Publication date: Available online 3 May 2020Source: Journal of Neuroscience MethodsAuthor(s): Li Fan, Boqi Xiang, Jun Xiong, Zhigang He, Hongbing Xiang
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Abstract Purpose of Review Duchenne muscular dystrophy is one of many neuromuscular disorders, but it frequently causes severe disability early in life and early death. Cardiac involvement is an important cause of morbidity and mortality. Recent Findings Heart disease in Duchenne muscular dystrophy can include a cardiomyopathy leading to end-stage heart failure...
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Related ArticlesEffect of work-related factors on the prevalence of peptic ulcer disease among Korean workers: a nationwide population-based study. Int Arch Occup Environ Health. 2020 Apr 30;: Authors: Choi YI, Chung JW, Kim KO, Kwon KA, Kim YJ, Park DK Abstract BACKGROUND: Working environment such as psychosocial factors impacts the health of workers. However, few studies have assessed the association of work-related factors with the prevalence of peptic...
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Vascular complications of diabetes mellitus, including the evolution of the retinal damage known as diabetic retinopathy, have been recognized for centuries. Over the past decade, advances in technology such as retinal imaging and the development of new therapies have dramatically improved the…
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Related ArticlesSurvival outcomes of resection for pulmonary malignancies including non-small cell lung cancer and pulmonary metastasis after esophagectomy for esophageal carcinoma. Gen Thorac Cardiovasc Surg. 2020 May 02;: Authors: Yamanashi K, Hamaji M, Tsunoda S, Nakanishi T, Omasa M, Nakajima N, Ohsumi A, Menju T, Chen-Yoshikawa TF, Date H Abstract OBJECTIVES: This study investigated survival outcomes of resection for pulmonary malignancies after...
Related ArticlesThoracic radiation oncology clinical trial accrual and reasons for non-enrollment: results of a large, prospective, multi-year analysis. Int J Radiat Oncol Biol Phys. 2020 Apr 29;: Authors: Mesko S, Ning MS, Lakomy D, Verma V, Chang JY, O'Reilly M, Jeter MD, Gandhi SJ, Lin SH, Nguyen QN, Liao Z, Welsh J, Chen AB, Hahn S, Gomez DR Abstract BACKGROUND: Clinical trials are considered the "gold-standard" in evidence-based medicine, yet few...
Related ArticlesSilencing of S-phase kinase-associated protein 2 enhances radiosensitivity of esophageal cancer cells through inhibition of PI3K/AKT signaling pathway. Genomics. 2020 Apr 29;: Authors: Wang C, Li S, Liu J, Cheng M, Wang D, Wang Y, Lu B Abstract We investigated the effect of S-phase kinase-associated protein 2 (SKP2) on radiosensitivity of esophageal cancer (EC) cells. Expression of SKP2, PI3K, AKT, Bcl-2 and Bax were assayed in EC. EC...
Related ArticlesPlasma metabolite biomarkers predictive of radiation induced cardiotoxicity. Radiother Oncol. 2020 Apr 20;: Authors: Unger K, Li Y, Yeh C, Barac A, Srichai MB, Ballew EA, Girgis M, Jayatilake M, Sridharan V, Boerma M, Cheema AK Abstract PURPOSE: Although advancements in cancer treatments using radiation therapy (RT) have led to improved outcomes, radiation-induced heart disease (RIHD) remains a significant source of morbidity and mortality...
Related ArticlesAssessment of energy intake and total energy expenditure in a series of patients who have undergone oesophagectomy following neoadjuvant treatment. Clin Nutr ESPEN. 2020 Jun;37:121-128 Authors: Ericson J, Lundell L, Lindblad M, Klevebro F, Nilsson M, Rouvelas I Abstract BACKGROUND: Assessment of malnutrition and its consequences are important aspects of curative management of patients with oesophageal cancer. The objective of the present...
Related ArticlesThe biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy. Mol Cancer. 2020 May 02;19(1):81 Authors: Wang X, Wang F, Zhong M, Yarden Y, Fu L Abstract Immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 antibodies (Abs) and anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) Abs, are effective for patients with various cancers. However, low response rates to ICI monotherapies and even hyperprogressive disease (HPD) have...
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Related ArticlesPredictive pharmacogenetic biomarkers for breast cancer recurrence prevention by simvastatin. Acta Oncol. 2020 Apr 30;:1-7 Authors: Ahern TP, Damkier P, Feddersen S, Kjærsgaard A, Lash TL, Hamilton-Dutoit S, Lythjohan CB, Ejlertsen B, Christiansen PM, Cronin-Fenton DP Abstract Background: Statins treat hyperlipidemia and prevent cardiovascular morbidity and mortality. Evidence suggests that they also have anti-neoplastic activity. Several...
