Cancers, Vol. 12, Pages 2293: Phase I/Ib Study of Tenalisib (RP6530), a Dual PI3K δ/γ Inhibitor in Patients with Relapsed/Refractory T-Cell Lymphoma Cancers doi: 10.3390/cancers12082293 Authors: Auris Huen Bradley M. Haverkos Jasmine Zain Ramchandren Radhakrishnan Mary Jo Lechowicz Sumana Devata Neil J. Korman Lauren Pinter-Brown Yasuhiro Oki Prajak J. Barde Ajit Nair Kasi Viswanath Routhu Srikant Viswanadha Swaroop Vakkalanka Swaminathan P. Iyer ...
Sat Aug 15, 2020 03:00
Cancers, Vol. 12, Pages 2291: Myelomonocytic Skewing In Vitro Discriminates Subgroups of Patients with Myelofibrosis with A Different Phenotype, A Different Mutational Profile and Different Prognosis Cancers doi: 10.3390/cancers12082291 Authors: Klaus Geissler Bettina Gisslinger Eva Jäger Roland Jäger Ana-Iris Schiefer Edith Bogner Elisabeth Fuchs Fiorella Schischlik Donat Alpar Ingrid Simonitsch-Klupp Robert Kralovics Heinz Gisslinger Normal hematopoietic...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2292: E-Cigarette Exposure Decreases Bone Marrow Hematopoietic Progenitor Cells Cancers doi: 10.3390/cancers12082292 Authors: Gajalakshmi Ramanathan Brianna Craver-Hoover Rebecca J. Arechavala David A. Herman Jane H. Chen Hew Yeng Lai Samantha R. Renusch Michael T. Kleinman Angela G. Fleischman Electronic cigarettes (E-cigs) generate nicotine containing aerosols for inhalation and have emerged as a popular tobacco product among adolescents...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2286: Programmed Death 1 Ligand Expression in the Monocytes of Patients with Hepatocellular Carcinoma Depends on Tumor Progression Cancers doi: 10.3390/cancers12082286 Authors: Akira Asai Hidetaka Yasuoka Masahiro Matsui Yusuke Tsuchimoto Shinya Fukunishi Kazuhide Higuchi Monocytes (CD14+ cells) from advanced-stage hepatocellular carcinoma (HCC) patients express programmed death 1 ligand (PD-L)/PD-1 and suppress the host antitumor immune response....
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2290: A 3D Heterotypic Breast Cancer Model Demonstrates a Role for Mesenchymal Stem Cells in Driving a Proliferative and Invasive Phenotype Cancers doi: 10.3390/cancers12082290 Authors: Pal Ashworth Collier Probert Jones Pernaut Leza Meakin A. Ritchie Onion Clarke Allegrucci Grabowska Previous indirect 2D co-culture studies have demonstrated that mesenchymal stem cells (MSCs) promote breast cancer (BC) progression through...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2288: Health-Related Quality of Life and Experiences of Sarcoma Patients during the COVID-19 Pandemic Cancers doi: 10.3390/cancers12082288 Authors: Younger Smrke Lidington Farag Ingley Chopra Maleddu Augustin Merry Wilson Benson Miah Zaidi McTiernan Strauss Dileo Gennatas Husson Jones Sarcomas are rare cancers with a spectrum of clinical needs and outcomes. We investigated care experiences...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2289: Adjuvant Chemotherapy in Elderly Colorectal Cancer Patients Cancers doi: 10.3390/cancers12082289 Authors: Bengt Glimelius Erik Osterman The value of adjuvant chemotherapy in elderly patients has been the subject of many overviews, with opinions varying from “not effective”, since randomized trials have not been performed, to “as effective as in young individuals”, based upon many retrospective analyses of randomized...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2287: Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers Cancers doi: 10.3390/cancers12082287 Authors: Yufeng Wang J. Jillian Zhang Xin-Yun Huang Fascin is an actin-bundling protein that is critical for filopodial formation and other cellular cytoskeletal structures. An elevated expression of fascin has been observed in tumor cells and is correlated with a shorter survival of cancer patients. Given its roles in tumor cell...