Biomolecules, Vol. 10, Pages 747: Transient Expression of Reck Under Hepatic Ischemia/Reperfusion Conditions Is Associated with Mapk Signaling Pathways Biomolecules doi: 10.3390/biom10050747 Authors: Ferrigno Pasqua Palladini Berardo Verta Richelmi Perlini Collotta Collino Vairetti In this study, we demonstrated the involvement of matrix metalloproteinases (MMPs) in hepatic ischemia/reperfusion (I/R) injury. Our aim is to evaluate the impact of reperfusion...
Mon May 11, 2020 03:00
Biomolecules, Vol. 10, Pages 748: Relationship of Zonulin with Serum PCSK9 Levels after a High Fat Load in a Population of Obese Subjects Biomolecules doi: 10.3390/biom10050748 Authors: Molina-Vega Castellano-Castillo Sánchez-Alcoholado Plaza-Andrade Perera-Martin Cabrera-Mulero Fernández-García Ramos-Molina Cardona Tinahones Despite the fact that circulating levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) remain unchanged after fat...
Mon May 11, 2020 03:00
Biomolecules, Vol. 10, Pages 745: A Novel Lysophosphatidic Acid Acyltransferase of Escherichia coli Produces Membrane Phospholipids with a cis-vaccenoyl Group and Is Related to Flagellar Formation Biomolecules doi: 10.3390/biom10050745 Authors: Yosuke Toyotake Masayoshi Nishiyama Fumiaki Yokoyama Takuya Ogawa Jun Kawamoto Tatsuo Kurihara Lysophosphatidic acid acyltransferase (LPAAT) introduces fatty acyl groups into the sn-2 position of membrane phospholipids (PLs). Various...
Mon May 11, 2020 03:00
Biomolecules, Vol. 10, Pages 744: Structure–Activity Relationship Study Reveals the Molecular Basis for Specific Sensing of Hydrophobic Amino Acids by the Campylobacter jejuni Chemoreceptor Tlp3 Biomolecules doi: 10.3390/biom10050744 Authors: Mohammad F. Khan Mayra A. Machuca Mohammad M. Rahman Cengiz Koç Raymond S. Norton Brian J. Smith Anna Roujeinikova Chemotaxis is an important virulence factor of the foodborne pathogen Campylobacter jejuni. Inactivation of chemoreceptor...
Mon May 11, 2020 03:00
Biomolecules, Vol. 10, Pages 743: Targeting Intrinsically Disordered Proteins through Dynamic Interactions Biomolecules doi: 10.3390/biom10050743 Authors: Jianlin Chen Xiaorong Liu Jianhan Chen Intrinsically disordered proteins (IDPs) are over-represented in major disease pathways and have attracted significant interest in understanding if and how they may be targeted using small molecules for therapeutic purposes. While most existing studies have focused on extending the traditional...
Mon May 11, 2020 03:00
Biosensors, Vol. 10, Pages 50: Fecal Volatile Organic Compound Profiles are Not Influenced by Gestational Age and Mode of Delivery: A Longitudinal Multicenter Cohort Study Biosensors doi: 10.3390/bios10050050 Authors: Deianova Hassani Niemarkt Cossey Kaam Jenken Weissenbruch Doedes Baelde Menezes Benninga Jonge Boer Meij Fecal volatile organic compounds (VOC) reflect human and gut microbiota metabolic pathways and their interaction....
Mon May 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 289: Changes in Developmental Trajectories of Preschool Children with Autism Spectrum Disorder during Parental Based Intensive Intervention Brain Sciences doi: 10.3390/brainsci10050289 Authors: Arianna Bentenuto Giulio Bertamini Silvia Perzolli Paola Venuti (1) Background: Research highlights the positive effects of early intensive intervention with parent and school involvement for preschool children with Autism Spectrum Disorder (ASD) on general...
Tue May 12, 2020 03:00
Brain Sciences, Vol. 10, Pages 287: Persistent Roseoloviruses Infection in Adult Patients with Epilepsy Brain Sciences doi: 10.3390/brainsci10050287 Authors: Rasa-Dzelzkaleja Gravelsina Chapenko Krukle Svirskis Suna Kashuba Karelis Murovska Background: Human herpesviruses (HHV)-6A, HHV-6B and HHV-7 are considered to be involved in the pathogenesis of epilepsy, a common neurological disorder. The objective of this study was to determine the association...
