Related ArticlesA Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods. J Vis Exp. 2020 Apr 24;(158): Authors: Belli ML, Mezzenga E, Di Iorio V, Celli M, Caroli P, Canali E, Matteucci F, Tardelli E, Grassi I, Sansovini M, Nicolini S, Severi S, Cremonesi M, Ferrari M, Paganelli G, Sarnelli A Abstract Peptide-receptor-radionuclide-therapy (PPRT) is a targeted therapy...
Tue May 12, 2020 16:32
Related ArticlesPreparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer. J Vis Exp. 2020 Apr 27;(158): Authors: Adir O, Sharf-Pauker N, Chen G, Kaduri M, Krinsky N, Shainsky-Roitman J, Shklover J, Schroeder A Abstract The bottom-up assembly approach for construction of synthetic cells is an effective tool for isolating and investigating cellular processes in a cell mimicking environment. Furthermore,...
Tue May 12, 2020 16:32
Related ArticlesFully Automated Leg Tracking in Freely Moving Insects using Feature Learning Leg Segmentation and Tracking (FLLIT). J Vis Exp. 2020 Apr 23;(158): Authors: Banerjee A, Wu S, Cheng L, Aw SS Abstract The Drosophila model has been invaluable for the study of neurological function and for understanding the molecular and cellular mechanisms that underlie neurodegeneration. While fly techniques for the manipulation and study of neuronal...
Tue May 12, 2020 16:32
Related ArticlesCollection of Frozen Rodent Brain Regions for Downstream Analyses. J Vis Exp. 2020 Apr 23;(158): Authors: Wager-Miller J, Murphy Green M, Shafique H, Mackie K Abstract As our understanding of neurobiology has progressed, molecular analyses are often performed on small brain areas such as the medial prefrontal cortex (mPFC) or nucleus accumbens. The challenge in this work is to dissect the correct area while preserving the microenvironment...
Tue May 12, 2020 16:32
Related ArticlesDevelopment of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss. J Vis Exp. 2020 Apr 24;(158): Authors: Holzhey A, Sonntag S, Rendenbach J, Ernesti JS, Kakkassery V, Grisanti S, Reinholz F, Freidank S, Vogel A, Ranjbar M Abstract Nd:YAG lasers have been used to perform noninvasive intraocular surgery, such as capsulotomy for several decades now. The incisive effect relies on the optical breakdown at...
Tue May 12, 2020 16:32
Related ArticlesAn Implantable System For Chronic In Vivo Electromyography. J Vis Exp. 2020 Apr 21;(158): Authors: Zealear D, Li Y, Huang S Abstract Electromyography (EMG) measures the muscle response to electrical stimulation or spontaneous activity of motor units and plays an important role in assessing neuromuscular function. Chronic recording of EMG activity reflecting a muscle's reinnervation status after nerve injury has been limited, due to...
Tue May 12, 2020 16:32
Related ArticlesA Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation. J Vis Exp. 2020 Apr 24;(158): Authors: Fu Q, Johnson CW, Wijayawardena BK, Kowalski MP, Kheradmand M, Van Eyk JE Abstract Sample preparation for mass spectrometry analysis in proteomics requires enzymatic cleavage of proteins into a peptide mixture. This process involves numerous incubation and liquid transfer steps in order to achieve denaturation,...
Tue May 12, 2020 16:32
Related ArticlesCorrection: Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation. Oncotarget. 2020 Apr 28;11(17):1575 Authors: Sun SQ, Gu X, Gao XS, Li Y, Yu H, Xiong W, Yu H, Wang W, Li Y, Teng Y, Zhou D Abstract [This corrects the article DOI: 10.18632/oncotarget.10347.].PMID: 32391126 [PubMed - in process]
Tue May 12, 2020 16:36
Related ArticlesCorrection: Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model. Oncotarget. 2020 Apr 28;11(17):1573-1574 Authors: Borst GR, Kumareswaran R, Yücel H, Telli S, Do T, McKee T, Zafarana G, Jonkers J, Verheij M, O'Connor MJ, Rottenberg S, Bristow RG Abstract [This corrects the article DOI: 10.18632/oncotarget.20936.].PMID: 32391125 [PubMed - in process]
Tue May 12, 2020 16:36
Related ArticlesLack of CD8+ T-cell co-localization with Kaposi's sarcoma-associated herpesvirus infected cells in Kaposi's sarcoma tumors. Oncotarget. 2020 Apr 28;11(17):1556-1572 Authors: Lidenge SJ, Tso FY, Ngalamika O, Kolape J, Ngowi JR, Mwaiselage J, Wood C, West JT Abstract Despite the close association between Kaposi's sarcoma (KS) and immune dysfunction, it remains unclear whether tumor infiltrating immune cells (TIIC), by their absence,...
