Related ArticlesNeurological adverse effects due to programmed death 1 (PD-1) inhibitors. J Neurooncol. 2020 Apr 29;: Authors: Shi S, Jaoube JA, Kanwar R, Jin MC, Amorin A, Varanasi V, Eisinger E, Thomas R, Moore JM Abstract PURPOSE: PD-1 Immunotherapy is integral in treating multiple cancers, but has been associated with neurological adverse events (nAEs). Our study was aimed at identifying the clinical spectrum of nAEs associated with pembrolizumab...
Fri May 01, 2020 13:53
Related ArticlesRecurrent Treatment in Ovarian Cancer Patients: What Are the Best Regimens and the Order They Should Be Given? Curr Treat Options Oncol. 2020 Apr 30;21(6):49 Authors: Glajzer J, Grabowski JP, Sehouli J, Pfisterer J Abstract OPINION STATEMENT: The choice of the right treatment regimen for recurrent ovarian cancer (rOC) remains a case-by-case decision. It is based on multiple factors that involve patient characteristics and biological factors...
Fri May 01, 2020 13:53
Related ArticlesInhibition of Brain EGFR Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries. Mol Pharmacol. 2020 Apr 29;: Authors: Tavassoly O, Sato T, Tavassoly I Abstract Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathological and behavioral conditions in neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and...
Fri May 01, 2020 13:53
Related ArticlesCEOP/IVE/GDP alternating regimen compared with CEOP as the first-line therapy for newly diagnosed patients with peripheral T cell lymphoma: results from a phase 2, multicenter, randomized, controlled clinical trial. Genome Med. 2020 Apr 30;12(1):41 Authors: Cai MC, Cheng S, Wang X, Hu JD, Song YP, Huang YH, Yan ZX, Jiang YJ, Fang XS, Zheng XY, Dong LH, Ji MM, Wang L, Xu PP, Zhao WL Abstract BACKGROUND: Cyclophosphamide, doxorubicin, vincristine,...
Fri May 01, 2020 13:53
Related ArticlesThe current reality of soft tissue sarcomas: advances, controversies, areas for improvement, and promising new treatments. Expert Rev Anticancer Ther. 2020 Apr 29;:1-11 Authors: Blay JY, Le Cesne A, Demetri GD Abstract Introduction: Soft tissue sarcomas (STS) encompass a group of rare and heterogeneous cancers. Rapid evolution in the field justifies a focused critical review of the clinical literature.Areas covered: Important advances,...
Fri May 01, 2020 13:53
Related ArticlesThe Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies. Nanomaterials (Basel). 2020 Apr 27;10(5): Authors: Mulens-Arias V, Rojas JM, Barber DF Abstract Over the last 20 years, iron oxide nanoparticles (IONPs) have been the subject of increasing investigation due to their potential use as theranostic agents. Their unique physical properties (physical identity),...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of lung cancer attributable to PM2.5 in Canada. Prev Med. 2019 05;122:91-99 Authors: Gogna P, Narain TA, O'Sullivan DE, Villeneuve PJ, Demers PA, Hystad P, Brenner DR, Friedenreich CM, King WD, ComPARe Study Team Abstract The International Agency for Research on Cancer has classified PM2.5 (fine particulate matter, PM2.5) as a lung cancer carcinogen in humans. We estimated the proportion of...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of cancer attributable to active and passive tobacco smoking in Canada. Prev Med. 2019 05;122:9-19 Authors: Poirier AE, Ruan Y, Grevers X, Walter SD, Villeneuve PJ, Friedenreich CM, Brenner DR, ComPARe Study Team Abstract Although previous studies have examined the burden of cancer attributable to tobacco smoking, updated estimates are needed given the dramatic changes in smoking behaviours...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of melanoma attributable to ultraviolet radiation in Canada. Prev Med. 2019 05;122:81-90 Authors: O'Sullivan DE, Brenner DR, Villeneuve PJ, Walter SD, Demers PA, Friedenreich CM, King WD, ComPARe Study Team Abstract Exposure to ultraviolet radiation (UVR) is an established cause of cutaneous melanoma. The purpose of this study was to estimate the current attributable and future avoidable burden...