Antibiotics, Vol. 9, Pages 251: Antimicrobial Resistance Profiles of Adherent Invasive Escherichia coli Show Increased Resistance to β-Lactams Antibiotics doi: 10.3390/antibiotics9050251 Authors: Martinez-Medina Strozzi Castillo Serrano-Morillas Bustins Martínez-Martínez The adherent invasive Escherichia coli (AIEC) pathotype has been associated with the aetiology of Crohn’s disease (CD). Scarce reports have shown the antimicrobial resistance (AMR) profiles...
Wed May 13, 2020 03:00
Antibiotics, Vol. 9, Pages 250: Discontinuation of Glycopeptides in Patients with Culture Negative Severe Sepsis or Septic Shock: A Propensity-Matched Retrospective Cohort Study Antibiotics doi: 10.3390/antibiotics9050250 Authors: Kim Kim Ahn Jeong Ku Choi Yeom Park Song Kim Implementation of antibiotic stewardship is difficult in patients with sepsis because of severity of disease. We evaluated the impact of glycopeptide discontinuation (GD) in patients...
Wed May 13, 2020 03:00
Antioxidants, Vol. 9, Pages 422: Smart Method for Carotenoids Characterization in Haematococcus pluvialis red phase and Evaluation of Astaxanthin Thermal Stability Antioxidants doi: 10.3390/antiox9050422 Authors: Casella Iovine Mehariya Marino Musmarra Molino Haematococcus pluvialis microalgae is a promising source of astaxanthin, an excellent antioxidant carotenoid. H. pluvialis, as well as other species, could find more extensive applications as healthy food for...
Wed May 13, 2020 03:00
Antioxidants, Vol. 9, Pages 420: Understanding the Redox Biology of Selenium in the Search of Targeted Cancer Therapies Antioxidants doi: 10.3390/antiox9050420 Authors: Stolwijk Garje Sieren Buettner Zakharia Selenium (Se) is an essential trace nutrient required for optimal human health. It has long been suggested that selenium has anti-cancer properties. However, clinical trials have shown inconclusive results on the potential of Se to prevent cancer. The suggested...
Wed May 13, 2020 03:00
Antioxidants, Vol. 9, Pages 421: Zinc Concentration Dynamics Indicate Neurological Impairment Odds after Traumatic Spinal Cord Injury Antioxidants doi: 10.3390/antiox9050421 Authors: Heller Sperl Seelig Haubruck Bock Werner Besseling Sun Schomburg Moghaddam Biglari Traumatic Spinal Cord Injury (TSCI) is debilitating and often results in a loss of motor and sensory function caused by an interwoven set of pathological processes. Oxidative stress...
Wed May 13, 2020 03:00
Antioxidants, Vol. 9, Pages 419: Piceatannol-Loaded Emulsomes Exhibit Enhanced Cytostatic and Apoptotic Activities in Colon Cancer Cells Antioxidants doi: 10.3390/antiox9050419 Authors: Alhakamy Badr-Eldin Ahmed Asfour Aldawsari Algandaby Eid Abdel-Naim Awan Alghaith Alaofi Mohamed Okbazghi Al-Rabia Fahmy Piceatannol (PIC), a naturally occurring polyphenolic stilbene, has pleiotropic pharmacological activities. It has reported...
Wed May 13, 2020 03:00
Antioxidants, Vol. 9, Pages 417: Palmitic Acid Affects Intestinal Epithelial Barrier Integrity and Permeability In Vitro Antioxidants doi: 10.3390/antiox9050417 Authors: Gori Altomare Cocca Solida Ribolsi Carotti Rainer Francesconi Morini Cicala Guarino Palmitic acid (PA), a long-chain saturated fatty acid, might activate innate immune cells. PA plays a role in chronic liver disease, diabetes and Crohn’s disease, all of which are associated...
