Related ArticlesA Novel Risk Calculator for Suboccipital Decompression for Adult Chiari Malformation. World Neurosurg. 2020 Apr 29;: Authors: Feghali J, Marinaro E, Lubelski D, Luciano MG, Huang J Abstract BACKGROUND: Patient counselling and selection for surgical therapy in adult Chiari malformation type I (CM-1) remains debatable. We aimed to develop a clinical calculator predicting the risk of non-home discharge and re-operation using the American...
Related ArticlesLocal Tumor Control for Metastatic Epidural Spinal Cord Compression following Separation Surgery with Adjuvant CyberKnife Stereotactic Radiotherapy or Image-guided Intensity Modulated Radiotherapy. World Neurosurg. 2020 Apr 29;: Authors: Hu JX, Gong YN, Jiang XD, Jiang L, Zhuang HQ, Meng N, Liu XG, Wei F, Liu ZJ Abstract PURPOSE: To compare local tumor control after conventionally-fractionated image-guided (IG) intensity modulated radiotherapy...
Related ArticlesPost-Operative Sexual Activity Recommendations: A Survey of Neurosurgeons/Spine Surgeons. World Neurosurg. 2020 Apr 29;: Authors: Thomas CM, Cajigas I, Levene HB Abstract The impact of various types of spinal surgeries on sexual health and post-operative sexual activity is a common question among both patients and healthcare professionals. Unfortunately, there is no clear answer to this question in the scientific literature. ...
Related ArticlesParent artery occlusion for treatment of a traumatic pericallosal artery aneurysm: a case report and literature review. World Neurosurg. 2020 Apr 29;: Authors: Tsuji Y, Miki T, Kakita H, Sato K, Yoshida T, Shimizu F Abstract BACKGROUND: Traumatic intracranial aneurysms are rare complications after head trauma. This report describes a case of patient with a traumatic pericallosal aneurysm. CASE DESCRIPTION: A 73-year-old male...
Related ArticlesAssessing the Role of Patient Race in Disparity of 90-Day Brain Tumor Resection Outcomes. World Neurosurg. 2020 Apr 29;: Authors: Haldar D, Glauser G, Winter E, Goodrich S, Shultz K, McClintock SD, Malhotra NR Abstract BACKGROUND: The present study assesses the influence of race on patient outcomes in a brain tumor surgery population. METHODS: Coarsened exact matching (CEM) was used to retrospectively analyze 1700 supratentorial...
Related ArticlesOutcome comparison between surgically treated brain arteriovenous malformation hemorrhage and spontaneous intracerebral hemorrhage. World Neurosurg. 2020 Apr 29;: Authors: Sun W, German MR, Sebök M, Fierstra J, Kulcsar Z, Keller A, Regli L Abstract BACKGROUND: Case fatality and poor outcome rates are different between brain arteriovenous malformation associated intracerebral hemorrhage (bAVM-ICH) and spontaneous intracerebral hemorrhage...
Related ArticlesIs facet joint distraction associated with functional outcome in patients with cervical spondylotic radiculopathy treated with single-segment anterior cervical discectomy and fusion? World Neurosurg. 2020 Apr 29;: Authors: Lin Z, Wang Z, Chen G, Lin T, Liu W Abstract STUDY DESIGN: A retrospective study. OBJECTIVE: To explore (1) whether the degree of facet joint distraction during single-segment anterior cervical discectomy and...
Related ArticlesSurgical Treatment of Symptomatic Small Medial Petrous Meningiomas Causing Trigeminal Neuralgia. World Neurosurg. 2020 Apr 29;: Authors: Khani M, Hundley K, Morris TW, Henson JC, Thomas K, Wong KH, Rodriguez A, Day JD Abstract BACKGROUND: Symptomatic trigeminal neuralgia caused by small (<3cm) skull base meningiomas is treated by radiosurgery or surgical resection. While radiosurgery is less invasive, surgical resection provides more...