Mon May 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 288: The Long Road of Immunotherapeutics against Multiple Sclerosis Brain Sciences doi: 10.3390/brainsci10050288 Authors: Apostolopoulos Rostami Matsoukas This commentary highlights novel immunomodulation and vaccine-based research against multiple sclerosis (MS) and reveals the amazing story that triggered this cutting-edge MS research in Greece and worldwide. It further reveals the interest and solid support of some of the world’s leading...
Mon May 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 286: Cellular Localization of gdnf in Adult Zebrafish Brain Brain Sciences doi: 10.3390/brainsci10050286 Authors: Chee Ern David Wong Khang Hua Simon Monis Anwar Norazit Suzita Mohd Noor Marc Ekker Glial cell line-derived neurotrophic factor (GDNF) was initially described as important for dopaminergic neuronal survival and is involved in many other essential functions in the central nervous system. Characterization of GDNF phenotype in mammals...
Mon May 11, 2020 03:00
Cancers, Vol. 12, Pages 1213: Hypoxic Roadmap of Glioblastoma—Learning about Directions and Distances in the Brain Tumor Environment Cancers doi: 10.3390/cancers12051213 Authors: Agnieszka Bronisz Elżbieta Salińska E. Antonio Chiocca Jakub Godlewski Malignant brain tumor—glioblastoma is not only difficult to treat but also hard to study and model. One of the reasons for these is their heterogeneity, i.e., individual tumors consisting of cancer cells that are unlike...
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Cancers, Vol. 12, Pages 1210: Advantages of Using Paclitaxel in Combination with Oncolytic Adenovirus Utilizing RNA Destabilization Mechanism Cancers doi: 10.3390/cancers12051210 Authors: Hossain Habiba Yanagawa-Matsuda Alam Ahmed Alam Yasuda Higashino Oncolytic virotherapy is a novel approach to cancer therapy. Ad-fosARE is a conditionally replicative adenovirus engineered by inserting AU-rich elements (ARE) in the 3’-untranslated region of the...
Tue May 12, 2020 03:00
Cancers, Vol. 12, Pages 1211: Neuroendocrine Carcinoma of the Uterine Cervix: A Clinicopathologic and Immunohistochemical Study with Focus on Novel Markers (Sst2–Sst5) Cancers doi: 10.3390/cancers12051211 Authors: Inzani Santoro Angelico Feraco Spadola Arciuolo Valente Carlino Piermattei Scaglione Scambia Rindi Zannoni Background. Gynecological neuroendocrine neoplasms (NENs) are extremely rare, accounting for 1.2–2.4% of the...
Tue May 12, 2020 03:00
Cancers, Vol. 12, Pages 1209: A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers Cancers doi: 10.3390/cancers12051209 Authors: Satoe Okuma Yuhei Matsuda Yoshiki Nariai Masaaki Karino Ritsuro Suzuki Takahiro Kanno This single-center retrospective observational study aimed to identify risk factors for developing denosumab-related osteonecrosis of the jaw (DRONJ) in stage IV...
Tue May 12, 2020 03:00
Cancers, Vol. 12, Pages 1212: Classification of Breast Cancer Cells Using the Integration of High-Frequency Single-Beam Acoustic Tweezers and Convolutional Neural Networks Cancers doi: 10.3390/cancers12051212 Authors: Hae Gyun Lim O-Joun Lee K. Kirk Shung Jin-Taek Kim Hyung Ham Kim Single-beam acoustic tweezers (SBAT) is a widely used trapping technique to manipulate microscopic particles or cells. Recently, the characterization of a single cancer cell using high-frequency...