Wed May 13, 2020 03:00
Antioxidants, Vol. 9, Pages 418: Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Properties Antioxidants doi: 10.3390/antiox9050418 Authors: Agulló-Chazarra Borrás-Linares Lozano-Sánchez Segura-Carretero Micol Herranz-López Barrajón-Catalán In the cosmetic industry, there is a continuous demand for new and innovative ingredients for product development. In the context of continual renovation,...
Wed May 13, 2020 03:00
Antioxidants, Vol. 9, Pages 416: Discovery of GLO1 New Related Genes and Pathways by RNA-Seq on A2E-Stressed Retinal Epithelial Cells Could Improve Knowledge on Retinitis Pigmentosa Antioxidants doi: 10.3390/antiox9050416 Authors: Luigi Donato Concetta Scimone Simona Alibrandi Giacomo Nicocia Carmela Rinaldi Antonina Sidoti Rosalia D’Angelo Endogenous antioxidants protect cells from reactive oxygen species (ROS)-related deleterious effects, and an imbalance in the oxidant/antioxidant...
Wed May 13, 2020 03:00
Arts, Vol. 9, Pages 59: Practices of Remembrance: The Experiences of Artists and Curators in the Centenary Commemoration of World War I Arts doi: 10.3390/arts9020059 Authors: Katherine Isobel Baxter The centenary of World War One was marked in the UK by an unprecedented national investment in the creative arts as a vehicle for remembrance. This scale of funding for commemorative arts, not least under a government whose mantra had been economic “austerity”, demonstrates...
Wed May 13, 2020 03:00
Atmosphere, Vol. 11, Pages 502: Stochastic Resonance Observed in Aerosol Optical Depth Time Series Atmosphere doi: 10.3390/atmos11050502 Authors: Falanga Lauro Martino We analyzed the aerosol optical depth time series retrieved from daily satellite Moderate-Resolution Imaging Spectroradiometer measurements. The investigated geographic area includes Italy and the Mediterranean Sea. By performing second- and fourth-order statistics analyses, the dynamics can be decomposed into...
Wed May 13, 2020 03:00
Atmosphere, Vol. 11, Pages 500: How Cool Are Allotment Gardens? A Case Study of Nocturnal Air Temperature Differences in Berlin, Germany Atmosphere doi: 10.3390/atmos11050500 Authors: Rost Liste Seidel Matscheroth Otto Meier Fenner Urban green infrastructures have been extensively studied for their ability to mitigate the urban heat island (UHI) effect. However, allotment gardens (AGs)—a prominent type of urban green infrastructure within many European...
Wed May 13, 2020 03:00
Atmosphere, Vol. 11, Pages 501: Optical and Physical Characteristics of Aerosol Vertical Layers over Northeastern China Atmosphere doi: 10.3390/atmos11050501 Authors: Su Li Zhang Bilal Wang Atique Zhang Zhang Han Qiu Ali The optical and physical characteristics of the aerosol vertical layers over Northeastern China (NEC) are investigated using the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) Level 2 layer products...
Wed May 13, 2020 03:00
Atmosphere, Vol. 11, Pages 498: Geobibliography and Bibliometric Networks of Polar Tourism and Climate Change Research Atmosphere doi: 10.3390/atmos11050498 Authors: Demiroglu Hall In late 2019, the Intergovernmental Panel on Climate Change (IPCC) released their much-awaited Special Report on the Ocean and Cryosphere in a Changing Climate (SROCC). High mountain areas, polar regions, low-lying islands and coastal areas, and ocean and marine ecosystems, were separately dealt by experts...
Wed May 13, 2020 03:00
Atmosphere, Vol. 11, Pages 499: Molecular Distributions and Compound-Specific Stable Carbon Isotopic Compositions of Plant Wax n-Alkanes in Marine Aerosols along a North–South Transect in the Arctic–Northwest Pacific Region Atmosphere doi: 10.3390/atmos11050499 Authors: Jung-Hyun Kim Jiyeon Park Sol-Bin Kim Kyung-Hoon Shin Sookwan Kim Yeontae Gim A geographical source of n-alkanes in marine aerosols was assessed along a North–South transect in the Arctic–Northwest...
