Related Articles The combination of histone deacetylase inhibitors and radiotherapy: a promising novel approach for cancer treatment. Future Oncol. 2020 Aug 20;: Authors: Shirbhate E, Patel P, Patel VK, Veerasamy R, Sharma PC, Rajak H Abstract HDAC inhibitors (HDACi) play an essential role in various cellular processes, such as differentiation and transcriptional regulation of key genes and cytostatic factors, cell cycle arrest and apoptosis...
Fri Aug 21, 2020 21:51
Related Articles A novel naphthalimide that selectively targets breast cancer via the arylhydrocarbon receptor pathway. Sci Rep. 2020 Aug 19;10(1):13978 Authors: Gilbert J, De Iuliis GN, McCluskey A, Sakoff JA Abstract We report that the naphthalimide analogue 2-(2-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (NAP-6) is a highly potent and selective breast cancer targeting molecule. These effects are mediated via the aryl hydrocarbon...
Fri Aug 21, 2020 21:51
Related Articles Antibiotic-induced epileptic seizures: mechanisms of action and clinical considerations. Seizure. 2020 Aug 14;81:167-174 Authors: Wanleenuwat P, Suntharampillai N, Iwanowski P Abstract In recent years, there has been growing interest in the development of epileptic seizures as an adverse effect of antibiotic therapy. The most commonly accepted mechanisms underlying the development of antibiotic-induced seizures include direct-...
Sun Aug 23, 2020 14:49
Related Articles Completion corpus callosotomy with stereotactic radiosurgery for drug-resistant, intractable epilepsy: Case report. World Neurosurg. 2020 Aug 19;: Authors: Sachdev S, Sita TL, Shlobin NA, Gopalakrishnan M, Sucholeiki R, Régis J, Bandt SK Abstract BACKGROUND: Stereotactic radiosurgery offers a noninvasive technique for division of the corpus callosum which can confer improved seizure control to patients suffering from frequent...
Sun Aug 23, 2020 14:49
Related Articles Temporal lobe epilepsy surgical outcomes can be inferred based on structural connectome hubs: a machine learning study. Ann Neurol. 2020 Aug 22;: Authors: Gleichgerrcht E, Keller SS, Drane DL, Munsell BC, Davis KA, Kaestner E, Weber B, Krantz S, Vandergrift WA, Edwards JC, McDonald CR, Kuzniecky R, Bonilha L Abstract OBJECTIVE: Medial temporal lobe epilepsy (TLE) is the most common form of medication-resistant focal epilepsy...
Sun Aug 23, 2020 14:49
Related Articles Commentary and Update on the Contribution of the GABA Hypothesis to Understanding the Mechanism of Action of Electroconvulsive Therapy. J ECT. 2020 Aug 18;: Authors: Seymour J Abstract Recent reviews of the literature suggest that one singular theory of the mechanism of action of electroconvulsive therapy (ECT) is unlikely to now emerge and suggest integrating competing hypotheses, for example the anticonvulsant and neuroplasticity...
Sun Aug 23, 2020 14:49
Related Articles Thalamic stimulation improves postictal cortical arousal and behavior. J Neurosci. 2020 Aug 21;: Authors: Xu J, Galardi MM, Pok B, Patel KK, Zhao CW, Andrews JP, Singla S, McCafferty CP, Feng L, Musonza ET, Kundishora AJ, Gummadavelli A, Gerrard JL, Laubach M, Schiff ND, Blumenfeld H Abstract Objective: The postictal state following seizures is characterized by impaired consciousness and has a major negative impact on individuals...
Sun Aug 23, 2020 14:49
Related Articles Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice. Mol Brain. 2020 Aug 21;13(1):114 Authors: Almeida Silva LF, Reschke CR, Nguyen NT, Langa E, Sanz-Rodriguez A, Gerbatin RR, Temp FR, de Freitas ML, Conroy RM, Brennan GP, Engel T, Henshall DC Abstract MicroRNAs perform important roles in the post-transcriptional regulation of gene expression....
