IJMS, Vol. 21, Pages 3547: RORγt Inhibitor-SR1001 Halts Retinal Inflammation, Capillary Degeneration, and the Progression of Diabetic Retinopathy International Journal of Molecular Sciences doi: 10.3390/ijms21103547 Authors: Thomas E. Zapadka Sarah I. Lindstrom Brooklyn E. Taylor Chieh A. Lee Jie Tang Zakary R. R. Taylor Scott J. Howell Patricia R. Taylor Diabetic retinopathy is a diabetes-mediated retinal microvascular disease that is the leading cause of blindness...
Sun May 17, 2020 03:00
IJMS, Vol. 21, Pages 3546: The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms21103546 Authors: Liu Hua Chen Lin The activation of p38 mitogen-activated protein kinases (MAPKs) through a phosphorylation cascade is the canonical mode of regulation. Here, we report a novel activation mechanism for p38α. We show that Arg49 and Arg149...
Sun May 17, 2020 03:00
IJMS, Vol. 21, Pages 3544: The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target International Journal of Molecular Sciences doi: 10.3390/ijms21103544 Authors: Mohamed Abu-Farha Thangavel Alphonse Thanaraj Mohammad G. Qaddoumi Anwar Hashem Jehad Abubaker Fahd Al-Mulla The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million people and resulted in the death of over one hundred thousand people at the time of writing...
Sun May 17, 2020 03:00
IJMS, Vol. 21, Pages 3545: Complete Mitochondrial Genomes of Two Toxin-Accumulated Nassariids (Neogastropoda: Nassariidae: Nassarius) and Their Implication for Phylogeny International Journal of Molecular Sciences doi: 10.3390/ijms21103545 Authors: Yi Yang Hongyue Liu Lu Qi Lingfeng Kong Qi Li The Indo-Pacific nassariids (genus Nassarius) possesses the highest diversity within the family Nassariidae. However, the previous shell or radula-based classification of Nassarius...
Sun May 17, 2020 03:00
IJMS, Vol. 21, Pages 3543: PHLD Class Proteins: A Family of New Players in the p53 Network International Journal of Molecular Sciences doi: 10.3390/ijms21103543 Authors: Taylor T. Fuselier Hua Lu The Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology (PH) domain. Though identified nearly 30 years ago,...
Sun May 17, 2020 03:00
IJMS, Vol. 21, Pages 3542: Single-Nucleotide Polymorphisms (SNPs) Both Associated with Hypertension and Contributing to Accelerated-Senescence Traits in OXYS Rats International Journal of Molecular Sciences doi: 10.3390/ijms21103542 Authors: Vasiliy A. Devyatkin Olga E. Redina Natalia A. Muraleva Nataliya G. Kolosova Aging is a major risk factor of numerous human diseases. Adverse genetic variants may contribute to multiple manifestations of aging and increase the number of...
Sun May 17, 2020 03:00
IJMS, Vol. 21, Pages 3541: Exosomal MiRNA Transfer between Retinal Microglia and RPE International Journal of Molecular Sciences doi: 10.3390/ijms21103541 Authors: Dorothea R. Morris Sarah E. Bounds Huanhuan Liu Wei-Qun Ding Yan Chen Yin Liu Jiyang Cai The retinal pigment epithelium (RPE), the outermost layer of the retina, provides essential support to both the neural retina and choroid. Additionally, the RPE is highly active in modulating functions of immune cells...
Sun May 17, 2020 03:00
IJMS, Vol. 21, Pages 3540: The Role of DNA Degradation in the Estimation of Post-Mortem Interval: A Systematic Review of the Current Literature International Journal of Molecular Sciences doi: 10.3390/ijms21103540 Authors: Tozzo Scrivano Sanavio Caenazzo The determination of the post-mortal interval (PMI) is an extremely discussed topic in the literature and of deep forensic interest, for which various types of methods have been proposed. The aim of the manuscript is to...
