Disseminated histoplasmosis, with the adrenal glands as being the only site of demonstrable disease in an immunocompetent adult, is a rare infection leading to adrenal insufficiency. This disease carries high mortality when unrecognised. We describe the first reported case of adrenal histoplasmosis in the Philippines in a 72-year-old immunocompetent, Filipino man who presented with a 3-month history of intermittent flank pain, weight loss and generalised weakness. His imaging demonstrated bilateral...
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We present a 48-year-old female patient who presented with features consistent with acquired partial lipodystrophy (APL) also known as ‘Barraquer-Simons syndrome’. It is a rare disease characterised by a gradual and progressive onset of lipoatrophy limited to the face, neck, upper limbs, thorax and abdomen and sparing the lower extremities. The resultant physical appearance can have significant psychosocial sequelae, further compounded by misdiagnosis and delay in recognition and management. Treatment...
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Critically ill patients are at risk of developing both acute kidney injury (AKI) and invasive fungal infections (IFIs). Prompt and efficient treatment of the IFI is essential for the survival of the patient. This article examines three distinct clinical situations where liposomal amphotericin B, a broad-spectrum antifungal agent, was successfully used in the setting of AKI. The first was Aspergillus infection in a 63-year-old man with bleeding oesophageal varices related to advanced liver disease....
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A 9-year-old girl attended the emergency department with right-sided abdominal pain and vomiting. Due to history and following examination, an ultrasound was requested which demonstrated a large complex midline mass. The most likely diagnosis was ovarian torsion, for which the patient underwent laparoscopy, detorsion and ovarian cystectomy. Histology revealed a mature cystic teratoma. Although less common than in the adult population, it is important to consider ovarian torsion in children and adolescents....
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Limb amputations are carried out for a number of reasons, which include trauma, vascular disorders, infection, oncology and congenital abnormalities. These patients can develop multiple complications postoperatively with phantom limb pain being a well-recognised issue. That being said, phantom radiculopathy is far less encountered and can therefore be easily overlooked. There are limited cases described in literature and as a result pathophysiology is poorly understood. In this report, we present...
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Zusammenfassung Hintergrund Die zugelassene Behandlungsmöglichkeiten für Patientinnen mit therapieresistentem, rezidiviertem oder metastasiertem Zervixkarzinom sind limitiert. Ziel der Arbeit In diesem Review werden Substanzen und deren Wirkstoffklassen dargestellt, für die publizierte Ergebnisse aus Phase-I- und Phase-II-Studien vorliegen. ...
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Abstract Pear juice concentrate (PJC) can be used as a natural sweetener in various processed foods. In this study, sesame bars were manufactured by adding PJC and rice syrup at mixing ratios of 0:30 (G-0), 1:29 (G-1), 3:27 (G-3), and 5:25 (G-5), and the bars were investigated for their physiochemical properties, antioxidants, morphology, and sensory attributes. Addition of PJC at more than 3% increased a* and b* values of bars, decreased cohesiveness, hardness, and compactness,...
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The COVID-19 outbreak prompted strong revenue growth in the digital radiography...Read more on AuntMinnieEurope.comRelated Reading: Agfa wraps up sale of assets to Dedalus Agfa wins large DR contract in Greece Agfa secures pediatric DR bid in Poland Agfa set to unveil range of new DR technology at ECR It's all change again in healthcare IT sector
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HBO's Silicon Valley is actually a reasonable representation of the real thing. Here's how to get your master's degree in startups by binge watching it.
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Rotating plane flow distributing pairs have been widely used in engineering. It is very important to reduce the frictional resistance between the pairs to improve the sensitivity and prolong service life. In this paper, the traditional rotating plane flow pair is improved, and the boss is introduced to keep the rotor and the stator in incomplete contact, and then a gap is formed between the flow pairs. The relationship between the pressure distribution and the friction resistance of the flow pairs...
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This paper examines the influence that members’ preferred service investments have on their decision-making and profits in a dual-channel supply chain. We discuss changes in the supplier’s and retailer’s decision-making and optimal profits with reference to their different preferred service investment combination modes and their different leader-follower relationships. We also provide classified comparisons of the supplier’s and retailer’s optimal profits by referring to four types of product characteristics...
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The effective prevention and reduction of the hazardous impact of landslide-generated impulse waves on the moored ships are crucial for the sustainable operation of the reservoirs. Although the investigations of landslide-generated impulse waves have been widely studied in the past decades, few efforts involved their impacts on the moored ships. The authors in this paper specifically examine the hazardous impact of the impulse waves on the moored ships by applying the physical experiments. Considering...
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Feature selection method is designed to select the representative feature subsets from the original feature set by different evaluation of feature relevance, which focuses on reducing the dimension of the features while maintaining the predictive accuracy of a classifier. In this study, we propose a feature selection method for text classification based on independent feature space search. Firstly, a relative document-term frequency difference (RDTFD) method is proposed to divide the features in...
