Biomedicines, Vol. 8, Pages 288: Gene Regulatory Network Analysis of Perivascular Adipose Tissue of Abdominal Aortic Aneurysm Identifies Master Regulators of Key Pathogenetic Pathways Biomedicines doi: 10.3390/biomedicines8080288 Authors: Luca Piacentini Mattia Chiesa Gualtiero Ivanoe Colombo The lack of medical therapy to treat abdominal aortic aneurysm (AAA) stems from our inadequate understanding of the mechanisms underlying AAA pathogenesis. To date, the only available treatment...
Fri Aug 14, 2020 03:00
Biomedicines, Vol. 8, Pages 287: Relationship between Diet, Microbiota, and Healthy Aging Biomedicines doi: 10.3390/biomedicines8080287 Authors: Elisa Sanchez-Morate Lucia Gimeno-Mallench Kristine Stromsnes Jorge Sanz-Ros Aurora Román-Domínguez Sergi Parejo-Pedrajas Marta Inglés Gloria Olaso Juan Gambini Cristina Mas-Bargues Due to medical advances and lifestyle changes, population life expectancy has increased. For this reason, it is important to achieve healthy...
Fri Aug 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1193: Mitochondrial HMG-Box Containing Proteins: From Biochemical Properties to the Roles in Human Diseases Biomolecules doi: 10.3390/biom10081193 Authors: Veronika Vozáriková Nina Kunová Jacob A. Bauer Ján Frankovský Veronika Kotrasová Katarína Procházková Vladimíra Džugasová Eva Kutejová Vladimír Pevala Jozef Nosek Ľubomír Tomáška Mitochondrial DNA (mtDNA) molecules are packaged into compact nucleo-protein structures called...
Sun Aug 16, 2020 03:00
Biomolecules, Vol. 10, Pages 1192: The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin Biomolecules doi: 10.3390/biom10081192 Authors: Line K. Skaanning Angelo Santoro Thomas Skamris Jacob Hertz Martinsen Anna Maria D’Ursi Saskia Bucciarelli Bente Vestergaard Katrine Bugge Annette Eva Langkilde Birthe B. Kragelund The intrinsically disordered protein α-synuclein (aSN) is, in its fibrillated state, the main component...
Sun Aug 16, 2020 03:00
Biomolecules, Vol. 10, Pages 1191: Natural Polymeric Compound Based on High Thermal Stability Catechin from Green Tea Biomolecules doi: 10.3390/biom10081191 Authors: Malgorzata Latos-Brozio Anna Masek Catechin is a plant polyphenol with valuable antioxidant and health-promoting properties. Polymerization is one way to stabilize flavonoids and may cause changes in their specific properties. The aim of this study is to obtain a polymeric complex catechin compound with high thermal stability....
Sun Aug 16, 2020 03:00
Biomolecules, Vol. 10, Pages 1190: Proteomic and Bioinformatic Profiling of Transporters in Higher Plant Mitochondria Biomolecules doi: 10.3390/biom10081190 Authors: Ian Max Møller R. Shyama Prasad Rao Yuexu Jiang Jay J. Thelen Dong Xu To function as a metabolic hub, plant mitochondria have to exchange a wide variety of metabolic intermediates as well as inorganic ions with the cytosol. As identified by proteomic profiling or as predicted by MU-LOC, a newly developed bioinformatics...
Sun Aug 16, 2020 03:00
Biomolecules, Vol. 10, Pages 1189: Free-Radical-Mediated Formation of Trans-Cardiolipin Isomers, Analytical Approaches for Lipidomics and Consequences of the Structural Organization of Membranes Biomolecules doi: 10.3390/biom10081189 Authors: Fabrizio Vetica Anna Sansone Cesare Meliota Gessica Batani Marinella Roberti Chryssostomos Chatgilialoglu Carla Ferreri Free-radical-mediated processes, such as peroxidation, isomerization and hydrogenation affecting fatty acid...
Sat Aug 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1188: C. elegans Models to Study the Propagation of Prions and Prion-Like Proteins Biomolecules doi: 10.3390/biom10081188 Authors: Carl Alexander Sandhof Simon Oliver Hoppe Jessica Tittelmeier Carmen Nussbaum-Krammer A hallmark common to many age-related neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), is that patients develop proteinaceous deposits...