Tue May 12, 2020 03:00
Cancers, Vol. 12, Pages 1207: The Proteasome Inhibitor Ixazomib Inhibits the Formation and Growth of Pulmonary and Abdominal Osteosarcoma Metastases in Mice Cancers doi: 10.3390/cancers12051207 Authors: Michael A. Harris Mark A. Miles Tanmay M. Shekhar Carmelo Cerra Smitha R. Georgy Stewart D. Ryan Claire M. Cannon Christine J. Hawkins Osteosarcoma is the most common form of primary bone cancer. Over 20% of osteosarcoma patients present with pulmonary metastases...
Mon May 11, 2020 03:00
Cancers, Vol. 12, Pages 1208: Methylation-Based Signatures for Gastroesophageal Tumor Classification
Cancers, Vol. 12, Pages 1208: Methylation-Based Signatures for Gastroesophageal Tumor Classification Cancers doi: 10.3390/cancers12051208 Authors: Nikolay Alabi Dropen Sheka Ashar Siddiqui Edwin Wang Contention exists within the field of oncology with regards to gastroesophageal junction (GEJ) tumors, as in the past, they have been classified as gastric cancer, esophageal cancer, or a combination of both. Misclassifications of GEJ tumors ultimately influence treatment options,...
Mon May 11, 2020 03:00
Cancers, Vol. 12, Pages 1206: Exploiting the Prevalence of Homologous Recombination Deficiencies in High-Grade Serous Ovarian Cancer Cancers doi: 10.3390/cancers12051206 Authors: Bouberhan Philp Hill Al-Alem Rueda High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecologic cancer in the United States. Genomic analysis revealed roughly half of HGSOC display homologous repair deficiencies. An improved understanding of the genomic and somatic mutations...
Mon May 11, 2020 03:00
Cancers, Vol. 12, Pages 1205: Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-Rich Elements Containing mRNA Cancers doi: 10.3390/cancers12051205 Authors: Mikawa Towfik Alam Hossain Yanagawa-Matsuda Kitamura Yasuda Habiba Ahmed Kitagawa Shindoh Higashino AU-rich elements (AREs) are RNA elements that enhance the rapid decay of mRNAs, including those of genes required for cell growth and proliferation. HuR, a member...
Mon May 11, 2020 03:00
Cancers, Vol. 12, Pages 1203: Inhibition of HIF-1α by Atorvastatin During 131I-RTX Therapy in Burkitt’s Lymphoma Model Cancers doi: 10.3390/cancers12051203 Authors: Eun-Ho Kim Hae Young Ko A Ram Yu Hyeongi Kim Javeria Zaheer Hyun Ji Kang Young-Cheol Lim Kyung Deuk Cho Hyun-Yoo Joo Min Kyoung Kang Jae Jun Lee Seung-Sook Lee Hye Jin Kang Sang Moo Lim Jin Su Kim Backgrounds: Radioimmunotherapy (RIT) serves as a targeted therapy for non-Hodgkin lymphomas...
Mon May 11, 2020 03:00
Cancers, Vol. 12, Pages 1204: Applications of Artificial Intelligence to Prostate Multiparametric MRI (mpMRI): Current and Emerging Trends Cancers doi: 10.3390/cancers12051204 Authors: Michelle D. Bardis Roozbeh Houshyar Peter D. Chang Alexander Ushinsky Justin Glavis-Bloom Chantal Chahine Thanh-Lan Bui Mark Rupasinghe Christopher G. Filippi Daniel S. Chow Prostate carcinoma is one of the most prevalent cancers worldwide. Multiparametric magnetic resonance...
Mon May 11, 2020 03:00
Cells, Vol. 9, Pages 1204: The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse AD Models Cells doi: 10.3390/cells9051204 Authors: Bécot Pardossi-Piquard Bourgeois Duplan Xiao Diwan Lee Lauritzen : Brains that are affected by Alzheimer’s disease (AD) are characterized by the overload of extracellular amyloid β (Aβ) peptides, but recent data from...
Tue May 12, 2020 03:00
Cells, Vol. 9, Pages 1202: Molecular Mechanisms of Heat Shock Factors in Cancer Cells doi: 10.3390/cells9051202 Authors: Mikael Christer Puustinen Lea Sistonen Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (HSFs), have been shown to play important roles in all of these biological...
