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Τρίτη 12 Μαΐου 2020


Breviscapine suppresses the growth and metastasis of prostate cancer through regulating PAQR4-mediated PI3K/Akt pathway
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Jiwei Ye, Mingquan Gao, Xinwu Guo, Henan Zhang, Fuchun Jiang
Biomedicine & Pharmacotherapy
Tue May 12, 2020 20:17
Dexmedetomidine pretreatment protects the heart against apoptosis in ischemia/reperfusion injury in diabetic rats by activating PI3K/Akt signaling <em>in vivo</em> and <em>in vitro</em>
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Jian-Hua Chang, Mei-Mei Jin, Jun-Tian Liu
Biomedicine & Pharmacotherapy
Tue May 12, 2020 20:17
Dehydroabietic acid alleviates high fat diet-induced insulin resistance and hepatic steatosis through dual activation of PPAR-γ and PPAR-α
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Zhishen Xie, Gai Gao, Hui Wang, Erwen Li, Yong Yuan, Jiangyan Xu, Zhenqiang Zhang, Pan Wang, Yu Fu, Huahui Zeng, Junying Song, Christian Hölscher, Hui Chen
Biomedicine & Pharmacotherapy
Tue May 12, 2020 20:17
Synthesis and trypanocidal activity of novel pyridinyl-1,3,4-thiadiazole derivatives
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Rosana H.C.N. Freitas, Juliana M.C. Barbosa, Patrícia Bernardino, Vitor Sueth-Santiago, Solange M.S.V. Wardell, James L. Wardell, Débora Decoté-Ricardo, Tatiana G. Melo, Edson F. da Silva, Kelly Salomão, Carlos A.M. Fraga
Biomedicine & Pharmacotherapy
Tue May 12, 2020 20:17
Deviating from clinical practice: Pharmacokinetics of Chinese materia medica faces a substantial challenge
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Zhirui Yang, Guofeng Pan, Luyong Zhang, Dan Yan
Biomedicine & Pharmacotherapy
Tue May 12, 2020 20:17
Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K/Akt/eNOS pathway
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Biming Zhan, Zongyu Xu, Yang Zhang, Kefei Wan, Hanyue Deng, Dimeng Wang, Huihui Bao, Qinghua Wu, Xiaohong Hu, Hong Wang, Xiao Huang, Xiaoshu Cheng
Biomedicine & Pharmacotherapy
Tue May 12, 2020 20:17
Tumor suppressor p53 independent apoptosis in HT-29 cells by auransterol from <em>Penicillium aurantiacobrunneum</em>
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Gerardo D. Anaya-Eugenio, Choon Yong Tan, L. Harinantenaina Rakotondraibe, Esperanza Carcache Carcache de Blanco
Biomedicine & Pharmacotherapy
Tue May 12, 2020 20:17
Effects of umbelliferone isolated from the <em>Ferulago pauciradiata</em> Boiss. & Heldr. Plant on cecal ligation and puncture-induced sepsis model in rats
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Z. Kutlu, M. Celik, A. Bilen, Z. Halıcı, S. Yıldırım, S. Karabulut, S. Karakaya, Delimustafaoğlu F. Bostanlık, P. Aydın
Biomedicine & Pharmacotherapy
Tue May 12, 2020 20:17
Tumor treating fields for high-grade gliomas
Publication date: July 2020Source: Biomedicine & Pharmacotherapy, Volume 127Author(s): Chengke Luo, Shengchao Xu, Gan Dai, Zhiqiang Xiao, Ling Chen, Zhixiong Liu
Biomedicine & Pharmacotherapy
Tue May 12, 2020 20:17
Circulating levels of oxidized low-density lipoprotein in patients with obstructive sleep apnea: a systematic review and meta-analysis
Abstract Background Obstructive sleep apnea (OSA) is associated with an increased risk of developing atherosclerotic cardiovascular disease (ASCVD). Patients with OSA have increased levels of oxidative stress and several studies have shown higher levels of oxidative stress markers. Oxidized-LDL (Ox-LDL) is an important risk factor for ASCVD and a number of studies have measured its levels in patients with OSA, though results from these...