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2279: Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo Cancers doi: 10.3390/cancers12082279 Authors: Alexandra Thomas Abhilash Samykutty Jorge G. Gomez-Gutierrez Wenyuan Yin Michael E. Egger Molly McNally Phillip Chuong William M. MacCuaig Sabrin Albeituni Matthew Zeiderman Min Li Barish H. Edil William E. Grizzle Kelly M. McMasters Lacey R. McNally ...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2277: Clonal Hematopoiesis in Liquid Biopsy: From Biological Noise to Valuable Clinical Implications Cancers doi: 10.3390/cancers12082277 Authors: Hiu Ting Chan Yoon Ming Chin Yusuke Nakamura Siew-Kee Low The use of blood liquid biopsy is being gradually incorporated into the clinical setting of cancer management. The minimally invasive nature of the usage of cell-free DNA (cfDNA) and its ability to capture the molecular alterations of tumors are great...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2280: The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors Cancers doi: 10.3390/cancers12082280 Authors: Melissa B. Aldrich John C. Rasmussen Caroline E. Fife Simona F. Shaitelman Eva M. Sevick-Muraca Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2284: Multi-Parametric Deep Learning Model for Prediction of Overall Survival after Postoperative Concurrent Chemoradiotherapy in Glioblastoma Patients Cancers doi: 10.3390/cancers12082284 Authors: Han Gyul Yoon Wonjoong Cheon Sang Woon Jeong Hye Seung Kim Kyunga Kim Heerim Nam Youngyih Han Do Hoon Lim This study aimed to investigate the performance of a deep learning-based survival-prediction model, which predicts the overall survival (OS)...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2282: C3G Is Upregulated in Hepatocarcinoma, Contributing to Tumor Growth and Progression and to HGF/MET Pathway Activation Cancers doi: 10.3390/cancers12082282 Authors: Celia Sequera Paloma Bragado Sara Manzano Maria Arechederra Sylvie Richelme Alvaro Gutiérrez-Uzquiza Aránzazu Sánchez Flavio Maina Carmen Guerrero Almudena Porras The complexity of hepatocellular carcinoma (HCC) challenges the identification of disease-relevant signals....
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2283: Pembrolizumab Activity in Recurrent High-Grade Gliomas with Partial or Complete Loss of Mismatch Repair Protein Expression: A Monocentric, Observational and Prospective Pilot Study Cancers doi: 10.3390/cancers12082283 Authors: Giuseppe Lombardi Valeria Barresi Stefano Indraccolo Michele Simbolo Matteo Fassan Susanna Mandruzzato Matteo Simonelli Mario Caccese Marco Pizzi Arianna Fassina Marta Padovan Elena Masetto Marina Paola...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2281: Elderly Hepatocellular Carcinoma Patients: Open or Laparoscopic Approach? Cancers doi: 10.3390/cancers12082281 Authors: Jong Man Kim Sangjin Kim Jinsoo Rhu Gyu-Seong Choi Choon Hyuck David Kwon Jae-Won Joh It remains unclear whether the short-term benefits and long-term outcomes of laparoscopic liver resection (LLR) accrue to elderly patients with medical comorbidities. The aim of the present study was to compare the outcomes between LLR and...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2278: Finding a Jill for JAK: Assessing Past, Present, and Future JAK Inhibitor Combination Approaches in Myelofibrosis Cancers doi: 10.3390/cancers12082278 Authors: Andrew T. Kuykendall Nathan P. Horvat Garima Pandey Rami Komrokji Gary W. Reuther Myelofibrosis (MF) is a myeloproliferative neoplasm hallmarked by the upregulation of the Janus kinase (JAK)—signal transducer and activator of transcription (STAT) pathway with associated extramedullary...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2285: YB-1 Knockdown Inhibits the Proliferation of Mesothelioma Cells through Multiple Mechanisms Cancers doi: 10.3390/cancers12082285 Authors: Johnson Schelch Lai Marzec Kennerson Grusch Reid Burgess Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein that has been shown to regulate proliferation, invasion and metastasis in a variety of cancer types. We previously demonstrated that YB-1 is overexpressed in mesothelioma...
