Publication date: Available online 3 May 2020Source: Autoimmunity ReviewsAuthor(s): Andreas Kronbichler, Maria Effenberger, Michael Eisenhut, Keum Hwa Lee, Jae Il Shin
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Publication date: Available online 3 May 2020Source: Autoimmunity ReviewsAuthor(s): David Bernal-Bello, Beatriz Jaenes-Barrios, Alejandro Morales-Ortega, José Manuel Ruiz-Giardin, Virginia García-Bermúdez, Begoña Frutos-Pérez, Ana Isabel Farfán-Sedano, Cristina de Ancos-Aracil, Fernando Bermejo-San José, Mario García-Gil, Antonio Zapatero-Gaviria, Juan Víctor San Martín-López
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Abstract Background Keloids are firm, fibrous nodules that form on an individual’s skin and are associated with difficult symptoms as well as high recurrence rates. This study aims to improve the surgical techniques that reduce local tension after surgical excision of keloids as well as applying adjuvant radiotherapy to suppress scar formation. Methods A total of 58 patients aged between 21 to 76 received surgical incision of keloid and immediate post‐operation low‐dose radiotherapy. All...
Sun May 03, 2020 20:10
Publication date: Available online 4 May 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): E. Walshaw, R. Taylor, S. Iyer, H. Cashman
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Publication date: Available online 4 May 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): H. Mirmohamadsadeghi, R. Zanganeh, B. Barati, R. Tabrizi
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Publication date: Available online 3 May 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): F. Allevi, A. Dionisio, U. Baciliero, P. Balercia, G.A. Beltramini, D. Bertossi, A. Bozzetti, L. Califano, P. Cascone, L. Colombo, C. Copelli, F.S. De Ponte, G. De Riu, M.D. Monaca, S. Fusetti, M. Galié, A.B. Giann, F. Longo, N. Mannucci, P.F. Nocini
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Publication date: Available online 3 May 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): V. Rao US, G. Arakeri, A. Subash, S. Thankur
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Cancers, Vol. 12, Pages 1154: Decreased Activity of Circulating Butyrylcholinesterase in Blood Is an Independent Prognostic Marker in Pancreatic Cancer Patients Cancers doi: 10.3390/cancers12051154 Authors: Eva Valentina Klocker Dominik Andreas Barth Jakob Michael Riedl Felix Prinz Joanna Szkandera Konstantin Schlick Peter Kornprat Karoline Lackner Jörg Lindenmann Herbert Stöger Michael Stotz Armin Gerger Martin Pichler Introduction:...
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Cancers, Vol. 12, Pages 1153: Metabolism and Immune Modulation in Patients with Solid Tumors: Systematic Review of Preclinical and Clinical Evidence Cancers doi: 10.3390/cancers12051153 Authors: Aurora Mirabile Licia Rivoltini Elena Daveri Claudio Vernieri Roberto Mele Luca Porcu Chiara Lazzari Alessandra Bulotta Maria Grazia Viganò Stefano Cascinu Vanesa Gregorc Several immunotherapy agents are the standard of care of many solid malignancies....
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Cancers, Vol. 12, Pages 1152: Pediatric Low-Grade Gliomas Cancers doi: 10.3390/cancers12051152 Authors: Collins Pollack Brain tumors constitute the largest source of oncologic mortality in children and low-grade gliomas are among most common pediatric central nervous system tumors. Pediatric low-grade gliomas differ from their counterparts in the adult population in their histopathology, genetics, and standard of care. Over the past decade, an increasingly detailed understanding...
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Abstract Purpose We aim to illustrate the diagnostic performance of diffusional kurtosis imaging (DKI) in the diagnosis of gliomas. Methods A review protocol was developed according to the (PRISMA-P) checklist, registered in the international prospective register of systematic reviews (PROSPERO) and published. A literature search in 4 databases was...
