Related ArticlesMetabolic switches from quiescence to growth in synchronized Saccharomyces cerevisiae. Metabolomics. 2019 08 29;15(9):121 Authors: Zhang J, Martinez-Gomez K, Heinzle E, Wahl SA Abstract INTRODUCTION: The switch from quiescence (G0) into G1 and cell cycle progression critically depends on specific nutrients and metabolic capabilities. Conversely, metabolic networks are regulated by enzyme-metabolite interaction and transcriptional regulation...
Fri May 01, 2020 13:42
Related ArticlesProlactin hormone exerts anti-tumorigenic effects in HER-2 overexpressing breast cancer cells through regulation of stemness. Stem Cell Res. 2019 10;40:101538 Authors: Hachim IY, López-Ozuna VM, Hachim MY, Lebrun JJ, Ali S Abstract BACKGROUND: Breast cancers characterized by HER2 overexpression, belong to HER-2 enriched or luminal B subtypes, are frequently associated with higher incidence of tumor recurrence and therapeutic failure....
Fri May 01, 2020 13:42
Related ArticlesOverexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity. Sci Rep. 2019 01 17;9(1):192 Authors: Tavernelli LE, Motta MCM, Gonçalves CS, da Silva MS, Elias MC, Alonso VL, Serra E, Cribb P Abstract Kinetoplastid parasites, included Trypanosoma cruzi, the causal agent of Chagas disease, present a unique genome organization and gene...
Fri May 01, 2020 13:42
Related ArticlesRevisiting Cationic Phosphorus Dendrimers as a Nonviral Vector for Optimized Gene Delivery Towards Cancer Therapy Applications. Biomacromolecules. 2020 Apr 29;: Authors: Chen L, Li J, Fan Y, Qiu J, Cao L, Laurent R, Mignani S, Caminade AM, Majoral JP, Shi X Abstract Gene delivery, one important cancer therapy mode, still remains to be challenging due to the shortage of highly efficient and safe non-viral vectors. Here, we revisit...
Thu Apr 30, 2020 14:21
Related ArticlesEvidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia. Schizophr Bull. 2020 Apr 29;: Authors: Esaki K, Balan S, Iwayama Y, Shimamoto-Mitsuyama C, Hirabayashi Y, Dean B, Yoshikawa T Abstract The disturbed integrity of myelin and white matter, along with dysregulation of the lipid metabolism, may be involved in schizophrenia pathophysiology. Considering the crucial role of sphingolipids...
Thu Apr 30, 2020 13:25
Related ArticlesCAR T-cell therapy for a relapsed/refractory acute B-cell lymphoblastic lymphoma patient in the context of Li-Fraumeni syndrome. J Immunother Cancer. 2020 Apr;8(1): Authors: Chen L, Xu B, Long X, Gu J, Lou Y, Wang D, Cao Y, Wang N, Li C, Wang G, Wang Y, Zhu L, Wang J, An H, Xiao M, Xiao Y, Zhou J Abstract BACKGROUND: Li-Fraumeni syndrome (LFS) is characterized as an autosomal dominant cancer predisposition disorder caused by germline...
Thu Apr 30, 2020 13:25
Related ArticlesNDRG2 gene expression pattern in ovarian cancer and its specific roles in inhibiting cancer cell proliferation and suppressing cancer cell apoptosis. J Ovarian Res. 2020 Apr 28;13(1):48 Authors: Kang F, Wang Y, Luo Y, Zhang Y Abstract BACKGROUND: The cancer cell metastasis and the acquisition of chemotherapy resistance remain huge challenge for ovarian cancer treatment. Previously, N-myc downstream-regulated gene 2 (NDRG2) serves...
