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Δευτέρα 4 Μαΐου 2020

Losing Ground: Current Medicaid Policy Threatens Children's Access to Health Care
From 2008 through 2016, the number of uninsured children in the United States decreased from 7.6 million to 3.6 million (Alker & Roygardner, 2019). However, since 2017 that trend has reversed. Over 4 million children are now uninsured—the highest rate of uninsured children since the implementation of the Affordable Care Act (ACA)—and over one-quarter of these children are aged under 6 years (Burak, Clark, & Roygardner, 2019). According to the periodicity schedule for preventive pediatric...
Journal of Pediatric Health Care
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Keep Calm and Nightingale On
Journal of Pediatric Health Care
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Brave New World
So, how do I start this? As I'm writing this, it is the 3rd week in March, and I'm grappling with how the COVID-19 pandemic has changed life as we knew it. Like many of you at this point, I'm struggling with how to be fully informed but not be overwhelmed with information that's not always accurate. We've rescheduled many patients in our pediatric primary care site, so while at home I'm doing online training in telehealth and will be helping to staff our clinic's call center. Being geographically...
Journal of Pediatric Health Care
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Psychological and Socioeconomic Burdens Faced by Family Caregivers of Children with Asthma: An Integrative Review
Asthma affects nearly 1 in every 12 children in the United States. Caring for a child with asthma poses significant challenges for the parent or caregiver. The purpose of this integrative review was to identify the psychological and socioeconomic burdens faced by family caregivers of children with asthma.
Journal of Pediatric Health Care
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Establishment and characterization of NCC-DFSP3-C1: a novel patient-derived dermatofibrosarcoma protuberans cell line
Abstract Dermatofibrosarcoma protuberans (DFSP) is the most common dermal sarcoma; it is characterized by the presence of the COL1A1–PDGFB translocation, which causes the constitutive activation of the platelet-derived growth factor β (PDGFB) signaling pathway. DFSP frequently exhibits local recurrence and is refractory to conventional chemotherapy. Therefore, a novel therapeutic strategy is required for improving the prognosis of DFSP. Although patient-derived cell lines are important...
Latest Results for Human Cell
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Gastric-cancer-derived mesenchymal stem cells: a promising target for resveratrol in the suppression of gastric cancer metastasis
Abstract The tumor microenvironment (TM) is an essential factor of tumor progression. Mesenchymal stem cells (MSCs) are important components of the TM and play critical roles in cancer metastasis. Resveratrol (RES) is a potential antitumor drug that has attracted extensive attention. However, it remains unclear whether RES can exert its antitumor activity by targeting MSCs located in the TM. In this study, we demonstrated that the conditioned medium of gastric-cancer-derived MSCs...
Latest Results for Human Cell
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MicroRNA-153-3p enhances the sensitivity of chronic myeloid leukemia cells to imatinib by inhibiting B-cell lymphoma-2-mediated autophagy
Abstract Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease caused by abnormal DNA replication of bone marrow stem cells and chemotherapy resistance is a major obstacle to the effective treatment of patients with CML. Imatinib (IM), a tyrosine kinase inhibitor (TKI), is a first-line drug clinically used for CML. Mounting evidence has indicated that the dysregulation of microRNAs (miRNAs) is associated with the chemoresistance of CML. In this study, miR-153-3p,...
Latest Results for Human Cell
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SDC1 promotes cisplatin resistance in hepatic carcinoma cells via PI3K-AKT pathway
Abstract This study is to analyze the potential contribution of Syndecan 1 (SDC1) to cisplatin resistance in hepatic carcinoma. Cell proliferation and viability were determined by direct counting and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, respectively. The protein levels of SDC1, p-AKT, AKT and β-actin were quantified by western blotting. The SDC1 transcript abundance was measured by real-time polymerase chain reaction. The relative expression of SDC1...
