Since their discovery (1), viroids—small (∼250 to 430 nt), non–protein-coding, circular RNAs—are thought to infect and cause disease only in plants (2); thus, the report that they infect and incite symptoms in filamentous phytopathogenic fungi (3) is surprising. Viroids are classified into two families (4). Members of the Pospiviroidae, including...
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How a new wave of research on venoms from an array of creatures could seed future pharma development. Pediatric neurosurgeon Amy Lee works by the small, bright light of a microscope, her gaze focused on the opened skull of a child. Lee moves her hands calmly and confidently over the...
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Researchers and policy makers worldwide are interested in measuring the subjective well-being of populations. When users post on social media, they leave behind digital traces that reflect their thoughts and feelings. Aggregation of such digital traces may make it possible to monitor well-being at large scale. However, social media-based methods...
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Self-organization, and transitions from reversible to irreversible behavior, of interacting particle assemblies driven by externally imposed stresses or deformation is of interest in comprehending diverse phenomena in soft matter. They have been investigated in a wide range of systems, such as colloidal suspensions, glasses, and granular matter. In different density...
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Myeloperoxidase (MPO)-mediated oxidative stress has been suggested to play an important role in the pathological dysfunction of epileptic brains. However, there is currently no robust brain-imaging tool to detect real-time endogenous hypochlorite (HClO) generation by MPO or a fluorescent probe for rapid high-throughput screening of antiepileptic agents that control the...
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Neurodegeneration is a shared feature of some infectious diseases, such as leprosy, and noninfectious conditions, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) (1). The type-1 reaction (T1R), a nerve damaging process seen in leprosy and caused by chronic Mycobacterium leprae infection (2), is a natural model for the...
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How reptiles adapted to marine life Artist’s conception of a metriorhynchid, an extinct crocodile relative. Shapes represent evolution of the inner ear (bony labyrinth) from terrestrial (Left) through semiaquatic (Middle) to pelagic (Right). Image credit: Bryan Christie Design. During major evolutionary transitions, the development of new body plans allows animals...
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People evaluate a stranger’s trustworthiness from their facial features in a fraction of a second, despite common advice “not to judge a book by its cover.” Evaluations of trustworthiness have critical and widespread social impact, predicting financial lending, mate selection, and even criminal justice outcomes. Consequently, understanding how people perceive...
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Coformycin and pentostatin are structurally related N-nucleoside inhibitors of adenosine deaminase characterized by an unusual 1,3-diazepine nucleobase. Herein, the cof gene cluster responsible for coformycin biosynthesis is identified. Reconstitution of the coformycin biosynthetic pathway in vitro demonstrates that it overlaps significantly with the early stages of l-histidine biosynthesis. Committed entry...
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The Great Unconformity marks a major gap in the continental geological record, separating Precambrian basement from Phanerozoic sedimentary rocks. However, the timing, magnitude, spatial heterogeneity, and causes of the erosional event(s) and/or depositional hiatus that lead to its development are unknown. We present field relationships from the 1.07-Ga Pikes Peak...
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Abstract Background and Objective SUVN-G3031 is a novel, potent, and selective histamine-3 receptor (H3R) inverse agonist in development for the treatment of narcolepsy. Our objective was to characterize the safety, tolerability, and pharmacokinetics of SUVN-G3031 in healthy young adults after single and multiple doses, and to evaluate the effect of food, gender, and age on the pharmacokinetics. ...
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The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
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An experiment reveals how difficult it is to use Bluetooth on phones to determine if people have been in close enough contact to spread the coronavirus
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Publication date: Available online 11 May 2020Source: Acta Otorrinolaringológica EspañolaAuthor(s): Jordi Coromina Isern, Robert Soler Rich, Joan Rius Tarruella, Jeanneth Zamora Bustamante
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Abstract HIF-1-mediated adaptation to changes in oxygen availability is a critical aspect of healthy physiology. HIF is regulated by a conserved mechanism whereby EGLN/PHD family members hydroxylate HIF in an oxygen-dependent manner, targeting it for ubiquitination by Von-Hippel-Lindau (VHL) family members, leading to its proteasomal degradation. The activity of the only C. elegans PHD family member, EGL-9, is also regulated by a hydrogen sulfide sensing cysteine-synthetase-like...