Sun Aug 23, 2020 14:49
Related Articles Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies. Brain Sci. 2020 Aug 20;10(9): Authors: Fusar-Poli L, Cavone V, Tinacci S, Concas I, Petralia A, Signorelli MS, Díaz-Caneja CM, Aguglia E Abstract The etiopathogenesis of autism spectrum disorder (ASD) remains largely unclear. Among other biological hypotheses, researchers have evidenced an imbalance in the endocannabinoid (eCB) system, which...
Sun Aug 23, 2020 14:49
Related Articles Electroencephalographic Abnormalities in Autism Spectrum Disorder: Characteristics and Therapeutic Implications. Medicina (Kaunas). 2020 Aug 19;56(9): Authors: Precenzano F, Parisi L, Lanzara V, Vetri L, Operto FF, Pastorino GMG, Ruberto M, Messina G, Risoleo MC, Santoro C, Bitetti I, Marotta R Abstract A large body of literature reports the higher prevalence of epilepsy in subjects with Autism Spectrum Disorder (ASD) compared...
Sun Aug 23, 2020 14:49
Distinguishing patients with idiopathic epilepsy from solitary cysticercus granuloma epilepsy and biochemical phenotype assessment using a serum biomolecule profiling platform. PLoS One. 2020;15(8):e0237064 Authors: Hanas JS, Hocker JRS, Evangeline B, Prabhakaran V, Oommen A, Rajshekhar V, Drevets DA, Carabin H Abstract A major source of epilepsy is Neurocysticercosis (NCC), caused by Taenia solium infection. Solitary cysticercus granuloma...
Sat Aug 22, 2020 13:24
Enantiomeric N-substituted phthalimides with excitatory amino acids protect zebrafish larvae against PTZ-induced seizures. Eur J Pharmacol. 2020 Aug 18;:173489 Authors: Campos-Rodriguez C, Fredrick E, Juan ER, Olsson R Abstract Epilepsy is a chronic neurological disease with high prevalence and adverse impacts on the quality of life of patients and caregivers. Up to one-third of individuals with epilepsy do not respond to current pharmacotherapy,...
Sat Aug 22, 2020 13:24
Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. Lancet Neurol. 2020 Sep;19(9):748-757 Authors: Lamberink HJ, Otte WM, Blümcke I, Braun KPJ, European Epilepsy Brain Bank writing group, study group, European Reference Network EpiCARE Abstract BACKGROUND: Surgery is a widely accepted treatment option for drug-resistant focal epilepsy. A detailed...
Sat Aug 22, 2020 13:24
Related Articles Treatment of Refractory Convulsive Status Epilepticus: A Comprehensive Review by the American Epilepsy Society Treatments Committee. Epilepsy Curr. 2020 Aug 21;:1535759720928269 Authors: Vossler DG, Bainbridge JL, Boggs JG, Novotny EJ, Loddenkemper T, Faught E, Amengual-Gual M, Fischer SN, Gloss DS, Olson DM, Towne AR, Naritoku D, Welty TE Abstract PURPOSE: Established tonic-clonic status epilepticus (SE) does not stop in one-third...
Sat Aug 22, 2020 13:24
Related Articles Temporal choroidal fissure cyst: a rare cause of temporal lobe epilepsy. Pan Afr Med J. 2020;36:120 Authors: Achour A, Mnari W, Miladi A, Hmida B, Maatouk M, Golli M, Zrig A Abstract Only a few cases of temporal choroidal fissure cyst are reported. We describe a new case of an 8 years old girl who manifested complex partial seizure. The diagnosis was made by magnetic resonance imagining (MRI). The signal intensity of the cyst...
Sat Aug 22, 2020 13:24
Related Articles Phyllathin From Phyllanthus Amarus Ameliorates Epileptic Convulsion and Kindling Associated Post-Ictal Depression in Mice via Inhibition of NF-κB/TLR-4 Pathway. Dose Response. 2020 Jul-Sep;18(3):1559325820946914 Authors: Tao Z, Chun-Yan H, Hua P, Bin-Bin Y, Xiaoping T Abstract Background: Epilepsy is a chronic, complex, unprovoked, and recurrent disorder of the nervous system that affected several people worldwide. Phyllanthus...