Sat Aug 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1187: Naphthoquinone-Based Meroterpenoids from Marine-Derived Streptomyces sp. B9173 Biomolecules doi: 10.3390/biom10081187 Authors: Xinqian Shen Xiaozheng Wang Tingting Huang Zixin Deng Shuangjun Lin Naphthoquinone-based meroterpenoids are hybrid polyketide-terpenoid natural products with chemical diversity and a broad range of biological activities. Here, we report the isolation of a group of naphthoquinone-containing compounds from Streptomyces...
Sat Aug 15, 2020 03:00
Biomolecules, Vol. 10, Pages 1186: Rapid Killing and Biofilm Inhibition of Multidrug-Resistant Acinetobacter baumannii Strains and Other Microbes by Iodoindoles Biomolecules doi: 10.3390/biom10081186 Authors: Chaitany Jayprakash Raorane Jin-Hyung Lee Jintae Lee Multi-drug resistant Acinetobacter baumannii is well-known for its rapid acclimatization in hospital environments. The ability of the bacterium to endure desiccation and starvation on dry surfaces for up to a month results...
Fri Aug 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1185: Synthesis and Characterization of Oxidized Polysaccharides for In Situ Forming Hydrogels Biomolecules doi: 10.3390/biom10081185 Authors: Muhammad Muhammad Christian Willems Julio Rodríguez-Fernández Gloria Gallego-Ferrer Thomas Groth Polysaccharides are widely used as building blocks of scaffolds and hydrogels in tissue engineering, which may require their chemical modification to permit crosslinking. The goal of this study was to generate...
Fri Aug 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1181: Histamine Intolerance: The Current State of the Art Biomolecules doi: 10.3390/biom10081181 Authors: Oriol Comas-Basté Sònia Sánchez-Pérez Maria Teresa Veciana-Nogués Mariluz Latorre-Moratalla María del Carmen Vidal-Carou Histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning...
Fri Aug 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1184: Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products Biomolecules doi: 10.3390/biom10081184 Authors: José Antonio Vázquez Ana I. Durán Araceli Menduíña Margarita Nogueira Based on a biotechnological strategy, in the present work several peptones are produced from the Alcalase hydrolysis (0.1–0.2% v/w, 56–64 °C, pH 8.27–8.98, 3 h) and...
Fri Aug 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1183: A Transmembrane Histidine Kinase Functions as a pH Sensor Biomolecules doi: 10.3390/biom10081183 Authors: Ana Bortolotti Daniela Belén Vazquez Juan Cruz Almada Maria Eugenia Inda Salvador Iván Drusin Juan Manuel Villalba Diego M. Moreno Jean Marie Ruysschaert Larisa Estefania Cybulski The two-component system DesK-DesR regulates the synthesis of unsaturated fatty acids in the soil bacteria Bacillus subtilis. This system is activated...
Fri Aug 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1182: Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory Epithelia Biomolecules doi: 10.3390/biom10081182 Authors: Maliha Zahid Timothy N. Feinstein Anthony Oro Molly Schwartz Alex D. Lee Cecilia W. Lo Background: Cilia are actin based cellular protrusions conserved from algae to complex multicellular organisms like Homo sapiens. Respiratory motile cilia line epithelial cells of the tracheobronchial...
Fri Aug 14, 2020 03:00
Biomolecules, Vol. 10, Pages 1180: Association between Circular RNA CDR1as and Post-Infarction Cardiac Function in Pig Ischemic Heart Failure: Influence of the Anti-Fibrotic Natural Compounds Bufalin and Lycorine Biomolecules doi: 10.3390/biom10081180 Authors: Julia Mester-Tonczar Johannes Winkler Patrick Einzinger Ena Hasimbegovic Nina Kastner Dominika Lukovic Katrin Zlabinger Andreas Spannbauer Denise Traxler Sandor Batkai Thomas Thum Mariann Gyöngyösi ...