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2275: Emerging Cancer Epigenetic Mechanisms Regulated by All-Trans Retinoic Acid Cancers doi: 10.3390/cancers12082275 Authors: Stefano Rossetti Nicoletta Sacchi All-trans retinoic acid (RA), which is the dietary bioactive derivative obtained from animal (retinol) and plant sources (beta-carotene), is a physiological lipid signal of both embryonic and postembryonic development. During pregnancy, either RA deficiency or an excessive RA intake is teratogenic....
Fri Aug 14, 2020 03:00
Cancers, Vol. 12, Pages 2276: Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach Cancers doi: 10.3390/cancers12082276 Authors: Zeinab Nouri Sajad Fakhri Keyvan Nouri Carly E. Wallace Mohammad Hosein Farzaei Anupam Bishayee Multiple dysregulated signaling pathways are implicated in the pathogenesis of cancer. The conventional therapies used in cancer prevention/treatment suffer from low efficacy, considerable toxicity, and high cost. Hence,...
Fri Aug 14, 2020 03:00
Cells, Vol. 9, Pages 1908: Nuclear Envelope Proteins Modulating the Heterochromatin Formation and Functions in Fission Yeast Cells doi: 10.3390/cells9081908 Authors: Yasuhiro Hirano Haruhiko Asakawa Takeshi Sakuno Tokuko Haraguchi Yasushi Hiraoka The nuclear envelope (NE) consists of the inner and outer nuclear membranes (INM and ONM), and the nuclear pore complex (NPC), which penetrates the double membrane. ONM continues with the endoplasmic reticulum (ER). INM and NPC can...
Sun Aug 16, 2020 03:00
Cells, Vol. 9, Pages 1907: Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication Cells doi: 10.3390/cells9081907 Authors: Andrey Anisenko Marina Kan Olga Shadrina Anna Brattseva Marina Gottikh The DNA dependent protein kinase (DNA-PK) is a trimeric nuclear complex consisting of a large protein kinase and the Ku heterodimer. The kinase activity of DNA-PK is required for efficient repair of DNA double-strand breaks (DSB) by non-homologous end joining (NHEJ)....
Sun Aug 16, 2020 03:00
Cells, Vol. 9, Pages 1906: Lysophosphatidic Acid Receptor 1- and 3-Mediated Hyperalgesia and Hypoalgesia in Diabetic Neuropathic Pain Models in Mice Cells doi: 10.3390/cells9081906 Authors: Hiroshi Ueda Hiroyuki Neyama Yosuke Matsushita Lysophosphatidic acid (LPA) signaling is known to play key roles in the initiation and maintenance of various chronic pain models. Here we examined whether LPA signaling is also involved in diabetes-induced abnormal pain behaviors. The high-fat...
Sun Aug 16, 2020 03:00
Cells, Vol. 9, Pages 1903: Myosin XVI in the Nervous System Cells doi: 10.3390/cells9081903 Authors: Elek Telek András Kengyel Beáta Bugyi The myosin family is a large inventory of actin-associated motor proteins that participate in a diverse array of cellular functions. Several myosin classes are expressed in neural cells and play important roles in neural functioning. A recently discovered member of the myosin superfamily, the vertebrate-specific myosin XVI (Myo16) class is expressed...
Sat Aug 15, 2020 03:00
Cells, Vol. 9, Pages 1905: In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles Cells doi: 10.3390/cells9081905 Authors: Leonard Kaps Nadine Leber Adrian Klefenz Niklas Choteschovsky Rudolf Zentel Lutz Nuhn Detlef Schuppan Macrophages are the front soldiers of the innate immune system and are vital for immune defense, tumor surveillance, and tissue homeostasis. In chronic diseases, including cancer...
Sat Aug 15, 2020 03:00
Cells, Vol. 9, Pages 1904: Oncology Therapeutics Targeting the Metabolism of Amino Acids Cells doi: 10.3390/cells9081904 Authors: Nefertiti Muhammad Hyun Min Lee Jiyeon Kim Amino acid metabolism promotes cancer cell proliferation and survival by supporting building block synthesis, producing reducing agents to mitigate oxidative stress, and generating immunosuppressive metabolites for immune evasion. Malignant cells rewire amino acid metabolism to maximize their access to nutrients....