Sat Aug 22, 2020 13:24
Related Articles Meta-analysis of drug efficacy in adult vs pediatric trials of patients with PGTC seizures. Neurology. 2020 04 28;94(17):e1845-e1852 Authors: Nordli DR, Bagiella E, Arzimanoglou A, Wang J, Kumar D, Laurenza A, French J Abstract OBJECTIVE: A meta-analysis of published studies was performed to determine whether the efficacy of antiseizure drugs in adults with primary generalized tonic-clonic seizures (PGTCS) is comparable with...
Sat Aug 22, 2020 13:24
Related Articles Novel CCM1 (KRIT1) Mutation Detection in Brazilian Familial Cerebral Cavernous Malformation: Different Genetic Variants in Inflammation, Oxidative Stress, and Drug Metabolism Genes Affect Disease Aggressiveness. World Neurosurg. 2020 06;138:535-540.e8 Authors: Fontes-Dantas FL, da Fontoura Galvão G, Veloso da Silva E, Alves-Leon S, Cecília da Silva Rêgo C, Garcia DG, Marques SA, Blanco Martinez AM, Reis da Silva M, Marcondes de Souza J ...
Sat Aug 22, 2020 13:24
Related Articles The effect of fornix deep brain stimulation in brain diseases. Cell Mol Life Sci. 2020 Sep;77(17):3279-3291 Authors: Liu H, Temel Y, Boonstra J, Hescham S Abstract Deep brain stimulation is used to alleviate symptoms of neurological and psychiatric disorders including Parkinson's disease, epilepsy, and obsessive-compulsive-disorder. Electrically stimulating limbic structures has been of great interest, and in particular, the...
Sat Aug 22, 2020 13:24
Related Articles Encephalopathy in a patient with loiasis treated with albendazole: A case report. Parasitol Int. 2020 Apr;75:102006 Authors: Volpicelli L, De Angelis M, Morano A, Biliotti E, Franchi C, Gabrielli S, Mattiucci S, Di Bonaventura C, Taliani G Abstract BACKGROUND: Loiasis is a vector-borne parasitic infection endemic across many areas of Central and West Africa. Its treatment is tricky due to the risk of serious neurologic adverse...
Sat Aug 22, 2020 13:24
Related Articles 5-Aminolevulinic Acid-Induced Fluorescence in Focal Cortical Dysplasia: Report of 3 Cases. Oper Neurosurg (Hagerstown). 2019 04 01;16(4):403-414 Authors: Roberts DW, Bravo JJ, Olson JD, Hickey WF, Harris BT, Nguyen LN, Hong J, Evans LT, Fan X, Wirth D, Wilson BC, Paulsen KD Abstract BACKGROUND: Three patients enrolled in a clinical trial of 5-aminolevulinic-acid (5-ALA)-induced fluorescence-guidance, which has been demonstrated...
Sat Aug 22, 2020 13:24
Related Articles Efficacy and safety of adjunctive lacosamide in the treatment of primary generalised tonic-clonic seizures: a double-blind, randomised, placebo-controlled trial. J Neurol Neurosurg Psychiatry. 2020 Aug 18;: Authors: Vossler DG, Knake S, O'Brien TJ, Watanabe M, Brock M, Steiniger-Brach B, Williams P, Roebling R, SP0982 trial investigators Abstract OBJECTIVE: To evaluate efficacy and safety of lacosamide (up to 12 mg/kg/day or...
Fri Aug 21, 2020 21:29
Related Articles Sex Differences in the Epilepsies and Associated Comorbidities: Implications for Use and Development of Pharmacotherapies. Pharmacol Rev. 2020 Oct;72(4):767-800 Authors: Christian CA, Reddy DS, Maguire J, Forcelli PA Abstract The epilepsies are common neurologic disorders characterized by spontaneous recurrent seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many cases, by associated comorbidities...