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Related ArticlesLeukocyte nadir as a predictive factor for efficacy of adjuvant chemotherapy in breast cancer. Results from the prospective trial SBG 2000-1. Acta Oncol. 2020 Apr 29;:1-8 Authors: Poikonen-Saksela P, Lindman H, Sverrisdottir A, Edlund P, Villman K, Tennvall Nittby L, Cold S, Bechmann T, Stenbygaard L, Ejlertsen B, Andersson M, Blomqvist C, Bergh J, Ahlgren J Abstract Background: Retrospective studies have suggested that chemotherapy-induced...
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Abstract Introduction Colorectal cancer is one of the most sprayed cancers; the gold standard of diagnostic is a colonoscopy. The quality of this examination is depended on many factors, which includes doctors’ experience. Purpose The purpose of this study is to establish the main factors affecting the completeness of colonoscopy in colorectal cancer screening....
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#GivingTuesdayNow is a global day of giving and unity that will take place on Tuesday, May 5, 2020, as an emergency response to the unprecedented need caused by the COVID-19 pandemic. The day is designed to drive an influx of grassroots generosity, citizen engagement, business and philanthropy activation, and support for communities and nonprofits around the world. It’s a day when we can come together and give back, no matter who or where we are.
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Related ArticlesAblation, consolidation and radiotherapy for the management of metastatic lesions of the spine: impact on the quality of life in a mid-term clinical and diagnostic follow-up in a pilot study. Med Oncol. 2020 May 02;37(6):53 Authors: Arrigoni F, de Cataldo C, Bruno F, Palumbo P, Zugaro L, Di Staso M, Gravina GL, Barile A, Masciocchi C Abstract Bone metastasis in the spine are lesions that are very challenging to manage because of pain,...
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Related ArticlesThe Effects of Cellulose on AOM/DSS-Treated C57BL/6 Colorectal Cancer Mice by Changing Intestinal Flora Composition and Inflammatory Factors. Nutr Cancer. 2020 Apr 30;:1-12 Authors: Li Q, Chen C, Liu C, Sun W, Liu X, Ci Y, Song Y Abstract Chronic intestinal inflammation is a key risk factor of colorectal cancer (CRC). It is known that microbial dysbiosis induces increased inflammatory factors which promote tumorigenesis and cellulose...
Related ArticlesThe Radioprotective Effect of Ascorbic Acid and Kefir against Genotoxicity Induced by Exposure in Mice Blood Lymphocytes. Nutr Cancer. 2020 Apr 30;:1-7 Authors: Koohian F, Shahbazi-Gahrouei D, Koohiyan M, Shanei A Abstract The aim of this research was to determine how coadministration of ascorbic acid prior to the beginning of X-irradiation influences the lymphocyte DNA damage and also if the kefir supplementation to irradiated mice may...
Related ArticlesCan Isoflavones Influence Prostate Specific Antigen Serum Levels in Localized Prostate Cancer? A Systematic Review. Nutr Cancer. 2020 Apr 29;:1-8 Authors: Ratha P, Neumann T, Schmidt CA, Schneidewind L Abstract Low risk prostate cancer does not always necessitate aggressive or invasive intervention and is best monitored through active surveillance, but in daily practice a majority of men seek a more proactive approach. Therefore, tertiary...
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Abstract Bone metastasis in the spine are lesions that are very challenging to manage because of pain, possible respiratory and neurological complications due to the closeness with the spinal cord. In fact, a fracture of a vertebra weakened by a pathological tissue can occur. In this paper, an experience of a single center in treating bone metastasis in the vertebral soma is reported (both fractured than with an increased risk of fracture) with a combined procedure of ablation,...
Abstract Non-surgical locally ablative treatments for primary liver cancer and liver metastases represent an effective therapeutic choice when surgery cannot be performed or is not indicated. Thermal ablative employing electric currents or electromagnetic fields have historically played an important role in this setting. Radiotherapy, in the last decades, due to a series of important technological development, has become an attractive option for the treatment of liver tumours,...
Abstract As we know more about the clinical and laboratory features of COVID-19, which is now accepted as a pandemic, many questions have been raised about how to manage and monitor the treatment of cancer patients. It was determined that the incidence of lymphopenia increased in COVID-19 and there was a significant relationship between lymphopenia and mortality. This can be thought of as an unresponsive problem in how to maintain anti-cancer drugs that cause lymphopenia. This...
Abstract Recent advances in computing capability allowed the development of sophisticated predictive models to assess complex relationships within observational data, described as Artificial Intelligence. Medicine is one of the several fields of application and Radiation oncology could benefit from these approaches, particularly in patients’ medical records, imaging, baseline pathology, planning or instrumental data. Artificial Intelligence systems could simplify many steps of...
Abstract Studies indicate that inhibiting a single signaling pathway or one single product of a gene is insufficient for the prevention and treatment of cancer. This is due to the fact that dysregulation must occur in more than 500 genes in order to produce a cancerous phenotype. Despite this evidence, available drugs used for cancer treatment focus on a single target. Meanwhile, berberine as a nutraceutical is capable of targeting various processes involved in tumor development...
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