Sun May 17, 2020 03:00
IJMS, Vol. 21, Pages 3539: Reduction of Secreted Frizzled-Related Protein 5 Drives Vascular Calcification through Wnt3a-Mediated Rho/ROCK/JNK Signaling in Chronic Kidney Disease International Journal of Molecular Sciences doi: 10.3390/ijms21103539 Authors: Yun Jung Oh Hyunsook Kim Ae Jin Kim Han Ro Jae Hyun Chang Hyun Hee Lee Wookyung Chung Hee-Sook Jun Ji Yong Jung Vascular calcification (VC) is commonly associated with bone loss in patients with chronic kidney...
Sun May 17, 2020 03:00
IJMS, Vol. 21, Pages 3538: Hematological Diseases and Osteoporosis International Journal of Molecular Sciences doi: 10.3390/ijms21103538 Authors: Agostino Gaudio Anastasia Xourafa Rosario Rapisarda Luca Zanoli Salvatore Santo Signorelli Pietro Castellino Secondary osteoporosis is a common clinical problem faced by bone specialists, with a higher frequency in men than in women. One of several causes of secondary osteoporosis is hematological disease. There are numerous...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3537: 6-Shogaol Protects Human Melanocytes against Oxidative Stress through Activation of the Nrf2-Antioxidant Response Element Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms21103537 Authors: Lingli Yang Fei Yang Lanting Teng Ichiro Katayama Skin is a major target of oxidative stress. Increasing evidence suggests that oxidative stress is the cause of melanocyte disappearance in vitiligo, which is an acquired pigmentary skin...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3535: Current Molecular Markers of Melanoma and Treatment Targets International Journal of Molecular Sciences doi: 10.3390/ijms21103535 Authors: Yang Oak Slominski Brożyna Slominski Melanoma is a deadly skin cancer that becomes especially difficult to treat after it metastasizes. Timely identification of melanoma is critical for effective therapy, but histopathologic diagnosis can frequently pose a significant challenge to this goal. Therefore, auxiliary...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3536: Vitamin D and Cardiovascular Risk: which Implications in Children? International Journal of Molecular Sciences doi: 10.3390/ijms21103536 Authors: Silvia Savastio Erica Pozzi Francesco Tagliaferri Roberta Degrandi Roberta Cinquatti Ivana Rabbone Gianni Bona Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3534: SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21103534 Authors: Julie Dardare Andréa Witz Jean-Louis Merlin Pauline Gilson Alexandre Harlé Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death worldwide. PDAC is an aggressive disease with an 11-month median overall survival and a five-year survival of less than 5%. Incidence...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3532: Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients International Journal of Molecular Sciences doi: 10.3390/ijms21103532 Authors: Francesca Pirini Luigi Pasini Gianluca Tedaldi Emanuela Scarpi Giorgia Marisi Chiara Molinari Daniele Calistri Alessandro Passardi Paola Ulivi Very few data are reported in the literature on the association between elevated microsatellite alterations...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3533: Enhanced Osseointegration and Bio-Decontamination of Nanostructured Titanium Based on Non-Thermal Atmospheric Pressure Plasma International Journal of Molecular Sciences doi: 10.3390/ijms21103533 Authors: Yuhao Zeng Satoshi Komasa Hisataka Nishida Akinori Agariguchi Tohru Sekino Joji Okazaki Alkali-treated titanate layer with nanonetwork structures (TNS) is a promising surface for improving osseointegration capacity in implants. Nevertheless,...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3531: The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21103531 Authors: Losurdo Salvatore D’Abramo Indellicati Lillo Ierardi Di Leo Small intestinal bacterial overgrowth (SIBO) is a condition hallmarked by an increase in the concentration of colonic-type bacteria in the small bowel. Watery diarrhea, bloating, abdominal pain and distension...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3530: Dual Deep Sequencing Improves the Accuracy of Low-Frequency Somatic Mutation Detection in Cancer Gene Panel Testing International Journal of Molecular Sciences doi: 10.3390/ijms21103530 Authors: Hiroki Ura Sumihito Togi Yo Niida Cancer gene panel testing requires accurate detection of somatic mosaic mutations, as the test sample consists of a mixture of cancer cells and normal cells; each minor clone in the tumor also has different somatic mutations....