Fri Aug 14, 2020 03:00
Biosensors, Vol. 10, Pages 99: Fast Adhesion of Gold Nanoparticles (AuNPs) to a Surface Using Starch Hydrogels for Characterization of Biomolecules in Biosensor Applications Biosensors doi: 10.3390/bios10080099 Authors: Frances L. Heredia Pedro J. Resto Elsie I. Parés-Matos Gold nanoparticles (AuNPs) are the most thoroughly studied nanoparticles because of their remarkable optical properties. Color changes in assays that use AuNPs can be easily observed with the naked eye, resulting...
Fri Aug 14, 2020 03:00
Brain Sciences, Vol. 10, Pages 561: Ruptured Thoracolumbar Perimedullary Arteriovenous Fistula during Pregnancy Complicated by Cerebral Subarachnoid Hemorrhage and Brainstem Hematoma: A Case Report Brain Sciences doi: 10.3390/brainsci10080561 Authors: Jan Sroubek Ladislava Janouskova Jan Klener Intradural spinal arteriovenous fistulas (sAVF) are spinal vascular lesions that usually manifest due to myelopathy or local symptoms caused by venous congestion and ischemia. In addition,...
Sat Aug 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 562: Support Vector Machine-Based Schizophrenia Classification Using Morphological Information from Amygdaloid and Hippocampal Subregions Brain Sciences doi: 10.3390/brainsci10080562 Authors: Yingying Guo Jianfeng Qiu Weizhao Lu Structural changes in the hippocampus and amygdala have been demonstrated in schizophrenia patients. However, whether morphological information from these subcortical regions could be used by machine learning algorithms for...
Sat Aug 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 560: Dorsolateral Prefrontal Cortex Activity during a Brain Training Game Predicts Cognitive Improvements after Four Weeks’ Brain Training Game Intervention: Evidence from a Randomized Controlled Trial Brain Sciences doi: 10.3390/brainsci10080560 Authors: Rui Nouchi Natasha Yuriko dos Santos Kawata Toshiki Saito Robin Maximilian Himmelmeier Ryo Nakamura Haruka Nouchi Ryuta Kawashima Background: Recent studies have demonstrated that brain...
Sat Aug 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 559: Consecutive Treatment with Brain-Derived Neurotrophic Factor and Electrical Stimulation Has a Protective Effect on Primary Auditory Neurons Brain Sciences doi: 10.3390/brainsci10080559 Authors: Verena Scheper Ira Seidel-Effenberg Thomas Lenarz Timo Stöver Gerrit Paasche Degeneration of neurons, such as the inner ear spiral ganglion neurons (SGN), may be decelerated or even stopped by neurotrophic factor treatment, such as brain-derived...
Sat Aug 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 558: Visual Attentional Training Improves Reading Capabilities in Children with Dyslexia: An Eye Tracker Study During a Reading Task Brain Sciences doi: 10.3390/brainsci10080558 Authors: Simona Caldani Christophe-Loïc Gerard Hugo Peyre Maria Pia Bucci Dyslexia is a specific disorder in reading abilities. The aim of this study was to explore whether a short visual attentional training could improve reading capabilities in children with reading disorders...
Sat Aug 15, 2020 03:00
Brain Sciences, Vol. 10, Pages 556: Age Differences in the Efficiency of Filtering and Ignoring Distraction in Visual Working Memory Brain Sciences doi: 10.3390/brainsci10080556 Authors: Mariana R. Maniglia Alessandra S. Souza Healthy aging is associated with decline in the ability to maintain visual information in working memory (WM). We examined whether this decline can be explained by decreases in the ability to filter distraction during encoding or to ignore distraction during...
Fri Aug 14, 2020 03:00
Brain Sciences, Vol. 10, Pages 557: Understanding Different Aspects of Caregiving for Individuals with Autism Spectrum Disorders (ASDs) a Narrative Review of the Literature Brain Sciences doi: 10.3390/brainsci10080557 Authors: Hadi Samadi Sayyed Ali Samadi Background: There has been a considerable endeavor to understand associated challenges of caregiving for a child with Autism Spectrum Disorders (ASDs) and to develop the necessary skills and approaches to assist parents of children...
Fri Aug 14, 2020 03:00
Brain Sciences, Vol. 10, Pages 555: Innovative Long-Dose Neurorehabilitation for Balance and Mobility in Chronic Stroke: A Preliminary Case Series Brain Sciences doi: 10.3390/brainsci10080555 Authors: Catherine Boissoneault Tyler Grimes Dorian Rose Michael F. Waters Anna Khanna Somnath Datta Janis J. Daly (1) Objective: The objective was two-fold: (a) test a protocol of combined interventions; (b) administer this combined protocol within the framework of a six-month,...
