Abstract Metastasis of cancer cells to the brain occurs frequently in patients with certain subtypes of breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are at high risk for the development of brain metastases. Despite recent advances in the treatment of primary breast tumors, the prognosis of breast cancer patients with brain metastases remains poor. A better understanding of the molecular and cellular mechanisms underlying brain metastasis...
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Abstract Chlorine dioxide (ClO2) degradation of the organophosphorus pesticides azamethiphos (AZA) and dimethoate (DM) (10 mg/L) in deionized water and in Sava River water was investigated for the first time. Pesticide degradation was studied in terms of ClO2 level (5 and 10 mg/L), degradation duration (0.5, 1, 2, 3, 6, and 24 h), pH (3.00, 7.00, and 9.00), and under light/dark conditions in deionized water. Degradation was monitored using high-performance liquid chromatography....
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Abstract Background To test the hypothesis that optic nerve sheath diameter (ONSD) correlates with real-time changes in intracranial pressure, we performed ultrasound measurements of the ONSD in ambulatory patients undergoing elective lumbar puncture (LP). We conducted a prospective cohort study, including adult patients undergoing LP in a non-emergent setting. We measured ONSD perpendicular to the optic nerve at 3 mm behind the...
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We present the rationale for a novel allo-priming approach to serve the elderly as a universal anti-virus vaccine, as well serving to remodel the aging immune system in order to reverse immunosenescence and in...
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Green tea drinking has been proven to lower lipid and exert cardiovascular protection, while the potential mechanism has not been fully determined. This study was to investigate whether the beneficial impact o...
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The association between blood pressure change and kidney damage in patients with abnormal blood glucose remains unclear. The current study aimed to identify systolic blood pressure (SBP) trajectories among the...
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Glutamate, a key intermediate in myocardial metabolism, may enhance myocardial recovery after ischemia and possibly reduce the incidence and severity of postoperative heart failure in coronary artery bypass su...
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Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation.
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ACS NanoDOI: 10.1021/acsnano.9b10123
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Affected by the inner properties and the external environmental conditions, medicinal and edible lotus seeds are susceptible to mildew with fungal infection under suitable temperature and humidity conditions, ...
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A large proportion of patients with a SARS-Cov-2-associated respiratory failure develop an acute respiratory distress syndrome (ARDS). It has been recently suggested that SARS-Cov-2-associated ARDS may differ ...
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Abstract Pinoxaden is the one of the acetyl-CoA carboxylases (ACCase) inhibiting herbicides and used for controlling grass weeds. In this study, cyto-genotoxic effects of Pinoxaden on the Allium cepa roots were investigated using Allium ana-telophase and comet assays by determining the root growth, mitotic index (MI), mitotic phases, chromosomal aberrations (CAs) and DNA damage. Different concentrations of Pinoxaden from 0.5 to 100 mg/L were employed on root tips for 96 h to find...
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Abstract Soil contaminated with heavy metals in general and radionuclides in particular represents an escalating problem for all living organisms. Since, Chernobyl nuclear power plant accident in 1986 in Ukraine, an exclusion zone of 30 km around the former power plant is uninhabitable land due to severe contamination. Two most notable beta emitters contributing to dose hazards for decades is radioactive 137Cs/90Sr. However, large parts of the zone are also highly contaminated...
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Abstract This panel study aimed to evaluate the associations between short-term exposure to indoor and outdoor PM2.5 and anxiety in schoolchildren. During 3 waves in March, July, and November 2018 with 7 days per wave, 52 children aged 10 years were recruited from two schools in a city in Korea. To assess outdoor exposure, we used PM2.5 concentration measures for every hour at the national measurement station (NMS) closest to the two participating schools. To assess indoor exposure,...
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Abstract Organophosphorus insecticides toxicity is still considered a major global health problem. Malathion is one of the most commonly used organophosphates nowadays, as being considered to possess relatively low toxicity compared with other organophosphates. However, widespread use may lead to excessive exposure from multiple sources. Mechanisms of MAL toxicity include inhibition of acetylcholinesterase enzyme, change of oxidants/antioxidants balance, DNA damage, and facilitation...
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Abstract The aims of this study were to investigate the effectiveness of fermented horse manure (HM) over vermicompost (VC), bamboo biochar (BB), and fly ash (FA) in suppressing Cd accumulation in rice plants and further to elucidate the underlying mechanisms of HM. Greenhouse experiments were conducted to determine the Cd concentration in rice tissues after the application of amendments to different Cd-contaminated soils. Chemical properties of root Fe plaque and pore water were...
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ObjectiveIn most European countries, political reforms gradually increase the statutory retirement age to counter the economic costs of a growing elderly population. However, working to a high age may be difficult for people with hard physical labour. We aim to study the impact of high physical work demands on working life expectancy (WLE).MethodsWe combined physical work demands assessed by job exposure matrix (JEM) and longitudinal high-quality national registers (outcome) in 1.6 million Danish...
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Abstract Introduction To compare all-cause and endometriosis-related healthcare resource utilization (HCRU) and healthcare costs by service categories (outpatient, inpatient, emergency room [ER], pharmacy) among patients with newly diagnosed endometriosis using opioids compared to patients with endometriosis not using opioids. Methods A retrospective...
