Abstract Mice lacking the superoxide anion scavenger CuZn superoxide dismutase (Sod1−/− mice) develop a number of age-related phenotypes, including an early progression of muscle atrophy and weakness (sarcopenia) associated with loss of innervation. The purpose of this study was to delineate the early development of sarcopenia in the Sod1−/− mice and to measure changes in the muscle transcriptome, proteome, and eicosanoid profile at the stage when sarcopenia is markedly induced...
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Tuberous Sclerosis Complex (TSC) is an autosomal dominant disease characterized by multi-organ hamartomas, including renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM). TSC2 deficiency leads to hyperactivation of mammalian Target of Rapamycin Complex 1 (mTORC1), a master regulator of cell growth and metabolism. Phospholipid metabolism is dysregulated upon TSC2 loss, causing enhanced production of lysophosphatidylcholine (LPC) species by TSC2-deficient tumor cells. LPC is the major...
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Although fibrotic stroma forms an integral component of pancreatic diseases, whether fibroblasts programmed by different types of pancreatic diseases are phenotypically distinct remains unknown. Here we show that fibroblasts isolated from patients with pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP), periampullary tumors (PAT), and adjacent normal (NA) tissue (N=34) have distinct mRNA and miRNA profiles. Compared to NA-fibroblasts, PDAC-associated fibroblasts were generally less...
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Although prostate cancer is the leading cause of cancer mortality for African men, the vast majority of known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies have used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities in genomic medicine, the Men of African Descent and Carcinoma of the Prostate (MADCaP) Network has developed a genotyping array that is optimized for African populations....
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Abstract Purpose Left untreated, obstructive sleep-disordered breathing (OSDB) are associated with adverse effects on growth and development. History and physical examination alone are used for diagnosing children with OSDB, as polysomnography is not always feasible. Our objective was to develop and validate a Hebrew version of the Pediatric Sleep Questionnaire (PSQ) to help to diagnose and follow-up children before and after adenotonsillectomy...
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Planta MedDOI: 10.1055/a-1157-1732Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant strains. Thus, development of new antituberculosis medicines should receive high priority. Plant-derived natural products are promising candidates for this purpose. We therefore screened alkaloid extracts obtained...
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Abstract The objective of this study was to analyze acute care utilization of sickle cell disease (SCD) and sickle cell trait (SCT) in children and identify trends in emergency department (ED) visits and inpatient admissions over a 10-year period. This is a retrospective population-based study of SCD- and SCT-related ED visits and admissions from 2006 to 2015. Data were acquired from the Healthcare Cost and Utilization Project (HCUP), National Inpatient Sample (NIS), and National...
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Rejuvenation Research, Ahead of Print.
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Weaning from mechanical ventilation (MV) is a cardiovascular stress test. Monitoring the regional oxygenation status has shown promising results in predicting the tolerance to spontaneously breathe in the proc...
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Biotransformation has the advantages of low cost and environmental protection and is a preferred method for production of compounds. At present, most 2,5-dihydroxymethylfuran (DHMF) is synthesized by chemical ...
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Abstract Adults with sleep problems are at higher risk for onset of musculoskeletal pain, but the evidence is less clear for children. This prospective cohort study investigated whether children with sleep problems are at higher risk for onset of musculoskeletal pain and explored whether sex is a modifier of this association. In a prospective cohort study of Australian schoolchildren (n = 1239, mean age 9 years), the associations between sleep problems at baseline and new onset...
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Abstract Microplastics (MPs) are physical anthropogenic pollutants and their ability to act as contaminant vectors in biological matrices is of serious ecosystem and human health concern. In the present study, we have, for the first time, screened and detected MPs in the stomach of a select group of commonly consumed fish species from a municipal water supply lake (Eleyele) in Nigeria. A total of 109 fish samples consisting of eight (8) species: Coptodon zillii (CZ: n = 38), Oreochromis...
