Metabolites, Vol. 10, Pages 343: Integrating Two-Dimensional Gas and Liquid Chromatography-Mass Spectrometry for Untargeted Colorectal Cancer Metabolomics: A Proof-of-Principle Study Metabolites doi: 10.3390/metabo10090343 Authors: Fang Yuan Seongho Kim Xinmin Yin Xiang Zhang Ikuko Kato Untargeted metabolomics is expected to lead to a better mechanistic understanding of diseases and thus applications of precision medicine and personalized intervention. To further increase...
Tue Aug 25, 2020 03:00
Metabolites, Vol. 10, Pages 344: Occurrence and Exposure Assessment of Mycotoxins in Ready-to-Eat Tree Nut Products through Ultra-High Performance Liquid Chromatography Coupled with High Resolution Q-Orbitrap Mass Spectrometry Metabolites doi: 10.3390/metabo10090344 Authors: Alfonso Narváez Yelko Rodríguez-Carrasco Luigi Castaldo Luana Izzo Giulia Graziani Alberto Ritieni Tree nuts have become popular snacks due to their attributed benefits in the health state. Nevertheless,...
Tue Aug 25, 2020 03:00
Metabolites, Vol. 10, Pages 342: A Metabolomics Workflow for Analyzing Complex Biological Samples Using a Combined Method of Untargeted and Target-List Based Approaches Metabolites doi: 10.3390/metabo10090342 Authors: Thomas Züllig Martina Zandl-Lang Martin Trötzmüller Jürgen Hartler Barbara Plecko Harald C. Köfeler In the highly dynamic field of metabolomics, we have developed a method for the analysis of hydrophilic metabolites in various biological samples. Therefore,...
Tue Aug 25, 2020 03:00
Microorganisms, Vol. 8, Pages 1297: A Novel Primer Mixture for GH48 Genes: Quantification and Identification of Truly Cellulolytic Bacteria in Biogas Fermenters Microorganisms doi: 10.3390/microorganisms8091297 Authors: Regina Rettenmaier Yat Kei Lo Larissa Schmidt Bernhard Munk Ilias Lagkouvardos Klaus Neuhaus Wolfgang Schwarz Wolfgang Liebl Vladimir Zverlov Genomic studies revealed the glycoside hydrolases of family 48 (GH48) as a powerful marker for the identification...
Tue Aug 25, 2020 03:00
Microorganisms, Vol. 8, Pages 1296: The Growth Promotion of Peppers (Capsicum annuum L.) by Trichoderma guizhouense NJAU4742-Based Biological Organic Fertilizer: Possible Role of Increasing Nutrient Availabilities Microorganisms doi: 10.3390/microorganisms8091296 Authors: Qiumei Liu Xiaohui Meng Tuo Li Waseem Raza Dongyang Liu Qirong Shen Trichoderma spp. is a cosmopolitan group of soil fungi which plays a remarkable role in stimulating plant growth after interacting with...
Tue Aug 25, 2020 03:00
Microorganisms, Vol. 8, Pages 1298: Formation and Maturation of the Phagosome: A Key Mechanism in Innate Immunity against Intracellular Bacterial Infection Microorganisms doi: 10.3390/microorganisms8091298 Authors: Hyo-Ji Lee Yunseo Woo Tae-Wook Hahn Young Mee Jung Yu-Jin Jung Phagocytosis is an essential mechanism in innate immune defense, and in maintaining homeostasis to eliminate apoptotic cells or microbes, such as Mycobacterium tuberculosis, Salmonella enterica, Streptococcus...
Tue Aug 25, 2020 03:00
Microorganisms, Vol. 8, Pages 1299: Tick-Borne Pathogens Shape the Native Microbiome Within Tick Vectors Microorganisms doi: 10.3390/microorganisms8091299 Authors: Abdulsalam Adegoke Deepak Kumar Cailyn Bobo Muhammad Imran Rashid Aneela Zameer Durrani Muhammad Sohail Sajid Shahid Karim Ticks are blood-feeding arthropods and transmit a variety of medically important viral, bacterial, protozoan pathogens to animals and humans. Ticks also harbor a diverse community of...