Latest Results for Human Cell
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The spatiotemporal control of human matriptase action on its physiological substrates: a case against a direct role for matriptase proteolytic activity in profilaggrin processing and desquamation
Abstract Studies of human genetic disorders and animal models indicate that matriptase plays essential roles in proteolytic processes associated with profilaggrin processing and desquamation at late stages of epidermal differentiation. The tissue distribution profile and zymogen activation status in human skin, however, suggests that matriptase physiological function in the skin more likely lies in the proliferating and differentiating keratinocytes in the basal and spinous layers....
Latest Results for Human Cell
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AGR2-induced glucose metabolism facilitated the progression of endometrial carcinoma via enhancing the MUC1/HIF-1α pathway
Abstract Anterior gradient 2 (AGR2) was proved to modulate cancer progression. However, the role of AGR2 on endometrial cancer was not established. Here, we investigated the effects of AGR2 expression on endometrial cancer and explored the regulation mechanism. In the study, we found that AGR2 was overexpressed in tumor tissues of 30 endometrial cancer patients. A high level of AGR2 promoted endometrial cancer cells proliferation, migration and invasion. AGR2 induced the expression...
Latest Results for Human Cell
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Establishment and characterization of NCC-ssRMS1-C1: a novel patient-derived spindle-cell/sclerosing rhabdomyosarcoma cell line
Abstract Spindle-cell/sclerosing rhabdomyosarcoma (ssRMS) is a rare subtype of rhabdomyosarcoma, characterized by unique pathological features. Although distinctive molecular backgrounds such as frequent mutations in MyoD1 have been reported, optimized therapy has not been fully developed, and further investigations are required. Patient-derived cancer models are critical tools for basic and pre-clinical studies. However, there is no model for ssRMS. Thus, this study aimed to develop...
Latest Results for Human Cell
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Long non-coding RNA MIAT promotes the growth of melanoma via targeting miR-150
Abstract Melanoma is a common skin cancer and it can lead to high mortality probably by early invasion and metastasis. LncRNA MIAT is involved in tumor proliferation, invasion and epithelial-to-mesenchymal transition (EMT). However, the roles of MIAT in melanoma still require further investigation. Thus, the aim of the study is to investigate the roles of MIAT in melanoma, especially the effects of MIAT on EMT of melanoma cancer cells. The results showed that the expression of...
Latest Results for Human Cell
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Effect of the extracellular component of bone marrow mesenchymal stromal cells from healthy donors on hematologic neoplasms and their angiogenesis
Abstract Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors are a promising source of cell therapy. However, their effectiveness in cancer remains less known. This study is the first to evaluate the quality of BM-MSCs obtained from young and elderly healthy volunteers (KNT cells). The KNT cells had normal karyotypes and were positive for MSC markers (CD90, CD73, CD105). When cultured under appropriate conditions, they showed adipogenic or osteogenic potential....
Latest Results for Human Cell
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Case 14-2020: A 37-Year-Old Man with Joint Pain and Eye Redness
Presentation of Case. Dr. John H. Stone: A 37-year-old man was evaluated in the rheumatology clinic of this hospital for joint pain and rash. The patient had been well until 2 years before this evaluation, when intermittent arthralgias developed in the joints of the hands. Four months before…
The New England Journal of Medicine: Search Results in Allergy\Immunology
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Immune Thrombocytopenic Purpura in a Patient with Covid-19
To rapidly communicate information on the global clinical effort against Covid-19, the Journal has initiated a series of case reports that offer important teaching points or novel findings. The case reports should be viewed as observations rather than as recommendations for evaluation or treatment.…
The New England Journal of Medicine: Search Results in Allergy\Immunology
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Covid-19 in Immune-Mediated Inflammatory Diseases — Case Series from New York
To the Editor: Data on Covid-19 in patients with immune-mediated inflammatory disease who have received anticytokine biologics, other immunomodulatory therapies, or both on a long-term basis are scarce. Trials to assess the efficacy of antirheumatic therapies such as hydroxychloroquine and…
The New England Journal of Medicine: Search Results in Allergy\Immunology
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Balancing the Effect of Leukotrienes in Asthma
Inflammation and its timely resolution represent a vital physiologic response to infection, injury, and "sterile provocation" by endogenous stimuli. There is a growing appreciation that the initiation, progression, and resolution of inflammation and the return of tissue to its original state are…
The New England Journal of Medicine: Search Results in Allergy\Immunology
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Performance of a novel in vitro assay for skin sensitization based on activation of T lymphocytes.
