IJMS, Vol. 21, Pages 3406: Protective Effect of Tetrahydroquinolines from the Edible Insect Allomyrina dichotoma on LPS-Induced Vascular Inflammatory Responses International Journal of Molecular Sciences doi: 10.3390/ijms21103406 Authors: Park Lee Yoo Shin Oh Kim Kim Hwang Bae Na The larva of Allomyrina dichotoma (family Scarabaeidae) is an edible insect that is registered in the Korean Food Standards Codex as a food resource. The chemical study on...
Tue May 12, 2020 03:00
IJMS, Vol. 21, Pages 3408: Implementing the CRISPR/Cas9 Technology in Eucalyptus Hairy Roots Using Wood-Related Genes International Journal of Molecular Sciences doi: 10.3390/ijms21103408 Authors: Dai Hu Dupas Medina Blandels Clemente Ladouce Badawi Hernandez-Raquet Mounet Grima-Pettenati Cassan-Wang Eucalypts are the most planted hardwoods worldwide. The availability of the Eucalyptus grandis genome highlighted many genes awaiting functional...
Tue May 12, 2020 03:00
IJMS, Vol. 21, Pages 3407: Interactive Actions of Aldosterone and Insulin on Epithelial Na+ Channel Trafficking International Journal of Molecular Sciences doi: 10.3390/ijms21103407 Authors: Rie Marunaka Yoshinori Marunaka Epithelial Na+ channel (ENaC) participates in renal epithelial Na+ reabsorption, controlling blood pressure. Aldosterone and insulin elevate blood pressure by increasing the ENaC-mediated Na+ reabsorption. However, little information is available on the interactive...
Tue May 12, 2020 03:00
IJMS, Vol. 21, Pages 3405: Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase—Implications for Diabetes Progression International Journal of Molecular Sciences doi: 10.3390/ijms21103405 Authors: Daiber Steven Vujacic-Mirski Kalinovic Oelze Lisa Münzel Oxidative stress plays a key role for the development of cardiovascular, metabolic, and neurodegenerative disease. This concept...
Tue May 12, 2020 03:00
IJMS, Vol. 21, Pages 3404: Modeling Cardiovascular Diseases with hiPSC-Derived Cardiomyocytes in 2D and 3D Cultures International Journal of Molecular Sciences doi: 10.3390/ijms21093404 Authors: Claudia Sacchetto Libero Vitiello Leon J. de Windt Alessandra Rampazzo Martina Calore In the last decade, the generation of cardiac disease models based on human-induced pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to overcome the lack of appropriate...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3385: Akkermansia muciniphila Aspartic Protease Amuc_1434* Inhibits Human Colorectal Cancer LS174T Cell Viability via TRAIL-Mediated Apoptosis Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21093385 Authors: Xin Meng Jinrui Zhang Hao Wu Dahai Yu Xuexun Fang Mucin2 (Muc2) is the main component of the intestinal mucosal layer and is highly expressed in mucous colorectal cancer. Previous studies conducted by our lab found that the recombinant...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3403: Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21093403 Authors: Jinyi Lee Zeyu Jin Donghan Lee Ji-Hye Yun Weontae Lee Human mitochondrial pyruvate carriers (hMPCs), which are required for the uptake of pyruvate into mitochondria, are associated with several metabolic diseases, including type 2 diabetes...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3383: Caviar Extract and Its Constituent DHA Inhibits UVB-Irradiated Skin Aging by Inducing Adiponectin Production International Journal of Molecular Sciences doi: 10.3390/ijms21093383 Authors: Kyung-Eun Lee Youn-Hwa Nho Seok Kyun Yun Sung-Min Park Seunghyun Kang Hyeonju Yeo In this study, caviar (sturgeon eggs) was used to elucidate its roles in adiponectin production and skin anti-aging. Recently, caviar has been largely used not only as a nutritional...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3402: NMR Investigations of Crystalline and Glassy Solid Electrolytes for Lithium Batteries: A Brief Review International Journal of Molecular Sciences doi: 10.3390/ijms21093402 Authors: Daniel J Morales Steven Greenbaum The widespread use of energy storage for commercial products and services have led to great advancements in the field of lithium-based battery research. In particular, solid state lithium batteries show great promise for future commercial use,...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3401: Fabrication of Mechanically Reinforced Gelatin/Hydroxyapatite Bio-Composite Scaffolds by Core/Shell Nozzle Printing for Bone Tissue Engineering International Journal of Molecular Sciences doi: 10.3390/ijms21093401 Authors: Haeri Kim Hanjun Hwangbo YoungWon Koo GeunHyung Kim In tissue engineering, biocompatible scaffolds are used as 3D cell niches to provide a similar environment to that of native tissue for seeded cells to regenerate the target tissue....