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3529: Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S International Journal of Molecular Sciences doi: 10.3390/ijms21103529 Authors: Magdalena Zaborowska Jadwiga Wyszkowska Agata Borowik The choice of the study objective was affected by numerous controversies and concerns around bisphenol F (BPF) and bisphenol S (BPS)—analogues of bisphenol A (BPA). The study focused on the determination and comparison of the...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3528: Neoadjuvant Endocrine Therapy in Breast Cancer: Current Knowledge and Future Perspectives International Journal of Molecular Sciences doi: 10.3390/ijms21103528 Authors: Giacomo Barchiesi Marco Mazzotta Eriseld Krasniqi Laura Pizzuti Daniele Marinelli Elisabetta Capomolla Domenico Sergi Antonella Amodio Clara Natoli Teresa Gamucci Enrico Vizza Paolo Marchetti Claudio Botti Giuseppe Sanguineti Gennaro Ciliberto Maddalena...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3527: Suppression of PKCδ/NF-κB Signaling and Apoptosis Induction through Extrinsic/Intrinsic Pathways Are Associated Magnolol-Inhibited Tumor Progression in Colorectal Cancer In Vitro and In Vivo International Journal of Molecular Sciences doi: 10.3390/ijms21103527 Authors: Chun-Min Su Yueh-Shan Weng Lin-Yen Kuan Jiann-Hwa Chen Fei-Ting Hsu Magnolol is one of the hydroxylated biphenyl compounds from the root and stem bark of Magnolia officinalis, which...
Sat May 16, 2020 03:00
IJMS, Vol. 21, Pages 3524: Overexpression of Melon Tonoplast Sugar Transporter CmTST1 Improved Root Growth under High Sugar Content International Journal of Molecular Sciences doi: 10.3390/ijms21103524 Authors: Baiyi Lu Suying Wen Peilu Zhu Haishun Cao Yixuan Zhou Zhilong Bie Jintao Cheng Sugar allocation is based on the source-to-sink and intracellular transport between different organelles, and sugar transporters are usually involved in these processes. Tonoplast...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3525: CARs: Beyond T Cells and T Cell-Derived Signaling Domains International Journal of Molecular Sciences doi: 10.3390/ijms21103525 Authors: Sievers Dörrie Schaft When optimizing chimeric antigen receptor (CAR) therapy in terms of efficacy, safety, and broadening its application to new malignancies, there are two main clusters of topics to be addressed: the CAR design and the choice of transfected cells. The former focuses on the CAR construct itself....
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3526: Ellagic Acid Controls Cell Proliferation and Induces Apoptosis in Breast Cancer Cells via Inhibition of Cyclin-Dependent Kinase 6 International Journal of Molecular Sciences doi: 10.3390/ijms21103526 Authors: Mohd Yousuf Anas Shamsi Parvez Khan Mohd Shahbaaz Mohamed F. AlAjmi Afzal Hussain Gulam Mustafa Hassan Asimul Islam Qazi Mohd Rizwanul Haque Md. Imtaiyaz Hassan Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3507: MiMIF-2 Effector of Meloidogyne incognita Exhibited Enzyme Activities and Potential Roles in Plant Salicylic Acid Synthesis International Journal of Molecular Sciences doi: 10.3390/ijms21103507 Authors: Jianlong Zhao Zhenchuan Mao Qinghua Sun Qian Liu Heng Jian Bingyan Xie Plant-parasitic nematodes secrete a series of effectors to promote parasitism by modulating host immunity, but the detailed molecular mechanism is ambiguous. Animal parasites...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3523: Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition International Journal of Molecular Sciences doi: 10.3390/ijms21103523 Authors: Pellegrini Daniele Antonioli Benvenuti D’Antongiovanni Piccarducci Pietrobono Citi Piragine Flori Ippolito Segnani Palazon-Riquelme Lopez-Castejon Martelli Colucci Bernardini...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3521: Functional Block of Interleukin-6 Reduces a Bone Pain Marker but Not Bone Loss in Hindlimb-Unloaded Mice International Journal of Molecular Sciences doi: 10.3390/ijms21103521 Authors: Wakabayashi Miyamura Nagao Kato Naito Sudo Interleukin-6 (IL-6) is widely accepted to stimulate osteoclasts. Our aim in this study was to examine whether the inhibitory effect of IL-6 on bone loss and skeletal pain associated with osteoporosis in hindlimb-unloaded...