With significant development of Internet of medical things (IoMT) and cloud-fog-edge computing, medical industry is now involving medical big data to improve quality of service in patient care. Karyotyping refers classifying human chromosomes. However, performing karyotyping task generally requires domain expertise in cytogenetics, long-period experience for high accuracy, and considerable manual efforts. An end-to-end chromosome karyotype analysis system is proposed over medical big data to automatically...
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In this work, a novel method for high spatial resolution U-Pb dating of zircon by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) at 10–16 μm spot diameter has been proposed. This was achieved by introducing 2% () water-ethanol vapours into ICP in combination with the shielded torch system to increase the sensitivity and suppress the isotopic fractionation effect. Precise and accurate concordant U-Pb ages for Plešovice, GJ-1, and 91500 zircons were obtained using the proposed...
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We consider monitoring applications in multihop wireless sensor networks (WSNs), where nodes rely on limited batteries so that energy efficiency and reliability are of paramount importance. Typically, lossy compression is aimed at saving transmission energy, yet affects the quality of transmitted data over lossy channels. Accordingly, using error correction coding (ECC) along with compression is required to guarantee both energy efficiency and high-fidelity reconstruction. In this paper, we analyze...
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Subcapsular renal hematoma (SRH) is a challenging condition, which may jeopardize kidney function or constitute a life-threatening event. This is particularly true in single-kidney patients, such as kidney-transplant recipients. SRH may exert an excessive pressure on the surrounding parenchyma, thus resulting in hypoperfusion and ischemia, with high risk of acute kidney failure and graft loss. Moreover, SRH may precede an overt renal rupture with subsequent hemorrhage and hemodynamic instability....
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A growing body of evidence has indicated that behaviors of cancers are defined by not only intrinsic activities of tumor cells but also tumor-infiltrating immune cells (TIICs) in the tumor microenvironment. However, it still lacks a well-structured and comprehensive analysis of TIICs and its therapeutic value in esophageal cancer (EC). The proportions of 22 TIICs were evaluated between 150 normal tissues and 141 tumor tissues of EC by the CIBERSORT algorithm. Besides, correlation analyses between...
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The aim of this work is to study the new generalized fractional differential equations involving generalized multiterms and equipped with multipoint boundary conditions. The nonlinear term is taken from Orlicz space. The existence and uniqueness results, with the help of contemporary tools of fixed point theory, are investigated. The Ulam stability of our problem is also presented. The obtained results are well illustrated by examples.
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The stage of social aging and further deepening of population aging has been witnessed in China. The demand for home care is increasingly growing; meanwhile, medical human resources are insufficient. In this context, a home health caregiver scheduling problem under the resource sharing mode is studied in this paper. Under such mode, two types of caregivers, i.e., full-time caregiver and part-time caregiver, are regarded as the main labor force by HHC institutions. In HHC planning, different working...
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Introduction. The purpose of this paper is to describe development and preliminary assessment of an instrument designed to assess facilitators and barriers of provider-provided, place-based exercise prescriptions, including provider attributes, perceptions, knowledge, and resource needs. Although the American Medical Association-Supported “Exercise is Medicine” initiative encourages the practice of exercise prescription among member providers, only a small proportion engages in this practice. Additionally,...
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Background. TB diagnostic and treatment services in India are provided free of cost in the programmatic context across the country. There are different costs incurred during health care utilization, and this study was conducted to estimate such costs. Methodology. A longitudinal study was conducted among patients of three urban tuberculosis units (TUs) of Davangere, Belagavi, and Bengaluru, Karnataka. Trained data collectors administered a validated questionnaire and recorded monthly costs incurred...
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In this study, hybrid state-action-reward-state-action (SARSA) and Q-learning algorithms are applied to different stages of an upper confidence bound applied to tree search for Tibetan Jiu chess. Q-learning is also used to update all the nodes on the search path when each game ends. A learning strategy that uses SARSA and Q-learning algorithms combining domain knowledge for a feedback function for layout and battle stages is proposed. An improved deep neural network based on ResNet18 is used for...
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Objective. To assess if incorporating ethanolic extract of propolis into ceramic-reinforced glass ionomer (Amalgomer CR) might have an influence on its physicomechanical properties. Materials and Methods. Three groups were assessed; group I: Amalgomer CR (control) and two experimental groups (II and III) of propolis added to the liquid of Amalgomer CR with 25 and 50 v/v %, respectively. Evaluation parameters were color stability, compressive strength, microhardness, and surface roughness. Representative...
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The paper discusses the issue of oil-in-place estimation for liquid-saturated shales in Lower Paleozoic (Silurian and Ordovician) organic-rich formations of the Baltic Basin in North Poland. The authors adopted a geochemical method based on Rock Eval results which directly measure hydrocarbon content present in rock samples. Its application on a real data set required the implementation of correction procedures to consider also those oil compounds which were lost before Rock Eval measurements were...
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With the rapid development of Internet technology, live broadcast industry has also flourished. However, in the public network live broadcast platform, live broadcast security issues have become increasingly prominent. The detection of suspected pornographic videos in live broadcast platforms is still in the manual detection stage, that is, through the supervision of administrators and user reports. At present, there are many online live broadcast platforms in China. In mainstream live streaming...