Related ArticlesRadial artery graft for giant common carotid artery pseudoaneurysm after carotid artery stenting. World Neurosurg. 2020 Apr 29;: Authors: Matano F, Suzuki M, Mizunari T, Yamada T, Murai Y, Morita A Abstract BACKGROUND: and Importance: We present a patient who underwent left superior temporal artery (STA) to right middle cerebral artery (MCA) bypass using a radial artery (RA) graft with resection of a giant right cervical common carotid...
Related ArticlesTranscortico-subcortical approach for left posterior mediobasal temporal region gliomas: a case series and anatomical review of relevant white matter tracts. World Neurosurg. 2020 Apr 29;: Authors: Brown DA, Hanalioglu S, Chaichana K, Duffau H Abstract BACKGROUND AND OBJECTIVE: The goal of this paper is to demonstrate using five illustrative cases that the transcortical route for resection of mediobasal temporal region (MBTR) lesions...
Related ArticlesFIP1L1-PDGFRA positive hypereosinophilia presenting with bilateral extracranial carotid artery aneurysms. World Neurosurg. 2020 Apr 29;: Authors: Cachapero Moalong KM, Bengzon Diestro JD, Espiritu AI, Cuevas Lucero JA, de la Cruz APRL, Valencia JM, Chua EM, Francisco Cenina AR, Spears J, Zarsadias San Jose MC PMID: 32360918 [PubMed - as supplied by publisher]
Related ArticlesNeutrophil-to-lymphocyte ratio and traumatic brain injury: A Review Study. World Neurosurg. 2020 Apr 29;: Authors: Sabouri E, Majdi A, Jangjui P, Rahigh-Aghasan S, Naseri Alavi SA Abstract Traumatic Brain Injury (TBI) is the leading cause of morbidity and mortality worldwide. Several prognostic factors have been developed to predict functional outcomes and mortality rates in patients with TBI. Neutrophil-to-lymphocyte ratio (NLR) is an...
Related ArticlesA Cost-Effective Method for 3D Printing Dynamic Multi-Object and Patient-Specific Brain Tumor Models: Technical Note. World Neurosurg. 2020 Apr 29;: Authors: Damon A, Clifton W, Valero-Moreno F, Quinones-Hinojosa A Abstract BACKGROUND: Three-dimensional (3D) printing is a powerful tool for replicating patient-specific anatomical features for education and surgical planning. The advent of "desktop" 3D printing has created a cost-effective...
Related ArticlesEmbolization of a basilar tip aneurysm via the ascending cervical artery. World Neurosurg. 2020 Apr 30;: Authors: Munger D, O'Neill B, Priest R Abstract BACKGROUND: and Importance Unusual vascular anatomy can present treatment challenges as traditional approaches may be unfeasible. CLINICAL PRESENTATION: In this case we describe a patient who presented with subarachnoid hemorrhage due to a ruptured basilar apex aneurysm, with...
Related ArticlesFactors in Residency Decision Making for Female Neurosurgery Applicants. World Neurosurg. 2020 Apr 30;: Authors: McNutt SE, Goss ML, Hallan DR, Bible JE Abstract BACKGROUND: Neurosurgery remains a specialty with one of the lowest gender diversities in the United States. Neurosurgery residency programs are highly motivated to attract the best female candidates in an effort to improve their program diversity, but no studies currently exist...
Related ArticlesDural based primary central nervous system lymphoma with bone invasion: a case report. World Neurosurg. 2020 Apr 30;: Authors: Lee SW, Jung TY, Baek HJ, Kim SK, Lee KH Abstract Primary central nervous system lymphoma (PCNSL) occurs frequently in a deep intraparenchymal location. It rarely occurs in the meninges, and bone invasion is uncommon. A 12-year-old boy was admitted to our hospital with a history of headache and seizures. Magnetic...
Related ArticlesCOVID-19 and Neurosurgery. Literature and Neurosurgical Societies Recommendations Update. World Neurosurg. 2020 Apr 30;: Authors: Germanò A, Raffa G, Angileri FF, Cardali SM, Tomasello F Abstract BACKGROUND: Since January 2020, 3 months ago, when the pathogen causing the Coronavirus-disease was identified in humans, the literature on COVID-19 has grown exponentially to over 4000 publications. There is the need to provide an update for...