Latest Results for Sleep and Breathing
Tue May 12, 2020 03:00
Increased frequency of obstructive sleep apnea in the patients with systemic sclerosis
Abstract Introduction Sleep problems, including obstructive sleep apnea (OSA), profoundly affect quality of life in patients with systemic sclerosis (SSc). This study aimed to determine the prevalence of OSA in patients with SSc and the factors affecting OSA. Methods Consecutive patients with SSc lung involvement who were referred to the “Outpatient...
Latest Results for Sleep and Breathing
Tue May 12, 2020 03:00
Association between sleep-disordered breathing and lower extremity artery disease: a meta-analysis
Abstract Objective Previous studies suggest a relationship between sleep disordered breathing (SDB) and lower extremity artery disease (LEAD) though disagreements remain. This study was performed to assess the association between SDB and LEAD in a metaanalysis. Methods PubMed and Embase databases were searched for observational studies. A random-effects...
Latest Results for Sleep and Breathing
Tue May 12, 2020 03:00
NOX4, MDA, IMA and oxidative DNA damage: can these parameters be used to estimate the presence and severity of OSA?
Abstract Purpose Obstructive sleep apnoea (OSA) involves recurrent obstructive apnoeas and hypopnoeas which cause cyclic hypoxia, reoxygenation and formation of reactive oxygen species (ROS). We aimed to investigate a member of the nicotinamide adenine dinucleotide phosphate oxidase (NOX) family of enzymes, specifically (NOX4), not previously studied in humans, as well as 8-OHdG/106dG, MDA and IMA, which are known to be associated with...
Latest Results for Sleep and Breathing
Tue May 12, 2020 03:00
Sleep quality and its association with health-related quality of life of patients on lung transplantation waitlist in Japan
Abstract Purpose Poor quality of sleep is a common feature in patients with various lung diseases and affects their health-related quality of life (HRQL). We evaluated sleep quality and HRQL in patients on the waitlist for lung transplantation in Japan. Methods In this prospective study, patient-reported and physiological data were collected from patients...
Latest Results for Sleep and Breathing
Tue May 12, 2020 03:00
Audiologische Zielparameter bei klinischen Studien mit implantierbaren Hörsystemen
Zusammenfassung Eine Vielzahl neuer implantierbarer Hörsysteme und Anwendungen eröffnet zusätzliche Möglichkeiten für bisher schlecht behandelbare Erkrankungen. Für viele dieser Hörsysteme gibt es nur eingeschränkt technische Möglichkeiten, um alle Anwendungen technisch zu charakterisieren. Deswegen sind klar strukturierte, klinische Studien, die die Anwendungen und Geräte für zusammenfassende Metastudien vergleichbar machen, dringend erforderlich. Dies ist nicht nur im Hinblick...
HNO
Tue May 12, 2020 03:00
Exosomen als Immunregulatoren in Kopf-Hals-Karzinomen
Zusammenfassung Exosomen, virusgroße Nanovesikel, werden als Botensysteme unseres Körpers zur Kommunikation mit anderen Körperzellen und Regulation von Immunfunktionen genutzt. Die von fast allen Körperzellen sezernierten Exosomen können unterwegs in der Blutzirkulation und in der Körperperipherie mit Immunzellen interagieren. Unterschiedliche Marker auf der Exosomenoberfläche sind für die Immunzelladhäsion und -interaktion nötig. Darüber hinaus sind mehrere Arten der Exosomen-Immunzell-Interaktion...
HNO
Tue May 12, 2020 03:00
Epithelial-to-mesenchymal transition is a prognostic marker for patient outcome in advanced stage HNSCC patients treated with chemoradiotherapy
About half of head and neck squamous cell carcinoma (HNSCC) patients present with advanced stage disease. In the case of hypopharyngeal, laryngeal and HPV-negative oropharyngeal carcinomas, chemoradiotherapy is the current treatment of choice for these patients[1]. Disease progression occurs in around 40%, stressing the need for additional treatment options for poor prognosis patients.
