Cancers, Vol. 12, Pages 1270: The Dynamic Relationship of Breast Cancer Cells and Fibroblasts in Fibronectin Accumulation at Primary and Metastatic Tumor Sites Cancers doi: 10.3390/cancers12051270 Authors: Sarah Libring Aparna Shinde Monica K. Chanda Maryam Nuru Heather George Aya M. Saleh Ammara Abdullah Tamara L. Kinzer-Ursem Sarah Calve Michael K. Wendt Luis Solorio In breast cancer (BC), tissue stiffening via fibronectin (FN) and collagen accumulation...
Sun May 17, 2020 03:00
Cancers, Vol. 12, Pages 1269: Complementary Targeting of Rb Phosphorylation and Growth in Cervical Cancer Cell Cultures and a Xenograft Mouse Model by SHetA2 and Palbociclib Cancers doi: 10.3390/cancers12051269 Authors: Amy L. Kennedy Rajani Rai Zitha Redempta Isingizwe Yan Daniel Zhao Stanley A. Lightfoot Doris M. Benbrook Cervical cancer is caused by high-risk human papillomavirus (HPV) types and treated with conventional chemotherapy with surgery and/or radiation. HPV...
Sun May 17, 2020 03:00
Cancers, Vol. 12, Pages 1265: Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview Cancers doi: 10.3390/cancers12051265 Authors: Md Ashraf Uz-Zaman Aditya Bhalerao Constantinos M. Mikelis Luca Cucullo Nadezhda A. German Chemoprevention of lung cancer is thought to significantly reduce the risk of acquiring these conditions in the subpopulation of patients with underlying health issues, such as chronic obstructive pulmonary disorder and smoking-associated...
Sun May 17, 2020 03:00
Cancers, Vol. 12, Pages 1268: Proteomic Tissue-Based Classifier for Early Prediction of Prostate Cancer Progression Cancers doi: 10.3390/cancers12051268 Authors: Yuqian Gao Yi-Ting Wang Yongmei Chen Hui Wang Denise Young Tujin Shi Yingjie Song Athena A. Schepmoes Claire Kuo Thomas L. Fillmore Wei-Jun Qian Richard D. Smith Sudhir Srivastava Jacob Kagan Albert Dobi Isabell A. Sesterhenn Inger L. Rosner Gyorgy Petrovics Karin D. Rodland Shiv...
Sun May 17, 2020 03:00
Cancers, Vol. 12, Pages 1266: Assessment and Management of Platinum-Related Ototoxicity in Children Treated for Cancer Cancers doi: 10.3390/cancers12051266 Authors: Alberto Romano Michele Antonio Capozza Stefano Mastrangelo Palma Maurizi Silvia Triarico Rolando Rolesi Giorgio Attinà Anna Rita Fetoni Antonio Ruggiero Platinum compounds are a group of chemotherapeutic agents included in many pediatric and adult oncologic treatment protocols. The main platinum compounds...
Sun May 17, 2020 03:00
Cancers, Vol. 12, Pages 1267: Metabolic Plasticity in Ovarian Cancer Stem Cells Cancers doi: 10.3390/cancers12051267 Authors: Ghoneum Gonzalez Abdulfattah Said Ovarian Cancer is the fifth most common cancer in females and remains the most lethal gynecological malignancy as most patients are diagnosed at late stages of the disease. Despite initial responses to therapy, recurrence of chemo-resistant disease is common. The presence of residual cancer stem cells (CSCs) with...
Sun May 17, 2020 03:00
Cancers, Vol. 12, Pages 1264: Risk Assessment by Presurgical Tractography Using Navigated TMS Maps in Patients with Highly Motor- or Language-Eloquent Brain Tumors Cancers doi: 10.3390/cancers12051264 Authors: Sollmann Zhang Fratini Wildschuetz Ille Schröder Zimmer Meyer Krieg Patients with functionally eloquent brain lesions are at risk of functional decline in the course of resection. Given tumor-related plastic reshaping and reallocation of function,...