Tue May 12, 2020 03:00
Cells, Vol. 9, Pages 1201: Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells Cells doi: 10.3390/cells9051201 Authors: Guillaume Bidault Marie Garcia Jacqueline Capeau Romain Morichon Corinne Vigouroux Véronique Béréziat Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging disorder notably characterized by precocious and deadly atherosclerosis. Almost 90% of HGPS patients carry a LMNA...
Tue May 12, 2020 03:00
Cells, Vol. 9, Pages 1203: Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions Cells doi: 10.3390/cells9051203 Authors: Magierowska Bakalarz Wójcik Korbut Danielak Głowacka Pajdo Buszewicz Ginter Surmiak Kwiecień Chmura Magierowski Brzozowski Exposure to acidic gastric content due to malfunction of lower esophageal sphincter leads to acute...
Tue May 12, 2020 03:00
Cells, Vol. 9, Pages 1200: Allosteric Antagonism of the A2A Adenosine Receptor by a Series of Bitopic Ligands Cells doi: 10.3390/cells9051200 Authors: Gao Toti Campbell Suresh Yang Jacobson Allosteric antagonism by bitopic ligands, as reported for many receptors, is a distinct modulatory mechanism. Although several bitopic A2A adenosine receptor (A2AAR) ligand classes were reported as pharmacological tools, their receptor binding and functional antagonism patterns,...
Tue May 12, 2020 03:00
Cells, Vol. 9, Pages 1198: A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM-/CD133- nonStem Cells into EpCAM+/CD133+ Liver Cancer Stem Cells in HCC Cell Line HuH7 Cells doi: 10.3390/cells9051198 Authors: Karagonlar Akbari Karabicici Sahin Avci Ersoy Ates Balli Karacicek Kaplan Celiker Atabey Erdal The complex and heterogeneous nature of hepatocellular carcinoma (HCC) hampers the identification of effective therapeutic...
Tue May 12, 2020 03:00
Cells, Vol. 9, Pages 1199: Platelet-Rich Plasma Modulates Gap Junction Functionality and Connexin 43 and 26 Expression During TGF-β1–Induced Fibroblast to Myofibroblast Transition: Clues for Counteracting Fibrosis Cells doi: 10.3390/cells9051199 Authors: Squecco Chellini Idrizaj Tani Garella Pancani Pavan Bambi Zecchi-Orlandini Sassoli Skeletal muscle repair/regeneration may benefit by Platelet-Rich Plasma (PRP) treatment owing to PRP pro-myogenic...
Tue May 12, 2020 03:00
Cells, Vol. 9, Pages 1197: An Innovative Lipidomic Workflow to Investigate the Lipid Profile in a Cystic Fibrosis Cell Line Cells doi: 10.3390/cells9051197 Authors: Dei Cas Zulueta Mingione Caretti Ghidoni Signorelli Paroni Altered lipid metabolism has been associated to cystic fibrosis disease, which is characterized by chronic lung inflammation and various organs dysfunction. Here, we present the validation of an untargeted lipidomics approach based on high-resolution...
Tue May 12, 2020 03:00
Cells, Vol. 9, Pages 1196: Therapeutic Potential of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists in Substance Use Disorders: A Synthesis of Preclinical and Human Evidence Cells doi: 10.3390/cells9051196 Authors: Matheson Le Foll Targeting peroxisome proliferator-activated receptors (PPARs) has received increasing interest as a potential strategy to treat substance use disorders due to the localization of PPARs in addiction-related brain regions and the ability of PPAR...
Tue May 12, 2020 03:00
Cells, Vol. 9, Pages 1194: Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain Cells doi: 10.3390/cells9051194 Authors: Tuoxin Cao Jessica J. Matyas Cynthia L. Renn Alan I. Faden Susan G. Dorsey Junfang Wu Brain-derived neurotrophic factor (BDNF), a major focus for regenerative therapeutics, has been lauded for its pro-survival characteristics and involvement in both development and recovery of function within the central nervous system (CNS)....