Radiotherapy and Oncology
Tue May 12, 2020 03:00
Clinical and radiographic adverse events after Gamma Knife radiosurgery for brainstem lesions: a dosimetric analysis
The brainstem is composed of several densely packed neural tracts that are critical for neurological function and survival. Progressing lesions near or on the brainstem often lead to rapid neurological decline and even death.[1-6] A 2017 study by Emery et al. found that brainstem metastases are associated with more than a three-fold risk of death when compared to supratentorial lesions.[7] Resection is typically avoided as a treatment option due to operative risk and poor outcomes, and instead, stereotactic...
Radiotherapy and Oncology
Tue May 12, 2020 03:00
ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy with electrons (IOERT) in breast cancer
In breast conserving treatment (BCT), radiation therapy following breast-conserving surgery (BCS) is performed as whole breast irradiation (WBI) or, increasingly, as accelerated partial breast irradiation (APBI), targeting the tissue surrounding the original tumour site (tumour bed) in selected patients with low local recurrence risks [1].
Radiotherapy and Oncology
Tue May 12, 2020 03:00
Cranberry capsules are not superior to placebo capsules in managing acute non-haemorrhagic radiation cystitis in prostate cancer patients: a phase III double blinded randomised placebo controlled clinical trial
Radiation-cystitis is an unavoidable side effect of external beam radiation therapy to the pelvis, even when delivered using normal tissue sparing delivery methods such as image guided radiation therapy (IGRT) and volumetric modulated arc therapy (VMAT). Cystitis symptoms include dysuria, urinary frequency, urgency, nocturia, the sensation of incomplete bladder voiding, haematuria and an increased risk of urinary tract infections. Acute radiation-cystitis develops during radiation therapy and generally...
Radiotherapy and Oncology
Tue May 12, 2020 03:00
Lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable
Conflict of Interest: DGK is on the scientific advisory board and owns stock in Lumicell, Inc which is developing intraoperative imaging technology. DGK is a co-founder of X-RAD Therapeutics, which is developing radiosensitizers. DGK reports research support from Merck, Bristol Myers Squibb, and X-RAD Therapeutics. MD reports research funding from Varian Medical Systems and Illumina, ownership interest in CiberMed, patent filings related to cancer biomarkers, paid consultancy from Roche, AstraZeneca,...
Radiotherapy and Oncology
Tue May 12, 2020 03:00
COVID-19 outbreak and cancer radiotherapy disruption in italy: Survey endorsed by the italian association of radiotherapy and clinical oncology (AIRO)
Italy experienced one of the world’s deadliest COVID-19 outbreaks and healthcare systems had to instantly reorganise activity. The Italian Radiation Oncology Departments adapted numerous solutions to minimize the disruptions. Information technologies, treatment prioritization and implementation of hypofractionation and protection procedures allowed balancing between cancer patient care and patient/healthcare workers safety.
Radiotherapy and Oncology
Tue May 12, 2020 03:00
Paciente con xerostomía posradioterapia por cáncer de cabeza y cuello tratado con células madre mesenquimales autólogas expandidas de tejido adiposo: una nueva oportunidad terapéutica
Publication date: Available online 11 May 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Jordi Coromina Isern, Robert Soler Rich, Joan Rius Tarruella, Jeanneth Zamora Bustamante
Acta Otorrinolaringológica Española
Tue May 12, 2020 20:01
Peer attitudes toward children with cleft (lip and) palate related to speech intelligibility, hypernasality and articulation
Publication date: Available online 12 May 2020Source: Journal of Communication DisordersAuthor(s): Kim Bettens, Cassandra Alighieri, Laura Bruneel, Lara De Meulemeester, Kristiane Van Lierde
Journal of Communication Disorders (open access)
Tue May 12, 2020 20:01
Innovations in applied decision theory for health and safety
ObjectivesThere are established methods for occupational epidemiological cohort analysis, such as proportional hazards regression, that are well suited to aetiological research and yield parameter estimates that allow for succinct communication among academics. However, these methods are not necessarily well suited for evaluation of health impacts of policy choices and communication to decision makers. An informed decision about a policy that impacts health and safety requires a valid estimate of...