Tue Aug 25, 2020 03:00
Microorganisms, Vol. 8, Pages 1295: Anti-Biofilm Activity of a Low Weight Proteinaceous Molecule from the Marine Bacterium Pseudoalteromonas sp. IIIA004 against Marine Bacteria and Human Pathogen Biofilms Microorganisms doi: 10.3390/microorganisms8091295 Authors: Ibtissem Doghri Emilie Portier Florie Desriac Jean Michel Zhao Alexis Bazire Alain Dufour Vincent Rochette Sophie Sablé Isabelle Lanneluc Pseudoalteromonas bacteria are known as potential bioactive metabolite...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3879: Ethnopharmacology of Fruit Plants: A Literature Review on the Toxicological, Phytochemical, Cultural Aspects, and a Mechanistic Approach to the Pharmacological Effects of Four Widely Used Species Molecules doi: 10.3390/molecules25173879 Authors: Aline T. de Carvalho Marina M. Paes Mila S. Cunha Gustavo C. Brandão Ana M. Mapeli Vanessa C. Rescia Silvia A. Oesterreich Gustavo R. Villas-Boas Fruit plants have been widely used by the population...
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Molecules, Vol. 25, Pages 3880: Zerumbone-Induced Analgesia Modulated via Potassium Channels and Opioid Receptors in Chronic Constriction Injury-Induced Neuropathic Pain Molecules doi: 10.3390/molecules25173880 Authors: Banulata Gopalsamy Jasmine Siew Min Chia Ahmad Akira Omar Farouk Mohd Roslan Sulaiman Enoch Kumar Perimal Zerumbone, a monocyclic sesquiterpene from the wild ginger plant Zingiber zerumbet (L.) Smith, attenuates allodynia and hyperalgesia. Currently, its mechanisms...
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Molecules, Vol. 25, Pages 3875: Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways Molecules doi: 10.3390/molecules25173875 Authors: Gerardo I. Arredondo-Mendoza Zacarías Jiménez-Salas Francisco Javier Guzmán-de la Garza Elizabeth Solís-Pérez Manuel López-Cabanillas-Lomelí Blanca Edelia González-Martínez Eduardo Campos-Góngora Hypertension (HT) is considered to be a potential risk...
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Molecules, Vol. 25, Pages 3877: In-Vitro and In-Silico Evaluations of Heterocyclic-Containing Diarylpentanoids as Bcl-2 Inhibitors Against LoVo Colorectal Cancer Cells Molecules doi: 10.3390/molecules25173877 Authors: Sze Wei Leong Suet Lin Chia Faridah Abas Khatijah Yusoff In the present study, we investigated the in-vitro anti-cancer potential of six diarylpentanoids against a panel of BRAF- and KRAS-mutated colorectal cancer cell lines including T84, SW620, LoVo, HT29, NCI-H508,...
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Molecules, Vol. 25, Pages 3876: Identification of Potential Chemical Substrates as Fuel for Hypoxic Tumors That May Be Linked to Invadopodium Formation in Hypoxia-Induced MDA-MB-231 Breast-Cancer Cell Line Molecules doi: 10.3390/molecules25173876 Authors: Hamad Ali Hamad Hamid Hammad Enezei Anmar Alrawas Noraina Muhamad Zakuan Nurul Akmaryanti Abdullah Yoke Kqueen Cheah Nur Fariesha Md Hashim Hypoxia plays a significant role in solid tumors by the increased expression...
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Molecules, Vol. 25, Pages 3874: The Inhibitory Effects of Heterotrigona Itama Honey Marinades on the Formation of Carcinogenic Heterocyclic Amines in Grilled Beef Satay Molecules doi: 10.3390/molecules25173874 Authors: Sharina Shamsudin Jinap Selamat Maimunah Sanny Nuzul Noorahya Jambari Rashidah Sukor Sarva Mangala Praveena Alfi Khatib Heterocyclic amines (HCAs) are carcinogenic food toxicants formed in cooked meats, which may increase the risk of cancer development...
