IJMS, Vol. 21, Pages 6054: Oxyresveratrol Inhibits IL-1β-Induced Inflammation via Suppressing AKT and ERK1/2 Activation in Human Microglia, HMC3 International Journal of Molecular Sciences doi: 10.3390/ijms21176054 Authors: Phateep Hankittichai Hua Jane Lou Nitwara Wikan Duncan R. Smith Saranyapin Potikanond Wutigri Nimlamool Oxyresveratrol (OXY), a major phytochemical component derived from several plants, has been proved to have several pharmacological properties. However,...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6051: Insights into the Role of Bioactive Food Ingredients and the Microbiome in Idiopathic Pulmonary Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21176051 Authors: Josep Mercader-Barceló Joan Truyols-Vives Carlos Río Nora López-Safont Ernest Sala-Llinàs Alice Chaplin Idiopathic pulmonary fibrosis (IPF) is a chronic disease mainly associated with aging and, to date, its causes are still largely unknown. It has been shown that...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6052: Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers International Journal of Molecular Sciences doi: 10.3390/ijms21176052 Authors: Rosita Curcio Paola Lunetti Vincenzo Zara Alessandra Ferramosca Federica Marra Giuseppe Fiermonte Anna Rita Cappello Francesco De De Leonardis Loredana Capobianco Vincenza Dolce Mitochondrial carriers are a family of structurally related proteins responsible...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6049: D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms21176049 Authors: Eva Pericuesta Ricardo Laguna-Barraza Priscila Ramos-Ibeas Julia L. Gutierrez-Arroyo Juan A. Navarro Katia Vera Carlos Sanjuan Elena Baixeras Fernando Rodríguez de Fonseca Alfonso Gutierrez-Adan Polycystic...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6050: Identification and Functional Analysis of AopN, an Acidovorax Citrulli Effector that Induces Programmed Cell Death in Plants International Journal of Molecular Sciences doi: 10.3390/ijms21176050 Authors: Xiaoxiao Zhang Mei Zhao Jie Jiang Linlin Yang Yuwen Yang Shanshan Yang Ron Walcott Dewen Qiu Tingchang Zhao Bacterial fruit blotch (BFB), caused by Acidovorax citrulli, seriously affects watermelon and other cucurbit crops, resulting...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6048: EVs and Bioengineering: From Cellular Products to Engineered Nanomachines
IJMS, Vol. 21, Pages 6048: EVs and Bioengineering: From Cellular Products to Engineered Nanomachines International Journal of Molecular Sciences doi: 10.3390/ijms21176048 Authors: Simona Villata Marta Canta Valentina Cauda Extracellular vesicles (EVs) are natural carriers produced by many different cell types that have a plethora of functions and roles that are still under discovery. This review aims to be a compendium on the current advancement in terms of EV modifications and...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6047: Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype International Journal of Molecular Sciences doi: 10.3390/ijms21176047 Authors: Huifangjie Li William C. Knight Pengfei Yang Yingqiu Guo Joel S. Perlmutter John C. Morris Randall J. Bateman Tammie L. S. Benzinger Jinbin Xu We found interactions between dopamine and oxidative damage in the striatum involved in advanced neurodegeneration,...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6046: Emerging Gene-Editing Modalities for Osteoarthritis International Journal of Molecular Sciences doi: 10.3390/ijms21176046 Authors: Alekya S. Tanikella Makenna J. Hardy Stephanie M. Frahs Aidan G. Cormier Kalin D. Gibbons Clare K. Fitzpatrick Julia Thom Oxford Osteoarthritis (OA) is a pathological degenerative condition of the joints that is widely prevalent worldwide, resulting in significant pain, disability, and impaired quality of life....
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6045: The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents International Journal of Molecular Sciences doi: 10.3390/ijms21176045 Authors: Filip Jovanovic Kenneth D. Candido Nebojsa Nick Knezevic Tryptophan (TRP) is an essential, aromatic amino acid catabolized by indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) enzymes into kynurenine. The IDO enzyme is expressed in peripheral...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6033: Identification of Novel Targets of Knee Osteoarthritis Shared by Cartilage and Synovial Tissue International Journal of Molecular Sciences doi: 10.3390/ijms21176033 Authors: Chenshuang Li Zhong Zheng Arthritis is the leading cause of disability among adults, while osteoarthritis (OA) is the most common form of arthritis that results in cartilage loss. However, accumulating evidence suggests that the protective hyaline cartilage should not be the sole focus...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6044: Colonic Mucosal Microbiota and Association of Bacterial Taxa with the Expression of Host Antimicrobial Peptides in Pediatric Ulcerative Colitis International Journal of Molecular Sciences doi: 10.3390/ijms21176044 Authors: Jonna Jalanka Jing Cheng Kaisa Hiippala Jarmo Ritari Jarkko Salojärvi Tarja Ruuska Marko Kalliomäki Reetta Satokari Inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn’s disease (CD), are chronic...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6043: Mitochondrial Dysfunction in Diabetic Cardiomyopathy: The Possible Therapeutic Roles of Phenolic Acids International Journal of Molecular Sciences doi: 10.3390/ijms21176043 Authors: Fatin Farhana Jubaidi Satirah Zainalabidin Vanitha Mariappan Siti Balkis Budin As the powerhouse of the cells, mitochondria play a very important role in ensuring that cells continue to function. Mitochondrial dysfunction is one of the main factors contributing to the development...
