Background. The impact of sex on the outcome of patients with acute coronary syndrome (ACS) has been suggested, but little is known about its impact on elderly patients with ACS. Methods. This study analyzed the impact of sex on in-hospital and 1-year outcomes of elderly (≥75 years of age) patients with ACS hospitalized in our department between January 2013 and December 2017. Results. A total of 711 patients were included: 273 (38.4%) women and 438 (61.6%) men. Their age ranged from 75 to 94 years,...
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To solve the problems associated with the application of multilevel security to actual networks, such as flexibility, availability, security, and secure communication, this study proposes a multilevel security network communication model based on multidimensional control. In the model, access control is retained on the basis of security labels. In addition, relational restraints among protection domains, credibility degree restraints of subjects on security attributes, aggregation inference control...
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An interstitial pregnancy that continues beyond the second trimester is a rare phenomenon. We report a patient with an interstitial pregnancy undiagnosed until the third trimester. A multiparous woman was referred to us because of preeclampsia at 26 weeks of gestation. The placental position was the right fundus, and color Doppler ultrasound revealed myometrial thinning and subplacental hypervascularity, leading to a suspicion of placenta accreta spectrum (PAS). Emergency cesarean section was performed...
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This paper presents a novel method of dynamic modeling and design optimization integrated with dynamics for parallel robot manipulators. Firstly, a computationally efficient modeling method, the discrete time transfer matrix method (DT-TMM), is proposed to establish the dynamic model of a 3-PRR planar parallel manipulator (PPM) for the first time. The numerical simulations are performed with both the proposed DT-TMM dynamic modeling and the ADAMS modeling. The applicability and effectiveness of DT-TMM...
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Background. A dry socket also referred to as alveolar osteitis (AO) is a common postoperative complication following tooth extraction, due to the disruption of the clot within the wound. This study aimed to evaluate the efficacy of concentrated growth factor (CGF) in the healing of alveolar osteitis following tooth extraction. Methods. The study was conducted at University Dental Hospital Sharjah, UAE. Patients undergoing tooth extraction at the oral surgery clinic were advised to return immediately...
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Alzheimer’s disease (AD) is a complex neurodegenerative disease. It is a chronic, lethal disease in which brain function is severely impaired and neuronal damage is irreversible. Huang-Pu-Tong-Qiao (HPTQ), a formula from traditional Chinese medicine, has been used in the clinical treatment of AD for many years, with remarkable effects. However, the neuroprotective mechanisms of HPTQ in AD have not yet been investigated. In the present study, we used AD models in vivo and in vitro, to investigate...
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A 37-year-old Japanese man had his right eye hit by a fist. His right eye developed hypotony maculopathy and secondary cataract, and his visual acuity decreased to 20/200 with an intraocular pressure of 4 mmHg. He underwent phacoemulsification and aspiration, implantation of the intraocular lens, and encircling with a silicone tire. His visual acuity improved to 20/20 and stable for more than one year postoperatively. The intraocular pressure in his right eye increased to 12 mmHg, and maculopathy...
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Based on the classical finite-time stability theory, the problem of finite-time stability (FTS) for time-varying nonlinear systems is investigated in this paper. Several FTS theorems involving global form and local form are presented, and an estimate of the settling-time of such systems is obtained. As an application, we consider the problem of asymptotic stabilization of the Brockett integrator subject to time-varying disturbance. By the switched finite-time controller design methodology, we establish...
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Purpose. To evaluate the regulating effect of Notch-Hes1 signaling on IL-17A+γδ+T cell expression and IL-17A secretion in mouse psoriasis-like skin inflammation. Materials and Methods. Experimental mice were randomly divided into control group, model group (5% imiquimod- (IMQ-) treated mice), and intervention group (IMQ and γ-secretase inhibitor DAPT cotreated mice). The severity of psoriasis-like skin inflammation was evaluated by target lesion score based on the clinical psoriasis area and severity...
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Parkinson’s disease is one of the main reasons for neurological consultation in Spain. Due to the nature of the disease, it impacts patients, families, and caregivers. Parkinson’s disease is a degenerative disease with no cure, although second-line therapies have recently improved the quality of life of patients in advanced stages. The aim of this study was to analyse the costs of the following therapies: deep brain stimulation (DBS), continuous duodenal levodopa/carbidopa infusion (CDLCI), and continuous...
