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Τρίτη 12 Μαΐου 2020


Immune-gene signature: a new tool for patient selection for checkpoint inhibitors?
Future Oncology, Ahead of Print.
Future Oncology
Tue May 12, 2020 07:00
The potentiality of immunotherapy for sarcomas: a summary of potential predictive biomarkers
Future Oncology, Ahead of Print.
Future Oncology
Tue May 12, 2020 06:34
Feasibility study of nivolumab as neoadjuvant chemotherapy for locally esophageal carcinoma: FRONTiER (JCOG1804E)
Future Oncology, Ahead of Print.
Future Oncology
Tue May 12, 2020 06:06
Metastasis of Papillary Thyroid Carcinoma to the Maxillary Sinus: Case Report and Review of the Literature
Metastasis of the thyroid carcinoma to the paranasal sinuses is rarely reported. Among these sinuses, metastasis to the maxillary sinus alone has been reported only in a few cases. This is the first reported case in a 76-year-old woman with papillary thyroid carcinoma metastasizing to the maxillary sinus alone and resected through endoscopic sinonasal surgery. When patients have sinus lesions and a history of malignancy, metastasis should be included in the differential diagnosis. If they have an...
Case Reports in Otolaryngology
Tue May 12, 2020 15:50
[ASAP] Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c00451
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue May 12, 2020 07:00
[ASAP] A Charged Coordination Cage-Based Porous Salt
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c02806
Journal of the American Chemical Society: Latest Articles (ACS Publications)
Tue May 12, 2020 07:00
Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome
A large proportion of patients with a SARS-Cov-2-associated respiratory failure develop an acute respiratory distress syndrome (ARDS). It has been recently suggested that SARS-Cov-2-associated ARDS may differ ...
Annals of Intensive Care - Latest Articles
Tue May 12, 2020 03:00
Correction: Steroidogenesis in the NCI-H295 Cell Line Model is Strongly Affected By Culture Conditions and Substrain
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1169-5951[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text
Experimental and Clinical Endocrinology & Diabetes
Tue May 12, 2020 02:00
Assessing the benefits and challenges of video consultations for the treatment of children with type 1 diabetes – A qualitative study among diabetes professionals
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1149-8814 Background Video consultations are promoted as a tool to effectively supplement paediatric diabetes outpatient care. However, knowledge about attitudes of diabetes professionals towards this new technology is lagging behind. Diabetologists and diabetes nurses participating in a controlled study (the VIDIKI study) with monthly video consultations for children with type 1 diabetes were interviewed about their experience with this type of communication....
Experimental and Clinical Endocrinology & Diabetes
Thu May 07, 2020 02:00
Rhinological Consequences of Microsurgical Endonasal-Transsphenoidal Surgery for Pituitary Tumors
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1155-6269 Background Transsphenoidal surgery for sellar lesions may affect patency and function of the nasal airways, smell and sinonasal quality of life. Below is our report on otorhinolaryngological data garnered from patients undergoing endonasal transsphenoidal pituitary microsurgery. Methods In a prospective study, 68 patients scheduled for...
Experimental and Clinical Endocrinology & Diabetes
Thu May 07, 2020 02:00
A ‘Speed-Dating’ Model of Wound Care? Rapid, High-Volume Assessment of Patients With Diabetes in a Multidisciplinary Foot Wound Clinic
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1151-4731 Background Diabetes is a major risk factor for foot ulceration and leg amputation, but the effect of intensive glycaemic control on wound healing is unknown. While an interdisciplinary approach has been shown to be important in the management of diabetic foot ulcer (DFU), there is no standardised definition of such an interdisciplinary...
Experimental and Clinical Endocrinology & Diabetes
Thu May 07, 2020 02:00
MicroCT X-ray comparison of aligner gap and thickness of six brands of aligners: an in-vitro study
To investigate and compare the gap (i.e. fit) and thickness of six aligner systems (Airnivol, ALL IN, Arc Angel, F22, Invisalign and Nuvola) using industrial computed tomography (CT). The null hypothesis was t...
Progress in Orthodontics - Latest Articles
Mon May 11, 2020 03:00
Clinical implementation of MRI-based organs-at-risk auto-segmentation with convolutional networks for prostate radiotherapy
Structure delineation is a necessary, yet time-consuming manual procedure in radiotherapy. Recently, convolutional neural networks have been proposed to speed-up and automatise this procedure, obtaining promis...
Radiation Oncology - Latest Articles
Mon May 11, 2020 03:00
Design and fabrication of a Nano-based neutron shield for fast neutrons from medical linear accelerators in radiation therapy
Photo-neutrons are produced at the head of the medical linear accelerators (linac) by the interaction of high-energy photons, and patients receive a whole-body-absorbed dose from these neutrons. The current st...
