Stem Cells and Development, Ahead of Print.
Tue May 12, 2020 10:00
46 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Gan To Kagaku Ryoho"[jour] These pubmed results were generated on 2020/05/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Thyroid, Volume 30, Issue 5, Page 785-786, May 2020.
Thu May 07, 2020 10:00
Thyroid, Volume 30, Issue 5, Page 786-787, May 2020.
Thu May 07, 2020 10:00
Bio-banding (BB) has been introduced to account for varying maturity and to improve the talent development of junior soccer players. To date, research that investigated the physiological and technical effects ...
Tue May 12, 2020 03:00
Advanced glycation end products (AGEs) are known to play important roles in the development of diabetes mellitus and atherosclerosis. Nε-(carboxymethyl)lysine (CML) is the major AGE, and is found in the arterial ...
Tue May 12, 2020 03:00
Coronavirus disease 2019 (COVID-19) is an infectious disease that is caused by severe respiratory syndrome coronavirus 2. Although elective surgical procedures are being cancelled in many parts of the world during the COVID-19 pandemic, acute craniomaxillofacial (CMF) trauma will continue to occur and will need to be appropriately managed. Surgical procedures involving the nasal, oral, or pharyngeal mucosa carry a high risk of transmission due to aerosolization of the virus which is known to be in...
Mon May 11, 2020 03:00
Introduction: Cervical necrotizing fasciitis (CNF) is a rapid progressing and potentially fatal infection of connective tissues that spreads along the fascial planes. It commonly develops from odontogenic sources. In this article, the authors present a case of CNF which was developed after open reduction and internal fixation (ORIF) of a mandibular fracture. Clinical case: A 19-year-old male patient with no past medical history was admitted due to a mandibular fracture. Following ORIF...
Mon May 11, 2020 03:00
No abstract available
Mon May 11, 2020 03:00
Paraneoplastic neurological syndromes (PNSs) are uncommon complications of immune-checkpoint inhibitor (ICI) therapy. This article reports a case of paraneoplastic encephalitis and enteric neuropathy associated with anti-Hu antibody in a patient with advanced small cell lung cancer. Symptoms presented in the third week after the second dose of sintilimab therapy and manifested as focal seizures and intestinal pseudo-obstruction. The patient’s neurological symptoms improved significantly after treatment...
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Colorectal cancer is one of the most commonly diagnosed tumors worldwide and a leading cause of cancer-related death. Although the majority of gastrointestinal cancers are generally considered poorly immunogenic, recent data from clinical trials have demonstrated that the subgroup of patients with DNA mismatch repair system is highly responsive to immune checkpoint inhibitor–based therapy. We present the case of a 74-year-old man with pulmonary autoimmune intersitiopathy and microsatellite instability...
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As new members of the CD28/B7 costimulatory superfamily, PD-1 (programmed cell death 1) and its ligand PD-L1 (programmed cell death ligand 1) mediate a negative costimulatory signal, which inhibits functioning and proliferation of T and B cells, and reduce interleukin-2, interleukin-10, and interferon-γ secretion. This inhibitory pathway plays an important role in immune escape and the microenvironment of the tumor, and closely related to tumor progression. sPD-1 and sPD-L1 are the soluble form of...
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Not only for cutaneous angiosarcoma (CAS) patients but also for advanced and therapy-refractory patients with classic Kaposi sarcoma (CKS) and human immunodeficiency virus (HIV)-associated Kaposi sarcoma (HIV-KS) there is a high need for more effective treatment modalities. The aim of this work was to study programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) protein expression and related immune parameters in CKS, HIV-KS, and CAS and correlate it with other immunologic parameters...
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Cancers, Vol. 12, Pages 1213: Hypoxic Roadmap of Glioblastoma—Learning about Directions and Distances in the Brain Tumor Environment Cancers doi: 10.3390/cancers12051213 Authors: Agnieszka Bronisz Elżbieta Salińska E. Antonio Chiocca Jakub Godlewski Malignant brain tumor—glioblastoma is not only difficult to treat but also hard to study and model. One of the reasons for these is their heterogeneity, i.e., individual tumors consisting of cancer cells that are...
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Reproducing efficiently in captivity is crucial for the survival of many wildlife species, yet reproductive success is often lower than in the wild. Currently, many zoo population management strategies prioritize the genetic diversity of captive populations. Scientists now argue that a broader perspective is required which also includes behavior, life-history, husbandry and environmental considerations. This would improve breeding success in zoos and the maintenance of the diversity of traits, behaviors,...
Tue May 12, 2020 20:44
Neuroblast migration is a critical aspect of nervous system development (e.g., neural crest migration). In an unbiased forward genetic screen, we identified a novel player in neuroblast migration, the ETR-1/CELF1 RNA binding protein. CELF1 RNA binding proteins are involved in multiple aspects of RNA processing including alternative splicing, stability, and translation. We find that a specific mutation in alternatively-spliced exon 8 results in migration defects of the AQR and PQR neurons, and not...
Tue May 12, 2020 23:30
The heterogeneous stock (HS) is an outbred rat population derived from eight inbred rat strains. HS rats are ideally suited for genome wide association studies; however, only a few genotyping microarrays have ever been designed for rats and none of them are currently in production. To address the need for an efficient and cost effective method of genotyping HS rats, we have adapted genotype-by-sequencing (GBS) to obtain genotype information at large numbers of single nucleotide polymorphisms (SNPs)....