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Kefir is a functional beverage that contains lactic and acetic acid bacteria (LAB, AAB) and yeasts. This work’s aim was to study the chemical, microbial, and functional characteristics of kefir produced from cow’s milk and soy milk. After fermentation, free amino acids were 20.92 mg 100 mL−1 and 36.20 mg 100 mL−1 for cow’s milk and soy milk kefir, respectively. Glutamic acid was majority in both, suggesting that microbial proteolysis leads to an increase in free amino acids including glutamic acid....
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Background. Few biomarkers are available for early identification of pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) in systemic sclerosis (SS) and scleroderma spectrum disorders (SSD). Aims. To evaluate Gas6, sAxl, and sMer as biomarkers for cardiopulmonary complications of SS and SSD. Methods. In a cross-sectional observational study, we recruited 125 consecutive patients, affected by SS and SSD and referred to a tertiary-level pulmonary hypertension outpatient clinic....
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Objective. To evaluate the effectiveness and safety of acupuncture treatment for dysphagia as a complication of stroke. Methods and Design. This is a multicenter, pragmatic, nonrandomized, self-controlled clinical trial. A total of 39 patients were recruited from several Chinese medicine outpatient clinics and hospital-affiliated speech therapy outpatient clinics in Hong Kong. 26 patients completed all the 24 sessions of acupuncture treatment within two months, and only 12 of them were used as self-control....
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Object detection plays an important role in many computer vision applications. Innovative object detection methods based on deep learning such as Faster R-CNN, YOLO, and SSD have achieved state-of the-art results in terms of detection accuracy. There have been few studies to date on object detection with the addition of new classes, however, though this problem is often encountered in the industry. Therefore, this issue has important research significance and practical value. On the premise that...
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This paper proposes a model to find the optimal location of autonomous vehicle lanes in a transportation network consisting of both Autonomous Vehicles (AVs) and Human-Driven Vehicles (HDVs) while accounting for the roadway capacity variation. The main contribution of the model is considering a generalized definition of capacity as a function of AV proportion on a link and incorporating it into the network design problem. A bilevel optimization model is proposed with total travel time as the objective...
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While coronary revascularization strategies guided by instantaneous wave-free ratio (iFR) are, in general, noninferior to those guided by fractional flow reserve (FFR) with respect to the rate of major adverse cardiac events at one-year follow-up in patients with stable angina or an acute coronary syndrome, the overall accuracy of diagnosis with iFR in large patient cohorts is about 80% compared with the diagnosis with FFR. So far, it remains incompletely understood what factors contribute to the...
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Background. Breast cancer is one of the most common cancers in women and has mental and emotional effects, which lead to a decline in their quality of life. This study is aimed at determining the prevalence of severe depression in Iranian women with breast cancer. Methods. This meta-analysis study was conducted at Zabol University of Medical Sciences in 2019. Seven electronic databases were searched and evaluated for original research papers published on the prevalence of severe depression in Iranian...
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Background. Imatinib mesylate is the gold standard for the treatment of all phases of Philadelphia-positive chronic myeloid leukemia. Patients on imatinib treatment may develop cytopenia due to drug toxicity. This study aimed to determine the types, grades, and time course of cytopenia in CML patients on imatinib at a Nairobi hospital. Methods. This was a cross-sectional descriptive study of adult patients aged ≥18 years followed up at the Glivec International Patient Access Program (GIPAP) clinic...
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CNS inflammation is a major driver of MS pathology. Differential immune responses, including the adaptive and the innate immune system, are observed at various stages of MS and drive disease development and progression. Next to these immune-mediated mechanisms, other mediators contribute to MS pathology. These include immune-independent cell death of oligodendrocytes and neurons as well as oxidative stress-induced tissue damage. In particular, the complex influence of oxidative stress on inflammation...
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Banana cultivars that are rich in provitamin A carotenoids and other nutrients may offer a potential food source to help alleviate vitamin A deficiencies, particularly in developing countries. The local plantain type banana, Agung Semeru (Musa paradisiaca L.), was investigated, in order to analyse the changes in the compositions of the provitamin A carotenoids and metabolite compounds, including the amino acids, organic acids, and sugars, during the ripening stage as this banana is widely processed...
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Objective. The increased blood pressure level in children and adolescents is recognized as an essential predictor of adulthood cardiovascular disease. This study aimed to ascertain the prevalence and the urban-rural disparity of childhood hypertension in the southwest of China. Methods. Using stratified cluster sampling in urban and rural areas, a total of 13597 primary school children aged 6∼12 years living in the Southwest of China were included. The prevalence of hypertension was analyzed. The...
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The anodization of the Ti-Cu (2%) alloy was carried out in a 5M H3PO4 solution for 2 minutes. The obtained layers are characterized by XPS, X-ray diffraction, and Raman spectroscopy. The results showed that the obtained films are composed of poorly crystallized TiO2 oxide. Electrochemical Impedance spectroscopy studies revealed that the thickness of the formed film increases with increasing anodization potential. Additionally, the resistance of charge transfer becomes higher when the anodization...
