Background and Objective. Musculoskeletal ultrasound imaging can play a role as an accurate tool in offering an accurate diagnosis of shoulder pain. However, it is still not commonly used in mainland China. The aim of this study was to explore the epidemiology and ultrasound imaging characteristics of shoulder pain patients in south China and hoping to use these data in the future development of artificial intelligent ultrasound interpretation of shoulder pathology. Methods. Patients with shoulder...
Tue Aug 25, 2020 19:05
Background. The purpose of this study was to establish the finite element analysis (FEA) model of acetabular bone defect in Crowe type II or III developmental dysplasia of the hip (DDH), which could evaluate the stability of the acetabular cup with different types of bone defects, different diameters of femoral ceramic heads, and the use of screws and analyze the stress distribution of screws. Methods. The FEA model was based on the CT scan of a female patient without any acetabular bone defect....
Tue Aug 25, 2020 18:50
Our previous research suggests that 3-deoxyglucosone (3DG), formed in the caramelization course and Maillard reactions in food, is an independent factor for the development of prediabetes. Since the relationship between type 2 diabetes (T2D) and intestinal microbiota is moving from correlation to causality, we investigated the alterations in the composition and function of the intestinal microbiota in 3DG-induced prediabetic rats. Rats were given 50 mg/kg 3DG by intragastric administration for two...
Tue Aug 25, 2020 17:50
The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks
Ionising radiation- (IR-) induced DNA double-strand breaks (DSBs) are considered to be the deleterious DNA lesions that pose a serious threat to genomic stability. The major DNA repair pathways, including classical nonhomologous end joining, homologous recombination, single-strand annealing, and alternative end joining, play critical roles in countering and eliciting IR-induced DSBs to ensure genome integrity. If the IR-induced DNA DSBs are not repaired correctly, the residual or incorrectly repaired...
Tue Aug 25, 2020 17:50
Background. Cancer remains a major clinical challenge because of the lack of effective drug for its treatment. To find out novel cancer chemotherapeutic molecules, we explored the anticancer effect of novel imidazopyridine compound 9i and also investigated the underlying molecular mechanism. Methods. Human cervical cancer cell (HeLa) viability was measured by an MTT assay after treatment with compound 9i. Clonogenicity of HeLa cells was investigated by an in vitro colony formation assay. Cell death...
Tue Aug 25, 2020 17:20
Aim. To investigate the different effects on osteolysis between commercial pure Ti particles and TiAl6V4 particles obtained from prosthesis of patients with aseptic loosening. Method. Scanning electron microscope, energy dispersive X-ray spectrometry, and X-ray diffraction were used for the size test, chemical composition test, and phase analysis of two kinds of Ti particles. Microcomputed tomography (micro-CT) and 3-dimensional reconstruction analysis were applied to analyze the bone loss quantitatively...
Tue Aug 25, 2020 17:05
Purpose. To evaluate the expression of tripartite motif-containing 33 (TRIM33) in ccRCC tissues and explore the biological effect of TRIM33 on the progress of ccRCC. Method. The Cancer Genome Atlas (TCGA) database was used to examine the mRNA expression levels of TRIM33 in ccRCC tissues and its clinical relevance. Immunohistochemistry (IHC) was performed to evaluate its expression in ccRCC tissues obtained from our hospital. The correlation between TRIM33 expression and clinicopathological features...
Tue Aug 25, 2020 11:35
In the present study, we investigated the genetic polymorphisms of 39 ancestry informative marker-insertion/deletion (AIM-InDel) loci in the Chinese Hui group using a previously self-developed panel, further clarified the genetic relationships between the Hui group and other reference populations, and assessed the ancestry inference efficiency of the AIM-InDel panel based on the worldwide population data from 1000 Genomes Phase 3. The results of the locus-specific informativeness () and pairwise...
Tue Aug 25, 2020 11:35
Background. Living donor liver transplantation (LDLT) provides an alternative to deceased donor liver transplantation (DDLT) for patients with end-stage liver disease in the circumstance of scarcity of deceased grafts. However, the outcomes of LDLT remain controversial. Method. A systematic review and meta-analysis were performed to compare the outcomes of LDLT with DDLT. Twelve outcomes were assessed. Results. Thirty-nine studies involving 38563 patients were included. LDLT was comparable in red...
Tue Aug 25, 2020 11:20
Plant-based products have expanded to include cancer immunotherapy, which has made great strides over recent years. Plants are considered inexpensive and facile production platforms for recombinant monoclonal antibody (mAb) due to the latest advancements and diversification of transgenic techniques. Current human biologics, including those based on mAbs produced by fermentation technologies using primarily mammalian cell cultures, have been replaced by plant-produced mAbs, which are cost effective,...
