Metabolites, Vol. 10, Pages 204: Modulatory Effect of Nicotinic Acid on the Metabolism of Caco-2 Cells Exposed to IL-1β and LPS Metabolites doi: 10.3390/metabo10050204 Authors: Maria Laura Santoru Cristina Piras Federica Murgia Martina Spada Laura Tronci Vera Piera Leoni Gabriele Serreli Monica Deiana Luigi Atzori Inflammatory bowel diseases (IBD) are the most common gastrointestinal inflammatory pathologies. Previous work evidenced a lower content of nicotinic...
Sat May 16, 2020 03:00
Metabolites, Vol. 10, Pages 203: Evaluation of Non-Uniform Sampling 2D 1H–13C HSQC Spectra for Semi-Quantitative Metabolomics Metabolites doi: 10.3390/metabo10050203 Authors: Bo Zhang Robert Powers Elizabeth M. O’Day Metabolomics is the comprehensive study of metabolism, the biochemical processes that sustain life. By comparing metabolites between healthy and disease states, new insights into disease mechanisms can be uncovered. NMR is a powerful analytical method to detect and...
Sat May 16, 2020 03:00
Metabolites, Vol. 10, Pages 200: Design, Synthesis, and Biological Evaluation of 1,2,3-Triazole-Linked Triazino[5,6-B]Indole-Benzene Sulfonamide Conjugates as Potent Carbonic Anhydrase I, II, IX, and XIII Inhibitors Metabolites doi: 10.3390/metabo10050200 Authors: Chinchilli Angeli Thacker Korra Biswas Arifuddin Supuran A series of 1,2,3-triazole-linked triazino[5,6-b]indole-benzene sulfonamide hybrids (6a–6o) was synthesized and evaluated for carbonic...
Fri May 15, 2020 03:00
Metabolites, Vol. 10, Pages 201: Metabolite Genome-Wide Association Study (mGWAS) and Gene-Metabolite Interaction Network Analysis Reveal Potential Biomarkers for Feed Efficiency in Pigs Metabolites doi: 10.3390/metabo10050201 Authors: Wang Kadarmideen Metabolites represent the ultimate response of biological systems, so metabolomics is considered the link between genotypes and phenotypes. Feed efficiency is one of the most important phenotypes in sustainable pig production and...
Fri May 15, 2020 03:00
Metabolites, Vol. 10, Pages 202: Metabolomics and Multi-Omics Integration: A Survey of Computational Methods and Resources Metabolites doi: 10.3390/metabo10050202 Authors: Eicher Kinnebrew Patt Spencer Ying Ma Machiraju Mathé As researchers are increasingly able to collect data on a large scale from multiple clinical and omics modalities, multi-omics integration is becoming a critical component of metabolomics research. This introduces a need for increased...
Fri May 15, 2020 03:00
Metabolites, Vol. 10, Pages 199: Using Metabolomics to Identify Cell Line-Independent Indicators of Growth Inhibition for Chinese Hamster Ovary Cell-based Bioprocesses Metabolites doi: 10.3390/metabo10050199 Authors: Alden Raju McElearney Lambropoulos Kshirsagar Gilbert Lee Chinese hamster ovary (CHO) cells are widely used for the production of biopharmaceuticals. Efforts to improve productivity through medium design and feeding strategy optimization have focused...
Fri May 15, 2020 03:00
Metabolites, Vol. 10, Pages 198: Dynamic Flux Balance Analysis to Evaluate the Strain Production Performance on Shikimic Acid Production in Escherichia coli Metabolites doi: 10.3390/metabo10050198 Authors: Yuki Kuriya Michihiro Araki Flux balance analysis (FBA) is used to improve the microbial production of useful compounds. However, a large gap often exists between the FBA solution and the experimental yield, because of growth and byproducts. FBA has been extended to dynamic FBA...
Fri May 15, 2020 03:00
Metabolites, Vol. 10, Pages 197: Metabolomics for Evaluating Flavor-Associated Metabolites in Plant-Based Products Metabolites doi: 10.3390/metabo10050197 Authors: Shruti Pavagadhi Sanjay Swarup Plant-based diets (PBDs) are associated with environmental benefits, human health promotion and animal welfare. There is a worldwide shift towards PBDs, evident from the increased global demand for fresh plant-based products (PBPs). Such shifts in dietary preferences accompanied by evolving...
Fri May 15, 2020 03:00
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