Tue May 12, 2020 23:30
Circular RNA (circRNA) is a covalently-closed single-stranded RNA molecule that plays an important role in transcriptional regulation of gene expression in a variety of species. Light intensity is a pivotal environmental factor affecting plant growth and development. However, little is known regarding photoresponsive plant circRNAs. Here, we aimed to investigate the expression and function of circRNAs in lettuce leaves in response to different light intensity treatments. We performed RNA sequencing...
Tue May 12, 2020 23:30
Although seed and pod traits are important for peanut breeding, little is known about the inheritance of these traits. A recombinant inbred line (RIL) population of 156 lines from a cross of Tifrunner x NC 3033 was genotyped with the Axiom_Arachis1 SNP array and SSRs to generate a genetic map composed of 1524 markers in 29 linkage groups (LG). The genetic positions of markers were compared with their physical positions on the peanut genome to confirm the validity of the linkage map and explore the...
Tue May 12, 2020 23:30
Inertial measurement units (IMUs) offer the ability to measure walking gait through a variety of biomechanical outcomes (e.g., spatiotemporal, kinematics, other). Although many studies have assessed their vali...
Mon May 11, 2020 03:00
Body-machine interfaces map movements onto commands to external devices. Redundant motion signals derived from inertial sensors are mapped onto lower-dimensional device commands. Then, the device users face tw...
Mon May 11, 2020 03:00
As the COVID-19 outbreak spreads, there is a growing need for a compilation of conserved RNA genome regions in the SARS-CoV-2 virus along with their structural propensities to guide development of antivirals and diagnostics. Here we present a first look at RNA sequence conservation and structural propensities in the SARS-CoV-2 genome. Using sequence alignments spanning a range of betacoronaviruses, we rank genomic regions by RNA sequence conservation, identifying 79 regions of length at least 15...
Tue May 12, 2020 21:22
Effective infection prevention and control strategies require reliable data describing the epidemiology of hospital acquired infections (HAIs), and this is currently lacking in Nigeria. The objective of this s...
Mon May 11, 2020 03:00
Burden of aspergillosis is reported to be significant from developing countries including those in South Asia. The estimated burden in Pakistan is also high on the background of tuberculosis and chronic lung d...
Mon May 11, 2020 03:00
A prospective observational study was performed to assess the epidemiology and clinical impact of carbapenem-non-susceptible Klebsiella pneumoniae (CNKP) in intensive care units (ICUs) of the national referral ho...
Mon May 11, 2020 03:00
The EphA2 receptor is found at high levels in tumors and low levels in normal tissue and high EphA2 expression in biopsies is a predictor of poor outcome in patients. Drug discovery groups have therefore sought to develop EphA2 based therapies using small molecule, peptide and nanoparticle-based approaches. However, until now only EphA2 targeting antibody drug conjugates (ADCs) have entered clinical development. For example, MEDI-547, is an EphA2 targeting ADC that displayed encouraging antitumor...
Tue May 12, 2020 10:05
British Journal of Cancer, Published online: 13 May 2020; doi:10.1038/s41416-020-0893-8Biomarker measurement in non-invasively sampled colorectal mucus as a novel approach to colorectal cancer detection: screening and triage implications
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British Journal of Cancer, Published online: 13 May 2020; doi:10.1038/s41416-020-0883-xAssociation between the National Cancer Screening Programme (NSCP) for gastric cancer and oesophageal cancer mortality
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Purpose: Preclinical studies suggest PARP inhibition (PARPi) induces immunostimulatory micromilieu in ovarian cancer thus complementing activity of immune checkpoint blockade. We conducted a phase 2 trial of PARPi olaparib and anti-PD-L1 durvalumab and collected paired fresh core biopsies and blood samples to test this hypothesis. Experimental Design: In a single-center, proof-of-concept phase 2 study, we enrolled women aged ≥18 with recurrent ovarian cancer. All patients were immune-checkpoint inhibitor...
Tue May 12, 2020 16:13
Treating BCR-ABL positive CML remains impeded by development of clinical resistance to imatinib. It has been demonstrated that berberine, a plant alkaloid, has activity against imatinib-resistant BCR-ABL mutants by inducing autophagic degradation of BCR-ABL, thereby preventing the acquisition of drug-resistant mutations.
Tue May 12, 2020 16:13
Purpose: To quantitatively predict the impact of cardio-pulmonary dose on overall survival (OS) after radiotherapy for locally-advanced Non-Small Cell Lung Cancer. Experimental Design: We used the NRG Oncology/RTOG 0617 dataset. The model building procedure was pre-registered on a public website. Patients were split between a training and a set-aside validation subset (N=306/131). The 191 candidate variables covered disease, patient, treatment, and dose-volume characteristics from multiple cardiopulmonary...
Tue May 12, 2020 16:13
Abstract Astaxanthin is a natural pigment, known for its strong antioxidant activity and numerous health benefits to human and animals. Its antioxidant activity is known to be substantially greater than β-carotene and about a thousand times more effective than vitamin E. The potential health benefits have generated a growing commercial interest, and the escalating demand has prompted the exploration of alternative supply chain. Astaxanthin naturally occurs in many sea creatures...
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Analytical ChemistryDOI: 10.1021/acs.analchem.0c00359
Tue May 12, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05110
Tue May 12, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05635
Tue May 12, 2020 07:00
Affected by the inner properties and the external environmental conditions, medicinal and edible lotus seeds are susceptible to mildew with fungal infection under suitable temperature and humidity conditions, ...
Tue May 12, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05167
Tue May 12, 2020 07:00
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