY, Lin YC, Hsu YS, Shih LC, Nelson T, Chang WD, Tsou YA Abstract The Velum, Oropharynx, Tongue base and Epiglottis (VOTE) classification on drug-induced sleep endoscopy (DISE) is used widely for obstructive sleep apnea (OSA)...
Sun Aug 23, 2020 14:06
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