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Abstract Purpose Silent new ischemic cerebral lesions (sNICL) detected by diffusion-weighted imaging (DWI) are common after carotid artery stenting (CAS). As part of the Revascularization of Extracranial Carotid Artery Stenosis (RECAS) study, this work aimed to determine predictors of sNICL detected by DWI following CAS. Methods A total of 694 patients...
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Abstract The spinal cord (SC) is a dense network of billions of fibers in a small volume surrounded by bones that makes tractography difficult to perform. We aim to provide a review collecting all technical settings of SC tractography and propose the optimal set of parameters to perform a good SC tractography rendering. The MEDLINE database was searched for articles reporting “spinal cord” “tractography” in “humans”. Studies were selected only when tractography rendering was displayed...
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Abstract Cervical nerve root infiltrations are frequently performed in patients with radiculopathy, and computed tomography (CT) is commonly used for image guidance. With the traditional anterolateral approach, catastrophic side events due to spinal ischemia have been reported. To minimize risk, a dorsal approach has been advised, but the safety of this dorsal approach has not been studied systematically. In a 5-year period, 137 cervical nerve root infiltrations using a dorsal...
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Abstract Purpose To analyze the surgical outcomes in terms of postoperative wound complications in a small case series of six patients treated with lateral cervical approach (LCA) for salvage total laryngectomy (STL) without prophylactic use of the pectoralis major myocutaneous flap (PMMF) or free flaps. Methods Between September 2018 and August...
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Abstract There is still controversy on the role of hyperinsulinemia and endogenous antisecretory factor (EAF) in Meniere’s disease. In the literature, there is no mention on glucose uptake or specially processed cereals (SPC). Nevertheless, the role of EAF and its inhibition by SPC should be taken into account in future research. In case of patients not responding to medical treatment and dietary changes, intratympanic (IT) treatment has been suggested. In Italy, generalists...
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Abstract Objective Septal deviation is an important cause of impaired nasal breathing among pediatric patients. A widespread solution to septal deviation is septoplasty. However, there are certain controversies surrounding the effect of this technique on pediatric patients and its influence on the growth centers of the nose. The objective of this review is to study if there is a strong and valid evidence in the literature that supports...
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Abstract Background Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral vertigo and its recurrence is fairly common. Several studies correlated the pathophysiological role of different comorbidities—such as diabetes, osteoporosis, vascular, psychiatric and autoimmune diseases—in the development and recurrence of BPPV. The aim of this study is to analyse the pharmacological history of patients with idiopathic...
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Abstract Purpose The advent of endoscopic otosurgery provides reduced tissue destruction with theoretically improved views, yet a quantification of the difference of exposure between microscopic and endoscopic approaches has not yet been performed in human specimens. The objective of this study was to assess the difference in views of cadaveric tympanic membranes when inspected with operating microscopes or endoscopes. ...
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Abstract Objective In this study, it was aimed to evaluate and compare biochemical and histopathological effects of platelet-rich plasma (PRP), ozone and hyperbaric oxygen (HBO) on wound healing which was formed experimentally in oral cavity of rats. Materials and methods In this study, thirty-six Wistar Hannover rats with weight of 250–350 g,...
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Ubiquitin‐specific protease 34 (USP34), a member of the ubiquitin‐specific protease family, regulates osteogenic differentiation of bone marrow mesenchymal stem cells via bone morphogenetic protein signaling. This study aimed to investigate the role of USP34 in fixation of titanium implants in mouse models. Eight‐week‐old Usp34‐knockout (Prx1‐Cre;Usp34f/f) mice and their Usp34 wild‐type (Usp34f/f) control littermates were used. Experimental titanium implants were inserted into the distal ends of...
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Abstract Objectives To evaluate the responsiveness of measures of pain and oral health‐related quality of life (OH‐QoL) in patients with oral lichen planus (OLP) and to determine thresholds for minimal important change (MIC) and minimal important difference (MID) for use in this patient population. Methods Data from baseline and 4‐month follow‐up including Visual Analog Scale (VAS), Numerical Rating Scale (NRS), 14‐item Oral Health Impact Profile (OHIP‐14), 15‐item and 26‐item Chronic...