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Purpose. Bilateral choroidal ganglioneuroma is extremely rare, and no cases have been described in the literature. Multimodal images are crucial for its diagnosis. Here, we evaluated multimodal images in the early stage of choroidal ganglioneuroma. Methods. A 6-year-old boy was recruited who had experienced gradually progressive vision loss and rapidly progressive myopia in both eyes over the past 2 years. His eyes were comprehensively evaluated via slit-lamp microscopy, ultrasound biomicroscopy,...
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Chronic obstructive pulmonary disease (COPD) is a widespread, preventable, and treatable disease. Emphysema is one of the primary components of COPD and manifests itself via decrease in elastic recoil, hyperinflation, and increase in air trapping. Various lung-volume-reduction treatments have come up in recent years for late-stage emphysema patients. Mental disorders and especially anxiety and depression are among the frequently encountered comorbid cases observed in COPD. The aim of our study was...
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The excessive use and ingestion of residues of sulfonamides harm the human body and the environment. To meet the requirements of the maximum residue limit specified by the Ministry of Agriculture of China, a rapid detection method urgently needs to be developed. In the present study, a molecularly imprinted polymer (MIP) that could selectively recognize sulfadiazine (SDZ) was prepared using SDZ as the template molecule and methacrylic acid as the functional monomer. Using MIP as biomimetic antibody...
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Metastasis of the thyroid carcinoma to the paranasal sinuses is rarely reported. Among these sinuses, metastasis to the maxillary sinus alone has been reported only in a few cases. This is the first reported case in a 76-year-old woman with papillary thyroid carcinoma metastasizing to the maxillary sinus alone and resected through endoscopic sinonasal surgery. When patients have sinus lesions and a history of malignancy, metastasis should be included in the differential diagnosis. If they have an...
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Purpose. To compare the patterns of relative peripheral refractions of myopic children who were currently on atropine treatment for myopia control and myopic children who did not use atropine. Methods. Chinese children (n = 209) aged 7 to 12 years participated in the study, 106 used atropine and 103 did not. Participants were also classified into three groups: emmetropes (SE: +0.50 to −0.50 D), low myopes (SE: −0.50 to −3.00 D), and moderate myopes (SE: −3.00 to −6.00 D). The central and peripheral...
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Glycyrrhetinic acid (GA), a hydrolysate of glycyrrhizic acid from licorice root extract, has been used to treat liver fibrotic diseases. However, the molecular mechanism involved in the antifibrotic effects of GA remains unclear. The involvement of miR-663a and its roles in TGF-β-1-induced hepatic stellate cell (HSC) activation remains unclear. In this study, we investigated the roles of miR-663a in the activation of HSCs and the antifibrosis mechanism of GA. MiR-663a expression was downregulated...
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The evaluation of blast effects from malicious or accidental detonation of an explosive device is really challenging especially on large buildings. Indeed, the time and space scales of the explosion together with the chemical reactions and fluid mechanics make the numerical model really difficult to achieve acceptable structural design. Nevertheless, finite element methods and especially Arbitrary Lagrangian Eulerian (ALE) have been extensively used in the past few decades with some simplifications....
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Objective. The present study was designed to evaluate the neuroprotective effects of D-(-)-quinic acid on aluminum chloride- (AlCl3-) induced neurobehavioral and biochemical changes in rats. This study showed the behavioral and biochemical effects of D-(-)-quinic acid on rats with particular emphasis on the hippocampus and frontal cortex which are associated with memory. Materials and Methods. Chronic administration of aluminum chloride at a dose of 175 mg/kg, p.o. for a period of 25 days markedly...
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Shale gas is the most important new energy source in the field of energy, and its exploitation is very important. The research on the dynamic mechanical properties of shale is the premise of exploitation. To study the dynamic mechanical properties of shale from the Changning-Weiyuan area of Sichuan Province, China, under confining pressure, we used a split Hopkinson pressure bar (SHPB) test system with an active containment device to carry out dynamic compression tests on shale with different bedding...
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Investigations of antibacterial, antioxidant, and anti-type 2 diabetes mellitus activities have been carried out on Garcinia macrophylla Mart. plant extract fractions. An isolate from a fraction of ethyl acetate extract was characterized with spectroscopic data. A new biflavonoid compound was found to have a skeleton of 5,7,4′,5″,7″,3‴,4‴-heptahydroxyflavanone[3-6″] flavones which was named macrophylloflavone (1). The compound was evaluated for its antibacterial activity against Escherichia coli...
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Objective. To analyze the potential active ingredients and related crucial targets of the ShengDiHuang Decoction (SDHD) formula in the treatment of dysfunctional uterine bleeding (DUB) by using network pharmacology and verification experiment. Methods. In this study, we determined the potential active ingredients from the traditional SDHD formula and their targets with the network pharmacology method. The network of “compound-disease-target” was constructed by the software of Cytoscape. Software...
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Background. The impact of sex on the outcome of patients with acute coronary syndrome (ACS) has been suggested, but little is known about its impact on elderly patients with ACS. Methods. This study analyzed the impact of sex on in-hospital and 1-year outcomes of elderly (≥75 years of age) patients with ACS hospitalized in our department between January 2013 and December 2017. Results. A total of 711 patients were included: 273 (38.4%) women and 438 (61.6%) men. Their age ranged from 75 to 94 years,...
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