Related ArticlesThe Management Of Neurosurgical Patients During The Covid-19 Pandemic. World Neurosurg. 2020 Apr 30;: Authors: Spina A, Boari N, Gagliardi F, Bailo M, Calvanese F, Mortini P Abstract The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is, to date, the major challenge for healthcare systems worldwide. Hospital represents one of main vector amplifying the spread of the disease among both patients and healthcare...
Related ArticlesCase Report of Immuno-Oncotherapy (IO) Provoked Encephalitis Mimicking Brain Metastasis in a Patient with History of Traumatic Brain Injury. World Neurosurg. 2020 Apr 30;: Authors: Bross SP, Mongelluzzo GJ, Conger AR, Patel MA, Vadakara J, Grant M, Gatson NTN Abstract BACKGROUND: Immuno-oncotherapy (IO) has revolutionized systemic cancer care but remains experimental in brain tumors. IO treatment risks multi-organ autoimmune inflammatory...
Related ArticlesTrans-Lamina Terminalis Approach to Laser-Assisted Resection of Thalamo-mesencephalic Cavernous Malformation. World Neurosurg. 2020 Apr 28;: Authors: Bigder MG, Li Y, Mandel M, Steinberg G Abstract Cavernous malformations of the midbrain require careful consideration of the risks and benefits of intervention, as well as optimal surgical approach for these challenging lesions. Excellent results can be achieved with careful surgical planning...
Related ArticlesRisk factors related to superior facet joint violation during lumbar percutaneous pedicle screw placement in minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). World Neurosurg. 2020 Apr 28;: Authors: Zhao Y, Yuan S, Tian Y, Liu X Abstract OBJECTIVE: To investigate the incidence of superior facet joint violation (FJV) during percutaneous pedicle screw placement in minimally invasive transforaminal lumbar interbody fusion...
Related ArticlesAnterior cerebral artery bypass for complex aneurysms: advances in intracranial-intracranial bypass techniques. World Neurosurg. 2020 Apr 28;: Authors: Labib MA, Gandhi S, Cavallo C, Nisson PL, Mooney MA, Catapano JS, Lang MJ, Chen T, Lawton MT Abstract BACKGROUND: Anterior cerebral artery (ACA) bypasses for complex aneurysms are infrequently performed, yet previous experience demonstrates the importance of intracranial-intracranial (IC-IC)...
Related ArticlesThe characteristics of the spectral power of the fluctuations of blood oxygen level dependent signals of supratentorial astrocytomas. World Neurosurg. 2020 Apr 28;: Authors: Metwali H, Raemaekers M, Ibrahim T, Samii A Abstract OBJECTIVE: In this study we are presenting the nature and characteristic of the fluctuation of the BOLD signals measured from the brain tumors. METHODS: Supratentorial astrocytomas, those were neither operated...
Related ArticlesDe-vascularization of a hemorrhagic pineocytoma by laser thermal ablation followed by endoscopic resection: a proof-of-principle case report. World Neurosurg. 2020 Apr 28;: Authors: Freeman D, Guillaume D, Bell WR, Chen CC PMID: 32360672 [PubMed - as supplied by publisher]
Related ArticlesBifurcation aneurysm treatment with PulseRider: Technical nuances, device selection, positioning strategies and overcoming geometrical challenges. World Neurosurg. 2020 Apr 28;: Authors: Spiotta AM, Kan P, Crowley RW Abstract BACKGROUND AND OBJECTIVE: Endovascular therapy is a viable alternative to surgical clipping for the treatment of intracranial aneurysms, however, aneurysms arising at bifurcations remain a challenge. The purpose...
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Abstract Pancreatic cancer is a highly progressive malignant tumor for which there is a critical unmet need for novel therapeutic strategies. A previous study of the authors indicated that VE-821, a selective inhibitor of the ataxia-telangiectasia-mutated and rad3-related protein (ATR), has antitumor efficacy. In this study, the effect of programmed death ligand 1 (PD-L1) on the sensitivity to VE-821 was investigated in p53 mutant pancreatic cancer cells. These results show that...