Radiation Oncology - Latest Articles
Mon May 11, 2020 03:00
Cross-Sectional Study on the Coping Strategies Among Glaucoma Patients Attending a Secondary Eye Clinic in Calabar, Nigeria
Clinical Ophthalmology
02:09
A Darwinian Selection Based Explanation of Peacock's Tail [NEW RESULTS]
There is no satisfactory explanation for why peacock possesses a tail, presence and especially courtship display of which makes the organism vulnerable to predation. Here, I present a model according to which in a polygynous mating system a mechanism which increases vulnerability to predation, a Zahavian handicap, evolves when other two mechanisms to identify high-quality males are either absent or are not sufficiently strong. The two mechanisms are: 1) male resource acquisition ability, and 2) male-male...
bioRxiv Subject Collection: Evolutionary Biology
Tue May 12, 2020 03:00
High physical work demands and working life expectancy in Denmark
ObjectiveIn most European countries, political reforms gradually increase the statutory retirement age to counter the economic costs of a growing elderly population. However, working to a high age may be difficult for people with hard physical labour. We aim to study the impact of high physical work demands on working life expectancy (WLE).MethodsWe combined physical work demands assessed by job exposure matrix (JEM) and longitudinal high-quality national registers (outcome) in 1.6 million Danish...
OEM Online First
01:20
Reduced inflammatory response and accelerated functional recovery following sciatic nerve crush lesion in CXCR3-deficient mice
Despite the regenerative capacity of the peripheral nerve system (PNS), functional recovery after mechanical nerve trauma is often incomplete, resulting in motor, sensory, and autonomic deficits. The elucidation of key molecules involved in trauma-induced Wallerian degeneration and the ensuing regeneration processes is a prerequisite for the development of disease modifying drugs. The chemokine (C-X-C motif) receptor 3 (CXCR3) has been implicated in the recruitment of macrophages, the major immune...
NeuroReport - Published Ahead-of-Print
Fri May 08, 2020 03:00
Second-tier trio exome sequencing after negative solo clinical exome sequencing: an efficient strategy to increase diagnostic yield and decipher molecular bases in undiagnosed developmental disorders
Abstract Developmental disorders (DD), characterized by malformations/dysmorphism and/or intellectual disability, affecting around 3% of worldwide population, are mostly linked to genetic anomalies. Despite clinical exome sequencing (cES) centered on genes involved in human genetic disorders, the majority of patients affected by DD remain undiagnosed after solo-cES. Trio-based strategy is expected to facilitate variant selection thanks to rapid parental segregation. We performed...
Human Genetics
Tue May 12, 2020 03:00
Biomarker measurement in non-invasively sampled colorectal mucus as a novel approach to colorectal cancer detection: screening and triage implications
Cancer
01:23
Association between the National Cancer Screening Programme (NSCP) for gastric cancer and oesophageal cancer mortality
Cancer
01:23
Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress
Oncogenesis, Published online: 12 May 2020; doi:10.1038/s41389-020-0230-3Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress
Oncogenesis - nature.com science feeds
Tue May 12, 2020 03:00
SOX9 interacts with FOXC1 to activate MYC and regulate CDK7 inhibitor sensitivity in triple-negative breast cancer
Oncogenesis, Published online: 12 May 2020; doi:10.1038/s41389-020-0232-1SOX9 interacts with FOXC1 to activate MYC and regulate CDK7 inhibitor sensitivity in triple-negative breast cancer
Oncogenesis - nature.com science feeds
Tue May 12, 2020 03:00
Temporal region myeloid sarcoma: When to suspect and how to approach?
Oral and Maxillofacial Surgery
Tue May 12, 2020 03:00
An unusual cause of a common presentation: a case of metastatic basal cell carcinoma
Metastasis of basal cell carcinoma is exceedingly rare and usually not considered in the differential diagnosis of neck lumps. We present a case highlighting the importance of a thorough history and consideration of metastatic basal cell carcinoma in patients with a basaloid metastasis and an unknown primary.
Oral and Maxillofacial Surgery
Tue May 12, 2020 03:00
Clinical Presentation and Microbiological Profile of Deep Neck Space Infections in Different Age Groups
Abstract Deep neck space infection (DNI), is defined as infections in the deep fascia enclosing potential spaces of the neck. In the past the diagnosis and treatment of DNI have challenged. The health care personnel at all levels. The complex anatomy and the deep location of this region remains a big problem with significant risks of morbidity and mortality. The aim of this study is to analyse the difference in clinical presentation and microbiology of DNI in different age groups....