Tue Aug 25, 2020 11:05
This study deals with α-glucosidase and β-secretase inhibitory screening of extract/fractions and isolated daturaolone (1), namely, 3-oxo-6-β-hydroxy-β-amyrin (daturaolone) from chloroform fraction of Datura metel L. Among entire fractions, the chloroform soluble fraction showed excellent activity against α-glucosidase with % inhibition 90.8 with IC50 μg and daturaolone (1) with 98.7% inhibition with IC50 μM, respectively. Similarly, extract and daturaolone (1) also exhibited significant activity...
Tue Aug 25, 2020 10:05
We explored the difference in expression of tubulin alpha 1b (TUBA1B) between Wilms’ tumor (WT) and normal tissues (NT) from in-house patients and databases, to determine TUBA1B expression in WT and the predictive pathways of coexpressed genes. In-house RNA-sequencing data were performed with WT and NT from three patients from our institute. Other four RNA-sequencing and microarray data were also downloaded from multiple public databases. The TUBA1B expression between WT and NT was analyzed by Student’s...
Tue Aug 25, 2020 09:50
Ulcerative colitis (UC) is one of the inflammatory bowel diseases (IBD) characterized by occurrence in the rectum and sigmoid colon of young adults. However, the functional roles of transcription factors (TFs) and their regulating target genes and pathways are not fully known in ulcerative colitis (UC). In this study, we collected gene expression data to identify differentially expressed TFs (DETFs). We found that differentially expressed genes (DEGs) were significantly enriched in the target genes...
Tue Aug 25, 2020 09:50
The molecular mechanism of osteosarcoma (OS) based on protein-coding genes has largely been studied in the past decades. However, much remains to be explored when it comes to the role that long noncoding RNAs (lncRNAs) play in the pathogenesis and progression of OS and how they are associated with OS metastasis. In the present study, we collected RNA-seq-based gene expression data of 82 OS samples from the Therapeutically Applicable Research To Generate Effective Treatments (TARGET) database, along...
Tue Aug 25, 2020 09:50
Background. The alarming spread of parasite resistance to current antimalarial agents is threatening malaria controlling efforts. This, consequently, urged the scientific community to discover novel antimalarial drugs. Successful and most potent antimalarial drugs were obtained from medicinal plants. Capsicum frutescens is claimed to possess an antiplasmodial activity in Ethiopian and Ugandan folkloric medicine. However, there is a lack of pharmacological evidence for its antiplasmodial activity....
Tue Aug 25, 2020 09:35
Detecting SNP-SNP interactions associated with disease is significant in genome-wide association study (GWAS). Owing to intensive computational burden and diversity of disease models, existing methods have drawbacks on low detection power and long running time. To tackle these drawbacks, a fast self-adaptive memetic algorithm (SAMA) is proposed in this paper. In this method, the crossover, mutation, and selection of standard memetic algorithm are improved to make SAMA adapt to the detection of SNP-SNP...
Tue Aug 25, 2020 07:35
Exposure to dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is reported to affect the autoimmune system and increase the risk of autoimmune disease. Generally, dioxin exerts its toxicity via aryl hydrocarbon receptor (AhR). Primary biliary cholangitis (PBC) is a chronic autoimmune disease, and its pathogenesis involves the interplay between immune and environmental factors. This study showed the effect of dendritic cells (DCs) activated by TCDD on naïve CD4+ T cell differentiation in...
Tue Aug 25, 2020 07:35
Cognitive scientists have paid very little attention to magic as a distinctly human activity capable of creating situations that are considered impossible because they violate expectations and conclude with the apparent transgression of well-established cognitive and natural laws. This illusory experience of the “impossible” entails a very particular cognitive dissonance that is followed by a subjective and complex “magical experience”. Here, from a perspective inspired by visual neuroscience and...
Tue Aug 25, 2020 03:00
Background Risk communication is widely accepted as a significant factor for policy makers, academic researchers, and practitioners in diverse fields. However, there remains a lack of comprehensive knowledge about how risk communication is currently conducted across fields and about the way risk communication is evaluated. Methodology This study systematically searched for materials from three scholarly search engines...