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of cancer attributable to sedentary behavior in Canada. Prev Med. 2019 05;122:73-80 Authors: Friedenreich CM, Pader J, Barberio AM, Ruan Y, Poirier AE, Grevers X, Walter SD, Villeneuve PJ, Brenner DR, ComPARe Study Team Abstract Leisure-time sedentary behavior is an emerging modifiable risk factor for cancer. We estimated the proportion of cancers attributed to leisure-time sedentary behavior...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of cancer attributable to lack of physical activity in Canada. Prev Med. 2019 05;122:65-72 Authors: Friedenreich CM, Barberio AM, Pader J, Poirier AE, Ruan Y, Grevers X, Walter SD, Villeneuve PJ, Brenner DR, ComPARe Study Team Abstract Physical activity reduces the risk of many cancers, yet the prevalence of inadequate physical activity among Canadians remains high. Here we estimated the current...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of cancer attributable to excess body weight and abdominal adiposity in Canada. Prev Med. 2019 05;122:49-64 Authors: Brenner DR, Poirier AE, Ruan Y, Hebert LA, Grevers X, Walter SD, Villeneuve PJ, Friedenreich CM, ComPARe Study Team Abstract The increasing prevalence of obesity among Canadians has important implications for newly diagnosed cases of cancer given that excess body weight and abdominal...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of cancer attributable to alcohol consumption in Canada. Prev Med. 2019 05;122:40-48 Authors: Grevers X, Ruan Y, Poirier AE, Walter SD, Villeneuve PJ, Friedenreich CM, Brenner DR, ComPARe Study Team Abstract Alcohol consumption is associated with elevated risk of oropharyngeal, laryngeal, esophageal, colon, rectal, breast, liver, pancreatic and stomach cancers. The purpose of this analysis was...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of cancer attributable to red and processed meat consumption in Canada. Prev Med. 2019 05;122:31-39 Authors: Ruan Y, Poirier AE, Hebert LA, Grevers X, Walter SD, Villeneuve PJ, Brenner DR, Friedenreich CM, ComPARe Study Team Abstract Red meat and processed meat have been consistently associated with an increased risk of colorectal, stomach, pancreatic cancer and esophageal cancer (processed...
Fri May 01, 2020 13:53
Related ArticlesThe burden of cancer attributable to modifiable risk factors in Canada: Methods overview. Prev Med. 2019 05;122:3-8 Authors: Brenner DR, Friedenreich CM, Ruan Y, Poirier AE, Walter SD, King WD, Franco EL, Demers PA, Villeneuve PJ, Grevers X, Nuttall R, Smith LM, Volesky KD, O'Sullivan DE, De P, ComPARe Study Team Abstract Up-to-date estimates of current and projected future cancer burden attributable to various exposures are essential...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of cancer attributable to low fruit and vegetable consumption in Canada. Prev Med. 2019 05;122:20-30 Authors: Poirier AE, Ruan Y, Hebert LA, Grevers X, Walter SD, Villeneuve PJ, Brenner DR, Friedenreich CM, ComPARe Study Team Abstract Low fruit and vegetable consumption is associated with colorectal cancer and may be associated with lung, breast, bladder, pancreatic, ovarian, liver, stomach,...
Fri May 01, 2020 13:53
Related ArticlesThe current and future burden of cancer attributable to modifiable risk factors in Canada: Summary of results. Prev Med. 2019 05;122:140-147 Authors: Poirier AE, Ruan Y, Volesky KD, King WD, O'Sullivan DE, Gogna P, Walter SD, Villeneuve PJ, Friedenreich CM, Brenner DR, ComPARe Study Team Abstract Nearly one in two Canadians are expected to be diagnosed with cancer in their lifetime. However, there are opportunities to reduce the impact...
Fri May 01, 2020 13:53
Related ArticlesThe current burden of cancer attributable to occupational exposures in Canada. Prev Med. 2019 05;122:128-139 Authors: Labrèche F, