Molecules, Vol. 25, Pages 2343: Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs Against Human Coronavirus 229E (HCoV-229E) Molecules doi: 10.3390/molecules25102343 Authors: Parang El-Sayed Kazeminy Tiwari Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for the treatment of COVID-19. The prodrug is metabolized to its active triphosphate form and interferes with the action of RNA-dependent RNA polymerase...
Sun May 17, 2020 03:00
Molecules, Vol. 25, Pages 2342: Sulfur Compounds Inhibit High Glucose-Induced Inflammation by Regulating NF-κB Signaling in Human Monocytes Molecules doi: 10.3390/molecules25102342 Authors: Eun Seong Jo Nipin Sp Dong Young Kang Alexis Rugamba Il Ho Kim Se Won Bae Qing Liu Kyoung-Jin Jang Young Mok Yang High glucose-induced inflammation leads to atherosclerosis, which is considered a major cause of death in type 1 and type 2 diabetic patients. Nuclear factor-kappa...
Sun May 17, 2020 03:00
Molecules, Vol. 25, Pages 2341: Improving Regulation of Enzymatic and Non-Enzymatic Antioxidants and Stress-Related Gene Stimulation in Cucumber mosaic cucumovirus-Infected Cucumber Plants Treated with Glycine Betaine, Chitosan and Combination Molecules doi: 10.3390/molecules25102341 Authors: Sofy Dawoud Sofy Mohamed Hmed El-Dougdoug : Cucumber mosaic cucumovirus (CMV) is a deadly plant virus that results in crop-yield losses with serious economic consequences. In...
Sun May 17, 2020 03:00
Molecules, Vol. 25, Pages 2339: Porous Activated Carbon from Lignocellulosic Agricultural Waste for the Removal of Acetampirid Pesticide from Aqueous Solutions Molecules doi: 10.3390/molecules25102339 Authors: Somaia G. Mohammad Sahar M. Ahmed Abd El-Galil E. Amr Ayman H. Kamel A facile eco-friendly approach for acetampirid pesticide removal is presented. The method is based on the use of micro- and mesoporous activated carbon (TPAC) as a natural adsorbent. TPAC was synthesized...
Sun May 17, 2020 03:00
Molecules, Vol. 25, Pages 2340: In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid Molecules doi: 10.3390/molecules25102340 Authors: Agnieszka Szkudlarek Michał Wilk Małgorzata Maciążek-Jurczyk The interaction of drugs with human serum albumin (HSA) is an important element of therapy. Albumin affects the distribution of the drug substance in the body, as well as its pharmacokinetic and pharmacodynamic properties. On the one...
Sun May 17, 2020 03:00
Molecules, Vol. 25, Pages 2338: Upcycling of Spent NiMH Battery Material—Reconditioned Battery Alloys Show Faster Activation and Reaction Kinetics than Pristine Alloys Molecules doi: 10.3390/molecules25102338 Authors: Yang Shen Erik Svensson Grape Dag Noréus Erika Widenkvist Stina Starborg During formation and cycling of nickel–metal hydride (NiMH cells), surface corrosion on the metal hydride particles forms a porous outer layer of needle-shaped rare-earth hydroxide...
Sun May 17, 2020 03:00
Molecules, Vol. 25, Pages 2337: Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family Molecules doi: 10.3390/molecules25102337 Authors: Darja Koutová Negar Maafi Radim Havelek Lubomír Opletal Gerald Blunden Martina Řezáčová Lucie Cahlíková Plants of the Amaryllidaceae family are promising therapeutic tools for human diseases and have been used as alternative medicines. The specific secondary metabolites of this...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2336: Anomalous Influence of Salt Concentration on Deposition of Poly(l-Lysine)/Cellulose Sulfate Multilayers Evidenced by In Situ ATR-FTIR Molecules doi: 10.3390/molecules25102336 Authors: Martin Müller The deposition of polyelectrolyte (PEL) multilayers (PEMs) of poly(l-lysine)/cellulose sulfate (PLL/CS) onto germanium (Ge) substrates depending on salt concentration (cS) and deposition step z at constant PEL concentration cPEL = 0.01 M and pH = 7.0 was studied....
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2334: Green Tea Seed Isolated Theasaponin E1 Ameliorates AD Promoting Neurotoxic Pathogenesis by Attenuating Aβ Peptide Levels in SweAPP N2a Cells Molecules doi: 10.3390/molecules25102334 Authors: Muhammad Imran Khan Jin Hyuk Shin Min Yong Kim Tai Sun Shin Jong Deog Kim Alzheimer’s disease (AD) is the most frequent type of dementia affecting memory, thinking and behaviour. The major hallmark of the disease is pathological neurodegeneration...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2335: Liquid Chromatographic Tandem Mass Spectrometric (LC-MS/MS) Determination of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) in the Yolk of Poultry Eggs in Malaysia Molecules doi: 10.3390/molecules25102335 Authors: Atiqah Tahziz Didi Erwandi Mohamad Haron Mohd Yusmaidie Aziz Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are widely used in products, and are known for their water and grease repellent properties....