Sun May 17, 2020 03:00
Cancers, Vol. 12, Pages 1262: Breath Analysis for Early Detection of Malignant Pleural Mesothelioma: Volatile Organic Compounds (VOCs) Determination and Possible Biochemical Pathways Cancers doi: 10.3390/cancers12051262 Authors: Di Gilio Catino Lombardi Palmisani Facchini Mongelli Varesano Bellotti Galetta de Gennaro Tangaro Malignant pleural mesothelioma (MPM) is a rare neoplasm, mainly caused by asbestos exposure, with a high mortality rate....
Sat May 16, 2020 03:00
Cancers, Vol. 12, Pages 1261: The Good, the Bad, the Question–H19 in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12051261 Authors: Lysann Tietze Sonja M. Kessler Hepatocellular carcinoma (HCC), the most common primary liver cancer, is challenging to treat due to its typical late diagnosis, mostly at an advanced stage. Therefore, there is a particular need for research in diagnostic and prognostic biomarkers and therapeutic targets for HCC. The use of long noncoding (lnc)...
Sat May 16, 2020 03:00
Cancers, Vol. 12, Pages 1263: Azasteroid Alkylators as Dual Inhibitors of AKT and ERK Signaling for the Treatment of Ovarian Carcinoma Cancers doi: 10.3390/cancers12051263 Authors: Dalezis Geromichalou Polonifi Sagredou Nikoleousakos Nikolaou Sarli Panayiotidis Trafalis (1) Background: Previous findings show that lactam steroidal alkylating esters display improved therapeutic efficacy with reduced toxicity. The aim of this study was to evaluate the anticancer...
Sat May 16, 2020 03:00
Cancers, Vol. 12, Pages 1259: Evaluation of Second-line Anti-VEGF after First-line Anti-EGFR Based Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Multicenter “SLAVE” Study Cancers doi: 10.3390/cancers12051259 Authors: Parisi Cortellini Cannita Venditti Camarda Calegari Salvatore Tortora Rossini Germani Boccaccino Dell’Aquila Fulgenzi Santini Tursi Tinari Marino Lombardi Keränen Álvaro Zurlo Corsi...
Sat May 16, 2020 03:00
Cancers, Vol. 12, Pages 1256: Detecting Endometrial Cancer by Blood Spectroscopy: A Diagnostic Cross-Sectional Study Cancers doi: 10.3390/cancers12051256 Authors: Maria Paraskevaidi Camilo L.M. Morais Katherine M. Ashton Helen F. Stringfellow Rhona J. McVey Neil A.J. Ryan Helena O’Flynn Vanitha N. Sivalingam Sarah J. Kitson Michelle L. MacKintosh Abigail E. Derbyshire Cecilia Pow Olivia Raglan Kássio M.G. Lima Maria Kyrgiou Pierre L. Martin-Hirsch...
Sat May 16, 2020 03:00
Cancers, Vol. 12, Pages 1258: Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma Cancers doi: 10.3390/cancers12051258 Authors: Tetsuya Sekita Tesshi Yamada Eisuke Kobayashi Akihiko Yoshida Toru Hirozane Akira Kawai Yuko Uno Hideki Moriyama Masaaki Sawa Yuichi Nagakawa Akihiko Tsuchida Morio Matsumoto Masaya Nakamura Robert Nakayama Mari Masuda Background: The treatment of patients with metastatic synovial sarcoma is...
Sat May 16, 2020 03:00
Cancers, Vol. 12, Pages 1257: PIOS (Patras Immunotherapy Score) Score Is Associated with Best Overall Response, Progression-Free Survival, and Post-Immunotherapy Overall Survival in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC) Treated with Anti-Program Cell Death-1 (PD-1) Inhibitors Cancers doi: 10.3390/cancers12051257 Authors: Foteinos-Ioannis Dimitrakopoulos Achilleas Nikolakopoulos Anastasia Kottorou Fotini Kalofonou Elias Liolis Theodora Frantzi Ioannis Pyrousis...