Abstract This study is to analyze differentially expressed genes (DEGs) and mutation signatures of pancreatic head cancer and pancreatic body/tail cancer. Pancreatic Adenocarcinoma (PAAD) RNA-seq data, mutation data and clinical data were downloaded and collected from The Cancer Genome Atlas (TCGA), FireHose and CBioPortal. According to the anatomic location, the patients were divided into 146 cases of pancreatic head cancer and 28 cases of pancreatic body/tail cancer. Then survival...
Abstract Therapy-related acute leukemias (t-ALs) represent approximately 10–20% of all acute leukemias, are frequently resistant to chemotherapy, and are associated with guarded outcomes. The national comprehensive cancer network data suggest that t-AL cases are diagnosed at increasing rates in breast cancer patients treated with chemotherapeutic agents targeting topoisomerase II. Two cases of BRCA1-mutated ovarian and breast carcinoma who developed therapy-related APL and ALL,...
Abstract Cholangiocarcinoma (CC) accounts for about 3% of the gastrointestinal and 10–25% of all hepatobiliary malignancies. It arises from the epithelium of the bile duct and it can be classified in intrahaepatic (ICC), perihilar (PCC) and distal (DCC) cholangiocarcinoma, depending on the anatomical location. About 50–60% of the cases are PCC. Early detection is very difficult for the lack of symptoms, and most of the patients are not resectable at the time of diagnosis. IRE...
Abstract Trillin is a constituent of total Trillium Tschonoskii Maxim (TTM), which is extracted from TTM and displayed anti-tumor effect in many tumor cell lines. However, the anti-tumor mechanism of trillin is still unclear. This study demonstrated that trillin could dramatically inhibit hepatoma carcinoma cell proliferation, induce apoptosis and decrease migration and invasion through suppressing phosphorylated STAT3 translocated to nucleus. Trillin could down-regulate Bcl-2...
Abstract Breast cancer is the most common cancer in women. Although several studies demonstrated cellular apoptosis susceptibility protein (CAS) involved in the development of breast cancer, the underlying mechanisms of CAS regulating cell processes in the breast cancer remain elusive. In the present study, we explored the possible mechanism of CAS in contributing to the cell proliferation in the breast cancer cell line MCF-7. Knockdown of CAS led to the reduction of cell viability...
Abstract Circular RNAs (circRNA) are covalently closed single-stranded RNA molecules that act as important regulators of gene expression through different mechanisms. Meanwhile, cancer stem cells (CSCs) are a small subpopulation of cells, with properties similar to normal stem cells that arise during the development of cancer and support tumor growth, induce resistance to therapy, and are responsible for metastatic spread. Since the elimination of CSCs is an important goal of...
Abstract To retrospectively assess the predictive value of the CT performed at 24 h, compared with the CT performed at 1 month, in the evaluation of the technical success of microwave (MW) ablation of hepatic lesions. In a single center, 50 patients with HCC underwent percutaneous MW ablation between November 2016 and March 2019. Each patient underwent a contrast-enhanced CT exam at 24 h and at 1 month after the procedure. For each patient, was assessed the presence or absence...
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Although there are many etiologies for delayed puberty in adolescent-aged girls, the pediatric provider should consider primary ovarian insufficiency if estradiol remains undetectable despite elevated levels of gonadotropins. Adolescent girls with this diagnosis will need holistic care from their primary care provider, focusing on both their medical and psychosocial needs. The following case study describes a 14-year-old girl who was referred to pediatric endocrinology for delayed puberty, in the...
Acute otitis media, acute bacterial rhinosinusitis, and community-acquired pneumonia are major drivers of pediatric antibiotic consumption. With many available options and the added challenges of navigating antibiotic allergies and de-escalating from intravenous treatment for children requiring hospitalization, prescribing for these relatively simple infections can be a source of confusion and error. The purpose of this article is to evaluate the pharmacokinetic and pharmacodynamic properties of...
During one recent half-day session at the hospital-based primary care clinic in New Haven, CT where I practice, I saw for a routine visit a teenager from a Syrian family that I had known for many years who were still coping with the aftereffects of war in that country, a 5 year old from an Afghan refugee family who was struggling in school, and a 6 year old (along with his uncle) who had arrived in the U.S. from Guatemala two weeks ago and had no record of any previous health care or immunizations.
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