Tue May 12, 2020 16:36
Related ArticlesCD44+/EPCAM+ cells detect a subpopulation of ALDHhigh cells in human non-small cell lung cancer: A chance for targeting cancer stem cells? Oncotarget. 2020 Apr 28;11(17):1545-1555 Authors: Masciale V, Grisendi G, Banchelli F, D'Amico R, Maiorana A, Sighinolfi P, Stefani A, Morandi U, Dominici M, Aramini B Abstract OBJECTIVES: Several studies demonstrated that aldehyde dehydrogenase (ALDH) and CD44 are the most considered cancer stem...
Tue May 12, 2020 16:36
Related ArticlesThe cytotoxicity of gallium maltolate in glioblastoma cells is enhanced by metformin through combined action on mitochondrial complex 1. Oncotarget. 2020 Apr 28;11(17):1531-1544 Authors: Alhajala HS, Markley JL, Kim JH, Al-Gizawiy MM, Schmainda KM, Kuo JS, Chitambar CR Abstract New drugs are needed for glioblastoma, an aggressive brain tumor with a dismal prognosis. We recently reported that gallium maltolate (GaM) retards the growth...
Tue May 12, 2020 16:36
Related ArticlesProteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients. Oncotarget. 2020 Apr 28;11(17):1515-1530 Authors: Sinai-Livne T, Pasmanik-Chor M, Cohen Z, Tsarfaty I, Werner H, Berger R Abstract Clinical, epidemiological and experimental data identified the insulin-like growth factor-1 receptor (IGF1R) as a candidate therapeutic target in oncology....
Tue May 12, 2020 16:36
Related ArticlesCrkL is required for donor T cell migration to GvHD target organs. Oncotarget. 2020 Apr 28;11(17):1505-1514 Authors: Roy NH, Mammadli M, Burkhardt JK, Karimi M Abstract The success of cancer therapies based on allogeneic hematopoietic stem cell transplant relies on the ability to separate graft-versus-host disease (GvHD) from graft-versus-tumor (GVT) responses. Controlling donor T cell migration into peripheral tissues is a viable...
Tue May 12, 2020 16:36
Related ArticlesLactate induces PD-L1 in HRASG12V-positive oropharyngeal squamous cell carcinoma. Oncotarget. 2020 Apr 28;11(17):1493-1504 Authors: Verma AK, Messerli SM, Miskimins WK Abstract Intratumoral lactate production negatively correlates with survival and tumor clearance in the setting of human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC). Robust anti-tumor immune activity is required for tumor clearance...
Tue May 12, 2020 16:36
Related ArticlesCombined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells. Oncotarget. 2020 Apr 28;11(17):1478-1492 Authors: Litchfield LM, Boehnke K, Brahmachary M, Mur C, Bi C, Stephens JR, Sauder JM, Gutiérrez SM, McNulty AM, Ye XS, Wu W, Lallena MJ, Gong X, Merzoug FF, Jansen VM, Buchanan SG Abstract Aberrant activation of mitogenic signaling pathways in cancer...
Tue May 12, 2020 16:36
Related ArticlesTime to Update Army Medical Doctrine. Mil Med. 2020 May 11;: Authors: Knight RM, Moore CH, Silverman MB PMID: 32390038 [PubMed - as supplied by publisher]
Tue May 12, 2020 16:36
Related ArticlesRestoration of cortical symmetry and binaural function: Cortical auditory evoked responses in adult cochlear implant users with single sided deafness. PLoS One. 2020;15(1):e0227371 Authors: Wedekind A, Rajan G, Van Dun B, Távora-Vieira D Abstract BACKGROUND: Cochlear implantation for single-sided deafness (SSD) is the only treatment option with the potential to restore binaural hearing cues. Significant binaural benefit has been measured...