Wed May 13, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 91: Instability of Personality Traits of Teachers in Risk Conditions due to Work-Related Stress Behavioral Sciences doi: 10.3390/bs10050091 Authors: Ruggieri Iervolino Mossi Santoro Boccia The following study aims to verify whether psychosocial risk conditions determine a variation in personality traits. The sample consisted of 301 teachers, comprising 84 men (27.1%) and 217 women (72.9%). The Big Five Questionnaire (BFQ) was used...
Wed May 13, 2020 03:00
Biology, Vol. 9, Pages 98: A Comparative Study of Rat Urine 1H-NMR Metabolome Changes Presumably Arising from Isoproterenol-Induced Heart Necrosis Versus Clarithromycin-Induced QT Interval Prolongation Biology doi: 10.3390/biology9050098 Authors: Dallons Delcourt Schepkens Podrecca Colet Cardiotoxicity remains a challenging concern both in drug development and in the management of various clinical situations. There are a lot of examples of drugs withdrawn from the market...
Wed May 13, 2020 03:00
Biomedicines, Vol. 8, Pages 119: Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy Biomedicines doi: 10.3390/biomedicines8050119 Authors: Saleha Anwar Taj Mohammad Anas Shamsi Aarfa Queen Shahnaz Parveen Suaib Luqman Gulam Mustafa Hasan Khalid A. Alamry Naved Azum Abdullah M. Asiri Md. Imtaiyaz Hassan Design and development of potential pyruvate dehydrogenase kinase 3 (PDK3) inhibitors...
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Biomolecules, Vol. 10, Pages 760: Peroxisome Proliferator Activator Receptor Gamma Coactivator-1α Overexpression in Amyotrophic Lateral Sclerosis: A Tale of Two Transgenics Biomolecules doi: 10.3390/biom10050760 Authors: Merina Varghese Wei Zhao Kyle J. Trageser Giulio M. Pasinetti Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder manifesting with upper and lower neuron loss, leading to impairments in voluntary muscle function and atrophy. Mitochondrial...
Wed May 13, 2020 03:00
Biomolecules, Vol. 10, Pages 762: Ameliorative Effect of Gum Acacia on Hookah Smoke-Induced Testicular Impairment in Mice Biomolecules doi: 10.3390/biom10050762 Authors: Ali Al-Salam Balushi Za’abi Adham Beegam Yuvaraju Manoj Nemmar We investigated some reproductive actions of hookah smoke (HS) exposure (30 min/day, for 30 days) in male mice, and the possible mitigative effect of the prebiotic agent gum acacia (GA) thereon. Control mice were air-exposed...
Wed May 13, 2020 03:00
Biomolecules, Vol. 10, Pages 763: Electron Paramagnetic Resonance as a Tool for Studying Membrane Proteins Biomolecules doi: 10.3390/biom10050763 Authors: Sahu Lorigan Membrane proteins possess a variety of functions essential to the survival of organisms. However, due to their inherent hydrophobic nature, it is extremely difficult to probe the structure and dynamic properties of membrane proteins using traditional biophysical techniques, particularly in their native environments....
Wed May 13, 2020 03:00
Biomolecules, Vol. 10, Pages 761: High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways Biomolecules doi: 10.3390/biom10050761 Authors: Song Hwang Under glucose deprivation, cells heavily mobilize oxidative phosphorylation to maintain energy homeostasis. This leads to the generation of high levels of ATP, as well as reactive oxygen species (ROS), from mitochondria. In nutrient starvation, autophagy is activated,...
Wed May 13, 2020 03:00
Biomolecules, Vol. 10, Pages 758: Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602 Biomolecules doi: 10.3390/biom10050758 Authors: Furqan Batool Habib Shah Kalasz Darvas Kuca Nepovimova Batool Nurulain The study documented here was aimed to find the molecular interactions of some of the cannabinoid constituents of cannabis with acetylcholinesterase...
Wed May 13, 2020 03:00
Biomolecules, Vol. 10, Pages 757: Dynamic Expansion and Functional Evolutionary Profiles of Plant Conservative Gene Family SBP-Box in Twenty Two Flowering Plants and the Origin of miR156 Biomolecules doi: 10.3390/biom10050757 Authors: Li Gao Zhang Liu Conservative gene families in plants, which are closely related to innovations in flowering plants, have long and complex evolutionary histories. Here, we used the SQUAMOSA promoter-binding protein (SBP-box) gene family as...
Wed May 13, 2020 03:00
Biomolecules, Vol. 10, Pages 759: An Ice-Binding Protein from an Antarctic Ascomycete Is Fine-Tuned to Bind to Specific Water Molecules Located in the Ice Prism Planes Biomolecules doi: 10.3390/biom10050759 Authors: Yamauchi Arai Kondo Sasaki Tsuda Many microbes that survive in cold environments are known to secrete ice-binding proteins (IBPs). The structure–function relationship of these proteins remains unclear. A microbial IBP denoted AnpIBP was recently...
Wed May 13, 2020 03:00
Biomolecules, Vol. 10, Pages 756: Spironolactone and XPB: An Old Drug with a New Molecular Target Biomolecules doi: 10.3390/biom10050756 Authors: Ryan D. Gabbard Robert R. Hoopes Michael G. Kemp Spironolactone (SP) is commonly used for the treatment of heart failure, hypertension, and complications of cirrhosis by antagonizing the mineralocorticoid receptor. However, SP also antagonizes the androgen receptor, and thus SP has also been shown to be effective in the treatment of acne,...
Wed May 13, 2020 03:00
Biomolecules, Vol. 10, Pages 755: Different Classes of Phytohormones Act Synergistically to Enhance the Growth, Lipid and DHA Biosynthetic Capacity of Aurantiochytrium sp. SW1 Biomolecules doi: 10.3390/biom10050755 Authors: Yusuf Nazir Hafiy Halim Pranesha Prabhakaran Xiaojie Ren Tahira Naz Hassan Mohamed Shaista Nosheen Kiren Mustafa Wu Yang Aidil Abdul Hamid Yuanda Song In the present study, the impact of eight phytohormones from six different classes...
Wed May 13, 2020 03:00
Biosensors, Vol. 10, Pages 52: Paper-Based Working Electrodes Coated with Mercury or Bismuth Films for Heavy Metals Determination Biosensors doi: 10.3390/bios10050052 Authors: Sánchez-Calvo Blanco-López Costa-García Paper-based carbon working electrodes were modified with mercury or bismuth films for the determination of trace metals in aqueous solutions. Both modification procedures were optimized in terms of selectivity and sensitivity for the determination of different heavy...
Wed May 13, 2020 03:00
Biosensors, Vol. 10, Pages 51: Yeast-Based Biosensors: Current Applications and New Developments Biosensors doi: 10.3390/bios10050051 Authors: Helene Martin-Yken Biosensors are regarded as a powerful tool to detect and monitor environmental contaminants, toxins, and, more generally, organic or chemical markers of potential threats to human health. They are basically composed of a sensor part made up of either live cells or biological active molecules coupled to a transducer/reporter...
Wed May 13, 2020 03:00
Brain Sciences, Vol. 10, Pages 290: Differential Changes in Early Somatosensory Evoked Potentials between the Dominant and Non-Dominant Hand, Following a Novel Motor Tracing Task Brain Sciences doi: 10.3390/brainsci10050290 Authors: Mahboobeh Zabihhosseinian Ryan Gilley Danielle Andrew Bernadette Murphy Paul Yielder During training in a novel dynamic environment, the non-dominant upper limb favors feedback control, whereas the dominant limb favors feedforward mechanisms....
