Myrrh (Commiphora myrrha (Nees) Engl.) has a long history of traditional use as a herbal medicine for different purposes. In ancient traditional Persian manuscripts, it has been noted that myrrh may act as ute...
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Dermal papilla cells (DPCs) play a key role in hair growth among the various cell types in hair follicles. Especially, DPCs determine the fate of hair follicle such as anagen to telogen transition and play a p...
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Elaeagnus umbellata is abundantly found in Himalayan regions of Pakistan which is traditionally used to treat various health disorders. However, the experimental evidence supporting the anti-amnesic effect is lim...
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Zusammenfassung Das Asthma bronchiale führt bei vielen Betroffenen mit und ohne Therapie zu teilweise erheblichen nächtlichen Symptomen, die eine Verminderung der Krankheitskontrolle und der Schlafqualität bedeuten. Die Ursachen der Symptomatik sind vielfältig. Veränderungen der Lungenfunktion, eine verstärkte nächtliche Hyperreagibilität, zelluläre Transmitter- und Entzündungsprozesse, aber auch Umwelteinflüsse und häufige Komorbiditäten konnten inzwischen als Ursachen identifiziert...
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Abstract A disturbed diurnal blood pressure profile is one of the most important risk factors of cardiovascular diseases. This review analyzes the use of simultaneous diurnal ambulatory blood pressure monitoring (ABPM) and motion activity monitoring (actigraphy) to obtain additional information for correct interpretation of ABPM results in clinically significant decision-making. The article considers practical aspects of actigraphy in expert ABPM for clock-independent calculation...
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Abstract Extranodal natural killer/T cell lymphoma, nasal type (ENKL) is a highly aggressive tumor with relatively poor prognosis. In this prospective study, we investigated the efficacy and toxicity of a novel GDP-ML regimen (combined gemcitabine, cisplatin, dexamethasone, methotrexate, and pegaspargase) as front-line treatment in newly diagnosed ENKL. Eligible newly diagnosed stage I/II ENKL patients received sandwich chemoradiation therapy. Patients with stage III/IV disease...
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Virtual reality could help domestic batterers identify with victims -- Read more on ScientificAmerican.com
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Metastatic lung adenocarcinoma patients may not be getting the correct molecular biomarker testing prior to first line therapy. We implement reflex ordered testing for molecular biomarkers at time of pathologic diagnosis of lung adenocarcinoma. We retrospectively compared reflex ordered testing to standard molecular testing. Reflex ordered testing lead significantly shorter turn around time and higher variant detection rate.
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Abstract The bio-resource utilization of sewage sludge is presented by preparation of novel waste sludge–doped graphite carbon nitride (g-C3N4) photocatalyst. The sludge flocs which constitute bacteria and organic substances served as a pore-forming framework in the catalyst, while the inorganic fractions including those transition metals and crustal metals can function as dopants for sludge-based g-C3N4 composite. The physicochemical properties of as-prepared catalyst were well...
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Bio-banding (BB) has been introduced to account for varying maturity and to improve the talent development of junior soccer players. To date, research that investigated the physiological and technical effects ...
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Advanced glycation end products (AGEs) are known to play important roles in the development of diabetes mellitus and atherosclerosis. Nε-(carboxymethyl)lysine (CML) is the major AGE, and is found in the arterial ...
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Summary Purpose Biotechnological substances (BSs) are strongly relied upon to prevent rejection of transplanted organs, and to treat oncological, allergological, and other inflammatory diseases. Allergic reactions to partly foreign biologics can occur due to their potential immunogenicity. The severity of an immune response to a biological drug may range from no clinical significance to a severe, life-threatening anaphylactic reaction....
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The modified polycystic ovary syndrome health-related quality-of-life questionnaire (MPCOSQ) is a 30-item instrument measuring quality-of-life in English-speaking patients with polycystic ovary syndrome (PCOS)...
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Capita di trovarci di fronte a una situazione difficile in cui non sappiamo cosa fare, non abbiamo idea di come affrontarla. Oppure ci mancano gli strumentLeggi tutto
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Cancers, Vol. 12, Pages 1213: Hypoxic Roadmap of Glioblastoma—Learning about Directions and Distances in the Brain Tumor Environment Cancers doi: 10.3390/cancers12051213 Authors: Agnieszka Bronisz Elżbieta Salińska E. Antonio Chiocca Jakub Godlewski Malignant brain tumor—glioblastoma is not only difficult to treat but also hard to study and model. One of the reasons for these is their heterogeneity, i.e., individual tumors consisting of cancer cells that are...
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Over the past years, EGFR tyrosine kinase inhibitors (TKI) revolutionized treatment response. 1st-generation (reversible) EGFR TKI and later the 2nd –generation irreversible EGFR TKI Afatinib were aimed to imp...
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Neurosurgical resection represents an important treatment option in the modern, multimodal therapy approach of brain metastases (BM). Guidelines for perioperative imaging exist for primary brain tumors to guid...