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3399: Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms International Journal of Molecular Sciences doi: 10.3390/ijms21093399 Authors: Dorian Forte Flaminia Fanelli Marco Mezzullo Martina Barone Giulia Corradi Giuseppe Auteri Daniela Bartoletti Marina Martello Emanuela Ottaviani Carolina Terragna Antonio Curti Uberto Pagotto Francesca Palandri Michele Cavo Lucia...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3398: Predictive Potential of Circulating Ube2h mRNA as an E2 Ubiquitin-Conjugating Enzyme for Diagnosis or Treatment of Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21093398 Authors: Key-Hwan Lim Jae-Yeol Joo Neurodegenerative disorders are caused by neuronal cell death, miscommunications between synapse, and abnormal accumulations of proteins in the brain. Alzheimer’s disease (AD) is one of the age-related disorders,...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3400: Bicalutamide Elicits Renal Damage by Causing Mitochondrial Dysfunction via ROS Damage and Upregulation of HIF-1 International Journal of Molecular Sciences doi: 10.3390/ijms21093400 Authors: Chen Chen Chen Tzou Peng Peng Combined androgen blockade using bicalutamide (Bic) is a therapeutic choice for treating prostate cancer (PCa). However, even at regular clinical dosages, Bic frequently shows adverse effects associated with cardiovascular...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3396: Behavioral, Biochemical and Electrophysiological Changes in Spared Nerve Injury Model of Neuropathic Pain International Journal of Molecular Sciences doi: 10.3390/ijms21093396 Authors: Francesca Guida Danilo De Gregorio Enza Palazzo Flavia Ricciardi Serena Boccella Carmela Belardo Monica Iannotta Rosmara Infantino Federica Formato Ida Marabese Livio Luongo Vito de Novellis Sabatino Maione Neuropathic pain is a pathological...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3395: Regulation of Iron Homeostasis and Use in Chloroplasts International Journal of Molecular Sciences doi: 10.3390/ijms21093395 Authors: Gretchen E. Kroh Marinus Pilon Iron (Fe) is essential for life because of its role in protein cofactors. Photosynthesis, in particular photosynthetic electron transport, has a very high demand for Fe cofactors. Fe is commonly limiting in the environment, and therefore photosynthetic organisms must acclimate to Fe availability...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3394: Different Roles of Auxins in Somatic Embryogenesis Efficiency in Two Picea Species International Journal of Molecular Sciences doi: 10.3390/ijms21093394 Authors: Hazubska-Przybył Ratajczak Obarska Pers-Kamczyc The effects of auxins 2,4-D (2,4-dichlorophenoxyacetic acid), NAA (1-naphthaleneacetic acid) or picloram (4-amino-3,5,6-trichloropicolinic acid; 9 µM) and cytokinin BA (benzyloadenine; 4.5 µM) applied in the early stages...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3397: Lysosome Dynamic Properties during Neuronal Stem Cell Differentiation Studied by Spatiotemporal Fluctuation Spectroscopy and Organelle Tracking International Journal of Molecular Sciences doi: 10.3390/ijms21093397 Authors: William Durso Manuella Martins Laura Marchetti Federico Cremisi Stefano Luin Francesco Cardarelli We investigated lysosome dynamics during neuronal stem cell (NSC) differentiation by two quantitative and complementary biophysical...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3393: Pan-Genome Analyses of Geobacillus spp. Reveal Genetic Characteristics and Composting Potential International Journal of Molecular Sciences doi: 10.3390/ijms21093393 Authors: Mengmeng Wang Han Zhu Zhijian Kong Tuo Li Lei Ma Dongyang Liu Qirong Shen The genus Geobacillus is abundant in ecological diversity and is also well-known as an authoritative source for producing various thermostable enzymes. Although it is clear now that Geobacillus...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3392: Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation International Journal of Molecular Sciences doi: 10.3390/ijms21093392 Authors: Peizhong Kong K.N. Yu Miaomiao Yang Waleed Abdelbagi Almahi Lili Nie Guodong Chen Wei Han Micheliolide (MCL) has shown promising anti-inflammatory and anti-tumor efficacy. However, whether and how MCL enhances the sensitivity of non-small-cell lung...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3384: A Data-Driven Review of the Genetic Factors of Pregnancy Complications International Journal of Molecular Sciences doi: 10.3390/ijms21093384 Authors: Yury A. Barbitoff Alexander A. Tsarev Elena S. Vashukova Evgeniia M. Maksiutenko Liudmila V. Kovalenko Larisa D. Belotserkovtseva Andrey S. Glotov Over the recent years, many advances have been made in the research of the genetic factors of pregnancy complications. In this work, we use publicly...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3391: Colorectal Cancer Invasion and Atrophy of the Enteric Nervous System: Potential Feedback and Impact on Cancer Progression International Journal of Molecular Sciences doi: 10.3390/ijms21093391 Authors: Janusz Godlewski Zbigniew Kmiec Colorectal cancer (CRC) invasion within the large intestine wall results in the replacement of normal tissue architecture by tumour mass. Cancer cells digest the extracellular matrix (ECM) by the release of proteolytic enzymes....