Tue May 12, 2020 14:33
Related ArticlesThe impact of aging on neurophysiological entrainment to a metronome. Neuroreport. 2019 07 03;30(10):730-734 Authors: Sauvé SA, Bolt ELW, Fleming D, Zendel BR Abstract In music, entrainment to the beat allows listeners to make predictions about upcoming events. Previous work has shown that neural oscillations will entrain to the beat of the music or rhythmic stimuli. Despite the fact that aging is known to impact both auditory and cognitive...
Tue May 12, 2020 14:33
Related ArticlesOverexpression of Foxc1 regenerates crushed rat facial nerves by promoting Schwann cells migration via the Wnt/β-catenin signaling pathway. J Cell Physiol. 2020 May 11;: Authors: Xia W, Zhu J, Wang X, Tang Y, Zhou P, Wei X, Chang B, Zheng X, Zhu W, Hou M, Li S Abstract Facial paralysis can result in severe implications for patients. A good prognosis depends on the degree of nerve regeneration. Schwann cells (SCs) play an important role...
Tue May 12, 2020 16:33
Related ArticlesMicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency. J Cell Physiol. 2020 May 11;: Authors: Zhang X, Dang Y, Liu R, Zhao S, Ma J, Qin Y Abstract Distinct microRNA (miRNA) profiles have been reported in premature ovarian insufficiency (POI), but their functional relevance in POI is not yet clearly stated. In this study, aberrant expressions of miR-127-5p and high mobility group box 2 (HMGB2)...
Tue May 12, 2020 16:33
Related Articles[Impact of benign parotid gland tumors on whole salivary flow rate]. Laryngorhinootologie. 2020 May 11;: Authors: Burghartz M, Sittel C, Fiz I, Taxis D, Plecko T, Kolkmeyer CA, Hagen R, Hackenberg S PMID: 32392602 [PubMed - as supplied by publisher]
Tue May 12, 2020 16:33
Related ArticlesLow-threshold motor units can be a pain during experimental muscle pain. J Physiol. 2020 May 11;: Authors: Mesquita RNO, Škarabot J, Pearcey GEP PMID: 32390211 [PubMed - as supplied by publisher]
Tue May 12, 2020 16:27
Related ArticlesBDNF as a novel therapeutic candidate for Kennedy's disease. J Physiol. 2020 May 11;: Authors: Yokota T PMID: 32390166 [PubMed - as supplied by publisher]
Tue May 12, 2020 16:27
Related ArticlesSerotonin affects our perception of fatigue when performing submaximal efforts - but is it all in our heads? J Physiol. 2020 May 11;: Authors: Pearcey GEP, Heckman CJ PMID: 32390162 [PubMed - as supplied by publisher]
Tue May 12, 2020 16:27
Related ArticlesUSING DICENTRIC DOSE ESTIMATES AND EARLY RADIATION-INDUCED BLOOD CELL COUNT CHANGES OF REAL CASE HISTORIES FOR VALIDATION OF THE HEMODOSE BIODOSIMETRY TOOL. Radiat Prot Dosimetry. 2020 May 11;: Authors: Haupt J, Ostheim P, Port M, Abend M Abstract HemoDose is a software tool, which estimates absorbed doses based on blood cell counts (BCC). The aim of our study was to validate HemoDose for early dose estimates. Dose estimates generated...
Tue May 12, 2020 16:26
Related ArticlesDose Assessment of Natural Terrestrial Radionuclides in Commonly Consumed Foods in North India. Radiat Prot Dosimetry. 2020 May 11;: Authors: Kaur S, Maheshwari P, Mehra R Abstract The present study aimed to record natural radionuclide content in branded food samples representative of a typical North Indian diet. Forty samples of various food items falling into three categories namely, cereal grains, pulses and beverages were collected...
Tue May 12, 2020 16:26
Related ArticlesExperimental Determination of Anisotropic Emission of Neutrons From 252Cf Neutron Source with the Spherical Protection Case. Radiat Prot Dosimetry. 2020 May 11;: Authors: Kowatari M, Nishino S, Romallosa KMD, Yoshitomi H, Tanimura Y, Ohishi T Abstract The anisotropic emission of neutrons from a cylindrical X1 252Cf source with the spherical external casing was experimentally determined. The influence of metal materials and shapes...
Tue May 12, 2020 16:26
Abstract Introduction Nonsyndromic, multi-suture craniosynostosis is not common, especially those involving unilateral coronal and lambdoid sutures. Based on the experience on 6 cases, we analyzed the skull morphology of combined unilateral coronal-lambdoid suture synostosis and evaluated the surgical outcome of suturectomy. Methods Patients who underwent...