Thu Apr 30, 2020 13:25
Related ArticlesA novel kefir product (PFT) inhibits Ehrlich ascites carcinoma in mice via induction of apoptosis and immunomodulation. BMC Complement Med Ther. 2020 Apr 28;20(1):127 Authors: Badr El-Din NK, Shabana SM, Abdulmajeed BA, Ghoneum M Abstract BACKGROUND: The popularity of fermented foods such as kefir, kuniss, and tofu has been greatly increasing over the past several decades, and the ability of probiotic bacteria to exert anticancer...
Thu Apr 30, 2020 13:25
Related ArticlesThe Effects of Human BDH2 on the Cell Cycle, Differentiation, and Apoptosis and Associations with Leukemia Transformation in Myelodysplastic Syndrome. Int J Mol Sci. 2020 Apr 25;21(9): Authors: Yang WC, Lin SF, Wang SC, Tsai WC, Wu CC, Wu SC Abstract Iron overload is related to leukemia transformation in myelodysplastic syndrome (MDS) patients. Siderophores help to transport iron. Type 2-hydroxybutyrate dehydrogenase (BDH2) is a rate-limiting...
Thu Apr 30, 2020 13:25
Related ArticlesSenescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing. Pharmaceutics. 2020 Apr 24;12(4): Authors: Blokland KEC, Waters DW, Schuliga M, Read J, Pouwels SD, Grainge CL, Jaffar J, Westall G, Mutsaers SE, Prêle CM, Burgess JK, Knight DA Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease marked by excessive accumulation of lung fibroblasts (LFs)...
Thu Apr 30, 2020 13:25
Related ArticlesHybrid Sterility with Meiotic Metaphase Arrest in Intersubspecific Mouse Crosses. J Hered. 2019 03 05;110(2):183-193 Authors: Nishino R, Petri S, Handel MA, Kunieda T, Fujiwara Y Abstract Although organisms belonging to different species and subspecies sometimes produce fertile offspring, a hallmark of the speciation process is reproductive isolation, characterized by hybrid sterility (HS) due to failure in gametogenesis. In mammals,...
Thu Apr 30, 2020 13:25
Related ArticlesVorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy. Ann Clin Transl Neurol. 2020 May 02;: Authors: Zierfuss B, Weinhofer I, Kühl JS, Köhler W, Bley A, Zauner K, Binder J, Martinović K, Seiser C, Hertzberg C, Kemp S, Egger G, Leitner G, Bauer J, Wiesinger C, Kunze M, Forss-Petter S, Berger J Abstract OBJECTIVE: To identify a pharmacological compound targeting macrophages, the most affected immune cells in inflammatory...
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Related ArticlesClinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia. Leukemia. 2020 May 01;: Authors: Bamopoulos SA, Batcha AMN, Jurinovic V, Rothenberg-Thurley M, Janke H, Ksienzyk B, Philippou-Massier J, Graf A, Krebs S, Blum H, Schneider S, Konstandin N, Sauerland MC, Görlich D, Berdel WE, Woermann BJ, Bohlander SK, Canzar S, Mansmann U, Hiddemann W, Braess J, Spiekermann K, Metzeler KH, Herold...
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Related ArticlesTechnology Use for Adolescent Health and Wellness. Pediatrics. 2020 May;145(Suppl 2):S186-S194 Authors: Radovic A, Badawy SM Abstract As avid users of technology, adolescents are a key demographic to engage when designing and developing technology applications for health. There are multiple opportunities for improving adolescent health, from promoting preventive behaviors to providing guidance for adolescents with chronic illness in supporting...
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Related ArticlesExtrapulmonary poorly differentiated NECs, including molecular and immune aspects. Endocr Relat Cancer. 2020 May 01;: Authors: McNamara MG, Scoazec JY, Walter T Abstract Patients with extrapulmonary poorly differentiated neuroendocrine carcinomas (EP-PD-NECs) have a poor prognosis. Surgery is offered for those with localised disease, but the majority of patients present with advanced disease. Treatment strategies adopted are analogous...
Sat May 02, 2020 15:00
Related ArticlesEffectiveness of a Quit Vaping Text Message Program in Promoting Abstinence Among Young Adult E-Cigarette Users: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2020 May 01;9(5):e18327 Authors: Graham AL, Jacobs MA, Amato MS, Cha S, Bottcher MM, Papandonatos GD Abstract BACKGROUND: Millions of young adults currently vape electronic cigarettes (e-cigarettes), yet little research on vaping cessation interventions exists. Text...
Sat May 02, 2020 15:00
Related ArticlesDinutuximab in adult-onset chemotherapy refractory high-risk neuroblastoma. J Oncol Pharm Pract. 2020 May 01;:1078155220918920 Authors: Garrovillo K, Garrett J, Bollin K, Nasraty F, Sikand H Abstract INTRODUCTION: Neuroblastoma is the most common extracranial solid tumor in pediatrics but is considerably uncommon in adults, with approximately 1 case per 10 million diagnosed per year and is associated with poor prognosis. There are no...
Sat May 02, 2020 15:00
Related ArticlesRecurrence pattern in the presence of hepatosteatosis in breast cancer: does it facilitate liver metastasis? Future Oncol. 2020 May 01;: Authors: Kus T, Cinkir HY, Aktas G, Abali H Abstract Aim: We aimed to investigate the impact of hepatosteatosis (HS) severity on the recurrence pattern of breast cancer and to clarify whether HS causes affinity to recurrence with liver metastasis. Materials & methods: The median follow-up was 80.0...
Sat May 02, 2020 15:00
Related ArticlesPhase II open-label study investigating apalutamide in patients with biochemical progression after radical prostatectomy. Future Oncol. 2020 May 01;: Authors: Dirix P, Strijbos M, den Mooter TV, Liefhooghe N, Bruwaene SV, Uvin P, Ghysel C, Ost D, Schatteman P, Bral S, Engels B, den Begin RV, Otte FX, Roumeguere T, Palumbo S, Neybuch Y, Fonteyne V, Ost P, Dirix L Abstract Apalutamide, a competent inhibitor of the androgen receptor, has...
Sat May 02, 2020 15:00
Related ArticlesAnalysis of differential metabolites in lung cancer patients based on metabolomics and bioinformatics. Future Oncol. 2020 May 01;: Authors: Zhao C, Kong X, Han S, Li X, Wu T, Zhou J, Guo Y, Bu Z, Liu C, Zhang C, Jia Y Abstract Aim: Based on metabonomics, the metabolic markers of lung cancer patients were analyzed, combined with bioinformatics to explore the underlying disease mechanism. Materials & methods: Based on case-control design,...
Sat May 02, 2020 15:00
Related ArticlesTelemedicine for cancer patients during COVID-19 pandemic: between threats and opportunities. Future Oncol. 2020 May 01;: Authors: Elkaddoum R, Haddad FG, Eid R, Kourie HR PMID: 32356460 [PubMed - as supplied by publisher]
Sat May 02, 2020 15:00
Related ArticlesHemostatic radiotherapy for inoperable gastric cancer: A pilot study. Br J Radiol. 2020 May 01;:20190958 Authors: Tanaka O, Sugiyama A, Omatsu T, Tawada M, Makita C, Matsuo M Abstract OBJECTIVES: Standard treatment for progressive gastric cancer with bleeding includes hemostatic radiotherapy (RT); however, the only prospective study using a fixed dose with fractions during hemostatic RT did not introduce re-irradiation. Therefore, we...
Sat May 02, 2020 15:00
Related ArticlesThe mediator role of unmet needs on quality of life in myeloma patients. Qual Life Res. 2020 Apr 30;: Authors: Pereira MG, Vilaça M, Pereira M, Ferreira G, Monteiro S, Coelho H, Geraldes C, Gonçalves C, da Costa FL, Marques H, Bacalhau R Abstract PURPOSE: The diagnosis of multiple myeloma (MM) has a significant impact on patients. This study analyzed the mediating role of patients' unmet needs in the relationship between psychological...