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Tuberculosis is associated with increased risk of cancer. However, the impact of tuberculosis on global cancer burden is unknown.
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Single nucleotide polymorphisms (SNPs) in DNA repair genes have a potential clinical value in predicting treatment outcomes. In the current study, we examined the association of SNPs in the genes XRCC1-rs25487...
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Thyroid Hurthle cell carcinoma (HCC) is a rare disease with high risk of invasion and metastasis and poor prognosis. The clinical characteristics, prognosis and treatment of HCC are still controversial, and cl...
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Abstract Knowledge about established breast carcinogens can support improved and modernized toxicological testing methods by identifying key mechanistic events. Ionizing radiation (IR) increases the risk of breast cancer, especially for women and for exposure at younger ages, and evidence overall supports a linear dose–response relationship. We used the Adverse Outcome Pathway (AOP) framework to outline and evaluate the evidence linking ionizing radiation with breast cancer from...
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British Journal of Cancer, Published online: 13 May 2020; doi:10.1038/s41416-020-0893-8Biomarker measurement in non-invasively sampled colorectal mucus as a novel approach to colorectal cancer detection: screening and triage implications
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British Journal of Cancer, Published online: 13 May 2020; doi:10.1038/s41416-020-0883-xAssociation between the National Cancer Screening Programme (NSCP) for gastric cancer and oesophageal cancer mortality
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Colicins are Escherichia coli–specific bacteriocins that translocate across the outer bacterial membrane by a poorly understood mechanism. Group A colicins typically parasitize the proton-motive force–linked Tol system in the inner membrane via porins after first binding an outer-membrane protein receptor. Recent studies have suggested that the pore-forming group A colicin N (ColN) instead uses lipopolysaccharide (LPS) as a receptor. Contrary to this prevailing view, using diffusion-precipitation...
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Findings from recent studies have indicated that enzymes containing more than one catalytic domain may be particularly powerful in the degradation of recalcitrant polysaccharides such as chitin and cellulose. Some known multi-catalytic enzymes contain several glycoside hydrolase (GH) domains and one or more carbohydrate-binding modules (CBMs). Here, using bioinformatics and biochemical analyses, we identified an enzyme, Jd1381 from the actinobacterium Jonesia denitrificans, that uniquely combines...
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Excessive activation of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) is a major cause of autoimmune diseases, including rheumatoid arthritis. TNF-α induces immune responses via TNF receptor 1 (TNFR1) and TNFR2. Signaling via TNFR1 induces proinflammatory responses, whereas TNFR2 signaling is suggested to suppress the pathophysiology of inflammatory diseases. Therefore, selective inhibition of TNFR1 signaling and preservation of TNFR2 signaling activities may be beneficial for managing...
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Microglia are tissue-resident macrophages in the central nervous system (CNS) that play essential roles in the regulation of CNS development and homeostasis. Yet, the genetic networks governing microglia development remain incompletely defined. Here, we report the identification and characterization of a microglia-defective zebrafish mutant wulonghkz12 (wulhkz12) isolated from an ethylnitrosourea (ENU)-based genetic screen. We show that wulhkz12 mutants harbors a missense point mutation in the gene...
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Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies, with an average life expectancy of ~6 months from the time of diagnosis. The genetic and epigenetic changes that underlie this malignancy are incompletely understood. We found that ASH1-like histone lysine methyltransferase (ASH1L) is over-expressed in ATC relative to the much less aggressive and more common differentiated thyroid cancer. This increased expression was due at least in part to reduced levels of microRNA-200b-3p...
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Fossils have revealed that after the extinction of the dinosaurs, anchovies evolved into metre-long predators with sharp sabre-like teeth to devour other fish
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[ Advance Publication ] [ Title ] Circulating microRNAs: Next-generation Cancer Detection [ Author ] Juntaro Matsuzaki,Takahiro Ochiya [ Advance Pub. date ] 2020-05-13 [ DOI ] https://doi.org/10.2302/kjm.2019-0011-OA
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Circular RNAs (circRNAs) play a vital role in the development of various cancers. Circ_100565 was found to be a highly expressed circRNA in non-small cell lung cancer (NSCLC) tissues screened by microarray pro...
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Colorectal neoplasia differentially expressed (CRNDE) is a long non-coding RNA which has been proved upregulated in various cancers. Meanwhile, CRNDE has been demonstrated to be involved in multiple biological...
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Paclitaxel is a first-line chemotherapy drug for pancreatic, ovarian, endometrial cancers and other malignancies. However, its efficacy is often compromised by decreased cell sensitivity or the development of ...
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Mounting evidences have indicated that long non-coding RNA (lncRNA) HOXD cluster antisense RNA 1 (HOXD-AS1) is dysregulated and participates into the progression of cancers. This study aims to investigate the ...
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David Miliband, head of the International Rescue Committee, says the world's richest countries still have time to help protect the most fragile countries from the spread of covid-19
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