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For the first time, the finite integral transform method is introduced to explore the accurate bending analysis of orthotropic rectangular thin plates with two adjacent edges free and the others clamped or simply supported. Previous solutions mostly focused on plates with simply supported and clamped edges, but the existence of free corner makes the solution procedure much complex to solve by conventional inverse/semi-inverse methods. Compared with the conventional methods, the employed method eliminates...
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The uncertainty of the engineering system increases with the growing complexity of the engineering system; therefore, the tolerance to the uncertainty is essential. In the design phase, the output performance should reach the design criterion, even under large variations of design parameters. The tolerance to design parameter variations may be measured by the size of a solution space in which the output performance is guaranteed to deliver the required performance. In order to decouple dimensions,...
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Background/Aim. Coronary artery disease (CAD) is a major health problem that has high morbidity and mortality around the world. In recent years, long noncoding RNA H19 has been reported to affect the proliferation and apoptosis of vascular cells, which directly or indirectly results in atherosclerosis. We performed a case-control study to explore the relationship between H19 gene polymorphisms (rs2735971, rs2839698, and rs3024270) and the risk of CAD. Methods. We collected 732 samples from Liaoning...
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Turmeric (Curcuma longa L.) is a popular natural drug, traditionally used for the treatment of a wide range of diseases. Its root, as its most popular part used for medicinal purposes, contains different types of phytochemicals and minerals. This review summarizes what is currently known on biochemistry, safety, pharmacological activities (mechanistically), and clinical applications of turmeric. In short, curcumin is considered as the fundamental constituent in ground turmeric rhizome. Turmeric possesses...
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This paper investigates the observer-based structural balance control for a class of complex dynamical networks. Generally speaking, a complete complex dynamical network is composed of two coupled subsystems, which are called node subsystem (NS) and connection relationship subsystem (CS), respectively. Similar to synchronization and stabilization of networks, the structural balance is another phenomenon of networks and determined by the state of connection relationships. However, it is not feasible...
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The W/S test under neutrosophic statistics is proposed in this paper. The Monte Carlo simulation under the neutrosophic statistical interval method is proposed and applied to study the sensitivity of various neutrosophic statistical distributions. The power of test curves for neutrosophic distributions is presented. The efficiency of the proposed W/S test under neutrosophic statistics is compared with that of the W/S test under classical statistics. The proposed test is explained with the aid of...
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Mammography remains the most prevalent imaging tool for early breast cancer screening. The language used to describe abnormalities in mammographic reports is based on the Breast Imaging Reporting and Data System (BI-RADS). Assigning a correct BI-RADS category to each examined mammogram is a strenuous and challenging task for even experts. This paper proposes a new and effective computer-aided diagnosis (CAD) system to classify mammographic masses into four assessment categories in BI-RADS. The mass...
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By constructing an evolutionary game model of green dairy industry chain from the perspective of green sustainable development, this paper analyzed the evolution process of strategy selection of dairy farmers and dairy enterprises under the supervision of the government. The study found the following. (1) In the absence of supervision, even if the initial cooperation willingness of dairy farmers and dairy enterprises is strong, once the additional cost of their input of “green production” is less...
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Pancreatic cancer (PC) is a pernicious cancer of the digestive system which remains a high degree of malignancy. Increasing studies demonstrated that regulating the gut microbiome may become a brand new strategy to improve the therapeutic outcomes of PC. This study is aimed at obtaining the pathway in the microbial tumorigenesis of PC. Microarray datasets GSE27890, GSE46234, and GSE17610 were downloaded from the GEO (Gene Expression Omnibus) database. Differential analysis was performed for every...
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The hysteresis nonlinearity greatly reduces the tracking precision of piezoceramic actuators for expected displacement in a high-accuracy positioning system. In order to effectively compensate the hysteresis for piezoelectric ceramics, a novel modeling method, namely, multislope PI (Prandtl–Ishlinskii) was proposed. In view of the minimum mean square error (MSE) criterion, the weights of an improved PI model were identified by the quadratic programming optimization algorithm. For verifying the accuracy...
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This paper focuses on the optimal reinsurance problem with consideration of joint interests of an insurer and a reinsurer. In our model, the risk process is assumed to follow a Brownian motion with drift. The insurer can transfer the risk to the reinsurer via proportional reinsurance, and the reinsurance premium is calculated according to the variance and standard deviation premium principles. The objective is to maximize the expected exponential utility of the weighted sum of the insurer’s and the...
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In this paper, we propose a new approximation method (we shall call this method as -parameterized differential transform method), which differs from the traditional differential transform method in calculating the coefficients of Taylor polynomials. Numerical examples are presented to illustrate the efficiency and reliability of our own method. Namely, two Sturm–Liouville problems are solved by the present -parameterized differential transform method, and the obtained results are compared with those...
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Primates are the mammals of the order Primate that is characterized by advanced development of binocular vision and enlargement of the cerebral hemispheres. The aim of this study was to investigate the abundance, diversity, and distribution of primates on Welel Mountain. From August 2017 to February 2018, we collected data from different parts of Welel Mountain during wet and dry seasons of the year and analyzed them using SPSS version 20. We identified four primate species: Chlorocebus aethiops,...