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ObjectivesThere are established methods for occupational epidemiological cohort analysis, such as proportional hazards regression, that are well suited to aetiological research and yield parameter estimates that allow for succinct communication among academics. However, these methods are not necessarily well suited for evaluation of health impacts of policy choices and communication to decision makers. An informed decision about a policy that impacts health and safety requires a valid estimate of...
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ObjectivesA historical cohort study of cancer mortality is being conducted among workers in a chrysotile mine and its enrichment factories in the town of Asbest, Russian Federation. Because individual-level information on tobacco use is not available for Asbest Chrysotile Cohort members, a cross-sectional survey of smoking behaviours was conducted among active and retired workers.MethodsSelf-administered questionnaires were completed by active workers during meetings organised by occupational safety...
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‘Come in Mr Smith, have a seat. It is very nice to meet you. I believe you are new to this region? Your GP has referred you to clinic with a brief letter saying you’ve had Crohn’s disease for 15 years and been under the care of Professor Brain at Ivory Tower University Hospital and are taking Infliximab and Azathioprine and need follow up in Inflammatory Bowel Disease (IBD) clinic? Could you help me fill in the details of your Crohn’s disease over the years?’ Many patients, relatives and most secondary...
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Abstract Background National and international aesthetic surgery society websites are an important source of information for patients and aesthetic surgeons. The current COVID-19 pandemic represents an unprecedented global health crisis. The aim of this study was to assess the information available on national and international aesthetic surgery society websites on the current pandemic of COVID-19. ...
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The coronavirus pandemic has exposed the vulnerability and weaknesses of already fragile global food systems, say the authors of a new report which finds one in every nine people in the world is...
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ACS NanoDOI: 10.1021/acsnano.0c01517
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ACS NanoDOI: 10.1021/acsnano.0c01407
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ACS NanoDOI: 10.1021/acsnano.0c00129
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Publication date: Available online 12 May 2020Source: Journal of BiomechanicsAuthor(s): Frédéric Marin, Kevin Lepetit, Laetitia Fradet, Clint Hansen, Khalil Ben Mansour
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Publication date: Available online 12 May 2020Source: Journal of BiomechanicsAuthor(s): Meng-Wei Lin, Wei Liu, Feng Yang
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Publication date: Available online 11 May 2020Source: Journal of BiomechanicsAuthor(s): Zwirner J, Ondruschka B, Scholze M, Hammer N
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Publication date: Available online 11 May 2020Source: Journal of BiomechanicsAuthor(s): Lorenzo Grassi, Joeri Kok, Anna Gustafsson, Yi Zheng, Sami P. Väänänen, Jukka S. Jurvelin, Hanna Isaksson
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Publication date: Available online 11 May 2020Source: Journal of BiomechanicsAuthor(s): Spudić Darjan, Smajla Darjan, Šarabon Nejc
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Publication date: Available online 11 May 2020Source: Journal of BiomechanicsAuthor(s): Bernard X.W. Liew, Laura Sullivan, Susan Morris, Kevin Netto
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Publication date: Available online 11 May 2020Source: Journal of BiomechanicsAuthor(s): Eva Maddox, Zachary A. Sievert, Hunter J. Bennett
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Publication date: Available online 11 May 2020Source: Journal of BiomechanicsAuthor(s): Joseph M. Moore, Kimberly Cessford, Alexander P. Willmott, Dipak Raj, Timothy A. Exell, Jenny Burbage, David R. Mullineaux
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Publication date: Available online 11 May 2020Source: Journal of BiomechanicsAuthor(s): Raine Viitala, Vesa Saikko
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