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Ground reaction force and impulse measurement is an established method for assessing the physical condition and efficacy of treatment for some animals. The primary aim of this study was to quantify the kinetic parameters of the limbs of healthy cats at different speeds. The second aim was to determine the explicit relationship between the kinetic parameters and speed. Peak vertical force (PVF), vertical impulse (VI), stance phase duration (SPD), and paw contact area (PCA) of each limb (forelimb,...
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To provide a basic guidance for the selection of nozzle layout, a mathematical model of the impingement depth for helical gears under oil jet lubrication is established. Furthermore, computational fluid dynamics (CFD) methods are adopted to validate the effectiveness and accuracy of the derived impingement model. Firstly, the distribution characteristics of the oil volume fraction and oil-gas pressure in meshing area were obtained in flow field simulation. Meanwhile, the influence of spray angle,...
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The aircraft wake vortex has important influence on the operation of the airspace utilization ratio. Particularly, the identification of aircraft wake vortex using the pulsed Doppler lidar characteristics provides a new knowledge of wake turbulence separation standards. This paper develops an efficient pattern recognition-based method for identifying the aircraft wake vortex measured with the pulsed Doppler lidar. The proposed method is outlined in two stages. (i) First, a classification model based...
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This paper has made proposition of a nested array and an estimation algorithm for direction-of-arrival (DOA) of two-dimensional (2D) coherently distributed (CD) sources. According to the difference coarray concept, double parallel hole-free virtual uniform linear arrays are generated by virtue of vectorization operation on cross-correlation matrices of subarrays. Sensor coordinates of virtual arrays are derived. Rational invariance relationships of virtual arrays are derived. According to the rotational...
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This study aimed at addressing the difficulties entailed in accurately determining the working loads of screwed joints (SJs) by establishing mechanical models and verifying the accuracy of the numerical calculation model of antiloosening performance under complex working conditions. First, considering the slip state of the interface and the stress state of the thread surface, a corresponding mechanical model was established to investigate the quantitative model of the interaction amongst structural...
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Companies need to develop new products towards customer's satisfaction in order to survive in the boom and bust cycle in todays’ economy. The capturing of customer satisfaction depends on customer needs, and generally, understanding emotions has a challenge for designers. Kansei engineering is a type of methodology to help customers and designers analyze needs and emotion for the new product development. Producing new product design with Kansei data increases customer satisfaction and helps to reach...
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Soil compaction is an important procedure of precision seeding operation. In this paper, a precise downforce control system based on fuzzy PID was proposed in order to improve the quality of the soil compaction and the accuracy of setting working parameters. The conventional mechanism of seeders for soil compaction was optimised. The compressing spring of the compaction mechanism was replaced by a linear motor, which is actively controlled to adjust downforce in real time. A force sensor was connected...
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The performance level of a multistate system (MSS) can vary among different values rather than only two states (perfect functioning and complete failure). To improve the reliability of MSSs, a maintenance strategy has been adopted to satisfy customer demand, and reliability modeling of MSS with preventive maintenance and customer demand is proposed. According to the regular degradation and random failure at each state, based on the Markov random process, the proposed MSS with preventive maintenance...
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Background. Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disease caused by a germline mutation in the STK11 gene. It is characterized by mucocutaneous pigmentation, gastrointestinal hamartomatous polyps, and cancer predisposition. Aims. We aimed to summarize the main clinical and genetic features of Chinese PJS patients and assessed the genotype-phenotype correlations. Methods. Thirty-eight patients clinically diagnosed with Peutz-Jeghers syndrome were included in this study...
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Abstract MicroRNAs (miRNAs) are non-coding RNAs with a length of 18–22 nucleotides that regulate about a third of the human genome at the post-transcriptional level. MiRNAs are involved in almost all biological processes, including cell proliferation, apoptosis, and cell differentiation, but also play a key role in the pathogenesis of many diseases. Most miRNAs are expressed within the cells themselves. Due to various forms of transport from cells like exosomes, circulating miRNAs...
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The UK government's "stay alert" messaging, use of statistics and outsourcing of coronavirus contact tracing have been criticised by an independent science committee
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An AI trained to spot objects hidden against a background is able to see through camouflage and outperforms existing algorithms at the task
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Abstract Objective The subset distribution and immunophenotype of circulating immune cells (“peripheral blood immune cell profile”) may reflect tumor development and response to cancer treatment. In order to use the peripheral blood immune cell profile as biomarker to monitor patients over time, it is crucial to know how immune cell subsets respond to therapeutic interventions. In this study, we investigated the effects of tumor resection...