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Cancers, Vol. 12, Pages 1230: The Effects of Obesity on Anti-Cancer Immunity and Cancer Immunotherapy Cancers doi: 10.3390/cancers12051230 Authors: Matthew J. Woodall Silke Neumann Katrin Campbell Sharon T. Pattison Sarah L. Young Cancer is one of the leading causes of morbidity and mortality worldwide. Traditional treatments include surgery, chemotherapy and radiation therapy, and more recently targeted therapies including immunotherapy are becoming routine care for some...
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Cancers, Vol. 12, Pages 1228: Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer Cancers doi: 10.3390/cancers12051228 Authors: Thomas Radhakrishnan Pancreatic cancer (PC) is the utmost stroma-rich cancer, which is accompanied by fibrotic reactions that stimulate interactions between tumor cells and stroma to promote tumor progression. Considerable research evidence denotes that insulin-like growth factor (IGF)/IGF binding proteins (IGFBP) signaling axis facilitate...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1229: MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas Cancers doi: 10.3390/cancers12051229 Authors: Gluud Willerslev-Olsen Gjerdrum Lindahl Buus Andersen Bonefeld Krejsgaard Litvinov Iversen Becker Persson Koralov Litman Geisler Woetmann Odum Cutaneous T-cell lymphoma (CTCL) represents a heterogeneous group of potentially devastating primary...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1227: LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity Cancers doi: 10.3390/cancers12051227 Authors: Dorn Glaß Neu Heydel Hüttelmaier Gutschner Haemmerle Pancreatic adenocarcinoma (PDAC) is one of the major causes of cancer-associated deaths worldwide, with a dismal prognosis that has not significantly changed over the last decades. Transcriptional analysis has provided valuable...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1219: Novel Gene Fusions in Glioblastoma Tumor Tissue and Matched Patient Plasma Cancers doi: 10.3390/cancers12051219 Authors: Lan Wang Anudeep Yekula Koushik Muralidharan Julia L. Small Zachary S. Rosh Keiko M. Kang Bob S. Carter Leonora Balaj Sequencing studies have provided novel insights into the heterogeneous molecular landscape of glioblastoma (GBM), unveiling a subset of patients with gene fusions. Tissue biopsy is highly invasive,...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1226: Erratum: Benelli, R., et al. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. Cancers 2020, 12, 971 Cancers doi: 10.3390/cancers12051226 Authors: Roberto Benelli Delfina Costa Luca Mastracci Federica Grillo Mark Jon Olsen Paola Barboro Alessandro Poggi Nicoletta Ferrari The authors wish to make the following corrections to this paper [...]
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1224: Merkel Cell Carcinoma Treatment in Finland in 1986–2016—A Real-World Data Study Cancers doi: 10.3390/cancers12051224 Authors: Helka Sahi Jenny Their Mika Gissler Virve Koljonen Merkel cell carcinoma (MCC) is a rare cutaneous carcinoma that has gained enormous interest since the discovery of Merkel cell polyoma virus, which is a causative oncogenic agent in the majority of MCC tumours. Increased research has focused on effective treatment options...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1225: Functional Link between miR-200a and ELK3 Regulates the Metastatic Nature of Breast Cancer Cancers doi: 10.3390/cancers12051225 Authors: Hyung-Keun Kim Joo Dong Park Seung Hee Choi Dong Jun Shin Sohyun Hwang Hae-Yun Jung Kyung-Soon Park Triple-negative breast cancer (TNBC) refers to breast cancer that does not have receptors for estrogen, progesterone, and HER2 protein. TNBC accounts for 10–20% of all cases of breast cancers and...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1223: Treatment of Smoldering Multiple Myeloma: Ready for Prime Time? Cancers doi: 10.3390/cancers12051223 Authors: E. Bridget Kim Andrew J. Yee Noopur Raje The current standard of care for smoldering multiple myeloma (SMM) is observation until there is end-organ involvement. With newer and more effective treatments available, a question that is increasingly asked is whether early intervention in patients with SMM will alter the natural history of their...
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