Sat Aug 15, 2020 03:00
Cells, Vol. 9, Pages 1902: Highlights on Genomics Applications for Lysosomal Storage Diseases Cells doi: 10.3390/cells9081902 Authors: Valentina La Cognata Maria Guarnaccia Agata Polizzi Martino Ruggieri Sebastiano Cavallaro Lysosomal storage diseases (LSDs) are a heterogeneous group of rare multisystem genetic disorders occurring mostly in infancy and childhood, characterized by a gradual accumulation of non-degraded substrates inside the lysosome. Although the cellular...
Fri Aug 14, 2020 03:00
Cells, Vol. 9, Pages 1901: MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment Cells doi: 10.3390/cells9081901 Authors: Julian Grabek Jasmin Straube Megan Bywater Steven W. Lane Myeloproliferative neoplasms (MPNs) constitute a group of disorders identified by an overproduction of cells derived from myeloid lineage. The majority of MPNs have an identifiable driver mutation responsible for cytokine-independent proliferative...
Fri Aug 14, 2020 03:00
Children, Vol. 7, Pages 98: Motor Performance in Children Diagnosed with Cancer: A Longitudinal Observational Study Children doi: 10.3390/children7080098 Authors: Lotta Hamari Päivi M. Lähteenmäki Heidi Pukkila Mikko Arola Anna Axelin Sanna Salanterä Liisa S. Järvelä Children with cancer are dealing with different side and long-term effects caused by cancer and its treatments, like vinca-alkaloids, which may have negative effects on motor performance. However, the affected...
Sat Aug 15, 2020 03:00
Children, Vol. 7, Pages 97: Targeted Therapy for Pulmonary Hypertension in Premature Infants Children doi: 10.3390/children7080097 Authors: Shannon N Nees Erika B Rosenzweig Jennifer L Cohen Gerson A Valencia Villeda Usha S Krishnan Pulmonary hypertension (PH) is common in premature infants with bronchopulmonary dysplasia (BPD) and is associated with significant mortality. Despite expert consensus suggesting the use of targeted therapies such as phosphodiesterase inhibitors,...
Sat Aug 15, 2020 03:00
Children, Vol. 7, Pages 96: The Addition of Intravenous Propofol and Ketorolac to a Sevoflurane Anesthetic Lessens Emergence Agitation in Children Having Bilateral Myringotomy with Tympanostomy Tube Insertion: A Prospective Observational Study Children doi: 10.3390/children7080096 Authors: Brandon d’Eon Thomas Hackmann A. Stuart Wright The aim of this prospective observational study was to determine if children undergoing bilateral myringotomy and tympanostomy tube insertion with...
Sat Aug 15, 2020 03:00
Children, Vol. 7, Pages 95: Physical Fitness Promotion among Adolescents: Effects of a Jump Rope-Based Physical Activity Afterschool Program Children doi: 10.3390/children7080095 Authors: Xiaofeng Yang Joonyoung Lee Xiangli Gu Xiaoxia Zhang Tao Zhang The major purpose of this study was to examine the effects of a jump rope-based physical activity afterschool program on middle school students’ physical fitness. Sixty students (Mage = 13.37, SD = 0.58; 53.3% female)...
Fri Aug 14, 2020 03:00
Cosmetics, Vol. 7, Pages 66: Laminarin Effects, a β-(1,3)-Glucan, on Skin Cell Inflammation and Oxidation Cosmetics doi: 10.3390/cosmetics7030066 Authors: Hélène Ozanne Hechmi Toumi Benoît Roubinet Ludovic Landemarre Eric Lespessailles Richard Daniellou Annabelle Cesaro Laminarin, a β-(1,3)-glucan from the seaweed Laminaria digitata, is a polysaccharide which provides anti-inflammatory and anti-oxidative properties. Its influence on both human dermal fibroblasts...