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2330: 3D-Printed Gastroretentive Sustained Release Drug Delivery System by Applying Design of Experiment Approach Molecules doi: 10.3390/molecules25102330 Authors: Hyeon Myeong Jeong Kwon-Yeon Weon Beom Soo Shin Soyoung Shin This study aimed to develop a novel oral drug delivery system for gastroretentive sustained drug release by using a capsular device. A capsular device that can control drug release rates from the inner immediate release (IR) tablet...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2332: Geographical Classification of Italian Saffron (Crocus sativus L.) by Multi-Block Treatments of UV-Vis and IR Spectroscopic Data Molecules doi: 10.3390/molecules25102332 Authors: Alessandra Biancolillo Martina Foschi Angelo Antonio D’Archivio One-hundred and fourteen samples of saffron harvested in four different Italian areas (three in Central Italy and one in the South) were investigated by IR and UV-Vis spectroscopies. Two different multi-block...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2333: Identification of the Volatile Components of Galium verum L. and Cruciata leavipes Opiz from the Western Italian Alps Molecules doi: 10.3390/molecules25102333 Authors: Aldo Tava Elisa Biazzi Domenico Ronga Pinarosa Avato The chemical composition of the volatile fraction from Galium verum L. (leaves and flowers) and Cruciata laevipes Opiz (whole plant), Rubiaceae, was investigated. Samples from these two plant species were collected at full bloom...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2327: Last Decade of Unconventional Methodologies for the Synthesis of Substituted Benzofurans Molecules doi: 10.3390/molecules25102327 Authors: Lucia Chiummiento Rosarita D’Orsi Maria Funicello Paolo Lupattelli This review describes the progress of the last decade on the synthesis of substituted benzofurans, which are useful scaffolds for the synthesis of numerous natural products and pharmaceuticals. In particular, new intramolecular and intermolecular...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2331: Exploiting the Indole Scaffold to Design Compounds Binding to Different Pharmacological Targets Molecules doi: 10.3390/molecules25102331 Authors: Sabrina Taliani Federico Da Da Settimo Claudia Martini Sonia Laneri Ettore Novellino Giovanni Greco Several indole derivatives have been disclosed by our research groups that have been collaborating for nearly 25 years. The results of our investigations led to a variety of molecules binding selectively...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2328: Broussoflavonol B from Broussonetia kazinoki Siebold Exerts Anti-Pancreatic Cancer Activity through Downregulating FoxM1 Molecules doi: 10.3390/molecules25102328 Authors: Ji Hye Jeong Jae-Ha Ryu Pancreatic cancer has a high mortality rate due to poor rates of early diagnosis. One tumor suppressor gene in particular, p53, is frequently mutated in pancreatic cancer, and mutations in p53 can inactivate normal wild type p53 activity and increase expression...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2329: Sustainable Process for the Depolymerization/Oxidation of Softwood and Hardwood Kraft Lignins Using Hydrogen Peroxide under Ambient Conditions Molecules doi: 10.3390/molecules25102329 Authors: Zaid Ahmad Waleed Wafa Al Dajani Michael Paleologou Chunbao (Charles) Xu The present study demonstrated a sustainable and cost-effective approach to depolymerize/oxidize softwood (SW) and hardwood (HW) kraft lignins using concentrated hydrogen peroxide at...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2326: Epigallocatechin-3-gallate (EGCG) Alters Histone Acetylation and Methylation and Impacts Chromatin Architecture Profile in Human Endothelial Cells Molecules doi: 10.3390/molecules25102326 Authors: Ciesielski Biesiekierska Balcerczyk Epigallocatechin gallate (EGCG), the main green tea polyphenol, exerts a wide variety of biological actions. Epigenetically, the catechin has been classified as a DNMTs inhibitor, however, its impact on histone modifications...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2325: Effect of Intra-Ply Hybrid Patches and Hydrothermal Aging on Local Bending Response of Repaired GFRP Composite Laminates Molecules doi: 10.3390/molecules25102325 Authors: J. Jefferson Andrew Vellayaraj Arumugam Hom N. Dhakal This study investigates the influence of intra-ply hybrid patches and hydrothermal aging on the indentation properties of patch repaired GFRP composites. Fabrics with various proportions of glass and Kevlar fibers were employed...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2324: 1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study Molecules doi: 10.3390/molecules25102324 Authors: Danuta Branowska Zbigniew Karczmarzyk Ewa Wolińska Waldemar Wysocki Maja Morawiak Zofia Urbańczyk-Lipkowska Anna Bielawska Krzysztof Bielawski In this study, we synthesized novel sulfonamides with a 1,2,4-triazine moiety according...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2323: Fresh-Cut Bell Peppers in Modified Atmosphere Packaging: Improving Shelf Life to Answer Food Security Concerns Molecules doi: 10.3390/molecules25102323 Authors: Carla Barbosa Thelma B. Machado Manuel Rui Alves Maria Beatriz P. P. Oliveira The influence of modified atmosphere packaging (MAP, 10% O2 and 45% CO2) on the quality characteristics of fresh-cut green, red and yellow bell peppers (Capsicum annuum L. var annuum) was investigated. Packaging...