Sat Aug 22, 2020 03:00
IJMS, Vol. 21, Pages 6042: Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology International Journal of Molecular Sciences doi: 10.3390/ijms21176042 Authors: Paola Bozzatello Maria Laura De Rosa Paola Rocca Silvio Bellino The usefulness of polyunsaturated fatty acids on inflammatory, cardiovascular, and the nervous system was studied in the last decades, but the mechanisms underlying their benefic properties are still partially unknown. These agents seem to...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6040: Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies International Journal of Molecular Sciences doi: 10.3390/ijms21176040 Authors: Ava Bachari Terrence. J. Piva Seyed Alireza Salami Negar Jamshidi Nitin Mantri Melanoma is the fourth most common type of cancer diagnosed in Australians after breast, prostate, and colorectal cancers. While there has been substantial progress in the treatment of cancer in general, malignant melanoma, in...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6039: There and Back Again: Leptin Actions in White Adipose Tissue International Journal of Molecular Sciences doi: 10.3390/ijms21176039 Authors: Noelia Martínez-Sánchez Leptin is a hormone discovered almost 30 years ago with important implications in metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the amount of fat. The discovery of leptin was a turning point for two principle reasons: on one hand, it generated promising expectations...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6038: Lipopolysaccharide-Linked Enterobacterial Common Antigen (ECALPS) Occurs in Rough Strains of Escherichia coli R1, R2, and R4 International Journal of Molecular Sciences doi: 10.3390/ijms21176038 Authors: Anna Maciejewska Marta Kaszowska Wojciech Jachymek Czeslaw Lugowski Jolanta Lukasiewicz Enterobacterial common antigen (ECA) is a conserved surface antigen characteristic for Enterobacteriaceae. It is consisting of trisaccharide repeating unit,...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6041: Revealing Metabolic Perturbation Following Heavy Methamphetamine Abuse by Human Hair Metabolomics and Network Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21176041 Authors: Suji Kim Won-Jun Jang Hyerim Yu Jihyun Kim Sang-Ki Lee Chul-Ho Jeong Sooyeun Lee Methamphetamine (MA) is a highly addictive central nervous system stimulant. Drug addiction is not a static condition but rather a chronically relapsing disorder. Hair...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6036: Transcriptomic Analysis of Short-Term Salt Stress Response in Watermelon Seedlings International Journal of Molecular Sciences doi: 10.3390/ijms21176036 Authors: Qiushuo Song Madhumita Joshi Vijay Joshi Watermelon (Citrullus lanatus L.) is a widely popular vegetable fruit crop for human consumption. Soil salinity is among the most critical problems for agricultural production, food security, and sustainability. The transcriptomic and the primary molecular...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6035: The Association of dp-ucMGP with Cardiovascular Morbidity and Decreased Renal Function in Diabetic Chronic Kidney Disease International Journal of Molecular Sciences doi: 10.3390/ijms21176035 Authors: Stefanos Roumeliotis Athanasios Roumeliotis Aikaterini Stamou Konstantinos Leivaditis Konstantia Kantartzi Stylianos Panagoutsos Vassilios Liakopoulos We aimed to investigate the possible association of the inactive, dephosphorylated, uncarboxylated...