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Molecules, Vol. 25, Pages 3878: Biosurfactant Production and Growth Kinetics Studies of the Waste Canola Oil-Degrading Bacterium Rhodococcus erythropolis AQ5-07 from Antarctica Molecules doi: 10.3390/molecules25173878 Authors: Salihu Ibrahim Khalilah Abdul Khalil Khadijah Nabilah Mohd Zahri Claudio Gomez-Fuentes Peter Convey Azham Zulkarnain Suriana Sabri Siti Aisyah Alias Gerardo González-Rocha Siti Aqlima Ahmad With the progressive increase in human activities...
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Molecules, Vol. 25, Pages 3872: Towards Higher Oil Yield and Quality of Essential Oil Extracted from Aquilaria malaccensis Wood via the Subcritical Technique Molecules doi: 10.3390/molecules25173872 Authors: M. Samadi Z. Zainal Abidin H. Yoshida R. Yunus D. R. Awang Biak A method that delivers a high yield and excellent quality of essential oil, which retains most of its value-added compounds, and undergoes least change after the extraction process, is greatly sought after....
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Molecules, Vol. 25, Pages 3873: Spray Drying for the Encapsulation of Oils—A Review Molecules doi: 10.3390/molecules25173873 Authors: Nameer Khairullah Mohammed Chin Ping Tan Yazid Abd Manap Belal J. Muhialdin Anis Shobirin Meor Hussin The application of the spray drying technique in the food industry for the production of a broad range of ingredients has become highly desirable compared to other drying techniques. Recently, the spray drying technique has been applied extensively...
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Molecules, Vol. 25, Pages 3871: Formation and Characterization of β-Lactoglobulin and Gum Arabic Complexes: the Role of pH Molecules doi: 10.3390/molecules25173871 Authors: Ziyuan Wang Jie Liu Jian Gao Mengna Cao Gerui Ren Hunjun Xie Mingfei Yao Protein–polysaccharide complexes have received increasing attention as delivery systems to improve the stability and bioavailability of multiple bioactive compounds. However, deep and comprehensive understanding of...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3870: Biased versus Partial Agonism in the Search for Safer Opioid Analgesics Molecules doi: 10.3390/molecules25173870 Authors: Joaquim Azevedo Neto Anna Costanzini Roberto De Giorgio David G. Lambert Chiara Ruzza Girolamo Calò Opioids such as morphine—acting at the mu opioid receptor—are the mainstay for treatment of moderate to severe pain and have good efficacy in these indications. However, these drugs produce a plethora...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3868: Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives Molecules doi: 10.3390/molecules25173868 Authors: Anna Czopek Anna Partyka Adam Bucki Maciej Pawłowski Marcin Kołaczkowski Agata Siwek Monika Głuch-Lutwin Paulina Koczurkiewicz Elżbieta Pękala Anna Jaromin Bożena Tyliszczak Anna Wesołowska Agnieszka Zagórska In this...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3869: Pu-erh Tea Extract Treatment Could Be an Efficient Way to Enhance the Yield and Nutritional Value of Soybean Sprout Molecules doi: 10.3390/molecules25173869 Authors: Jeong-Ho Kim Yong-Han Yoon Il-Doo Kim Sanjeev Kumar Dhungana Dong-Hyun Shin Soybean sprouts are one of the most inexpensive and nutritious food items that can be easily grown year-round. Several studies have been conducted to increase their yield and nutritional values. This study...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3867: N2O Decomposition over Fe-ZSM-5: A Systematic Study in the Generation of Active Sites Molecules doi: 10.3390/molecules25173867 Authors: Bryan Bromley Chiara Pischetola Linda Nikoshvili Fernando Cárdenas-Lizana Lioubov Kiwi-Minsker We have carried out a systematic investigation of the critical activation parameters (i.e., final temperature (673–1273 K), atmosphere (He vs. O2/He), and final isothermal hold (1 min–15 h) on...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3866: Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity Molecules doi: 10.3390/molecules25173866 Authors: Irina Negut Valentina Grumezescu Alexandru Mihai Grumezescu Alexandra Cătălina Bîrcă Alina Maria Holban Iuliana Urzica Sorin Marius Avramescu Bianca Gălățeanu Ariana Hudiță Plant extracts are highly valuable pharmaceutical complexes recognized for their biological properties, including antibacterial,...