Sat May 16, 2020 03:00
Molecules, Vol. 25, Pages 2322: Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs Molecules doi: 10.3390/molecules25102322 Authors: Martin Kellert Imola Sárosi Rajathees Rajaratnam Eric Meggers Peter Lönnecke Evamarie Hey-Hawkins Ruthenium-based complexes have received much interest as potential metallodrugs. In this work, four RuII complexes bearing a dicarbollide moiety, a carbonyl ligand, and a phenanthroline-based ligand were synthesized and characterized,...
Fri May 15, 2020 03:00
Molecules, Vol. 25, Pages 2320: Finding Value in Wastewaters from the Cork Industry: Carbon Dots Synthesis and Fluorescence for Hemeprotein Detection Molecules doi: 10.3390/molecules25102320 Authors: Marta R. Alexandre Alexandra I. Costa Mário N. Berberan-Santos José V. Prata Valorisation of industrial low-value waste residues was preconized. Hence, carbon dots (C-dots) were synthesized from wastewaters of the cork industry—an abundant and affordable, but environmentally-problematic...
Fri May 15, 2020 03:00
Molecules, Vol. 25, Pages 2321: Comparison of the Polyphenolic Profile of Medicago sativa L. and Trifolium pratense L. Sprouts in Different Germination Stages Using the UHPLC-Q Exactive Hybrid Quadrupole Orbitrap High-Resolution Mass Spectrometry Molecules doi: 10.3390/molecules25102321 Authors: Elena Roxana Chiriac Carmen Lidia Chiţescu Daniela Borda Mariana Lupoae Cerasela Elena Gird Elisabeta-Irina Geană Giorgiana-Valentina Blaga Rica Boscencu Identification and...
Fri May 15, 2020 03:00
Molecules, Vol. 25, Pages 2319: Cellulose Nanofibrils Filled Poly(Lactic Acid) Biocomposite Filament for FDM 3D Printing Molecules doi: 10.3390/molecules25102319 Authors: Qianqian Wang Chencheng Ji Lushan Sun Jianzhong Sun Jun Liu As direct digital manufacturing, 3D printing (3DP) technology provides new development directions and opportunities for the high-value utilization of a wide range of biological materials. Cellulose nanofibrils (CNF) and polylactic acid (PLA) biocomposite...
Fri May 15, 2020 03:00
Molecules, Vol. 25, Pages 2318: Exploring the Effect of Water Content and Anion on the Pretreatment of Poplar with Three 1-Ethyl-3-methylimidazolium Ionic Liquids Molecules doi: 10.3390/molecules25102318 Authors: Florence J. V. Gschwend Jason P. Hallett Agnieszka Brandt-Talbot We report on the pretreatment of poplar wood with three different 1-ethyl-3-methylimidazolium ionic liquids, [EMim][OAc], [EMim][MeSO3], and [EMim][HSO4], at varying water contents from 0–40 wt%...
Fri May 15, 2020 03:00
Molecules, Vol. 25, Pages 2317: New Donor-Acceptor Stenhouse Adducts as Visible and Near Infrared Light Polymerization Photoinitiators Molecules doi: 10.3390/molecules25102317 Authors: Guillaume Noirbent Yangyang Xu Aude-Héloise Bonardi Sylvain Duval Didier Gigmes Jacques Lalevée Frédéric Dumur Polymerization photoinitiators that can be activated under low light intensity and in the visible range are being pursued by both the academic and industrial communities. To...
Fri May 15, 2020 03:00
Molecules, Vol. 25, Pages 2316: The Geraniin-Rich Extract from Reunion Island Endemic Medicinal Plant Phyllanthus phillyreifolius Inhibits Zika and Dengue Virus Infection at Non-Toxic Effect Doses in Zebrafish Molecules doi: 10.3390/molecules25102316 Authors: Juliano G. Haddad Dovilė Grauzdytė Andrea Cristine Koishi Wildriss Viranaicken Petras Rimantas Venskutonis Claudia Nunes Duarte dos Santos Philippe Desprès Nicolas Diotel Chaker El Kalamouni The mosquito-borne...
Fri May 15, 2020 03:00
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