Tue Aug 25, 2020 03:00
Background The reproductive pattern of most scale insects is ovoviviparity. The solanum mealybug, Phenacoccus solani (Hemiptera: Pseudococcidae), is known as a thelytokous parthenogenetic species, but there is still debate about the reproductive strategies of this species. Methods Here, we investigated the oviposition characteristics of P. solani and used scanning/transmission electron microscopy and RNA-seq to identify...
Tue Aug 25, 2020 03:00
Background One reason for the development of insulin resistance is the chronic inflammation in obesity. Materials & Methods Scientific articles in the field of knowledge on the involvement of mitochondria and mitochondrial DNA (mtDNA) in obesity and type 2 diabetes were analyzed. Results Oxidative stress developed during obesity contributes to the formation...
Tue Aug 25, 2020 03:00
Marine reserves are an essential component of modern fishery management. Marine reserves, which represent a management tradeoff between harvesting and conservation, are fundamental to maintenance of fisheries. Finding optimal reserve sizes that improve fishing yields is not only of theoretical interest, but also of practical importance to facilitate decision making. Also, since the migratory behavior of some species influences the spillover effect of a marine reserve, this is a key consideration...
Tue Aug 25, 2020 03:00
Background Infectious diseases are a significant threat in both healthcare and community settings. Healthcare associated infections (HCAIs) in particular are a leading cause of complications during hospitalisation. Contamination of the healthcare environment is recognised as a source of infectious disease yet the significance of porous surfaces including healthcare textiles as fomites is not well understood. It is currently assumed there is little infection risk from textiles due...
Tue Aug 25, 2020 03:00
Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia. Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are involved in the regulation of physiological and pathophysiological processes. CircHIPK3 has been identified as the one of the most crucial regulators in cardiac fibrosis. However, the mechanisms by which circHIPK3 regulates cardiac fibrosis under hypoxia remain unclear. Our study aimed to determine circHIPK3 expression...
Tue Aug 25, 2020 03:00
Background Lower respiratory tract infection (LRTI) is one of the leading cause of death in children under 5 years old around the world between 1980 and 2016. Distinguishing between viral and bacterial infection is challenging when children suffered from LRTI in the absence of pathogen detection. The aim of our study is to analyze the difference of serum β2-microglobulin (β2-MG) between viral LRTI and bacterial LRTI in children. Methods This retrospective study included children with...
Tue Aug 25, 2020 03:00
Background Photosynthesis and cellular respiration play major roles in energy metabolism and are important Life Science topics for K16 Biology students. Algae beads are used for photosynthesis and cellular respiration labs. Currently there are a few companies that sell biology educational kits for making algae beads using non-motile green micro-algae to introduce students to photosynthesis. These kits are expensive and, do not come with detailed guidelines for trouble shooting and...
Tue Aug 25, 2020 03:00
Publication date: Available online 25 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Anders S. Vittrup, Kari Tanderup, Søren M. Bentzen, Nina B.K. Jensen, Sofia Spampinato, Lars U. Fokdal, Jacob C. Lindegaard, Alina Sturdza, Maximilian Schmid, Barbara Segedin, Ina M. Jürgenliemk-Schulz, Kjersti Bruheim, Umesh Mahantshetty, Christine Haie-Meder, Bhavana Rai, Rachel Cooper, Elzbieta van der Steen-Banasik, Marit Sundset, Fleur Huang, Remi A. Nout
Tue Aug 25, 2020 21:31
Publication date: Available online 25 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Deborah C. Marshall, Elizabeth S. Tarras, Kenneth Rosenzweig, Sue S. Yom, Jona Hattangadi-Gluth, James Murphy, Deborah Korenstein, Susan Chimonas
Tue Aug 25, 2020 21:31
Publication date: Available online 24 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Abhilash Menon, Shyama Prem S, Dr. Rashmi Kumari
Tue Aug 25, 2020 21:31
Publication date: Available online 24 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): William C. Jackson, Ming Tang, Christopher Maurino, Mishal Mendiratta-Lala, Neehar D. Parikh, Martha M. Matuszak, Janell S. Dow, Yue Cao, Charles S. Mayo, Randall K. Ten Haken, Matthew J. Schipper, Kyle C. Cuneo, Dawn Owen, Theodore S. Lawrence
Tue Aug 25, 2020 21:31
Publication date: Available online 24 August 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Wang-Zhong Li, Shu-Hui Lv, Guo-Ying Liu, Hu Liang, Xiang Guo, Xing Lv, Kui-Yuan Liu, Meng-Yun Qiang, Xi Chen, Sophie Z. Gu, Chang-Qing Xie, Wei-Xiong Xia, Yan-Qun Xiang
Tue Aug 25, 2020 21:31
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