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3853: Identifying Active Compounds and Targets of Fritillariae thunbergii against Influenza-Associated Inflammation by Network Pharmacology Analysis and Molecular Docking Molecules doi: 10.3390/molecules25173853 Authors: Minjee Kim Ki Hoon Park Young Bong Kim Complications due to influenza are often associated with inflammation with excessive release of cytokines. The bulbs of Fritillariae thunbergii (FT) have been traditionally used to control airway...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3865: 5′-Nor-3-Deaza-1′,6′-Isoneplanocin, the Synthesis and Antiviral Study Molecules doi: 10.3390/molecules25173865 Authors: Qi Chen Stewart W. Schneller Chong Liu Kathryn L. Jones Tyler Singer The arbocyclic nucleosides aristeromycin and neplanocin have been studied as a source for new antiviral agents. A convenient synthesis of C-5′-truncated 3-deaza-1′,6′-isoneplanocin, which combines the features of antiviral candidates...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3864: A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABAA Receptor Molecules doi: 10.3390/molecules25173864 Authors: Guanguan Li Amanda N. Nieman Md Yeunus Mian Nicolas M. Zahn Brandon N. Mikulsky Michael M. Poe Kashi R. Methuku Yongfeng Liu James M. Cook Douglas C. Stafford Leggy A. Arnold Analgesic and anti-inflammatory properties mediated by the κ...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3863: Microencapsulation of Lactobacillus plantarum NRRL B-1927 with Skim Milk Processed via Ultra-High-Pressure Homogenization Molecules doi: 10.3390/molecules25173863 Authors: Kevin E. Mis Solval George Cavender Nan Jiang Jinru Chen Rakesh Singh Several health benefits are associated with the consumption of probiotic foods. Lyophilized probiotic cultures are commonly used to manufacture probiotic-containing products. Spray drying (SDR) is a cost-effective...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3861: Plant Nitrilase Homologues in Fungi: Phylogenetic and Functional Analysis with Focus on Nitrilases in Trametes versicolor and Agaricus bisporus Molecules doi: 10.3390/molecules25173861 Authors: Lenka Rucká Natalia Kulik Petr Novotný Anastasia Sedova Lucie Petrásková Romana Příhodová Barbora Křístková Petr Halada Miroslav Pátek Ludmila Martínková Fungi contain many plant-nitrilase (NLase) homologues according to database searches....
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3860: Role of GSH and Iron-Sulfur Glutaredoxins in Iron Metabolism—Review Molecules doi: 10.3390/molecules25173860 Authors: Trnka Daniel Hossain Md Faruq Jordt Laura Magdalena Gellert Manuela Lillig Christopher Horst Glutathione (GSH) was initially identified and characterized for its redox properties and later for its contributions to detoxification reactions. Over the past decade, however, the essential contributions of glutathione to cellular...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3858: The Role of Surface Exposed Lysine in Conformational Stability and Functional Properties of Lipase from Staphylococcus Family Molecules doi: 10.3390/molecules25173858 Authors: Nurul Nadirah Ahmad Nor Hafizah Ahmad Kamarudin Adam Thean Chor Leow Raja Noor Zaliha Raja Abd. Rahman Surface charge residues have been recognized as one of the stability determinants in protein. In this study, we sought to compare and analyse the stability and conformational...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3862: Acquisition of Torrefied Biomass from Jerusalem Artichoke Grown in a Closed Circular System Using Biogas Plant Waste Molecules doi: 10.3390/molecules25173862 Authors: Szufa Piersa Adrian Sielski Grzesik Romanowska-Duda Piotrowski Lewandowska The aim of the research was to investigate the effect of biogas plant waste on the physiological activity, growth, and yield of Jerusalem artichoke and the energetic usefulness of the biomass...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3859: Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product Molecules doi: 10.3390/molecules25173859 Authors: Bin Bin Huang Ya Yi Liu Peng Fei Zhu Yi Cheng Jiang Ming-An Ouyang The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials....