Sat May 02, 2020 13:12
Related ArticlesCharacteristics and Clinical Outcomes of Non-small Cell Lung Cancer Patients in Korea With MET Exon 14 Skipping. In Vivo. 2020 May-Jun;34(3):1399-1406 Authors: Hur JY, Ku BM, Shim JH, Jung HA, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ Abstract BACKGROUND/AIM: MET exon 14 skipping occurs in 3-4% of patients with lung adenocarcinomas. In this study, we performed a comprehensive analysis of clinical data from Korean non-small cell lung cancer...
Sat May 02, 2020 13:12
Related ArticlesTargeting Hippo-dependent and Hippo-independent YAP1 signaling for the treatment of childhood rhabdomyosarcoma. Cancer Res. 2020 Apr 30;: Authors: Slemmons KK, Yeung C, Baumgart JT, Martinez Juarez JO, McCalla A, Helman LJ Abstract Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma, yet patients with metastatic or recurrent disease continue to do poorly, indicating a need for new treatments. The SRC family tyrosine...
Sat May 02, 2020 13:12
Related ArticlesWhole-Blood DNA Methylation Markers in Early Detection of Breast Cancer: A Systematic Literature Review. Cancer Epidemiol Biomarkers Prev. 2019 03;28(3):496-505 Authors: Guan Z, Yu H, Cuk K, Zhang Y, Brenner H Abstract Whole-blood DNA methylation markers have been suggested as potential biomarkers for early detection of breast cancer. We conducted a systematic review of the literature on whole-blood DNA methylation markers for breast...
Sat May 02, 2020 13:12
Induced pluripotent stem cell-derived myeloid cells expressing OX40 ligand amplify antigen-specific T cells in advanced melanoma. Pigment Cell Melanoma Res. 2020 Apr 30;: Authors: Kimura T, Fukushima S, Okada E, Kuriyama H, Kanemaru H, Kadohisa-Tsuruta M, Kubo Y, Nakahara S, Tokuzumi A, Kajihara I, Makino K, Miyashita A, Aoi J, Makino T, Tsukamoto H, Nishimura Y, Inozume T, Zhang R, Uemura Y, Senju S, Ihn H Abstract Immune checkpoint inhibitors improved...
Fri May 01, 2020 13:53
Suggestions Regarding the GEICAM/2003-11_CIBOMA/2004-01 Trial: Future Treatment Options for Early Triple-Negative Breast Cancer. J Clin Oncol. 2020 Apr 30;:JCO1903406 Authors: Usui Y, Ishiki H, Shimomura A, Satomi E PMID: 32352859 [PubMed - as supplied by publisher]
Fri May 01, 2020 13:53
Treatment sequence of first and second generation tyrosine kinase inhibitor followed by osimertinib in EGFR-mutated non-small-cell lung cancer: a real life study. Future Oncol. 2020 Apr 30;: Authors: Girard N, Moro-Sibilot D, Bouée S, Emery C, Torreton E, Le Lay K, Luciani L, Maritaz C, Chouaid C Abstract Background: We aimed to assess the effectiveness and cost of patients with first line tyrosine kinase inhibitors (TKIs) sequence of first (1G) and...
Fri May 01, 2020 13:53
IMbrave 050: a Phase III trial of atezolizumab plus bevacizumab in high-risk hepatocellular carcinoma after curative resection or ablation. Future Oncol. 2020 Apr 30;: Authors: Hack SP, Spahn J, Chen M, Cheng AL, Kaseb A, Kudo M, Lee HC, Yopp A, Chow P, Qin S Abstract Hepatocellular carcinoma recurs in 70-80% of cases following potentially curative resection or ablation and the immune component of the liver microenvironment plays a key role in recurrence....
Fri May 01, 2020 13:53
Philip John DiSaia, MD: Available Light & The Origin of Storms. J Obstet Gynaecol Res. 2020 Apr 30;: Authors: Tewari KS, Monk BJ Abstract During a career, which spanned nearly 60 years, Professor Philip J. DiSaia (1937-2018) trailblazed a path forward in academic medicine, which would become the standard by which Departments of Obstetrics and Gynecology and Gynecologic Oncology Divisions and Cancer Centers would be measured throughout the United...