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6037: Anti-Metastatic Activity of an Anti-EGFR Monoclonal Antibody against Metastatic Colorectal Cancer with KRAS p.G13D Mutation International Journal of Molecular Sciences doi: 10.3390/ijms21176037 Authors: Tomokazu Ohishi Yukinari Kato Mika K. Kaneko Shun-ichi Ohba Hiroyuki Inoue Akiko Harakawa Manabu Kawada The now clinically-used anti-epidermal growth factor receptor (EGFR) monoclonal antibodies have demonstrated significant efficacy only in...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6034: Activating Telomerase TERT Promoter Mutations and Their Application for the Detection of Bladder Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21176034 Authors: Zvereva Pisarev Hosen Kisil Matskeplishvili Kubareva Kamalov Tivtikyan Manel Vian Kamalov Ecke Calvez-Kelm This review summarizes state-of-the-art knowledge in early-generation and novel urine biomarkers targeting the telomerase...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6031: Dietary Intake of Rosmarinic Acid Increases Serum Inhibitory Activity in Amyloid A Aggregation and Suppresses Deposition in the Organs of Mice International Journal of Molecular Sciences doi: 10.3390/ijms21176031 Authors: Xuguang Lin Kenichi Watanabe Masahiro Kuragano Yukina Kurotaki Ushio Nakanishi Kiyotaka Tokuraku Serum amyloid A (SAA) is one of the most important precursor amyloid proteins and plays a vital step in AA amyloidosis, although...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6032: Phenolic Metabolites from Barley in Contribution to Phenome in soil Moisture Deficit International Journal of Molecular Sciences doi: 10.3390/ijms21176032 Authors: Anna Piasecka Aneta Sawikowska Anetta Kuczyńska Piotr Ogrodowicz Krzysztof Mikołajczak Paweł Krajewski Piotr Kachlicki Eight barley varieties from Europe and Asia were subjected to moisture deficit at various development stages. At the seedling stage and the flag leaf stage combined...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6030: Adipose Tissue Fibrosis: Mechanisms, Models, and Importance International Journal of Molecular Sciences doi: 10.3390/ijms21176030 Authors: Megan K. DeBari Rosalyn D. Abbott Increases in adipocyte volume and tissue mass due to obesity can result in inflammation, further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like other fibrotic diseases, adipose tissue fibrosis is the accumulation and increased production of extracellular...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6029: Intratumoral Distribution and pH-Dependent Drug Release of High Molecular Weight HPMA Copolymer Drug Conjugates Strongly Depend on Specific Tumor Substructure and Microenvironment International Journal of Molecular Sciences doi: 10.3390/ijms21176029 Authors: Anne-Kathrin Noack Henrike Lucas Petr Chytil Tomáš Etrych Karsten Mäder Thomas Mueller Stimulus-sensitive polymer drug conjugates based on high molecular weight N-(2-hydroxypropyl) methacrylamide...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6028: Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation International Journal of Molecular Sciences doi: 10.3390/ijms21176028 Authors: Thomas Dugé de Bernonville Stéphane Maury Alain Delaunay Christian Daviaud Cristian Chaparro Jörg Tost Sarah Ellen O’Connor Vincent Courdavault Catharanthus roseus produces a wide spectrum of monoterpene...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6027: Tepotinib Inhibits the Epithelial–Mesenchymal Transition and Tumor Growth of Gastric Cancers by Increasing GSK3β, E-Cadherin, and Mucin 5AC and 6 Levels International Journal of Molecular Sciences doi: 10.3390/ijms21176027 Authors: Sung-Hwa Sohn Hee Jung Sul Bohyun Kim Bum Jun Kim Hyeong Su Kim Dae Young Zang Aberrant expression of mucins (MUCs) can promote the epithelial–mesenchymal transition (EMT), which leads to enhanced tumorigenesis....