Performance of a novel in vitro assay for skin sensitization based on activation of T lymphocytes. ALTEX. 2020 Apr 21;: Authors: Hou F, Xing C, Li B, Cheng J, Chen W Abstract There are currently no skin sensitization assays based on T cell activation. We built a novel in vitro model to assess T cell activation and test its performance to discriminate skin sensitizers from non-sensitizers using 52 reference chemicals. Jurkat Clone E6-1 human T lymphocytes...
Mitteleuropäische Gesellschaft für Alternativmethoden zu Tierversuchen Johns Hopkins Center for Alternatives to Animal Testing European Society for Alternatives to Animal Testing
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The Ryanodine Receptor Contributes to the Lysophosphatidylcholine-Induced Mineralization in Valvular Interstitial Cells
Abstract Purpose Fibrocalcific aortic valve disease (CAVD) is caused by the deposition of calcific nodules in the aortic valve leaflets, resulting in progressive loss of function that ultimately requires surgical intervention. This process is actively mediated by the resident valvular interstitial cells (VICs), which, in response to oxidized lipids, transition from a quiescent to an osteoblast-like state. The purpose of this study was...
Latest Results for Cardiovascular Engineering and Technology
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Non-Invasive Quantification of Ventricular Contractility, Arterial Elastic Function and Ventriculo-Arterial Coupling from a Single Diagnostic Encounter Using Simultaneous Arterial Tonometry and Magnetic Resonance Imaging
Abstract Purpose Optimal assessment of cardiovascular performance requires simultaneous measurement of load independent left ventricular (LV) contractility, arterial function and LV/arterial coupling. We aimed to demonstrate feasibility of non-invasive ventricular pressure–volume and aortic pressure-flow-impedance measurements using simultaneous arterial tonometry (AT) and cardiovascular magnetic resonance imaging (CMRI). ...
Latest Results for Cardiovascular Engineering and Technology
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Large-Eddy Simulations of Flow in the FDA Benchmark Nozzle Geometry to Predict Hemolysis
Abstract Purpose Modeling of hemolysis due to fluid stresses faces significant methodological challenges, particularly in geometries with turbulence or complex flow patterns. It is currently unclear how existing phenomenological blood-damage models based on laminar viscous stresses can be implemented into turbulent computational fluid dynamics simulations. The aim of this work is to generalize the existing laminar models to turbulent flows...
Latest Results for Cardiovascular Engineering and Technology
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The pan-Bcl-2 inhibitor obatoclax promotes differentiation and apoptosis of acute myeloid leukemia cells
Summary One of the key features of acute myeloid leukemia (AML) is the arrest of differentiation at the early progenitor stage of myelopoiesis. Therefore, the identification of new agents that could overcome this differentiation block and force leukemic cells to enter the apoptotic pathway is essential for the development of new treatment strategies in AML. Regarding this, herein we report the pro-differentiation activity of the pan-Bcl-2 inhibitor, obatoclax. Obatoclax promoted...
Latest Results for Investigational New Drugs
13m
Apatinib, a novel VEGFR-2 tyrosine kinase inhibitor, for relapsed and refractory nasopharyngeal carcinoma: data from an open-label, single-arm, exploratory study
Summary Purpose Apatinib, a new tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, has shown promising efficacy against several solid cancers, but evidence of its efficacy against relapsed and refractory nasopharyngeal carcinoma is limited. We investigated the efficacy and safety of apatinib for relapsed and refractory nasopharyngeal carcinoma in an open-label, single-arm, phase II clinical trial. Fifty-one patients with relapsed and refractory nasopharyngeal...