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Summary The tumour volume of a cancer within the prostate gland is commonly measured with multiparametric MRI. The measurement has a role in many clinical scenarios including focal therapy, but the accuracy of it has never been systematically reviewed. We included articles if they compared tumour volume measurements obtained by mpMRI with a reference volume measurement obtained after radical prostatectomy. Correlation and concordance statistics were summarised. A simple accuracy score was derived...
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This course will cover intra-operative electrocochleography measurements to monitor cochlear trauma during cochlear implant electrode placement and the use of electrocochleography to predict post-operative residual hearing in cochlear implants.
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This course will provide an overview of the Widex Evoke platform including the recent evolutions and enhancements. This will include a discussion of the core features, options (including new models), and apps/accessories.
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Summary One of the key features of acute myeloid leukemia (AML) is the arrest of differentiation at the early progenitor stage of myelopoiesis. Therefore, the identification of new agents that could overcome this differentiation block and force leukemic cells to enter the apoptotic pathway is essential for the development of new treatment strategies in AML. Regarding this, herein we report the pro-differentiation activity of the pan-Bcl-2 inhibitor, obatoclax. Obatoclax promoted...
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Summary Purpose Apatinib, a new tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, has shown promising efficacy against several solid cancers, but evidence of its efficacy against relapsed and refractory nasopharyngeal carcinoma is limited. We investigated the efficacy and safety of apatinib for relapsed and refractory nasopharyngeal carcinoma in an open-label, single-arm, phase II clinical trial. Fifty-one patients with relapsed and refractory...
Sun May 03, 2020 03:00
Abstract Purpose The i-gel is a supraglottic airway device with non-inflatable cuff which can suffer insertion failure if its standard placement technique is implemented. The aim of this study was to compare the placement technique proposed by the manufacturer of i-gel with the triple airway maneuver in terms of successful device insertion time and first-attempt success. ...
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Abstract Objectives To determine the incidence, trends, maternal and neonatal risk factors of severe intraventricular hemorrhage (IVH) among infants born 24–32 weeks and/or < 1500 g, and to evaluate the impact of changing of hospital policies and unit clinical practice on the IVH incidence. Study design Retrospective chart review of preterm infants...
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Abstract Objectives Compelling evidence from observational studies shows that dietary patterns play a role in the development of depression and depressive symptoms in the general population. However, few studies have specifically sought to explore the association between maternal diet in the postpartum period and PPD. The purpose of this literature review was to synthesise data from existing published studies, examining the association...
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Abstract Directed evolution has become an important method to unleash the latent potential of enzymes to make them uniquely suited for human purposes. However, the need for a large reagent volume and sophisticated instrumentation hampers its broad implementation. In an attempt to address this problem, here we report a paper-based high-throughput screening approach that should find broad application in generating desired enzymes. As an example case, the dehalogenation reaction...
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The last two decades have witnessed two large-scale pandemics caused by coronaviruses, including severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS). At the end of 2019, another novel coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), hit Wuhan, a city in the center of China, and subsequently spread rapidly to the whole world. Latest reports revealed that more than 800 thousand people in over 200 countries are involved in...
Wed Apr 29, 2020 12:35
Abstract To investigate the effects of subliminal micropulse yellow laser application on the central macular thickness and best-corrected visual acuity in cystoid macular edema secondary to retinitis pigmentosa patients. This prospective open-label clinical trial, conducted between January 2018 and October 2019, included 32 eyes of 29 patients who had cystoid macular edema secondary to retinitis pigmentosa. Patients were treated by subliminal micropulse yellow laser for one session....
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Abstract We have previously reported the protective effects of blue light-emitting diode (BLED)–stimulated cell metabolites on cell injury. To further examine the effect of conditioned media (CM) derived from BLED (5 J/cm2)-exposed human normal fibroblasts (CMBL5) for clinical application, we have used the choline chloride and phenol red–free media and then concentrated CMBL5 using a centrifugal filter unit. The collected CMBL5-lower part (CMBL5-LO) has evaluated the inflammatory...
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