Fri Aug 21, 2020 21:29
Related Articles Patterns and prognostic markers for treatment response in generalized epilepsies. Neurology. 2020 Aug 14;: Authors: Gesche J, Hjalgrim H, Rubboli G, Beier CP Abstract OBJECTIVE: To determine pattern of treatment response in patients with idiopathic generalized epilepsy (IGE) and whether routinely assessed clinical and neurophysiological parameters allow predicting response to lamotrigine, levetiracetam or valproic acid. ...
Fri Aug 21, 2020 21:29
Related Articles Neuroimaging Advances in Deep Brain Stimulation: Review of Indications, Anatomy, and Brain Connectomics. AJNR Am J Neuroradiol. 2020 Aug 13;: Authors: Middlebrooks EH, Domingo RA, Vivas-Buitrago T, Okromelidze L, Tsuboi T, Wong JK, Eisinger RS, Almeida L, Burns MR, Horn A, Uitti RJ, Wharen RE, Holanda VM, Grewal SS Abstract Deep brain stimulation is an established therapy for multiple brain disorders, with rapidly expanding...
Fri Aug 21, 2020 21:29
Related Articles Synthesis, characterization, and biological studies of chalcone derivatives containing Schiff bases: Synthetic derivatives for the treatment of epilepsy and Alzheimer's disease. Arch Pharm (Weinheim). 2020 Aug 20;:e2000202 Authors: Koçyiğit ÜM, Gezegen H, Taslimi P Abstract In this study, first, Schiff base-containing chalcone derivatives were synthesized. The human carbonic anhydrase (hCA) isoenzymes I and II were then purified...
Fri Aug 21, 2020 21:29
Related Articles White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study. Brain. 2020 Aug 20;: Authors: Hatton SN, Huynh KH, Bonilha L, Abela E, Alhusaini S, Altmann A, Alvim MKM, Balachandra AR, Bartolini E, Bender B, Bernasconi N, Bernasconi A, Bernhardt B, Bargallo N, Caldairou B, Caligiuri ME, Carr SJA, Cavalleri GL, Cendes F, Concha L, Davoodi-Bojd E, Desmond PM, Devinsky O, Doherty CP, Domin M, Duncan JS, Focke...
Fri Aug 21, 2020 21:29
Related Articles Efficacy and tolerability of Lacosamide for focal epileptic patients: Study from epilepsy clinic in Makkah. CNS Neurol Disord Drug Targets. 2020 Aug 18;: Authors: Alkhotani A, Abualula H, Almatrafi Y, Ghoniem S, Alkhotani A Abstract BACKGROUND: Lacosamide characterized by a novel dual mode of action in its components, in which it has a func-tionalized amino acid that selectively pro, motes inactivation of voltage-gated sodium...
Fri Aug 21, 2020 21:29
Related Articles A brief review of women reporting seizures. Post Reprod Health. 2019 Dec;25(4):215-216 Authors: Briggs P PMID: 31941378 [PubMed - indexed for MEDLINE]
Fri Aug 21, 2020 21:29
Related Articles [Epilepsy and breastfeeding: from myth to reality]. Rev Neurol. 2019 Jul 16;69(2):68-76 Authors: Cabo-Lopez I, Canneti B, Puy-Nunez A Abstract INTRODUCTION: In clinical practice, it is common to find cases of epileptic women being treated with antiepileptic drugs (AEDs) whom we have to advise on the compatibility of these AEDs with breastfeeding. AIMS: In order to offer correct guidance, we must be well informed about...
Fri Aug 21, 2020 21:29
Related Articles [Frequency, semiology and prognosis of Panayiotopoulos syndrome]. Rev Neurol. 2019 May 01;68(9):369-374 Authors: Ramos-Lizana J, Martinez-Espinosa G, Jimenez-Iniesta E, Aguirre-Rodriguez J Abstract INTRODUCTION: Panayiotopoulos syndrome (PS) is an epileptic syndrome of childhood. Until now only a small number of studies have been published about this syndrome. AIM: To study the frequency, semiology and prognosis of...