Latest Results for Investigational New Drugs
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The near-infrared fluorescent dye IR-780 was coupled with cabazitaxel for castration-resistant prostate cancer imaging and therapy
Summary A new drug, Caba-780, was synthesized by chemical coupling of the heptamethyl phthalocyanine near-infrared fluorescent (NIRF) dye IR-780 and the paclitaxel-based chemotherapeutic drug cabazitaxel. Then, the potential value of Caba-780 in the diagnosis and treatment of castration-resistant prostate cancer (CRPC) was evaluated. The CRPC cell lines DU145 and PC-3, as well as the normal human prostate stromal cell line WPMY-1, were used to evaluate the uptake of Caba-780 and...
Latest Results for Investigational New Drugs
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Tivantinib inhibits the VEGF signaling pathway and induces apoptosis in gastric cancer cells with c-MET or VEGFA amplification
Summary Tivantinib has been described as a selective inhibitor of c-Met and is being studied in various types of cancer. In this study, we evaluated the effects of tivantinib on the suppression of gastric cancer (GC) cell migration and apoptosis. We also examined the mechanism of action of tivantinib by oncogenic pathway analysis. We applied an RNA-sequencing approach in 34 GC patients to identify oncogenes that are differentially expressed in GC tissues. To examine the inhibitory...
Latest Results for Investigational New Drugs
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A phase I study of the VEGFR kinase inhibitor vatalanib in combination with the mTOR inhibitor, everolimus, in patients with advanced solid tumors
Summary Purpose Combining small-molecule inhibitors of different targets was shown to be synergistic in preclinical studies. Testing this concept in clinical trials is, however, daunting due to challenges in toxicity management and efficacy assessment. This study attempted to evaluate the safety and efficacy of vatalanib plus everolimus in patients with advanced solid tumors and explore the utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) studies as a predictive...
Latest Results for Investigational New Drugs
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Targeting c-Met in triple negative breast cancer: preclinical studies using the c-Met inhibitor, Cpd A
Summary Introduction Triple negative breast cancer (TNBC) represents a heterogeneous subtype of breast cancer that carries a poorer prognosis. There remains a need to identify novel drivers of TNBC, which may represent targets to treat the disease. c-Met overexpression is linked with decreased survival and is associated with the basal subtype of breast cancer. Cpd A, a kinase inhibitor selective/specific for Met kinase has demonstrated preclinical anti-cancer efficacy in TNBC....
Latest Results for Investigational New Drugs
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Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir
Summary Introduction Oral formulations of docetaxel have successfully been developed as an alternative for intravenous administration. Co-administration with the enzyme inhibitor ritonavir boosts the docetaxel plasma exposure. In dose-escalation trials, the maximum tolerated doses for two different dosing regimens were established and dose-limiting toxicities (DLTs) were recorded. The aim of current analysis was to develop a pharmacokinetic...
Latest Results for Investigational New Drugs
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Structure-based design, synthesis, and evaluation of the biological activity of novel phosphoroorganic small molecule IAP antagonists
Summary One of the strategies employed by novel anticancer therapies is to put the process of apoptosis back on track by blocking the interaction between inhibitor of apoptosis proteins (IAPs) and caspases. The activity of caspases is modulated by the caspases themselves in a caspase/procaspase proteolytic cascade and by their interaction with IAPs. Caspases can be released from the inhibitory influence of IAPs by proapoptotic proteins such as secondary mitochondrial activator...
Latest Results for Investigational New Drugs
13m
Phase 1 dose escalation trial of TAS-102 (trifluridine/tipiracil) and temozolomide in the treatment of advanced neuroendocrine tumors
Summary Neuroendocrine tumors (NETs) are understudied and have limited systemic treatment options. Prior studies for patients with advanced NETs have demonstrated promising results when antimetabolite agents, including fluoropyrimidines, were combined with temozolomide TMZ. TAS-102 (trifluridine/tipiracil) is an antineoplastic agent that is non-cross resistant with 5-fluorouracil and capecitabine and that has a different toxicity profile. This study evaluated the safety of TAS-102...