Fri Aug 14, 2020 03:00
Brain Sciences, Vol. 10, Pages 554: Endovascular Approaches to the Cavernous Sinus in the Setting of Dural Arteriovenous Fistula Brain Sciences doi: 10.3390/brainsci10080554 Authors: Justin Dye Gary Duckwiler Nestor Gonzalez Naoki Kaneko Robert Goldberg Daniel Rootman Reza Jahan Satoshi Tateshima Viktor Szeder Dural arteriovenous fistulas involving the cavernous sinus can lead to orbital pain, vision loss and, in the setting of associated cortical venous reflux,...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2307: Phase II Clinical Trial of Pembrolizumab in Patients with Progressive Metastatic Pheochromocytomas and Paragangliomas Cancers doi: 10.3390/cancers12082307 Authors: Camilo Jimenez Vivek Subbiah Bettzy Stephen Junsheng Ma Denai Milton Mingxuan Xu Abdualrazzak Zarifa Fechukwu Omolara Akhmedzhanov Apostolia Tsimberidou Mouhammed Amir Habra Jordi Rodon Rodon Anhert Siqing Fu Aung Naing Metastatic pheochromocytomas and paragangliomas...
Sun Aug 16, 2020 03:00
Cancers, Vol. 12, Pages 2306: The Role of Primary Tumor Resection in Colorectal Cancer Patients with Asymptomatic, Synchronous, Unresectable Metastasis: A Multicenter Randomized Controlled Trial Cancers doi: 10.3390/cancers12082306 Authors: Eun Jung Park Jeong-Heum Baek Gyu-Seog Choi Won Cheol Park Chang Sik Yu Sung-Bum Kang Byung Soh Min Jae Hwang Kim Hyeong Rok Kim Bong Hwa Lee Jae Hwan Oh Seung-Yong Jeong Minkyu Jung Joong Bae Ahn Seung Hyuk Baik...
Sun Aug 16, 2020 03:00
Cancers, Vol. 12, Pages 2304: Retinoblastoma: Etiology, Modeling, and Treatment Cancers doi: 10.3390/cancers12082304 Authors: Rossukon Kaewkhaw Duangnate Rojanaporn Retinoblastoma is a retinal cancer that is initiated in response to biallelic loss of RB1 in almost all cases, together with other genetic/epigenetic changes culminating in the development of cancer. RB1 deficiency makes the retinoblastoma cell-of-origin extremely susceptible to cancerous transformation, and the tumor...
Sun Aug 16, 2020 03:00
Cancers, Vol. 12, Pages 2305: Distinct Mechanisms Are Responsible for Nrf2-Keap1 Pathway Activation at Different Stages of Rat Hepatocarcinogenesis Cancers doi: 10.3390/cancers12082305 Authors: Claudia Orrù Andrea Perra Marta Anna Kowalik Sabrina Rizzolio Elisabetta Puliga Lavinia Cabras Silvia Giordano Amedeo Columbano Activation of the Nrf2-Keap1 pathway, the main intracellular defense against environmental stress, has been observed in several human cancers, including...
Sun Aug 16, 2020 03:00
Cancers, Vol. 12, Pages 2301: Evaluation of Uterine Brachytherapy as Primary Treatment Option for Elderly Patients with Medically Inoperable Endometrial Cancer—A Single-Center Experience and Review of the Literature Cancers doi: 10.3390/cancers12082301 Authors: Nathalie Arians Jan Tobias Oelmann-Avendano Daniela Schmitt Eva Meixner Antje Wark Juliane Hoerner-Rieber Rami A. El Shafie Kristin Lang Markus Wallwiener Jürgen Debus We aimed to gain more evidence...
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2303: Macrophage-Mediated Antibody Dependent Effector Function in Aggressive B-Cell Lymphoma Treatment is Enhanced by Ibrutinib via Inhibition of JAK2 Cancers doi: 10.3390/cancers12082303 Authors: Verena Barbarino Sinika Henschke Stuart James Blakemore Elena Izquierdo Michael Michalik Nadine Nickel Indra Möllenkotte Daniela Vorholt Linda Müller Reinhild Brinker Oleg Fedorchenko Nelly Mikhael Tamina Seeger-Nukpezah Michael Hallek...