Sun Aug 16, 2020 03:00
Dentistry Journal, Vol. 8, Pages 93: Do Lasers Have an Adjunctive Role in Initial Non-Surgical Periodontal Therapy? A Systematic Review Dentistry Journal doi: 10.3390/dj8030093 Authors: Donald Coluzzi Eugenia Anagnostaki Valina Mylona Steven Parker Edward Lynch (1) Background: dental lasers have numerous applications for periodontal therapy which include surgical procedures of soft tissue and osseous structures, and non-surgical treatments such as pathogen reduction, removal...
Sun Aug 16, 2020 03:00
Diagnostics, Vol. 10, Pages 599: Design of Liver Functional Reserve Estimation Technique Based on Optical Densitometry Diagnostics doi: 10.3390/diagnostics10080599 Authors: Ekaterina Savchenko Ilya Kolokolnikov Elena Velichko Victor Osovskikh Lyubov Kiseleva Zhyldyz Musakulova This work is aimed at creating a modified invasive technique for assessing the liver’s functional reserves. A study of the degree of hepatodepression is carried out by measuring the plasma...
Sun Aug 16, 2020 03:00
Diagnostics, Vol. 10, Pages 598: Somatostatin Receptor PET/CT Imaging for the Detection and Staging of Pancreatic NET: A Systematic Review and Meta-Analysis Diagnostics doi: 10.3390/diagnostics10080598 Authors: Matteo Bauckneht Domenico Albano Salvatore Annunziata Giulia Santo Priscilla Guglielmo Viviana Frantellizzi Alessia Branca Cristina Ferrari Antonio Vento Alessia Mirabile Anna Giulia Nappi Laura Evangelista Pierpaolo Alongi Riccardo Laudicella...
Sun Aug 16, 2020 03:00
Diagnostics, Vol. 10, Pages 597: Recommendations for Lung Ultrasound in Internal Medicine Diagnostics doi: 10.3390/diagnostics10080597 Authors: Natalia Buda Wojciech Kosiak Marcin Wełnicki Agnieszka Skoczylas Robert Olszewski Jakub Piotrkowski Szymon Skoczyński Elżbieta Radzikowska Ewa Jassem Elżbieta Magdalena Grabczak Piotr Kwaśniewicz Gebhard Mathis Tudor P. Toma A growing amount of evidence prompts us to update the first version of recommendations...
Sun Aug 16, 2020 03:00
Diagnostics, Vol. 10, Pages 595: Clinicopathological Characteristics of Pleomorphic High-Grade Squamous Intraepithelial Lesion of the Uterine Cervix: A Single-Institutional Series of 31 Cases Diagnostics doi: 10.3390/diagnostics10080595 Authors: Hyunjin Kim Sangjoon Choi Sung-Im Do Sang Hwa Lee Nara Yoon Hyun-Soo Kim We investigated the clinicopathological characteristics of 31 cases of pleomorphic high-grade squamous intraepithelial lesions (PHSIL) of the uterine cervix....
Sat Aug 15, 2020 03:00
Diagnostics, Vol. 10, Pages 596: Recent Advances in Ultrasound Diagnosis of Carpal Tunnel Syndrome Diagnostics doi: 10.3390/diagnostics10080596 Authors: Yuichi Yoshii Chunfeng Zhao Peter C. Amadio With the widespread use of high-resolution ultrasonography, ultrasonic examination has been shown to be useful as a diagnostic method for carpal tunnel syndrome. The main advantages of ultrasonography are that it is simple, quick, non-invasive, and economical. Another advantage is that...
Sat Aug 15, 2020 03:00
Diagnostics, Vol. 10, Pages 594: Proposal of De Novo Antigen Test for COVID-19: Ultrasensitive Detection of Spike Proteins of SARS-CoV-2 Diagnostics doi: 10.3390/diagnostics10080594 Authors: Yuta Kyosei Mayuri Namba Sou Yamura Rikiya Takeuchi Noriko Aoki Kazunari Nakaishi Satoshi Watabe Etsuro Ito Polymerase chain reaction (PCR)-based antigen tests are technically difficult, time-consuming, and expensive, and may produce false negative results requiring follow-up...
Fri Aug 14, 2020 03:00
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