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3389: Rheumatic Manifestations in Patients Treated with Immune Checkpoint Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms21093389 Authors: Konstantinos Melissaropoulos Kalliopi Klavdianou Alexandra Filippopoulou Fotini Kalofonou Haralabos Kalofonos Dimitrios Daoussis Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that activate the immune system, aiming at enhancing antitumor immunity. Their clinical efficacy...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3388: Special Issue about Head and Neck Cancers: HPV Positive Cancers International Journal of Molecular Sciences doi: 10.3390/ijms21093388 Authors: Panagiota Economopoulou Ioannis Kotsantis Amanda Psyrri The oropharynx has become the leading primary site for Human Papilloma Virus (HPV)-associated head and neck cancer. HPV positive oropharyngeal squamous cell carcinoma (HPV+ OSCC) has emerged as an epidemic not easily recognized by many physicians, resulting...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3386: Probing Nanoelectroporation and Resealing of the Cell Membrane by the Entry of Ca2+ and Ba2+ Ions International Journal of Molecular Sciences doi: 10.3390/ijms21093386 Authors: Wenfei Bo Mantas Silkunas Uma Mangalanathan Vitalij Novickij Maura Casciola Iurii Semenov Shu Xiao Olga N. Pakhomova Andrei G. Pakhomov The principal bioeffect of the nanosecond pulsed electric field (nsPEF) is a lasting cell membrane permeabilization, which is...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3387: The Interplay between MicroRNAs and the Components of the Tumor Microenvironment in B-Cell Malignancies International Journal of Molecular Sciences doi: 10.3390/ijms21093387 Authors: Sherien M. El-Daly Recep Bayraktar Simone Anfossi George A. Calin An increased focus is being placed on the tumorigenesis and contexture of tumor microenvironment in hematopoietic and solid tumors. Despite recent clinical revolutions in adoptive T-cell transfer approaches...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3390: The Bacterial Toxin CNF1 Protects Human Neuroblastoma SH-SY5Y Cells against 6-Hydroxydopamine-Induced Cell Damage: The Hypothesis of CNF1-Promoted Autophagy as an Antioxidant Strategy International Journal of Molecular Sciences doi: 10.3390/ijms21093390 Authors: Sara Travaglione Stefano Loizzo Rosa Vona Giulia Ballan Roberto Rivabene Danila Giordani Marco Guidotti Maria Luisa Dupuis Zaira Maroccia Monica Baiula Roberto Rimondini Gabriele...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3382: Effects of PDE3 Inhibitor Olprinone on the Respiratory Parameters, Inflammation, and Apoptosis in an Experimental Model of Acute Respiratory Distress Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms21093382 Authors: Petra Kosutova Pavol Mikolka Sona Balentova Marian Adamkov Andrea Calkovska Daniela Mokra This study aimed to investigate whether a selective phosphodiesterase-3 (PDE3) inhibitor olprinone can positively influence...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3381: Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21093381 Authors: Daisuke Oikawa Yusuke Sato Hidefumi Ito Fuminori Tokunaga The linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin ligase composed of the Heme-oxidized IRP2 ubiquitin ligase-1L (HOIL-1L), HOIL-1L-interacting protein (HOIP), and Shank-associated RH domain interactor (SHARPIN)...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3380: Characterization of FcXTH2, a Novel Xyloglucan Endotransglycosylase/Hydrolase Enzyme of Chilean Strawberry with Hydrolase Activity International Journal of Molecular Sciences doi: 10.3390/ijms21093380 Authors: Luis Morales-Quintana Dina Beltrán Ángela Mendez-Yañez Felipe Valenzuela-Riffo Raúl Herrera María Alejandra Moya-León Xyloglucan endotransglycosylase/hydrolases (XTHs) are cell wall enzymes with hydrolase (XEH) and/or endotransglycosylase...
Mon May 11, 2020 03:00
IJMS, Vol. 21, Pages 3379: Interplay between Cytokine Circuitry and Transcriptional Regulation Shaping Helper T Cell Pathogenicity and Plasticity in Inflammatory Bowel Disease International Journal of Molecular Sciences doi: 10.3390/ijms21093379 Authors: Shin-Huei Fu Ming-Wei Chien Chao-Yuan Hsu Yu-Wen Liu Huey-Kang Sytwu Inflammatory bowel disease (IBD) is a chronic disorder manifested as Crohn’s disease (CD) and ulcerative colitis (UC) characterized by intestinal...