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2302: Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue Cancers doi: 10.3390/cancers12082302 Authors: Alba Costales-Carrera Asunción Fernández-Barral Pilar Bustamante-Madrid Orlando Domínguez Laura Guerra-Pastrián Ramón Cantero Luis del Peso Aurora Burgos Antonio Barbáchano Alberto Muñoz Colon and rectal tumors, often referred to as colorectal cancer, show different gene expression patterns...
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2294: SP8 Promotes an Aggressive Phenotype in Hepatoblastoma via FGF8 Activation Cancers doi: 10.3390/cancers12082294 Authors: Alexandra Elisabeth Wagner Thomas Schwarzmayr Beate Häberle Christian Vokuhl Irene Schmid Dietrich von Schweinitz Roland Kappler Hepatoblastoma (HB) is the most common malignant liver tumor in childhood and it generally has a good prognosis. However, if associated with aggressive metastatic disease, outcome is still poor....
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2298: AT101 [(-)-Gossypol] Selectively Inhibits MCL1 and Sensitizes Carcinoma to BH3 Mimetics by Inducing and Stabilizing NOXA Cancers doi: 10.3390/cancers12082298 Authors: David J. Mallick Alan Eastman Anti-apoptotic BCL2 proteins are important targets for cancer therapy as cancers depend on their activity for survival. Direct inhibitors of MCL1 have entered clinical trials, although their efficacy may be limited by toxicity. An alternative approach may be...
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2299: Prognostic Biomarkers of Salvage Chemotherapy Following Nivolumab Treatment for Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma Cancers doi: 10.3390/cancers12082299 Authors: Takahiro Wakasaki Ryuji Yasumatsu Muneyuki Masuda Toranoshin Takeuchi Tomomi Manako Mioko Matsuo Rina Jiromaru Ryutaro Uchi Noritaka Komune Teppei Noda Takashi Nakagawa Recent studies have suggested the benefit of salvage chemotherapy (SCT)...
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2296: Transcription Factors in Cancer Development and Therapy Cancers doi: 10.3390/cancers12082296 Authors: Vishnoi Viswakarma Rana Rana Cancer is a multi-step process and requires constitutive expression/activation of transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical for carcinogenesis. These include pro-inflammatory TFs, hypoxia-inducible factors (HIFs), cell proliferation and epithelial–mesenchymal...
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2297: Lymphatic Valves and Lymph Flow in Cancer-Related Lymphedema Cancers doi: 10.3390/cancers12082297 Authors: Drishya Iyer Melanie Jannaway Ying Yang Joshua P. Scallan Lymphedema is a complex disease caused by the accumulation of fluid in the tissues resulting from a dysfunctional or damaged lymphatic vasculature. In developed countries, lymphedema most commonly occurs as a result of cancer treatment. Initially, impaired lymph flow causes edema, but...
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2295: Impact of Vasectomy on the Development and Progression of Prostate Cancer: Preclinical Evidence Cancers doi: 10.3390/cancers12082295 Authors: Takashi Kawahara Yuki Teramoto Yi Li Hitoshi Ishiguro Jennifer Gordetsky Zhiming Yang Hiroshi Miyamoto Some observational studies have implied a link between vasectomy and an elevated risk of prostate cancer. We investigated the impact of vasectomy on prostate cancer outgrowth, mainly using preclinical...
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2300: Exosomes-Mediated Transfer of Itga2 Promotes Migration and Invasion of Prostate Cancer Cells by Inducing Epithelial-Mesenchymal Transition Cancers doi: 10.3390/cancers12082300 Authors: Rofaida Gaballa Hamdy E. A. Ali Mohamed O. Mahmoud Johng S. Rhim Hamed I. Ali Heba F. Salem Mohammad Saleem Mohamed A. Kandeil Stefan Ambs Zakaria Y. Abd Elmageed Although integrin alpha 2 subunit (ITGA2) mediates cancer progression and metastasis,...
Sat Aug 15, 2020 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου