Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00531B, PaperYuming Zhang, Yuncong Chen, Bai Yang, Xueling Xue, Weijiang He, Zijian GuoReal time monitor of hydrogen sulphide (H2S) level change is of crucial importance for the study of its complicated roles in physiology. Herein, we developed a FRET strategy for designing...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00522C, PaperPurim Jarujamrus, Akarapong Prakobkij, Sodsai Puchum , Sawida Chaisamdaeng, Rattapol Meelapsom, wipark anutrasakda, Maliwan Amatatongchai, Sanoe Chairam, Daniel CitterioThis work presents the development and application of a novel analytical approach for the determination of acid and base concentrations by titration using a microfluidic thread-based analytical device (µTAD). This...The content of this RSS Feed (c) The Royal Society...
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Cancers, Vol. 12, Pages 1157: Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib Cancers doi: 10.3390/cancers12051157 Authors: Changhong Ke Huan Hou Jiayu Li Kui Su Chaohong Huang Yue Lin Zhiqiang Lu Zhiyun Du Wen Tan Zhengqiang Yuan Tumour necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) is a promising anti-cancer agent that rapidly induces apoptosis in cancer...
Cancers, Vol. 12, Pages 1156: Impact and Diagnostic Gaps of Comprehensive Genomic Profiling in Real-World Clinical Practice Cancers doi: 10.3390/cancers12051156 Authors: Aditi P. Singh Elaine Shum Lakshmi Rajdev Haiying Cheng Sanjay Goel Roman Perez-Soler Balazs Halmos Purpose: next-generation sequencing based comprehensive genomic profiling (CGP) is becoming common practice. Although numerous studies have shown its feasibility to identify actionable genomic...
Cancers, Vol. 12, Pages 1155: MHC Class I Regulation: The Origin Perspective Cancers doi: 10.3390/cancers12051155 Authors: Alicja Sznarkowska Sara Mikac Magdalena Pilch Viral-derived elements and non-coding RNAs that build up “junk DNA” allow for flexible and context-dependent gene expression. They are extremely dense in the MHC region, accounting for flexible expression of the MHC I, II, and III genes and adjusting the level of immune response to the...
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Abstract Purpose An intraoperative real-time respiratory tumor motion prediction system with magnetic tracking technology is presented. Based on respiratory movements in different body regions, it provides patient and single/multiple tumor-specific prediction that facilitates the guiding of treatments. Methods...
Abstract Purpose We propose a novel methodology for generating synthetic X-rays from 2D RGB images. This method creates accurate simulations for use in non-diagnostic visualization problems where the only input comes from a generic camera. Traditional methods are restricted to using simulation algorithms on 3D computer models. To solve this problem, we propose a method of synthetic X-ray generation using conditional generative adversarial...
Abstract Purpose The aim of this work is to propose a classification algorithm to automatically detect treatment for scoliosis (brace, implant or no treatment) in postero-anterior radiographs. Such automatic labelling of radiographs could represent a step towards global automatic radiological analysis. Methods Seven hundred and ninety-six frontal radiographies...
Abstract Purpose Demonstrate the feasibility of a fully automatic computer-aided diagnosis (CAD) tool, based on deep learning, that localizes and classifies proximal femur fractures on X-ray images according to the AO classification. The proposed framework aims to improve patient treatment planning and provide support for the training of trauma surgeon residents. Material and...
Abstract Purpose Fluoroscopy is the standard imaging modality used to guide hip surgery and is therefore a natural sensor for computer-assisted navigation. In order to efficiently solve the complex registration problems presented during navigation, human-assisted annotations of the intraoperative image are typically required. This manual initialization interferes with the surgical workflow and diminishes any advantages gained from navigation....
Abstract Purpose In the last decade, there has been a great effort to bring mixed reality (MR) into the operating room to assist surgeons intraoperatively. However, progress towards this goal is still at an early stage. The aim of this paper is to propose a MR visualisation platform which projects multiple imaging modalities to assist intraoperative surgical guidance. Methodology...
Abstract Purpose Eye gaze tracking is proving to be beneficial in many biomedical applications. The performance of systems based on eye gaze tracking is very much dependent on how accurate their calibration is. It has been reported that the gaze tracking accuracy deteriorates cumulatively and significantly with usage time. This impedes the wide use of gaze tracking in user interfaces. ...
Abstract Purpose Surgical simulations play an increasingly important role in surgeon education and developing algorithms that enable robots to perform surgical subtasks. To model anatomy, finite element method (FEM) simulations have been held as the gold standard for calculating accurate soft tissue deformation. Unfortunately, their accuracy is highly dependent on the simulation parameters,...
Abstract Purpose Basal cell carcinoma (BCC) is the most commonly diagnosed cancer and the number of diagnosis is growing worldwide due to increased exposure to solar radiation and the aging population. Reduction of positive margin rates when removing BCC leads to fewer revision surgeries and consequently lower health care costs, improved cosmetic outcomes and better patient care. In this study, we propose the first use of a perioperative...
Abstract Purpose Neuronavigation systems making use of augmented reality (AR) have been the focus of much research in the last couple of decades. In recent years, there has been considerable interest in using mobile devices for AR in the operating room (OR). We propose a complete system that performs real-time AR video augmentation on a mobile device in the context of image-guided neurosurgery. ...
Abstract Purpose For laparoscopic ablation to be successful, accurate placement of the needle to the tumor is essential. Laparoscopic ultrasound is an essential tool to guide needle placement, but the ultrasound image is generally presented separately from the laparoscopic image. We aim to evaluate an augmented reality (AR) system which combines laparoscopic ultrasound image, laparoscope video, and the needle trajectory in a unified view....
Abstract Purpose Minimally invasive surgery (MIS) has become the standard for many surgical procedures as it minimizes trauma, reduces infection rates and shortens hospitalization. However, the manipulation of objects in the surgical workspace can be difficult due to the unintuitive handling of instruments and limited range of motion. Apart from the advantages of robot-assisted systems such...
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Related ArticlesEstimated effect of COVID-19 lockdown on melanoma thickness and prognosis: a rate of growth model. J Eur Acad Dermatol Venereol. 2020 May 02;: Authors: Tejera-Vaquerizo A, Nagore E Abstract The coronavirus COVID-19 pandemic, which emerged in Wuhan, China several months ago,1 has led to large-scale lockdown in many countries around the world, including Spain. Uncertainty about the duration of these measures led us to consider the potential...
Related ArticlesClinical trials and the COVID-19 pandemic. Hell J Nucl Med. 2020 Jan-Apr;23(1):4-5 Authors: Retsas S Abstract "...but why think? Why not try the experiment?..." John Hunter (1728-1793), in a letter to Edward Jenner. August 2nd, 1775. When Galen of Pergamum (2nd c. A.D.), physician, philosopher and experimentalist, sought to ascertain the therapeutic properties of Theriac, an antidote of repute against poisons, he resorted to an experiment....
Related ArticlesTreatment response monitoring in patients with advanced malignancies using cell-free SHOX2 and SEPT9 DNA methylation in blood: An observational prospective study. J Mol Diagn. 2020 Apr 30;: Authors: de Vos L, Jung M, Koerber RM, Bawden EG, Holderried TAW, Dietrich J, Bootz F, Brossart P, Kristiansen G, Dietrich D Abstract Patients with incurable cancer usually receive palliative treatment with significant toxicity and limited efficacy....
Related Articles22β-hydroxytingenone reduces proliferation and invasion of human melanoma cells. Toxicol In Vitro. 2020 Apr 29;:104879 Authors: Aranha ESP, da Silva EL, Mesquita FP, de Sousa LB, da Silva FMA, Rocha WC, Lima ES, Koolen HHF, de Moraes MEA, Montenegro RC, de Vasconcellos MC Abstract Melanoma is a skin cancer with high invasive potential and high lethality. Considering that quinonemethide triterpenes are described as promising anticancer...
Related ArticlesTechnological advances for the detection of melanoma: Part II. Advances in molecular techniques. J Am Acad Dermatol. 2020 Apr 29;: Authors: Fried L, Tan A, Bajaj S, Liebman TN, Polsky D, Stein JA Abstract The growth of molecular technologies analyzing skin cells and inherited genetic variations has the potential to address current gaps in both diagnostic accuracy and prognostication in melanoma patients or in individuals at risk for developing...
Related ArticlesDietary supplements in dermatology: a review of the evidence for zinc, biotin, vitamin D, nicotinamide, and polypodium. J Am Acad Dermatol. 2020 Apr 29;: Authors: Thompson KG, Kim N Abstract Dietary supplements are commonly recommended by dermatologists in the treatment of skin, hair, and nail disorders. This review of oral over the counter (OTC) supplement use in dermatology summarizes current evidence for the use of zinc, biotin, vitamin...
Related ArticlesOnline Skin Cancer Education for Organ Transplant Recipients: A Missed Opportunity. J Am Acad Dermatol. 2020 Apr 29;: Authors: Dabade TS, Nguyen BM PMID: 32360754 [PubMed - as supplied by publisher]
Related ArticlesNumber Needed to Biopsy (NNB) Ratio and Diagnostic Accuracy for Melanoma Detection. J Am Acad Dermatol. 2020 Apr 28;: Authors: Marchetti MA, Yu A, Nanda J, Tschandl P, Kittler H, Marghoob AA, Halpern AC, Dusza SW Abstract BACKGROUND: The number needed to biopsy (NNB) ratio for melanoma diagnosis is calculated by dividing the total number of biopsies by the number of biopsied melanomas. It is the inverse of positive predictive value (PPV),...
Related ArticlesClinical and dermoscopic characteristics of congenital and non-congenital nevus-associated melanomas. J Am Acad Dermatol. 2020 Apr 28;: Authors: Zalaudek I, Conforti C, Guarneri F, Vezzoni R, Deinlein T, Hofmann-Wellenhof R, Caterina Longo, Moscarella E, Harald Kittler, Giuseppe Argenziano, Giuffrida R Abstract BACKGROUND: No specific features of nevus-associated melanoma (NAM) are currently defined. OBJECTIVE: To identify clinical/dermoscopic...
Related ArticlesRegulation of eIF2α by RNF4 promotes melanoma tumorigenesis and therapy resistance. J Invest Dermatol. 2020 Apr 29;: Authors: Avitan-Hersh E, Feng Y, Vaisman AO, Ahmed YA, Zohar Y, Zhang T, Lee JS, Lazar I, Khalil SS, Feiler Y, Kluger H, Kahana C, Brown K, Ruppin E, Ronai ZA, Orian A Abstract Among the hallmarks of melanoma, are impaired proteostasis and the rapid development of resistance to targeted therapy, that represent a major clinical...
Related ArticlesEZH2 cooperates with DNA methylation to downregulate key tumour suppressors and interferon gene signatures in melanoma. J Invest Dermatol. 2020 Apr 29;: Authors: Tiffen J, Gallagher S, Filipp F, Gunatilake D, Al Emran A, Cullinane C, Dutton-Register K, Aoude L, Hayward N, Chatterjee A, Rodger EJ, Eccles MR, Hersey P Abstract The histone methylase EZH2 is frequently dysregulated in melanoma and is associated with DNA methylation and silencing...
Related ArticlesPalliative endoscopic treatment of metastatic uveal melanoma to the upper and lower urinary tract. Urology. 2020 Apr 28;: Authors: Leong JY, Clark CB, Syed A, Hubosky SG Abstract We report a rare case of uveal melanoma demonstrating simultaneous metastatic foci to the upper and lower urinary tract. A 60-year-old female with metastatic uveal melanoma was referred for incidental right hydronephrosis. Diagnostic cystoscopy and ureteroscopy...
Related ArticlesResults of surgical treatment for primary malignant melanoma of the esophagus: A multicenter retrospective study. J Thorac Cardiovasc Surg. 2020 Mar 20;: Authors: Dai L, Wang ZM, Xue ZQ, He M, Yuan Y, Shang XQ, Chen KN, Chinese Cooperative Primary Malignant Melanoma of the Esophagus Group (CCPMMEG) Abstract OBJECTIVE: Few large-sample research data sets exist on long-term survival and prognostic factors among patients with primary malignant...
Related ArticlesClear Cell Sarcoma of the Achilles Tendon: A Case Report. J Foot Ankle Surg. 2020 Apr 29;: Authors: Ngissah R, Choi JY, Kim HS, Lee DJ, Park JH, Suh JS Abstract Clear cell sarcoma of the Achilles tendon is an extremely rare condition, with a handful of cases reported in the literature over the past 3 decades. Patients usually present late because of the slow progress of the disease and seemingly benign nature of its presentation. Clinical...
Related ArticlesHair(y) Matters in Melanoma Biology. Trends Mol Med. 2020 May;26(5):441-449 Authors: Bedogni B, Paus R Abstract Melanocyte stem cells (MeSCs), one candidate for the cellular origin of melanoma, reside in the bulge region of the hair follicle (HF), an immune-privileged tissue niche with impaired tumor immunosurveillance. Surprisingly, however, primary melanoma is only very rarely associated with HFs. Here, we explore the hypothesis that...
Related ArticlesDysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma. Cell. 2020 Apr 30;181(3):747 Authors: Li H, van der Leun AM, Yofe I, Lubling Y, Gelbard-Solodkin D, van Akkooi ACJ, van den Braber M, Rozeman EA, Haanen JBAG, Blank CU, Horlings HM, David E, Baran Y, Bercovich A, Lifshitz A, Schumacher TN, Tanay A, Amit I PMID: 32359441 [PubMed - as supplied by publisher]
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Related ArticlesStingray spear injury to the pediatric spinal cord: case report and review of the literature. Childs Nerv Syst. 2020 May 02;: Authors: Caceres A, Schlobin NA, Lam S, Zamora J, Segura JL Abstract Stingray injuries are rare, mostly causing injuries to the lower extremities but occasionally fatal if there is direct puncture of the thorax, abdomen, or neck. Direct combined stingray injury to the central nervous system has not been reported...
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Related ArticlesGenetic and Immune Changes Associated with Disease Progression under the Pressure of Oncolytic Therapy in A Neuroblastoma Outlier Patient. Cancers (Basel). 2020 Apr 28;12(5): Authors: Franco-Luzón L, García-Mulero S, Sanz-Pamplona R, Melen G, Ruano D, Lassaletta Á, Madero L, González-Murillo Á, Ramírez M Abstract Little is known about the effect of oncolytic adenovirotherapy on pediatric tumors. Here we present the clinical case of a...
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Related ArticlesNeural correlates of NOS1 ex1f-VNTR allelic variation in panic disorder and agoraphobia during fear conditioning and extinction in fMRI. Neuroimage Clin. 2020 Apr 23;27:102268 Authors: Ridderbusch IC, Yang Y, Weber H, Reif A, Herterich S, Ströhle A, Pfleiderer B, Arolt V, Wittchen HU, Lueken U, Kircher T, Straube B Abstract Neuronal nitric oxide synthase (NOS-I) impacts on fear/anxiety-like behavior in animals. In humans, the short (S)...
Related ArticlesA hierarchical analysis of the latent trait of borderline personality disorder and its possible clinical implications. Psychiatry Res. 2020 Apr 17;288:113023 Authors: Dreyße K, Beller J, Armbrust M, Kröger C Abstract Borderline personality disorder (BPD) is a severe mental disorder which is accompanied by impaired functioning, complex psychosocial problems and incurs large costs. However, it rarely has been examined whether BPD symptoms...
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Related ArticlesA review on recent advances and applications of fish collagen. Crit Rev Food Sci Nutr. 2020 Apr 29;:1-11 Authors: Subhan F, Hussain Z, Tauseef I, Shehzad A, Wahid F Abstract During the processing of the fishery resources, the significant portion is either discarded or used to produce low-value fish meal and oil. However, the discarded portion is the rich source of valuable proteins such as collagen, vitamins, minerals, and other bioactive...
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Abstract Purpose of Review Transthyretin amyloidosis is an increasingly recognized cause of restrictive cardiomyopathy related to amyloid fibril deposition in cardiac tissues. As treatment therapies have emerged for transthyretin amyloidosis (ATTR), so has interest in using biomarkers to identify disease prior to advanced presentation. Recent Findings Lower...
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