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3855: Oxidative Stress Biomarkers and Peripheral Endothelial Dysfunction in Rheumatoid Arthritis: A Monocentric Cross-Sectional Case-Control Study Molecules doi: 10.3390/molecules25173855 Authors: Stefania Bassu Angelo Zinellu Salvatore Sotgia Arduino Aleksander Mangoni Alberto Floris Giuseppina Farina Giuseppe Passiu Ciriaco Carru Gian Luca Erre Previous studies have suggested that oxidative stress may heighten atherosclerotic burden...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3856: Chemical Vapour Deposition of Graphene—Synthesis, Characterisation, and Applications: A Review Molecules doi: 10.3390/molecules25173856 Authors: Maryam Saeed Yousef Alshammari Shereen A. Majeed Eissa Al-Nasrallah Graphene as the 2D material with extraordinary properties has attracted the interest of research communities to master the synthesis of this remarkable material at a large scale without sacrificing the quality. Although Top-Down and Bottom-Up...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3857: FLIm and Raman Spectroscopy for Investigating Biochemical Changes of Bovine Pericardium upon Genipin Cross-Linking Molecules doi: 10.3390/molecules25173857 Authors: Tanveer Ahmed Shaik Alba Alfonso-Garcia Martin Richter Florian Korinth Christoph Krafft Laura Marcu Jürgen Popp Biomaterials used in tissue engineering and regenerative medicine applications benefit from longitudinal monitoring in a non-destructive manner. Label-free imaging...
Tue Aug 25, 2020 03:00
Molecules, Vol. 25, Pages 3854: Evaluation of Met-Val-Lys as a Renal Brush Border Enzyme-Cleavable Linker to Reduce Kidney Uptake of 68Ga-Labeled DOTA-Conjugated Peptides and Peptidomimetics Molecules doi: 10.3390/molecules25173854 Authors: Shreya Bendre Zhengxing Zhang Hsiou-Ting Kuo Julie Rousseau Chengcheng Zhang Helen Merkens Áron Roxin François Bénard Kuo-Shyan Lin High kidney uptake is a common feature of peptide-based radiopharmaceuticals, leading to reduced...
Tue Aug 25, 2020 03:00
Nanomaterials, Vol. 10, Pages 1668: Improved Removal Capacity and Equilibrium Time of Maghemite Nanoparticles Growth in Zeolite Type 5A for Pb(II) Adsorption Nanomaterials doi: 10.3390/nano10091668 Authors: Juan A. Ramos-Guivar Katterine Taipe Miguel Angelo Schettino Eloi Silva Marco Antonio Morales Torres Edson Caetano Passamani Fred Jochen Litterst Novel magnetic zeolite type 5A nanocomposites were synthesized by the co-precipitation method and applied to lead removal...
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Nanomaterials, Vol. 10, Pages 1667: Manipulation and Applications of Hotspots in Nanostructured Surfaces and Thin Films Nanomaterials doi: 10.3390/nano10091667 Authors: Xiaoyu Zhao Jiahong Wen Aonan Zhu Mingyu Cheng Qi Zhu Xiaolong Zhang Yaxin Wang Yongjun Zhang The synthesis of nanostructured surfaces and thin films has potential applications in the field of plasmonics, including plasmon sensors, plasmon-enhanced molecular spectroscopy (PEMS), plasmon-mediated chemical...
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Nanomaterials, Vol. 10, Pages 1666: Heterostructure Composites of CoS Nanoparticles Decorated on Ti3C2Tx Nanosheets and Their Enhanced Electromagnetic Wave Absorption Performance Nanomaterials doi: 10.3390/nano10091666 Authors: Hui Liu Ling Li Guangzhen Cui Xinxin Wang Zhi Zhang Xuliang Lv As a typical two-dimensional material, MXene possesses excellent conductivity and tunable interlayer space, which makes it have an impressive development potential in the field of electromagnetic...
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