Otolaryngology Indian
Tue May 12, 2020 03:00
Efficacy of repeated PSMA PET-directed radiotherapy for oligorecurrent prostate cancer after initial curative therapy
Abstract Purpose To assess the outcome of prostate cancer (PCa) patients diagnosed with oligorecurrent disease and treated with a first and a second PSMA (prostate-specific membrane antigen ligand) PET(positron-emission tomography)-directed radiotherapy (RT). Patients and methods Thirty-two patients with oligorecurrent relapse after curative therapy...
Strahlentherapie und Onkologie
Tue May 12, 2020 03:00
Smart drug delivery against Helicobacter pylori : pectin-coated, mucoadhesive liposomes with antiadhesive activity and antibiotic cargo
Abstract The first step in the development of Helicobacter pylori pathogenicity is the receptor-mediated adhesion to the gastric epithelium. Inhibition of outer membrane proteins of H. pylori (e.g. BabA) by antiadhesive drugs will contribute to reduced recolonization and infection. Pectin from apple inhibits the BabA and LPS-mediated adhesion of H. pylori to human stomach cells. Pectin-coated liposomes with encapsulated amoxicillin were characterized for...
Latest Results for Applied Microbiology and Biotechnology
Tue May 12, 2020 03:00
Jupiter has a spooky new look in this sharp infrared photo
Because infrared light gets trapped by thick clouds, the infrared images of the planet create a jack-o-lantern effect, as seen above: Jupiter’s atmosphere glows bright in thin haze and light cloud coverage but dark in areas of thick clouds. (International Gemini Observatory/NOIRLab/NSF/AURA M.H. Wong (UC Berkeley) and team Acknowledgments: Mahdi Zamani./)If you think understanding and predicting Earth’s weather is a doozy, Jupiter’s is quite literally a raging nightmare. Scientists have known for...
Popular Science
00:00
The role of nitric oxide (NO) levels in patients with obstructive sleep apnea-hypopnea syndrome: a meta-analysis
Abstract Purpose The pathogenesis of cardiovascular disease (CVD) in patients with obstructive sleep apnea (OSA) is unclear. Several studies have suggested that CVD may be caused by oxidative stress from chronic intermittent hypoxia and associated vascular endothelial dysfunction. Oxidative stress in patients with OSA can induce endothelial cell apoptosis, aggravate vascular endothelial damage, and promote the expression of redox-sensitive...
Latest Results for Sleep and Breathing
Tue May 12, 2020 03:00
Bond strength of CAD-CAM and conventional veneering materials to different frameworks
Publication date: Available online 12 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Felicitas Wiedenmann, Markus Klören, Daniel Edelhoff, Bogna Stawarczyk
The Journal of Prosthetic Dentistry
Tue May 12, 2020 23:37
No evidence for differences among language regions in their temporal receptive windows
Publication date: Available online 11 May 2020Source: NeuroImageAuthor(s): Idan A. Blank, Evelina Fedorenko
NeuroImage
Tue May 12, 2020 23:33
Interindividual variability and lateralization of μ-opioid receptors in the human brain
Publication date: Available online 11 May 2020Source: NeuroImageAuthor(s): Tatu Kantonen, Tomi Karjalainen, Janne Isojärvi, Pirjo Nuutila, Jouni Tuisku, Juha Rinne, Jarmo Hietala, Valtteri Kaasinen, Kari Kalliokoski, Harry Scheinin, Jussi Hirvonen, Aki Vehtari, Lauri Nummenmaa
NeuroImage
Tue May 12, 2020 23:33
XTRACT - Standardised protocols for automated tractography in the human and macaque brain
Publication date: Available online 11 May 2020Source: NeuroImageAuthor(s): S. Warrington, K.L. Bryant, A.A. Khrapitchev, J. Sallet, M. Charquero-Ballester, G. Douaud, S. Jbabdi, R.B. Mars, S.N. Sotiropoulos
NeuroImage
Tue May 12, 2020 23:33
[ASAP] Microvolume Screening of Extraction and Phase Behavior in a Liquid–Liquid Microsystem
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01050
Analytical Chemistry
Tue May 12, 2020 07:00
[ASAP] High-Speed Capillary Electrophoresis Using a Thin-Wall Fused-Silica Capillary Combined with Backscatter Interferometry
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05881
Analytical Chemistry
Tue May 12, 2020 07:00
[ASAP] Turbulent Supercritical Fluid Chromatography in Open-Tubular Columns for High-Throughput Separations
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01578
Analytical Chemistry
Tue May 12, 2020 07:00
[ASAP] Factors Affecting the Limit of Detection for HPLC/Tandem Mass Spectrometry Experiments Based on Gas-Phase Ion–Molecule Reactions
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05369
Analytical Chemistry
Tue May 12, 2020 07:00
[ASAP] Selective Maleylation-Directed Isobaric Peptide Termini Labeling for Accurate Proteome Quantification
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01059
Analytical Chemistry
Tue May 12, 2020 07:00

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