Latest Results for Investigational New Drugs
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Consortium of Otolaryngology Journal Editors-Collegiality and Contributions.
Related ArticlesConsortium of Otolaryngology Journal Editors-Collegiality and Contributions. JAMA Otolaryngol Head Neck Surg. 2020 Apr 30;: Authors: Sataloff RT, Chandra R, Fisher EW, Goldenberg D, Hanna EY, Johnson J, Kennedy DW, Kraus DH, Krouse JH, Link M, Lustig LR, O'Malley BW, Piccirillo JF, Ruben R, Schwartz S, Selesnick SH, Sindwani R, Smith RJ, Stewart MG, Tysome J, Weber PC, Welling DB PMID: 32352503 [PubMed - as supplied by publisher]
pubmed: "jama otolaryngol he...
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Burning Mouth Syndrome-Opening the Door to a Psychosomatic Approach in the Era of Patient-Centered Medicine.
Related ArticlesBurning Mouth Syndrome-Opening the Door to a Psychosomatic Approach in the Era of Patient-Centered Medicine. JAMA Otolaryngol Head Neck Surg. 2020 Apr 30;: Authors: Galli F, Pravettoni G PMID: 32352502 [PubMed - as supplied by publisher]
pubmed: "jama otolaryngol he...
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The Puzzle of Medically Unexplained Symptoms-A Holistic View of the Patient With Laryngeal Symptoms.
Related ArticlesThe Puzzle of Medically Unexplained Symptoms-A Holistic View of the Patient With Laryngeal Symptoms. JAMA Otolaryngol Head Neck Surg. 2020 Apr 30;: Authors: Misono S, Dietrich M, Piccirillo JF PMID: 32352490 [PubMed - as supplied by publisher]
pubmed: "jama otolaryngol he...
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Thyroid Nodules.
Related ArticlesThyroid Nodules. JAMA Otolaryngol Head Neck Surg. 2020 Apr 30;: Authors: Wu J PMID: 32352488 [PubMed - as supplied by publisher]
pubmed: "jama otolaryngol he...
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Chronic Pain Syndromes and Their Laryngeal Manifestations.
Related ArticlesChronic Pain Syndromes and Their Laryngeal Manifestations. JAMA Otolaryngol Head Neck Surg. 2020 Apr 30;: Authors: Piersiala K, Akst LM, Hillel AT, Best SR Abstract Importance: Fibromyalgia syndrome (FMS), irritable bowel syndrome (IBS), and chronic fatigue syndrome (CFS) are traditionally considered as distinct entities grouped under chronic pain syndrome (CPS) of an unknown origin. However, these 3 disorders may exist on a spectrum...
pubmed: "jama otolaryngol he...
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Association Between Burning Mouth Syndrome and the Development of Depression, Anxiety, Dementia, and Parkinson Disease.
Related ArticlesAssociation Between Burning Mouth Syndrome and the Development of Depression, Anxiety, Dementia, and Parkinson Disease. JAMA Otolaryngol Head Neck Surg. 2020 Apr 30;: Authors: Kim JY, Kim YS, Ko I, Kim DK Abstract Importance: Burning mouth syndrome is a chronic oral pain disorder that is characterized by a generalized or localized burning sensation without the presence of any specific mucosal lesions. It remains unclear, however, whether...
pubmed: "jama otolaryngol he...
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Acalabrutinib - a new option in CLL.
Related ArticlesAcalabrutinib - a new option in CLL. Nat Rev Clin Oncol. 2020 May 01;: Authors: Romero D PMID: 32358576 [PubMed - as supplied by publisher]
Nature reviews. Clinical oncology.
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Anti-CD22 CAR T cells in ALL.
Related ArticlesAnti-CD22 CAR T cells in ALL. Nat Rev Clin Oncol. 2020 May 01;: Authors: Killock D PMID: 32358575 [PubMed - as supplied by publisher]
Nature reviews. Clinical oncology.
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