New Findings What is the central question of this study? Is neuromuscular fatigability interrelated between different muscle groups from the same individual during isometric all‐out exercise? What is the main finding and its importance? Although the average decrease can vary between muscles, an individual demonstrates interrelated fatigability etiology regardless of the muscle group tested. The inter‐individual variability provides evidence of different profiles common between muscles...
Fri Aug 21, 2020 18:54
New Findings What is the central question of this study? Does achieving energy balance mainly with ingested fat in a ‘sleep‐low’ model of training with low muscle glycogen affect the early training adaptive response during recovery? What is the main finding and its importance? Replenishing the energy expended during exercise mainly from ingested fat to achieve energy balance in a ‘sleep‐low’ model does not enhance the response of skeletal muscle markers of early adaptation to training and impairs...
Fri Aug 21, 2020 14:25
New Findings What is the central question of this study? β‐adrenergic receptor activation modulates cutaneous vasodilatation and sweating in young adults. In this study, we assessed if age‐related differences in β‐adrenergic regulation of these responses exist and if they differ between men and women. What is the main finding and its importance? We showed that ageing augmented β‐adrenergic cutaneous vasodilatation, albeit the pattern of response differed between men and women. Ageing...
Thu Aug 20, 2020 20:40
New Findings What is the central question of this study? MiR‐92b‐3p was reduced in a rat model of middle cerebral artery occlusion, however, the functions of miR‐92b‐3p in oxygen and glucose deprivation/reperfusion (OGD/R) remains unclear. What is the main finding and its importance? This study determined that miR‐92b‐3p abated apoptosis, mitochondrial dysfunction, and inflammation caused by OGD/R via targeting TRAF3, suggesting that miR‐92b‐3p may serve as a potential therapeutic...
Thu Aug 20, 2020 20:40
New Findings What is the central question of this study? Does dietary nitrate supplementation with beetroot juice attenuate thermoregulatory and cardiovascular strain in older adults during severe heat stress? What is the main finding and its importance? A 7‐day nitrate supplementation regimen lowered resting mean arterial pressure in thermoneutral conditions. During heat stress, core and mean skin temperatures, vasodilatory responses, sweat loss, heart rate, and left ventricular...
Thu Aug 20, 2020 17:06
Abstract NETosis is a type of regulated cell death dependent on the formation of neutrophil extracellular traps (NET), where net-like structures of decondensed chromatin and proteases are produced by polymorphonuclear (PMN) granulocytes. These structures immobilise pathogens and restrict them with antimicrobial molecules, thus preventing their spread. Whilst NETs possess a fundamental anti-microbial function within the innate immune...
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Abstract Chronic prostatitis/chronic pelvic pain syndromes (CP/CPPS) is a clinical tricky problem due to its enigmatic etiology, low cure rate, and high recurrence rate. The research on its pathogenesis has never stopped. In this experimental autoimmune prostatitis (EAP) model, male C57BL/6 mice were subcutaneously immunized with prostate extracts in an adequate adjuvant. For mice in the antibody intervention group, anti-T2 polyclonal antibodies were intraperitoneally injected...
Sat Aug 22, 2020 03:00
Key points Proprioceptive sensory information from the ankle joint is critical for the control of upright posture and balance We examined the influence of age (n = 54 healthy adults, 20–82 yrs old) on lower limb muscle responses to proprioceptive perturbations evoked by Achilles tendon vibration during standing The frequency bandwidth of the muscle response became narrower, and the gain (the muscle response relative to the stimulus) and scaling (increases in response amplitude with increases...
Fri Aug 21, 2020 18:35
Abstract Sarcomeric gene mutations are associated with the development of hypertrophic cardiomyopathy (HCM). Current drug therapeutics for HCM patients are effective in relieving symptoms, but do not prevent or reverse disease progression. Moreover, due to heterogeneity in the clinical manifestations of the disease, patients experience variable outcomes in response to therapeutics. Mechanistically, alterations in calcium handling, sarcomeric disorganisation, energy metabolism and contractility participate...
Fri Aug 21, 2020 18:34
Key points Parkinson's disease (PD) is associated with respiratory dysfunction. The 6‐OHDA rat model exhibited a reduction in respiratory frequency and minute ventilation during normoxia and hypercapnia stimulus. Respiratory dysfunction is caused by neuronal death of medullary respiratory nuclei in the 6‐OHDA model of PD. Oxidative stress can be considered a strong candidate for neurodegeneration via miR‐34c downregulation and pro‐apoptotic signalling in respiratory neurons preceding the functional...
Fri Aug 21, 2020 12:41
Key points Skeletal muscle relaxation has been primarily studied by assessing the kinetics of force decay. Little is known about the resultant dynamics of structural changes in myosin heads during relaxation. The naturally occurring nucleotide 2‐deoxy‐ATP (dATP) is a myosin activator that enhances cross‐bridge binding and kinetics. X‐ray diffraction data indicates that with elevated dATP myosin heads were extended closer to actin in relaxed muscle and myosin heads return to an ordered, resting...
Thu Aug 20, 2020 20:41
Key points Maximum fascicle shortening/rotation was significantly decreased in paretic medial gastrocnemius (MG) muscles compared to non‐paretic MG muscles. Fascicle gear ratio on both sides decreased as the ankle became dorsiflexed, but the slope of fascicle gear ratio over ankle joint angle was significantly lower on the paretic side. There was a strong correlation between side‐to‐side slope difference and the relative maximum joint torque or the relative shear wave speed, suggesting that...
Thu Aug 20, 2020 20:3rk above section as reaNo more articles here.
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