Mon May 11, 2020 03:00
Cells, Vol. 9, Pages 1195: TNF-α Pretreatment Improves the Survival and Function of Transplanted Human Neural Progenitor Cells Following Hypoxic-Ischemic Brain Injury Cells doi: 10.3390/cells9051195 Authors: Miri Kim Kwangsoo Jung Younhee Ko Il-Sun Kim Kyujin Hwang Jae-Hyung Jang Jeong Eun Shin Kook In Park Neural progenitor cells (NPCs) therapy offers great promise in hypoxic-ischemic (HI) brain injury. However, the poor survival of implanted NPCs in the HI host...
Mon May 11, 2020 03:00
Cells, Vol. 9, Pages 1192: The Connection of Azole Fungicides with Xeno-Sensing Nuclear Receptors, Drug Metabolism and Hepatotoxicity Cells doi: 10.3390/cells9051192 Authors: Philip Marx-Stoelting Constanze Knebel Albert Braeuning Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity. A number of previous...
Mon May 11, 2020 03:00
Cells, Vol. 9, Pages 1193: Dichotomous Regulation of Acquired Immunity by Innate Lymphoid Cells Cells doi: 10.3390/cells9051193 Authors: Ebihara The concept of innate lymphoid cells (ILCs) includes both conventional natural killer (NK) cells and helper ILCs, which resemble CD8+ killer T cells and CD4+ helper T cells in acquired immunity, respectively. Conventional NK cells are migratory cytotoxic cells that find tumor cells or cells infected with microbes. Helper ILCs are localized...
Mon May 11, 2020 03:00
Cells, Vol. 9, Pages 1191: Super-Resolution Localisation of Nuclear PI(4)P and Identification of Its Interacting Proteome Cells doi: 10.3390/cells9051191 Authors: Veronika Fáberová Ilona Kalasová Alžběta Krausová Pavel Hozák Phosphoinositides are glycerol-based phospholipids, and they play essential roles in cellular signalling, membrane and cytoskeletal dynamics, cell movement, and the modulation of ion channels and transporters. Phosphoinositides are also associated with fundamental...
Mon May 11, 2020 03:00
Cells, Vol. 9, Pages 1190: MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins Cells doi: 10.3390/cells9051190 Authors: Young Jin Lee Seung Han Son Chang Su Lim Min Young Kim Si Woo Lee Sangwon Lee Jinseon Jeon Dae Hyun Ha Na Rae Jung Su Youne Han Byung-Rok Do Insung Na Vladimir N. Uversky Chul Geun Kim Chromatin remodeling, including histone modification, chromatin (un)folding, and nucleosome...
Mon May 11, 2020 03:00
Cells, Vol. 9, Pages 1187: Genome-Wide Transcriptomic Analysis Identifies Pathways Regulated by Sterculic Acid in Retinal Pigmented Epithelium Cells Cells doi: 10.3390/cells9051187 Authors: Ana Pariente Álvaro Pérez-Sala Rodrigo Ochoa Rafael Peláez Ignacio M. Larráyoz In addition to its predominant role in lipid metabolism and body weight control, SCD1 has emerged recently as a potential new target for the treatment of various diseases. Sterculic acid (SA) is a cyclopropene...
Mon May 11, 2020 03:00
Cells, Vol. 9, Pages 1188: Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst Cells doi: 10.3390/cells9051188 Authors: Cristina B. Hebeda Silvana Sandri Cláudia M. Benis Marina de Paula-Silva Rodrigo A. Loiola Chris Reutelingsperger Mauro Perretti Sandra H. P. Farsky Embryo implantation into the uterine wall is a highly modulated, complex process. We previously demonstrated that Annexin A1 (AnxA1), which is a protein secreted...
Mon May 11, 2020 03:00
Cells, Vol. 9, Pages 1189: Increasing the Duration of Light Physical Activity Ameliorates Insulin Resistance Syndrome in Metabolically Healthy Obese Adults Cells doi: 10.3390/cells9051189 Authors: Fatema Al-Rashed Abdulwahab Alghaith Rafaat Azim Dawood AlMekhled Reeby Thomas Sardar Sindhu Rasheed Ahmad Obesity is a well-known risk factor for insulin resistance syndrome (IRS). Nevertheless, limited data are available regarding the effects of physical activity (PA) intensity...
Mon May 11, 2020 03:00
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