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The combination of tavo and pembrolizumab was associated with a higher than anticipated response rate in patients with advanced melanoma with low frequencies of checkpoint positive cytotoxic lymphocytes. (Source: CancerNetwork)
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Researchers found a steady increase in racial inequalities of the mortality rate from liver cancer from 1998-2016 after lifesaving drugs for hepatitis C virus were introduced. (Source: CancerNetwork)
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A clinically applicable mathematical model was developed by researchers to predict outcomes to immunotherapy for patients with cancer previously treated with anti –CTLA-4 or anti–PD-1/PD-L1 antibodies. (Source: CancerNetwork)
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Researchers found that 2 studied strategies, which combined nivolumab and doxorubicin, vinblastine, and dacarbazine, are feasible, highly effective, and result in excellent 12-month progression-free survival. (Source: CancerNetwork)
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Abstract The spatial and temporal variation in the distribution, abundance and assemblage structure of zooplankton were examined in a mining-impacted stretch of river Ganga. The collection of samples has been done from three different sampling zones such as Z1 (Chandi Bridge Ghat) as reference zone, Z2 (Shyampur), and Z3 (Bisanpur) as mining-intruded area from May 2017 to April 2018. During the analysis, twenty-eight species of zooplankton kindred to four groups mainly Rotifera...
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Aidoc has secured a contract with Telemedicine Clinic, the teleradiology unit...Read more on AuntMinnieEurope.comRelated Reading: Aidoc secures CE Mark for incidental PE triage software Aidoc raises 24M euros in funding round Aidoc receives CE Mark for pulmonary embolism AI Aidoc wins Belgian contract
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Abstract Purpose Here, first experiences with a prototype tool for high throughput (passive) permeability profiling, a 96-well plate comprising the Permeapad® membrane, are reported. The permeabilities of a set of drugs were determined and compared to published measures of oral absorption, such as human fraction absorbed (Fa) and in vitro permeability values obtained using other tools. ...
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Abstract Purpose Sorafenib is a multi-targeted tyrosine kinase inhibitor (TKI) used for the treatment of advanced renal cell carcinoma, hepatocellular carcinoma and radioactive iodine resistant thyroid carcinoma. Neoplastic diseases are the cause of pain, which may occur regardless of the stage of the disease. Paracetamol is a non-opioid analgesic used alone or in combination with opioids for the treatment of cancer pain. Numerous studies...
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This report characterizes the role of the polyamine spermidine as a Foxp3+ Treg inducer, both in vitro and in vivo in a T cell transfer-induced colitis model.
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Crucial roles of hematologic and immunologic responses in progression of COVID-19 remains largely unclear.
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Anaphylactic patients exhibit relative lack of PGE2; PGE2 stabilization or agonism at EP2/EP4 protects from ANA in mice and may be of therapeutic or preventive value in high-risk ANA patients.
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Capsule Summary: The HEROES trial demonstrated that an anti-IL-13 antibody reduced eosinophil counts and improved clinical features in adults with active EoE. These new findings demonstrate an improvement in EMT biomarkers in esophageal tissue after 16 weeks of treatment.
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Publication date: Available online 10 May 2020Source: The Journal of Emergency MedicineAuthor(s): Samantha K. Ong, Xujia Li, Tina Chen
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Publication date: Available online 10 May 2020Source: The Journal of Emergency MedicineAuthor(s): Jessica J. McCoy, Kim Aldy, Elizabeth Arnall, Joshua Petersen
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Publication date: Available online 10 May 2020Source: The Journal of Emergency MedicineAuthor(s): David Toomey, Emily Wiener, Nattaly Greene, Ashley Weisman, Kathleen Wittels, Susan R. Wilcox
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External auditory canal (EAC) carcinoma is a rare and unusual malignancy. The complex anatomy and relationship between the tumor and surrounding tissues in a limited space render it difficult to attain safe resection margins during surgery. A high jugular bulb (HJB) is one such anatomical variation that has important surgical implications that complicate the surgical procedure for EAC carcinoma. A 73-year-old woman presented with a 3-month history of right ear pain. Pathological findings and computed...
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To investigate the effects of long-term moderate noise on hearing functions, MOCR, and MEMR.
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ACS NanoDOI: 10.1021/acsnano.0c01012
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[ASAP] Nanostructured Architectures Promote the Mesenchymal–Epithelial Transition for Invasive Cells
ACS NanoDOI: 10.1021/acsnano.9b07350
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Abstract Purpose Colorectal cancer (CRC) is the third most common cancer in the USA. The objective of this study was to compare quality of life (QoL) across long-term colorectal cancer survivors and unaffected matched controls while adjusting for comorbidities. Methods The National Cancer Institute (NCI)-funded Colon Cancer Family Registry (CCFR) was used...
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