OEM Online First
Tue May 12, 2020 19:00
Tobacco smoking among chrysotile asbestos workers in Asbest in the Russian Federation
ObjectivesA historical cohort study of cancer mortality is being conducted among workers in a chrysotile mine and its enrichment factories in the town of Asbest, Russian Federation. Because individual-level information on tobacco use is not available for Asbest Chrysotile Cohort members, a cross-sectional survey of smoking behaviours was conducted among active and retired workers.MethodsSelf-administered questionnaires were completed by active workers during meetings organised by occupational safety...
OEM Online First
Tue May 12, 2020 19:00
Pregnancy and Aortic Dissection
Publication date: Available online 12 May 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Carlota F. Prendes, Christina Christersson, Kevin Mani
ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery
Tue May 12, 2020 19:50
Vascular Life during the COVID-19 Pandemic Reminds Us to Prepare for the Unexpected
Publication date: Available online 12 May 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Andrés Reyes Valdivia, Claudio Gandarias Zúñiga, Vicente Riambau
ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery
Tue May 12, 2020 19:50
Endovascular Revision Using Distal Inflow: EndoRUDI
Publication date: Available online 12 May 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Alexandros Mallios, William C. Jennings
ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery
Tue May 12, 2020 19:50
Correction to: Chemoradiation in elderly patients with glioblastoma from the multi‑institutional GBM‑molRPA cohort: is short‑course radiotherapy enough or is it a matter of selection?
The name of author Do Hoon Lim was incorrect in the initial online publication. The original article has been corrected.
Neuro-Oncology
Tue May 12, 2020 03:00
Role of Gas6 and TAM Receptors in the Identification of Cardiopulmonary Involvement in Systemic Sclerosis and Scleroderma Spectrum Disorders
Background. Few biomarkers are available for early identification of pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) in systemic sclerosis (SS) and scleroderma spectrum disorders (SSD). Aims. To evaluate Gas6, sAxl, and sMer as biomarkers for cardiopulmonary complications of SS and SSD. Methods. In a cross-sectional observational study, we recruited 125 consecutive patients, affected by SS and SSD and referred to a tertiary-level pulmonary hypertension outpatient clinic....
Disease Markers
Tue May 12, 2020 18:50
[ASAP] A Novel Application of Dopants in Ion Mobility Spectrometry: Suppression of Fragment Ions of Citric Acid
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01318
Analytical Chemistry
Tue May 12, 2020 07:00
Reduction of visceral fat could be related to the improvement of TBS in diabetes mellitus
Abstract Introduction Diabetes has been proposed as a risk factor for increased skeletal fragility. Visceral fat is known to yield adverse effects on bone metabolism in people with diabetes. We investigated the relationship between the change in visceral fat mass over time and TBS or BMD. Materials and methods This retrospective study enrolled 690...
Journal of Bone and Mineral Metabolism
Tue May 12, 2020 03:00
Amyloid-Rich Pancreatic Neuroendocrine Tumors: a Potential Diagnostic Pitfall in Endoscopic Ultrasound–Guided Fine Needle Aspiration Cytology (EUS-FNAC)
Abstract Pancreatic neuroendocrine tumors (PanNETs) are rare neoplasms that include even rarer variants that may pose different diagnostic problems, especially in fine needle aspiration cytology (FNAC). We describe the diagnostic clues of the amyloid-rich variant of PanNETs in endoscopic ultrasound (EUS)–guided fine needle aspiration cytology (EUS-FNAC). Three cases of PanNETs with an amyloid-rich stromal component were retrieved and retrospectively reviewed. For every case, the...
Endocrine Pathology
Tue May 12, 2020 03:00
[ASAP] Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00861
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue May 12, 2020 07:00
[ASAP] Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04091
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue May 12, 2020 07:00
[ASAP] Photoelimination of Nitrogen from Diazoalkanes: Involvement of Higher Excited Singlet States in the Carbene Formation
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02221
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue May 12, 2020 07:00
[ASAP] Using Strand Displacing Polymerase To Program Chemical Reaction Networks
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02240
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue May 12, 2020 07:00
[ASAP] Assessing Site-Specific Enhancements Imparted by Hyperpolarized Water in Folded and Unfolded Proteins by 2D HMQC NMR
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00807
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue May 12, 2020 07:00

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