Fri Aug 21, 2020 21:29
Related Articles Development of chemotherapeutics for unresectable advanced esophageal cancer. Expert Rev Anticancer Ther. 2020 Aug 21;: Authors: Imazeki H, Kato K Abstract INTRODUCTION: The prognosis of unresectable advanced esophageal squamous cell carcinoma (ESCC) has gradually improved due to efforts for the development of systemic chemotherapy or concurrent chemoradiotherapy. Areas covered: Chemotherapeutic agents such as cytotoxic agents,...
Sat Aug 22, 2020 13:08
Related Articles A multidisciplinary approach to soft-tissue sarcoma of the extremities. Expert Rev Anticancer Ther. 2020 Aug 21;: Authors: Nakayama R, Mori T, Okita Y, Shiraishi Y, Endo M Abstract INTRODUCTION: Soft-tissue sarcoma (STS) denotes a group of rare and highly heterogeneous malignant tumors of mesenchymal origin. Accurate histological diagnosis is critical for selecting appropriate treatment. Complete tumor resection is the primary...
Sat Aug 22, 2020 13:08
Related Articles The potential of PSMA-targeted alpha therapy in the management of prostate cancer. Expert Rev Anticancer Ther. 2020 Aug 21;: Authors: Filippi L, Chiaravalloti A, Schillaci O, Bagni O Abstract INTRODUCTION: Alpha emitters present several advantages for cancer therapy. The radiopharmaceutical 223Ra-dichloride has been recently introduced for the targeted alpha therapy (TAT) of metastastic castration-resistant prostate cancer (mCRPC)....
Sat Aug 22, 2020 13:08
Related Articles The Value of Integrating Fluorescent Imaging and Immunohistochemistry for Future Anatomical Studies in Aesthetic Surgery: Lessons From the Cerebrospinal Fluid (CSF) Circulatory System of Human Nerves and Brain. Aesthet Surg J. 2020 Aug 22;: Authors: Pessa JE, Smith D, Sieber DA, Kenkel JM, Arbique G, Nahai F, Heldermon CD, Scott EW Abstract BACKGROUND: During their work on the CSF circulatory system of human nerves and...
Sun Aug 23, 2020 13:18
Related Articles Insight into the divergent role of TRAIL in non-neoplastic neurological diseases. J Cell Mol Med. 2020 Aug 22;: Authors: Gao S, Fang Y, Tu S, Chen H, Shao A Abstract Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumour necrosis factor (TNF) superfamily which mainly induces apoptosis of tumour cells and transformed cell lines with no systemic toxicity, whereas they share high sequence...
Sun Aug 23, 2020 13:18
Related Articles Anti-PD-1 and Anti-PD-L1 Monoclonal Antibodies in People Living with HIV and Cancer. Curr HIV/AIDS Rep. 2020 Aug 22;: Authors: Lurain K, Ramaswami R, Yarchoan R, Uldrick TS Abstract PURPOSE OF REVIEW: Immune checkpoint inhibitors targeting the programmed cell death-1 (PD-1) pathway are a class of anti-cancer immunotherapy agents changing treatment paradigms of many cancers that occur at higher rates in people living with...
Sun Aug 23, 2020 13:18
Related Articles Chemotherapy decision-making in advanced lung cancer: a prospective qualitative study. BMJ Support Palliat Care. 2020 Aug 21;: Authors: Nelson A, Longo M, Byrne A, Sivell S, Noble S, Lester J, Radley L, Jones D, Sampson C, Anagnostou D Abstract OBJECTIVE: To study how treatment decisions are made alongside the lung cancer clinical pathway. METHODS: A prospective, multicentre, multimethods, five-stage, qualitative...
Sun Aug 23, 2020 13:18
Related Articles An LC-MRM assay for the quantification of metanephrines from dried blood spots for the diagnosis of pheochromocytomas and paragangliomas. Anal Chim Acta. 2020 Sep 01;1128:140-148 Authors: Richard VR, Zahedi RP, Eintracht S, Borchers CH Abstract The quantitation of metanephrine (MN), normetanephrine (NMN), and 3-methoxytyramine (3-MT) - referred to as metanephrines -- by LC-MS/MS is the gold-standard for screening for pheochromocytoma...
Sun Aug 23, 2020 13:18
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