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Simple Methods to Synthesize YVO4 Nanocrystals or Microcrystals without Any Templates or Surfactants
YVO4 crystals with different sizes and shapes were produced through hydrothermal treatment and sonication method without any surfactants or templates. X-ray powder diffraction (XRD), transmission electron microscopy (TEM), and photoluminescence (PL) were used to characterize the obtained products. YVO4 nanocrystals with spindle-like shape had been produced through the two different treating methods. YVO4 crystals, which are bipyramid-capped and micrometer-sized, had been obtained through a simple...
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The construction of urban underground cross-interchange transfer subway stations often encounters the difficulties of shallow-buried, different surrounding rock, large spans and heights, congested road traffic, and surrounding buildings sensitive to the construction sequence. Therefore, there is a need for an underground project that controls the stability of underground space and ground subsidence. Based on the construction difficulties of a certain station (the maximum excavation area over 760 m2),...
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Dye wastewater from textile industries shows very low biodegradability due to high molecular weight and complex structures of dyes. So far, the most simple method for treatment of this type of wastewater has been coagulation and flocculation. This study determined the removal of turbidity and other pollutants from dye wastewater by mucilage extracted from the peel of dragon fruit (Hylocereus undatus) and its effect in reducing synthetic chemical polyaluminum chloride (PACl) used in coagulation and...
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Unmanned helicopter for mission inspection has good application value in intelligent coal mining, and attitude control is important. In this paper, membrane computing is introduced to realize attitude optimization control of an unmanned helicopter. First, we give the application scenarios of unmanned helicopters in coal mines. Secondly, we establish a dynamic model of an unmanned helicopter with environmental participation, and the attitude model of the helicopter is deduced based on this model....
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The steel plate-concrete structure, with its advantages of modular construction, good seismic capacity, and strong impact resistance, has been gradually replacing the reinforced concrete structure in the containment vessel and internal workshop structure of nuclear power plants in recent years. In this study, the out-of-plane single-point loading test and parametric finite element simulation analysis were conducted on five steel plate-concrete wall slab specimens with different stud spacings, shear...
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Blast furnace (BF) is the main method of modern iron-making. Ensuring the stability of the BF conditions can effectively improve the quality and output of iron and steel. However, operations of BF depend on mainly human experience, which causes two problems: (1) human experience is not objective and is difficult to inherit and learn and (2) it is difficult to acquire knowledge that contains time information among multiple variables in BF. To address these problems, a data-driven method is proposed....
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Proteases BACE1 (β-secretases) enzymes have been recognized as a promising target associated with Alzheimer’s disease (AD). This study was carried out on the principles of molecular docking, chemical synthesis, and enzymatic inhibition of BACE1 enzymes via biaryl guanidine-based ligands. Based on virtual screening, thirteen different compounds were synthesized and subsequently evaluated via in vitro and in vivo studies. Among them, 1,3-bis(5,6-difluoropyridin-3-yl)guanidine (compound (9)) was found...
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MicroRNAs (miRNAs) have been identified as negative posttranscriptional regulators of target genes and are involved directly in the pathological processes of tumors, including drug resistance. However, the exact function of miR-520h in breast cancer remains poorly understood. The aim of this study was to investigate the molecular mechanisms of miR-520h in paclitaxel resistance in the MCF-7 breast cancer cell line. Ectopic expression of miR-520h could promote the proliferation of breast cancer cells...
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Alveolar echinococcosis (AE) is an infectious zoonotic disease that is caused by Echinococcus multilocularis. The disease is generally identified accidentally because of the long asymptomatic period, has a malignant behaviour, and mainly occurs in the liver. Usually it is diagnosed in adults and is very rare in pediatric patients. We report two cases of AE and 1 differential case between AE and cystic echinococcosis (CE) in children: two of them had lesions in the liver and one had rare extrahepatic...
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Background. A new endemic disease has spread across Wuhan City, China, in December 2019. Within few weeks, the World Health Organization (WHO) announced a novel coronavirus designated as coronavirus disease 2019 (COVID-19). In late January 2020, WHO declared the outbreak of a “public-health emergency of international concern” due to the rapid and increasing spread of the disease worldwide. Currently, there is no vaccine or approved treatment for this emerging infection; thus, the objective of this...
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They have slowed for now. But as we begin to emerge from our homes, we need to brace for a resurgence -- Read more on ScientificAmerican.com
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Abstract Objection We aimed to evaluate the role of bone scintigraphy (BS) which has long been the imaging modality of choice in prostate cancer (PCa) and performed a head-to-head comparison between BS, BS + SPECT/CT and 68 Ga-PSMA-PET/CT, for the detection of bone metastasis of PCa. Methods We evaluated 138 PCa patients who underwent BS and 68 Ga-PSMA PET/CT...
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Before Greenhalgh and colleagues’ excellent article on assessing patients remotely for covid-19 was published,1 my practice had made lists of “covid likely” patients based on consultations and...
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