Mon May 11, 2020 03:00
JCM, Vol. 9, Pages 1443: Can Circulating Cardiac Biomarkers Be Helpful in the Assessment of LMNA Mutation Carriers? Journal of Clinical Medicine doi: 10.3390/jcm9051443 Authors: Chmielewski Michalak Kowalik Franaszczyk Sobieszczanska-Malek Truszkowska Stepien-Wojno Biernacka Foss-Nieradko Lewandowski Oreziak Bilinska Kusmierczyk Tesson Grzybowski Zielinski Ploski Bilinska Mutations in the lamin A/C gene are variably...
Tue May 12, 2020 03:00
JCM, Vol. 9, Pages 1441: Analysis of Systemic Inflammatory Factors and Survival Outcomes in Endometrial Cancer Patients Staged I-III FIGO and Treated with Postoperative External Radiotherapy Journal of Clinical Medicine doi: 10.3390/jcm9051441 Authors: Katarzyna Holub Fabio Busato Sebastien Gouy Roger Sun Patricia Pautier Catherine Genestie Philippe Morice Alexandra Leary Eric Deutsch Christine Haie-Meder Albert Biete Cyrus Chargari Background: The causal...
Tue May 12, 2020 03:00
JCM, Vol. 9, Pages 1440: Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease Journal of Clinical Medicine doi: 10.3390/jcm9051440 Authors: Picca Guerra Calvani Coelho-Junior Bossola Landi Bernabei Bucci Marzetti Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their vital functions, mitochondrial quality control (MQC) systems are in place to support organelle plasticity as well...
Tue May 12, 2020 03:00
JCM, Vol. 9, Pages 1436: Impact of Aging on the Accuracy of 3D-Printed Dental Models: An In Vitro Investigation Journal of Clinical Medicine doi: 10.3390/jcm9051436 Authors: Joda Matthisson Zitzmann The aim of this in vitro study was to analyze the impact of model aging on the accuracy of 3D-printed dental models. A maxillary full-arch reference model with prepared teeth for a three-unit fixed dental prosthesis was scanned ten times with an intraoral scanner (3Shape TRIOS Pod)...
Tue May 12, 2020 03:00
JCM, Vol. 9, Pages 1438: Treatment Motivations and Expectations in Patients with Actinic Keratosis: A German-Wide Multicenter, Cross-Sectional Trial Journal of Clinical Medicine doi: 10.3390/jcm9051438 Authors: Steeb Wessely von Bubnoff Dirschka Drexler Falkenberg Hassel Hayani Hüning Kähler Karrer Krammer Leiter Lill Marsela Meiwes Nashan Nasifoglu Schmitz Sirokay Thiem Utikal Zink Berking Heppt...
Tue May 12, 2020 03:00
JCM, Vol. 9, Pages 1439: Catheter-Based Therapies and Other Management Strategies for Deep Vein Thrombosis and Post-Thrombotic Syndrome Journal of Clinical Medicine doi: 10.3390/jcm9051439 Authors: Thukral Vedantham Acute deep vein thrombosis (DVT) causes substantial short-term and long-term patient morbidity. Medical, lifestyle, and compressive therapies have been investigated for the prevention of pulmonary embolism (PE) and recurrence of venous thromboembolism (VTE). However,...
Tue May 12, 2020 03:00
JCM, Vol. 9, Pages 1437: Which Risk Factors Predict Knee Ligament Injuries in Severely Injured Patients?—Results from an International Multicenter Analysis Journal of Clinical Medicine doi: 10.3390/jcm9051437 Authors: Weber Solomon Lefering Horst Kobbe Hildebrand DGU Introduction: Ligament injuries around the knee joint and knee dislocations are rare but potentially complex injuries associated with high-energy trauma. Concomitant neurovascular injuries further...
Tue May 12, 2020 03:00
JCM, Vol. 9, Pages 1442: Roflumilast in Severely Ill Patients with Chronic Obstructive Pulmonary Disease with Frequent Exacerbations: Risk of Pneumonia Hospitalization and Severe Exacerbations Journal of Clinical Medicine doi: 10.3390/jcm9051442 Authors: Alispahic Sørensen Eklöf Sivapalan Løkke Seersholm Vestergaard Jensen Roflumilast is given as an add-on to inhalation medication in patients with chronic obstructive pulmonary disease (COPD) and chronic bronchitis....
Tue May 12, 2020 03:00
JCM, Vol. 9, Pages 1435: The Impact of Alcohol Hangover on Simulated Driving Performance During a ‘Commute to Work’—Zero and Residual Alcohol Effects Compared Journal of Clinical Medicine doi: 10.3390/jcm9051435 Authors: Alford Broom Carver Johnson Lands Reece Verster Driving is increasing across the world and road traffic accidents are a major cause of serious injuries and fatalities. The link between alcohol consumption and impaired driving has long been established...
Tue May 12, 2020 03:00
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