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Abstract China is the world’s largest country on ammonia (NH3) emission, which results in sever air pollution there. China’s updated Clean Air Act has started to pay attention to NH3 reduction, but it is believed that solutions are mainly constrained by implementation of suitable technologies. Here we argued that socioeconomic barriers are the key to hinder the reduction of agricultural NH3 emission for better air quality in China. We found that small farm size is the key driving...
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Abstract A biosurfactant (BS) is a surface-active metabolite that is secreted by microbial metabolism, and can be used as a substitute for chemically synthesized surfactants. The first and most critical step to the successful application of BSs is to isolate bacterial strains with strong BS-producing capabilities. In this study, a BS-producing Serratia marcescens ZCF25 was isolated from the sludge of an oil tanker. Through polyphasic characterization using Fourier-transform infrared...
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Abstract Deep neck space infection (DNI), is defined as infections in the deep fascia enclosing potential spaces of the neck. In the past the diagnosis and treatment of DNI have challenged. The health care personnel at all levels. The complex anatomy and the deep location of this region remains a big problem with significant risks of morbidity and mortality. The aim of this study is to analyse the difference in clinical presentation and microbiology of DNI in different age groups....
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Publication date: Available online 11 May 2020Source: Experimental Cell ResearchAuthor(s): Shaoping Han, Lili Song, Yang Chen, Min Hou, Xiaoyue Wei, Dongsheng Fan
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Publication date: Available online 11 May 2020Source: Experimental Cell ResearchAuthor(s): Junjun Chen, Jie Dai, Zhiming Kang, Ting Yang, Qi Zhao, Jinxiu Zheng, Xinxin Zhang, Jisheng Zhang, Jun Xu, Gongqin Sun, Lijun Yang, Tao Yang
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ACS NanoDOI: 10.1021/acsnano.0c01550
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Abstract Soil fungi have been widely studied, but the effects of heavy metal contamination at various levels as well as the abundance and diversity of heavy metal tolerant fungi in the contaminated paddy soils are still unknown. The purpose of this study is to analyze the adaptability of fungi at different levels of heavy metal contamination to identify species that have strong adaptability to heavy metals. In this research, the technology of high-throughput sequencing was applied...
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Abstract Frequent heavy air pollution occurred during the winter heating season of northern China. In this study, PM2.5 (particles with an aerodynamic diameter less than 2.5 μm) was collected from a coastal city of China during the winter heating season from January 1 to March 31, 2018, and the soluble ions, organic carbon (OC), elemental carbon (EC), bacterial, endotoxin, and fungal concentration in PM2.5 were analyzed. During the winter heating season, PM2.5 and bioaerosols increased...
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Abstract The asymmetrical impacts of globalization and tourism on pollution emissions of 5 South Asian countries for the period from 1980 to 2018 are examined through a non-linear autoregressive distributed lag (NARDL) technique, which shows that both short and long-run coefficients are asymmetric. The findings suggest that positive and negative shocks in globalization affect carbon emissions differently in the case of Bangladesh, India, and Pakistan, while similar results are...
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Abstract Purpose To assess the outcome of prostate cancer (PCa) patients diagnosed with oligorecurrent disease and treated with a first and a second PSMA (prostate-specific membrane antigen ligand) PET(positron-emission tomography)-directed radiotherapy (RT). Patients and methods Thirty-two patients with oligorecurrent relapse after curative therapy received...
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Abstract Purpose The pathogenesis of cardiovascular disease (CVD) in patients with obstructive sleep apnea (OSA) is unclear. Several studies have suggested that CVD may be caused by oxidative stress from chronic intermittent hypoxia and associated vascular endothelial dysfunction. Oxidative stress in patients with OSA can induce endothelial cell apoptosis, aggravate vascular endothelial damage, and promote the expression of redox-sensitive...
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Publication date: Available online 11 May 2020Source: Clinical BiochemistryAuthor(s): Kamisha L. Johnson-Davis, Candice Farnsworth, Christian Law, Rebecca Parker
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Publication date: Available online 11 May 2020Source: Clinical BiochemistryAuthor(s): D. Ardalić, A. Stefanović, G. Banjac, P. Cabunac, M. Miljkovic, V. Mandić-Marković, S. Stanimirović, B. Damnjanović Pažin, S. Spasić, V. Spasojević-Kalimanovska, N. Karadžov- Orlić, Z. Miković
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Zusammenfassung Hintergrund Nach Einführung neuer Sequenzierungsmethoden ergeben sich neue Möglichkeiten in der Diagnostik maligner Erkrankungen. Dies erfordert allerdings eine Anpassung der klinischen Abläufe. Die Informationen müssen in den richtigen Kontext gebracht werden, um therapierelevante Aussagen treffen zu können. Um dies zu gewährleisten, müssen bereits etablierte Experten aus den verschiedenen Bereichen der Onkologie geschult...
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Zusammenfassung Hintergrund Die zugelassene Behandlungsmöglichkeiten für Patientinnen mit therapieresistentem, rezidiviertem oder metastasiertem Zervixkarzinom sind limitiert. Ziel der Arbeit In diesem Review werden Substanzen und deren Wirkstoffklassen dargestellt, für die publizierte Ergebnisse aus Phase-I- und Phase-II-Studien vorliegen. ...
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