Tue May 12, 2020 03:00
Abstract The purpose of this study was to evaluate early vascular and tomographic changes in the retina of diabetic patients using artificial intelligence (AI). The study included 74 age‐matched normal eyes, 171 diabetic eyes without retinopathy (DWR) eyes and 69 mild non‐proliferative diabetic retinopathy (NPDR) eyes. All patients underwent optical coherence tomography angiography (OCTA) imaging. Tomographic features (thickness and volume) were derived from the OCTA B‐scans. These features were...
Mon May 11, 2020 22:00
Related ArticlesTumor Necrosis Factor α Blockade: An Opportunity to Tackle Breast Cancer. Front Oncol. 2020;10:584 Authors: Mercogliano MF, Bruni S, Elizalde PV, Schillaci R Abstract Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality by malignancy in women and represents a main problem for public health worldwide. Tumor necrosis factor α (TNFα) is a pro-inflammatory cytokine whose expression is increased in a variety...
Tue May 12, 2020 16:26
Related ArticlesIGF-1 Interacted With Obesity in Prognosis Prediction in HER2-Positive Breast Cancer Patients. Front Oncol. 2020;10:550 Authors: Tong Y, Wu J, Huang O, He J, Zhu L, Chen W, Li Y, Chen X, Shen K Abstract Purpose: Dysmetabolism and high circulating insulin-like growth factor 1 (IGF-1) would increase breast cancer risk, but its association with survival in HER2+ breast cancer patients has not been well-studied. Herein, we aim to evaluate...
Tue May 12, 2020 16:26
Adequate personal protective equipment is needed to reduce the rate of transmission of COVID-19 to health care workers. Otolaryngology groups are recommending a higher level of personal protective equipment fo...
Mon May 11, 2020 03:00
Related ArticlesUrticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology. Clin Mol Allergy. 2020;18:8 Authors: Nettis E, Foti C, Ambrifi M, Baiardini I, Bianchi L, Borghi A, Caminati M, Canonica GW, Casciaro M, Colli L, Colombo G, Corazza M, Cristaudo A, De Feo G, De Pita' O, Di Gioacchino M, Di Leo E, Fassio F, Gangemi S, Gatta A, Hansel K,...
Tue May 12, 2020 18:18
Publication date: Available online 12 May 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Thomas B. Dodson
Tue May 12, 2020 14:17
Abstract According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance Bacillus pumilus QST 2808. To assess the occurrence of Bacillus pumilus QST 2808 residues in primary crops, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Commission Regulation (EU) No 188/2011, as well as the European authorisations reported...
Mon May 11, 2020 11:57
Related ArticlesA Viewpoint on Angiotensin-Converting Enzyme 2, Anti-Hypertensives and Coronavirus Disease 2019 (COVID-19). Infect Disord Drug Targets. 2020 May 10;: Authors: Mali SN, Thorat BR, Chopade AR Abstract TO THE EDITOR, The current life threatening pandemic outbreak of coronavirus disease 2019 (COVID-19) is hitting the whole world in terms of mortality as well as economic losses [1,2]. It has thought to be originated from Wuhan, China, in December...
Tue May 12, 2020 17:16
Related ArticlesFirst Report on the Characteristics of Methicillin Resistant Staphylococcus Capitis Isolates and a NRCS-A-clone Related Isolate Obtained from Iranian Children. Infect Disord Drug Targets. 2020 May 10;: Authors: Asadolahi P, Farzan B, Rezaei F, Delfani S, Ashrafi B, Soroush S Abstract BACKGROUND: Methicillin-resistant Staphylococcus capitis (MRSC) NRCS-A clone (Multi-resistant and vancomycin-non susceptible) has been recently described...
Tue May 12, 2020 17:16
Related ArticlesPromising in vitro Anti-Toxoplasma gondii effects of commercial Chitosan. Infect Disord Drug Targets. 2020 May 10;: Authors: Esboei BR, Keighobadi M, Hezarjaribi HZ, Fakhar M, Daryani A, Chabra A, Soosaraei M, Yalveh R Abstract BACKGROUND: Toxoplasmosis is a disease that results from infection with an obligate intracellular T. gondii parasite, one of the world's most common parasites. Considering the complications of chemical drugs and...
Tue May 12, 2020 17:16
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