Sat May 16, 2020 03:00
Cancers, Vol. 12, Pages 1260: Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles Cancers doi: 10.3390/cancers12051260 Authors: Eman A. Taha Chiharu Sogawa Yuka Okusha Hotaka Kawai May Wathone Oo Abdellatif Elseoudi Yanyin Lu Hitoshi Nagatsuka Satoshi Kubota Ayano Satoh Kuniaki Okamoto Takanori Eguchi The tumor organoid (tumoroid) model in three-dimensional (3D) culture systems has been developed to reflect more closely the...
Sat May 16, 2020 03:00
Cancers, Vol. 12, Pages 1255: T Cells Expressing a TCR-Like Antibody Selected Against the Heteroclitic Variant of a Shared MAGE-A Epitope Do Not Recognise the Cognate Epitope Cancers doi: 10.3390/cancers12051255 Authors: Mesha Saeed Erik Schooten Mandy van Brakel David K. Cole Timo L. M. ten Hagen Reno Debets Antibodies-recognising peptides bound to the major histocompatibility complex (pMHC) represent potentially valuable and promising targets for chimeric antigen receptor...
Sat May 16, 2020 03:00
Cancers, Vol. 12, Pages 1254: Characteristics of MGUS and Multiple Myeloma According to the Target of Monoclonal Immunoglobulins, Glucosylsphingosine, or Epstein-Barr Virus EBNA-1 Cancers doi: 10.3390/cancers12051254 Authors: Bosseboeuf Mennesson Allain-Maillet Tallet Piver Decaux Moreau Moreau Lehours Mégraud Salle Bigot-Corbel Harb Hermouet : Chronic stimulation by infectious or self-antigens initiates subsets of monoclonal gammopathies...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1252: BRCA Detection Rate in an Italian Cohort of Luminal Early-Onset and Triple-Negative Breast Cancer Patients without Family History: When Biology Overcomes Genealogy Cancers doi: 10.3390/cancers12051252 Authors: Toss Molinaro Venturelli Domati Marcheselli Piana Barbieri Grandi Piombino Marchi Tenedini Tagliafico Tazzioli Cortesi NCCN Guidelines recommend BRCA genetic testing in individuals with a probability...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1251: Proposal of a Two-Tier System in Grouping Adenocarcinoma of the Uterine Cervix Cancers doi: 10.3390/cancers12051251 Authors: Hiroko Machida Koji Matsuo Shinya Matsuzaki Wataru Yamagami Yasuhiko Ebina Yoichi Kobayashi Tsutomu Tabata Masanori Kaneuchi Satoru Nagase Takayuki Enomoto Mikio Mikami (1) Background: This study examined the use of a two-tier system in grouping cervical adenocarcinoma for survival discrimination. (2)...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1253: CCL2 Expression in Tumor Cells and Tumor-Infiltrating Immune Cells Shows Divergent Prognostic Potential for Bladder Cancer Patients Depending on Lymph Node Stage Cancers doi: 10.3390/cancers12051253 Authors: Eckstein Epple Jung Weigelt Lieb Sikic Stöhr Geppert Weyerer Bertz Kehlen Hartmann Wullich Taubert Wach Bladder cancer (BCa) is the ninth most commonly diagnosed cancer worldwide. Although there...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1246: Beyond MicroRNAs: Emerging Role of Other Non-Coding RNAs in HPV-Driven Cancers Cancers doi: 10.3390/cancers12051246 Authors: Mariateresa Casarotto Giuseppe Fanetti Roberto Guerrieri Elisa Palazzari Valentina Lupato Agostino Steffan Jerry Polesel Paolo Boscolo-Rizzo Elisabetta Fratta Persistent infection with high-risk Human Papilloma Virus (HPV) leads to the development of several tumors, including cervical, oropharyngeal, and anogenital...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1250: A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids Cancers doi: 10.3390/cancers12051250 Authors: Jamie Lee Fritz Olga Collins Parima Saxena Adrian Buensuceso Yudith Ramos Valdes Kyle E. Francis Kevin R. Brown Brett Larsen Karen Colwill Anne-Claude Gingras Robert Rottapel Trevor G. Shepherd Epithelial ovarian cancer (EOC) has a unique mode of metastasis,...