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3520: Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers International Journal of Molecular Sciences doi: 10.3390/ijms21103520 Authors: Yamaguchi Kimura Ohno Nakahara Akiyama Takemori Yagi X-ray diffraction and tension measurement experiments were conducted on rat left ventricular skinned fibers with or without...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3522: Epigenetic Alterations in Oesophageal Cancer: Expression and Role of the Involved Enzymes International Journal of Molecular Sciences doi: 10.3390/ijms21103522 Authors: Lopes Correia Henrique Jerónimo Oesophageal cancer is a life-threatening disease, accounting for high mortality rates. The poor prognosis of this malignancy is mostly due to late diagnosis and lack of effective therapies for advanced disease. Epigenetic alterations may constitute...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3509: Ultramicronized Palmitoylethanolamide and Paracetamol, a New Association to Relieve Hyperalgesia and Pain in a Sciatic Nerve Injury Model in Rat International Journal of Molecular Sciences doi: 10.3390/ijms21103509 Authors: Alessio Filippo Peritore Rosalba Siracusa Roberta Fusco Enrico Gugliandolo Ramona D’Amico Marika Cordaro Rosalia Crupi Tiziana Genovese Daniela Impellizzeri Salvatore Cuzzocrea Rosanna Di Paola Inflammation...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3518: AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen? International Journal of Molecular Sciences doi: 10.3390/ijms21103518 Authors: Evans Hardie We live and to do so we must breathe and eat, so are we a combination of what we eat and breathe? Here, we will consider this question, and the role in this respect of the AMP-activated protein kinase (AMPK). Emerging evidence suggests that AMPK facilitates central and peripheral reflexes that...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3519: The Apolipoprotein A-I Mimetic L-4F Attenuates Monocyte Activation and Adverse Cardiac Remodeling after Myocardial Infarction International Journal of Molecular Sciences doi: 10.3390/ijms21103519 Authors: Tariq Hamid Mohamed Ameen Ismahil Shyam S. Bansal Bindiya Patel Mehak Goel C. Roger White G. M. Anantharamaiah Sumanth D. Prabhu Excessive inflammation after myocardial infarction (MI) can promote infarct expansion and adverse left ventricular...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3513: Small RNA Sequencing Analysis of miRNA Expression Reveals Novel Insihts into Root Formation under Root Restriction Cultivation in Grapevine (Vitis vinifera L.) International Journal of Molecular Sciences doi: 10.3390/ijms21103513 Authors: Hui Li Zhen Gao Muhammad Salman Zahid Dongmei Li Hafiz Umer Javed Lei Wang Shiren Song Liping Zhao Wenping Xu Caixi Zhang Chao Ma Shiping Wang Root restriction cultivation (RRC) can influence...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3516: The Effects of High Molecular Weight Hyaluronic Acid Eye Drop Application in Environmental Dry Eye Stress Model Mice International Journal of Molecular Sciences doi: 10.3390/ijms21103516 Authors: Kojima Nagata Kudo Müller-Lierheim van Setten Dogru Tsubota Hyaluronic acid (HA) ophthalmic solution is widely used in dry eye treatment worldwide. However, there are no reports comparing the dry eye treatment effects of high molecular weight...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3515: Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes International Journal of Molecular Sciences doi: 10.3390/ijms21103515 Authors: Jieliang Zhou Bernard Su Min Chern Peter Barton-Smith Jessie Wai Leng Phoon Tse Yeun Tan Veronique Viardot-Foucault Chee Wai Ku Heng Hao Tan Jerry Kok Yen Chan Yie Hou Lee Endometriosis is a common inflammatory gynecological disorder which causes pelvic scarring, pain, and infertility,...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3517: Transcriptomics in Alzheimer’s Disease: Aspects and Challenges International Journal of Molecular Sciences doi: 10.3390/ijms21103517 Authors: Eva Bagyinszky Vo Van Giau SeongSoo A. An Alzheimer’s disease (AD) is the most common cause of dementia. Although the heritability of AD is high, the knowledge of the disease-associated genes, their expression, and their disease-related pathways remain limited. Hence, finding the association between gene...