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Drug hypersensitivity is one of the most frequent causes of anaphylaxis, particularly in adults and in hospitalized patients. Drug-induced anaphylaxis (DIA) is also associated with more severe outcomes than other anaphylaxis triggers, and drugs are responsible for the majority of deaths due to anaphylaxis. We here review the current knowledge on the incidence, prevalence, drugs involved, mortality, and mortality risk factors for DIA. The incidence of both anaphylaxis and DIA seems to be increasing...
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Publication date: Available online 12 May 2020Source: Cellular SignallingAuthor(s): Bingyuan Ji, Liyan Shang, Chunmei Wang, Lei Wan, Baohua Cheng, Jing Chen
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Publication date: Available online 12 May 2020Source: The Journal of Emergency MedicineAuthor(s): Skyler Lentz, Alexandra Grossman, Alex Koyfman, Brit Long
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Publication date: Available online 12 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Jaime B. Hyman, Shradha D. Khadge, Eliezer Kinberg, Brett Miles, Adam Levine
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Publication date: Available online 12 May 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Ross Hofmeyr, Richard Llewellyn, Johannes J. Fagan
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CorrectionThis Endgames article (BMJ, 2019, 367; doi:10.1136/bmj.l6257; https://www.bmj.com/content/367/bmj.l6257) has been corrected to make it clear that the epidural abscess that was causing this...
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Antibiotics, Vol. 9, Pages 248: Natural Oregano Essential Oil May Replace Antibiotics in Lamb Diets: Effects on Meat Quality Antibiotics doi: 10.3390/antibiotics9050248 Authors: Ivan A. Garcia-Galicia Jose A. Arras-Acosta Mariana Huerta-Jimenez Ana L. Rentería-Monterrubio Jose L. Loya-Olguin Luis M. Carrillo-Lopez Juan M. Tirado-Gallegos Alma D. Alarcon-Rojo A study was conducted to investigate the effect of oregano essential oil (OEO) and monensin sodium...
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female genital schistosomiasisSchistosoma infection
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AbstractWe compared risk of recurrent fever in patients with acute myeloid leukemia undergoing induction chemotherapy with febrile neutropenia without an infectious source in which antibacterials were de-escalated before neutrophil recovery versus continued. There was less recurrent fever when antibacterials were de-escalated early with no increased adverse events.
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AbstractWith the rising prevalence of heart disease in the United States, there is increasing reliance on durable mechanical circulatory support (MCS) to treat patients with end-stage heart failure. Left ventricular assist devices (LVADs), the most common form of durable MCS, are implanted mechanical pumps that connect to an external power source through a transcutaneous driveline. First-generation LVADs were bulky, pulsatile pumps that were frequently complicated by infection. Second-generation...
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Publication date: Available online 11 May 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): B. Jie, B. Yao, R. Li, J. An, Y. Zhang, Y. He
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Infections are thought to trigger CD8; +; cytotoxic T lymphocyte (CTL) responses during autoimmunity. However, the transcriptional programs governing the tissue-destructive potential of CTLs remain poorly defined. In a model of central nervous system (CNS) inflammation, we found that infection with lymphocytic choriomeningitis virus (LCMV), but not Listeria monocytogenes (Lm), drove autoimmunity. The DNA-binding factor TOX was induced in CTLs during LCMV infection and was essential for their encephalitogenic...
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Publication date: May 2020Source: Advances in Biological Regulation, Volume 76Author(s):
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John Snow removed the handle of the Broad Street pump to halt a cholera epidemic. His approach was not to find the organism but to block transmission.1 One way to contain covid-19 is to assess...
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“This programme is called IRIS, which stands for identification and referral to improve safety of women affected by domestic violence and abuse. It helps GPs working at the coalface to engage...
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Publication date: Available online 11 May 2020Source: Journal of Fluency DisordersAuthor(s): Mark Onslow, Ellen M. Kelly
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Once upon a time (two months ago), if I saw a patient with a notifiable infectious disease I’d make a clinical diagnosis, usually send a sample to the hospital laboratory, and email the local public...
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Background: There are very few animal models of balloon angioplasty injury in arteriovenous fistula (AVF), hindering insight into the pathophysiologic processes following angioplasty in AVF. The objective of the study was to develop and characterize a rat model of AVF angioplasty injury. Methods: Balloon angioplasty in 12- to 16-week-old Sprague-Dawley rats was performed at the arteriovenous anastomosis 14 days post-AVF creation with a 2F Fogarty balloon catheter. Morphometry and protein expression...
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Background: Atherosclerosis has been extensively studied in thalassemia major (TM) and sickle cell disease but not yet in β thalassemia intermedia (TI). Previous studies concerned with TM were performed in children. TI patients usually live longer and, thus, are more prone to complications of atherosclerosis. Aim: In our study, we applied color Doppler for the determination of arterial conduit and flow velocities in β TI patients. Methods: For central circulation, we measured right and left middle...
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