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Reduced-dose dual-layer spectral CT is feasible in routine practice, despite...Read more on AuntMinnieEurope.comRelated Reading: CT system developers utilize AI to boost patient care Dual-energy CT enhances segmentation for 3D printing Advanced CT can boost outcomes in pancreatic cancer Mobile stroke units, spectral CT take spots on ECRI watch list Philips launches French spectral CT collaboration
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Antibiotics, Vol. 9, Pages 249: Isonitrile-Based Multicomponent Synthesis of β-Amino Boronic Acids as β-Lactamase Inhibitors Antibiotics doi: 10.3390/antibiotics9050249 Authors: Bassini Gazzotti Sannio Presti Sgrignani Docquier Grazioso Silvani The application of various isonitrile-based multicomponent reactions to protected (2-oxoethyl)boronic acid (as the carbonyl component) is described. The Ugi reaction, both in the four components and in...
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The coronavirus pandemic has exposed the vulnerability and weaknesses of already fragile global food systems, say the authors of a new report which finds one in every nine people in the world is...
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A GP who was suspended for forging his supervisor’s signature when he was a trainee may resume work under set conditions, after an emergency physician asked the Medical Practitioners Tribunal Service...
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The UK government must alter its current strategy for tackling covid-19 or face a further wave of infections and subsequent lockdowns, a report from an independent group of scientists has warned.The...
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Abstract Background Obstructive sleep apnea (OSA) is associated with an increased risk of developing atherosclerotic cardiovascular disease (ASCVD). Patients with OSA have increased levels of oxidative stress and several studies have shown higher levels of oxidative stress markers. Oxidized-LDL (Ox-LDL) is an important risk factor for ASCVD and a number of studies have measured its levels in patients with OSA, though results from these...
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Abstract Introduction Sleep problems, including obstructive sleep apnea (OSA), profoundly affect quality of life in patients with systemic sclerosis (SSc). This study aimed to determine the prevalence of OSA in patients with SSc and the factors affecting OSA. Methods Consecutive patients with SSc lung involvement who were referred to the “Outpatient Service...
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Abstract Objective Previous studies suggest a relationship between sleep disordered breathing (SDB) and lower extremity artery disease (LEAD) though disagreements remain. This study was performed to assess the association between SDB and LEAD in a metaanalysis. Methods PubMed and Embase databases were searched for observational studies. A random-effects model...
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Abstract Purpose Obstructive sleep apnoea (OSA) involves recurrent obstructive apnoeas and hypopnoeas which cause cyclic hypoxia, reoxygenation and formation of reactive oxygen species (ROS). We aimed to investigate a member of the nicotinamide adenine dinucleotide phosphate oxidase (NOX) family of enzymes, specifically (NOX4), not previously studied in humans, as well as 8-OHdG/106dG, MDA and IMA, which are known to be associated with...
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Abstract Purpose Poor quality of sleep is a common feature in patients with various lung diseases and affects their health-related quality of life (HRQL). We evaluated sleep quality and HRQL in patients on the waitlist for lung transplantation in Japan. Methods In this prospective study, patient-reported and physiological data were collected from patients...
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Publication date: 11 May 2020Source: Cancer Cell, Volume 37, Issue 5Author(s): Wendy Béguelin, Matt Teater, Cem Meydan, Kenneth B. Hoehn, Jude M. Phillip, Alexey A. Soshnev, Leandro Venturutti, Martín A. Rivas, María T. Calvo-Fernández, Johana Gutierrez, Jeannie M. Camarillo, Katsuyoshi Takata, Karin Tarte, Neil L. Kelleher, Christian Steidl, Christopher E. Mason, Olivier Elemento, C. David Allis, Steven H. Kleinstein, Ari M. Melnick
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Publication date: 11 May 2020Source: Cancer Cell, Volume 37, Issue 5Author(s): Jian Carrot-Zhang, Nyasha Chambwe, Jeffrey S. Damrauer, Theo A. Knijnenburg, A. Gordon Robertson, Christina Yau, Wanding Zhou, Ashton C. Berger, Kuan-lin Huang, Justin Y. Newberg, R. Jay Mashl, Alessandro Romanel, Rosalyn W. Sayaman, Francesca Demichelis, Ina Felau, Garrett M. Frampton, Seunghun Han, Katherine A. Hoadley, Anab Kemal, Peter W. Laird
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Publication date: 11 May 2020Source: Cancer Cell, Volume 37, Issue 5Author(s): Lauren E. Colbert, Ramez Kouzy, Joseph Abi Jaoude, Ethan B. Ludmir, Cullen M. Taniguchi
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