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3512: Keratin Biomembranes as a Model for Studying Onychomycosis International Journal of Molecular Sciences doi: 10.3390/ijms21103512 Authors: Anton Valkov Michael Zinigrad Alexander Sobolev Marina Nisnevitch Difficulties in obtaining human nails that are large enough for examining the penetration of drug formulations led us to produce keratin films regenerated from human hair. We assume that these films can simulate human nail plates in drug penetration...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3510: Identification, Localization in the Central Nervous System and Novel Myostimulatory Effect of Allatostatins in Tenebrio molitor Beetle International Journal of Molecular Sciences doi: 10.3390/ijms21103510 Authors: Jan Lubawy Paweł Marciniak Grzegorz Rosiński Allatostatins (ASTs) are pleiotropic insect neuropeptides that are potent myoinhibitors of muscle contractions. In this study, we identified and immunolocalized peptides from the MIP/AST and PISCF/AST...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3511: Novel 3′-Substituted-1′,2′,4′-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo International Journal of Molecular Sciences doi: 10.3390/ijms21103511 Authors: Markov Sen’kova Popadyuk Salomatina Logashenko Komarova Ilyina Salakhutdinov Zenkova A series of novel 18βH-glycyrrhetinic acid (GA) derivatives...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3508: Myostatin Inhibits Vascular Smooth Muscle Cell Proliferation and Local 14q32 microRNA Expression, But Not Systemic Inflammation or Restenosis International Journal of Molecular Sciences doi: 10.3390/ijms21103508 Authors: Eveline A.C. Goossens Margreet R. de Vries J. Wouter Jukema Paul H.A. Quax A. Yaël Nossent Myostatin is a negative regulator of muscle cell growth and proliferation. Furthermore, myostatin directly affects the expression of 14q32...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3514: Molecular and Functional Characterization of Elovl4 Genes in Sparus aurata and Solea senegalensis Pointing to a Critical Role in Very Long-Chain (>C24) Fatty Acid Synthesis during Early Neural Development of Fish International Journal of Molecular Sciences doi: 10.3390/ijms21103514 Authors: Sofia Morais Miguel Torres Francisco Hontoria Óscar Monroig Inma Varó María José Agulleiro Juan Carlos Navarro Very long-chain fatty acids (VLC-FA)...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3501: Physical Activity Dynamically Regulates the Hippocampal Proteome along the Dorso-Ventral Axis International Journal of Molecular Sciences doi: 10.3390/ijms21103501 Authors: Surina Frey Rico Schieweck Ignasi Forné Axel Imhof Tobias Straub Bastian Popper Michael A. Kiebler The hippocampus is central for higher cognition and emotions. In patients suffering from neuropsychiatric or neurodegenerative diseases, hippocampal signaling is altered causing...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3497: Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in Drosophila Intestinal Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21103497 Authors: Joung-Sun Park Yung-Jin Kim Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restriction...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3505: From Environment to Genome and Back: A Lesson from HFE Mutations International Journal of Molecular Sciences doi: 10.3390/ijms21103505 Authors: Raffaela Rametta Marica Meroni Paola Dongiovanni The environment and the human genome are closely entangled and many genetic variations that occur in human populations are the result of adaptive selection to ancestral environmental (mainly dietary) conditions. However, the selected mutations may become maladaptive...