Fri May 01, 2020 13:53
Parent Knowledge of Screening and Genetic Testing in Retinoblastoma. J Ophthalmol. 2020;2020:3839792 Authors: Xiao W, Ji X, Ye H, Zeng H, Gao Y, Chen R, Chen X, Mao Y, Yang H Abstract Purpose: To evaluate parent knowledge of screening and genetic testing for retinoblastoma and its potential correlation with demographics, clinical features, and socioeconomical factors. Methods: It was a cross-sectional study conducted at the ocular oncology unit...
Fri May 01, 2020 13:53
Colorectal signet ring cell carcinoma: advancing research in a rare cancer. Future Oncol. 2020 Apr 30;: Authors: Barresi V, Pedrazzani C PMID: 32351144 [PubMed - as supplied by publisher]
Fri May 01, 2020 13:53
Gmcsf and Ifnα gene therapy improves the response to BCG immunotherapy in a murine model of bladder cancer. Future Oncol. 2020 Apr 30;: Authors: Tham SM, Mahendran R, Chiong E, Wu QH, Esuvaranathan K Abstract Aim: To develop a strategy to improve response to bacillus Calmette-Gueri (BCG) using cytokine gene therapy (Gmcsf + Ifnα). Materials & methods: MB49-PSA tumor-bearing C57BL/6N mice were assigned into four groups: control; Gmcsf + Ifnα therapy;...
Fri May 01, 2020 13:53
COVID 19 outbreak: impact of the quarantine-induced stress on cardiovascular disease risk burden. Future Cardiol. 2020 Apr 30;: Authors: Mattioli AV, Nasi M, Cocchi C, Farinetti A PMID: 32351128 [PubMed - as supplied by publisher]
Fri May 01, 2020 13:53
Related ArticlesRestoration of Functional Sperm Production in Irradiated Pubertal Rhesus Monkeys by Spermatogonial Stem Cell Transplantation. Andrology. 2020 Apr 29;: Authors: Shetty G, Mitchell JM, Meyer JM, Wu Z, Lam TNA, Phan TT, Zhang J, Hill L, Tailor RC, Peters KA, Penedo MC, Hanna C, Orwig KE, Meistrich ML Abstract BACKGROUND: In male prepubertal cancer patients, radiation and chemotherapy impact future fertility by eradication of spermatogonial...
Fri May 01, 2020 13:53
Related ArticlesNeurological adverse effects due to programmed death 1 (PD-1) inhibitors. J Neurooncol. 2020 Apr 29;: Authors: Shi S, Jaoube JA, Kanwar R, Jin MC, Amorin A, Varanasi V, Eisinger E, Thomas R, Moore JM Abstract PURPOSE: PD-1 Immunotherapy is integral in treating multiple cancers, but has been associated with neurological adverse events (nAEs). Our study was aimed at identifying the clinical spectrum of nAEs associated with pembrolizumab...
Fri May 01, 2020 13:53
Related ArticlesRecurrent Treatment in Ovarian Cancer Patients: What Are the Best Regimens and the Order They Should Be Given? Curr Treat Options Oncol. 2020 Apr 30;21(6):49 Authors: Glajzer J, Grabowski JP, Sehouli J, Pfisterer J Abstract OPINION STATEMENT: The choice of the right treatment regimen for recurrent ovarian cancer (rOC) remains a case-by-case decision. It is based on multiple factors that involve patient characteristics and biological factors...
Fri May 01, 2020 13:53
Related ArticlesInhibition of Brain EGFR Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries. Mol Pharmacol. 2020 Apr 29;: Authors: Tavassoly O, Sato T, Tavassoly I Abstract Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathological and behavioral conditions in neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and...
Fri May 01, 2020 13:53
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