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6025: Blockade of Hemichannels Normalizes the Differentiation Fate of Myoblasts and Features of Skeletal Muscles from Dysferlin-Deficient Mice International Journal of Molecular Sciences doi: 10.3390/ijms21176025 Authors: Luis A. Cea Gabriela Fernández Guisselle Arias-Bravo Mario Castillo-Ruiz Rosalba Escamilla María C. Brañes Juan C. Sáez Dysferlinopathies are muscle dystrophies caused by mutations in the gene encoding dysferlin, a relevant protein...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6026: Transient Receptor Potential Melastatin 2 (TRPM2) Inhibition by Antioxidant, N-Acetyl-l-Cysteine, Reduces Global Cerebral Ischemia-Induced Neuronal Death International Journal of Molecular Sciences doi: 10.3390/ijms21176026 Authors: Dae Ki Hong A Ra Kho Song Hee Lee Jeong Hyun Jeong Beom Seok Kang Dong Hyeon Kang Min Kyu Park Kyoung-Ha Park Man-Sup Lim Bo Young Choi Sang Won Suh A variety of pathogenic mechanisms, such as cytoplasmic...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6024: Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers International Journal of Molecular Sciences doi: 10.3390/ijms21176024 Authors: Lyna Kara-Terki Lucas Treps Christophe Blanquart Delphine Fradin Extracellular vesicles (EVs), such as exosomes, are critical mediators of intercellular communication between tumor cells and other cells located in the microenvironment but also in more distant sites. Exosomes are small...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6023: Asymmetric Conservation within Pairs of Co-Occurred Motifs Mediates Weak Direct Binding of Transcription Factors in ChIP-Seq Data International Journal of Molecular Sciences doi: 10.3390/ijms21176023 Authors: Victor Levitsky Dmitry Oshchepkov Elena Zemlyanskaya Tatyana Merkulova (1) Background: Transcription factors (TFs) are main regulators of eukaryotic gene expression. The cooperative binding to genomic DNA of at least two TFs is the widespread...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6021: Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity International Journal of Molecular Sciences doi: 10.3390/ijms21176021 Authors: Choong-Hwan Kwak Ling Jin Jung Ho Han Chang Woo Han Eonmi Kim MyoungLae Cho Tae-Wook Chung Sung-Jin Bae Se Bok Jang Ki-Tae Ha In cancer cells, aerobic glycolysis rather than oxidative phosphorylation (OxPhos) is generally preferred for the...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6020: Molecular Biomarkers in Multiple Sclerosis and Its Related Disorders: A Critical Review International Journal of Molecular Sciences doi: 10.3390/ijms21176020 Authors: Maryam Gul Amirhossein Azari Jafari Muffaqam Shah Seyyedmohammadsadeq Mirmoeeni Safee Ullah Haider Sadia Moinuddin Ammar Chaudhry Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS) which can lead to severe disability. Several diseases...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6022: Electronic-Cigarette Vehicles and Flavoring Affect Lung Function and Immune Responses in a Murine Model International Journal of Molecular Sciences doi: 10.3390/ijms21176022 Authors: Brittany N. Szafran Rakeysha Pinkston Zakia Perveen Matthew K. Ross Timothy Morgan Daniel B. Paulsen Arthur L. Penn Barbara L. F. Kaplan Alexandra Noël The use of electronic nicotine delivery systems (ENDS), also known as electronic-cigarettes (e-cigs),...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6019: Remodeling of Kv7.1 and Kv7.5 Expression in Vascular Tumors International Journal of Molecular Sciences doi: 10.3390/ijms21176019 Authors: Clara Serrano-Novillo Anna Oliveras Joan Carles Ferreres Enric Condom Antonio Felipe Voltage-dependent potassium (Kv) channels contribute to the excitability of nerves and muscles. In addition, Kv participates in several cell functions, including cell cycle progression and proliferation. Kv channel remodeling...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6016: Infrapatellar Fat Pad Gene Expression and Protein Production in Patients with and without Osteoarthritis International Journal of Molecular Sciences doi: 10.3390/ijms21176016 Authors: Elisa Belluzzi Veronica Macchi Chiara Giulia Fontanella Emanuele Luigi Carniel Eleonora Olivotto Giuseppe Filardo Gloria Sarasin Andrea Porzionato Marnie Granzotto Assunta Pozzuoli Antonio Berizzi Manuela Scioni Raffaele De Caro Pietro Ruggieri...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6018: Antibody Conjugation of Nanoparticles as Therapeutics for Breast Cancer Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21176018 Authors: Alberto Juan Francisco J. Cimas Iván Bravo Atanasio Pandiella Alberto Ocaña Carlos Alonso-Moreno Breast cancer is the most common invasive tumor in women and the second leading cause of cancer-related death. Nanomedicine raises high expectations for millions of patients as it can provide...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6017: Integrated Analysis of Small RNA, Transcriptome, and Degradome Sequencing Reveals the Water-Deficit and Heat Stress Response Network in Durum Wheat International Journal of Molecular Sciences doi: 10.3390/ijms21176017 Authors: Haipei Liu Amanda J. Able Jason A. Able Water-deficit and heat stress negatively impact crop production. Mechanisms underlying the response of durum wheat to such stresses are not well understood. With the new durum wheat genome...
Fri Aug 21, 2020 03:00
IJMS, Vol. 21, Pages 6015: The Flow of the Redox Energy in Quercetin during Its Antioxidant Activity in Water International Journal of Molecular Sciences doi: 10.3390/ijms21176015 Authors: Zhengwen Li Mohamed Moalin Ming Zhang Lily Vervoort Erik Hursel Alex Mommers Guido R. M. M. Haenen Most studies on the antioxidant activity of flavonoids like Quercetin (Q) do not consider that it comprises a series of sequential reactions. Therefore, the present study examines how...
Fri Aug 21, 2020 03:00
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