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3504: Role of the Hyaluronan Receptor, Stabilin-2/HARE, in Health and Disease International Journal of Molecular Sciences doi: 10.3390/ijms21103504 Authors: Harris Baker Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3495: Inhalation Toxicology of Vaping Products and Implications for Pulmonary Health International Journal of Molecular Sciences doi: 10.3390/ijms21103495 Authors: Traboulsi Cherian Abou Rjeili Preteroti Bourbeau Smith Eidelman Baglole E-cigarettes have a liquid that may contain flavors, solvents, and nicotine. Heating this liquid generates an aerosol that is inhaled into the lungs in a process commonly referred to as vaping. E-cigarette...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3503: Otoprotective Effects of Zingerone on Cisplatin-Induced Ototoxicity International Journal of Molecular Sciences doi: 10.3390/ijms21103503 Authors: Lee Lee Lee Kim Previous studies have described the effects of zingerone (ZO) on cisplatin (CXP)-induced injury to the kidneys, liver, and other organs but not to the cochlea. This study aimed to investigate the effects of ZO on CXP-induced ototoxicity. Eight-week-old Sprague–Dawley rats were...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3502: Does the Urothelium of Old Mice Regenerate after Chitosan Injury as Quickly as the Urothelium of Young Mice? International Journal of Molecular Sciences doi: 10.3390/ijms21103502 Authors: Erzar Kerec Kos Lakota Veranič Erman The aging of organisms leads to a decreased ability of tissue to regenerate after injury. The regeneration of the bladder urothelium after induced desquamation with biopolymer chitosan has been studied in young mice but...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3493: Homo- and Hetero-Oligonuclear Complexes of Platinum Group Metals (PGM) Coordinated by Imine Schiff Base Ligands International Journal of Molecular Sciences doi: 10.3390/ijms21103493 Authors: Barbara Miroslaw Chemistry of Schiff base (SB) ligands began in 1864 due to the discovery made by Hugo Schiff (Schiff, H., Justus Liebigs Ann. der Chemie 1864, 131 (1), 118–119). However, there is still a vivid interest in coordination compounds based on imine...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3496: Novel Cell-Based and Tissue Engineering Approaches for Induction of Angiogenesis as an Alternative Therapy for Diabetic Retinopathy International Journal of Molecular Sciences doi: 10.3390/ijms21103496 Authors: Elmira Jalilian Kenneth Elkin Su Ryon Shin Diabetic retinopathy (DR) is the most frequent microvascular complication of long-term diabetes and the most common cause of blindness, increasing morbidity in the working-age population. The most effective...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3500: Serotonin in Health and Disease International Journal of Molecular Sciences doi: 10.3390/ijms21103500 Authors: De Deurwaerdère Di Giovanni The International Journal of Molecular Sciences Special Issue “Serotonin in health and diseases” covers several aspects of the multiple and still mysterious functions of serotonin (5-hydroxytryptamine; 5-HT). 5-HT is neurotransmitter acting in the central nervous system (CNS), blood factor, and neurohormone...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3494: The Neuropeptide System and Colorectal Cancer Liver Metastases: Mechanisms and Management International Journal of Molecular Sciences doi: 10.3390/ijms21103494 Authors: Aldona Kasprzak Agnieszka Adamek Colorectal cancer (CRC), classified as the third most prevalent cancer worldwide, remains to be a clinical and research challenge. It is estimated that ~50% of CRC patients die from distant metastases, with treatment of this complication still posing significant...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3499: Identification and Characterization of Verticillium longisporum Lineage A1/D1 from Brassica Crops in Manitoba, Canada International Journal of Molecular Sciences doi: 10.3390/ijms21103499 Authors: Zhongwei Zou Vikram Bisht W. G. Dilantha Fernando Verticillium stripe in canola (Brassica napus L.) caused by Verticillium longisporum was first reported in Manitoba in 2014. In this study, Brassica crops including canola, mustard (Brassica juncea) and radish...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3492: Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19 International Journal of Molecular Sciences doi: 10.3390/ijms21103492 Authors: Valentino Clemente Padraig D’Arcy Martina Bazzaro Following the outbreak of novel severe acute respiratory syndrome (SARS)-coronavirus (CoV)2, the majority of nations are struggling with countermeasures to fight infection, prevent spread and improve patient survival. Considering that...