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1248: Multi-Modal PET and MR Imaging in the Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) Model for Initial in Vivo Testing of Target-Specific Radioligands Cancers doi: 10.3390/cancers12051248 Authors: Gordon Winter Andrea B. F. Koch Jessica Löffler Mika Lindén Christoph Solbach Alireza Abaei Hao Li Gerhard Glatting Ambros J. Beer Volker Rasche The validation of novel target-specific radioligands requires animal experiments mostly...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1249: F-Box Proteins and Cancer Cancers doi: 10.3390/cancers12051249 Authors: Kanae Yumimoto Yuhei Yamauchi Keiichi I. Nakayama Controlled protein degradation is essential for the operation of a variety of cellular processes including cell division, growth, and differentiation. Identification of the relations between ubiquitin ligases and their substrates is key to understanding the molecular basis of cancer development and to the discovery of novel targets...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1247: Harnessing Gene Expression Profiles for the Identification of Ex Vivo Drug Response Genes in Pediatric Acute Myeloid Leukemia Cancers doi: 10.3390/cancers12051247 Authors: David G.J. Cucchi Costa Bachas Marry M. van den Heuvel-Eibrink Susan T.C.J.M. Arentsen-Peters Zinia J. Kwidama Gerrit J. Schuurhuis Yehuda G. Assaraf Valérie de Haas Gertjan J.L. Kaspers Jacqueline Cloos Novel treatment strategies are of paramount importance...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1244: Co-Expression of Androgen Receptor and Cathepsin D Defines a Triple-Negative Breast Cancer Subgroup with Poorer Overall Survival Cancers doi: 10.3390/cancers12051244 Authors: Hanane Mansouri Lindsay B. Alcaraz Caroline Mollevi Aude Mallavialle William Jacot Florence Boissière-Michot Joelle Simony-Lafontaine Valérie Laurent-Matha Pascal Roger Emmanuelle Liaudet-Coopman Séverine Guiu Background: In the triple-negative breast cancer...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1245: Mechanisms of Long Non-Coding RNAs in Cancers and Their Dynamic Regulations Cancers doi: 10.3390/cancers12051245 Authors: Xiao-Zhen Zhang Hao Liu Su-Ren Chen Long non-coding RNA (lncRNA), which is a kind of noncoding RNA, is generally characterized as being more than 200 nucleotide transcripts in length. LncRNAs exhibit many biological activities, including, but not limited to, cancer development. In this review, a search of the PubMed database was...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1243: Non-Coding RNAs: Regulating Disease Progression and Therapy Resistance in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12051243 Authors: Debashri Manna Devanand Sarkar Hepatocellular carcinoma (HCC), the primary liver cancer arising from hepatocytes, is a universal health problem and one of the most common malignant tumors. Surgery followed by chemotherapy as well as tyrosine kinase inhibitors (TKIs), such as sorafenib, are primary treatment procedures...
Fri May 15, 2020 03:00
Cancers, Vol. 12, Pages 1242: Long-Term Survival, Vascular Occlusive Events and Efficacy Biomarkers of First-Line Treatment of CML: A Meta-Analysis Cancers doi: 10.3390/cancers12051242 Authors: Hélène Haguet Carlos Graux François Mullier Jean-Michel Dogné Jonathan Douxfils Large randomized clinical trials and prior meta-analyses indicate that second-generation BCR-ABL tyrosine kinase inhibitors (TKIs) improve surrogate biomarkers in patients with chronic myeloid leukemia...
Fri May 15, 2020 03:00
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