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3498: Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21103498 Authors: Ma Lim Benda Lou Goyette Gaus T cell activation is initiated when ligand binding to the T cell receptor (TCR) triggers intracellular phosphorylation of the TCR-CD3 complex. However, it remains unknown how biophysical properties of TCR engagement result in biochemical phosphorylation events. Here,...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3506: Targeting Mitochondria during Cold Storage to Maintain Proteasome Function and Improve Renal Outcome after Transplantation International Journal of Molecular Sciences doi: 10.3390/ijms21103506 Authors: Sorena B. Lo Richard T. Blaszak Nirmala Parajuli Kidney transplantation is the preferred treatment for end-stage kidney disease (ESKD). Compared to maintenance dialysis, kidney transplantation results in improved patient survival and quality of life. Kidneys...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3491: Toxic Effects of Nonylphenol on Neonatal Testicular Development in Mouse Organ Culture International Journal of Molecular Sciences doi: 10.3390/ijms21103491 Authors: Hyun-Jung Park Mingtian Zhang Won-Young Lee Kwon-Ho Hong Jeong Tae Do Chankyu Park Hyuk Song Nonylphenol (NP) is an alkylphenol that is widely used in chemical manufacturing. Exposure to this toxic environmental contaminant has been shown to negatively affect the reproductive...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3490: Methylmercury Poisoning Induces Cardiac Electrical Remodeling and Increases Arrhythmia Susceptibility and Mortality International Journal of Molecular Sciences doi: 10.3390/ijms21103490 Authors: Mara Cristina P. Santos Ruybal Monica Gallego Thais Bazoti B. Sottani Emiliano H. Medei Oscar Casis Jose Hamilton M. Nascimento This study aims to investigate the cardiac electrical remodeling associated with intoxication by methylmercury (MeHg). We evaluated...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3488: Super-Resolution Microscopy Reveals Diversity of Plant Centromere Architecture International Journal of Molecular Sciences doi: 10.3390/ijms21103488 Authors: Veit Schubert Pavel Neumann André Marques Stefan Heckmann Jiri Macas Andrea Pedrosa-Harand Ingo Schubert Tae-Soo Jang Andreas Houben Centromeres are essential for proper chromosome segregation to the daughter cells during mitosis and meiosis. Chromosomes of most eukaryotes studied...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3486: Concentration and Duration of Indoxyl Sulfate Exposure Affects Osteoclastogenesis by Regulating NFATc1 via Aryl Hydrocarbon Receptor International Journal of Molecular Sciences doi: 10.3390/ijms21103486 Authors: Wen-Chih Liu Jia-Fwu Shyu Paik Seong Lim Te-Chao Fang Chien-Lin Lu Cai-Mei Zheng Yi-Chou Hou Chia-Chao Wu Yuh-Feng Lin Kuo-Cheng Lu Indoxyl sulfate (IS) is a chronic kidney disease (CKD)-specific renal osteodystrophy metabolite...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3487: Eyeing the Extracellular Matrix in Vascular Development and Microvascular Diseases and Bridging the Divide between Vascular Mechanics and Function International Journal of Molecular Sciences doi: 10.3390/ijms21103487 Authors: Brahim Chaqour Charles Karrasch The extracellular matrix (ECM) is critical in all aspects of vascular development and health: supporting cell anchorage, providing structure, organization and mechanical stability, and serving as a sink...
Fri May 15, 2020 03:00
IJMS, Vol. 21, Pages 3489: New Insights on Vitamin K Metabolism in Senegalese sole (Solea senegalensis) Based on Ontogenetic and Tissue-Specific Vitamin K Epoxide Reductase Molecular Data International Journal of Molecular Sciences doi: 10.3390/ijms21103489 Authors: Silvia Beato Carlos Marques Vincent Laizé Paulo J. Gavaia Ignacio Fernández Vitamin K (VK) is a key nutrient for several biological processes (e.g., blood clotting and bone metabolism). To fulfill VK nutritional...
Fri May 15, 2020 03:00
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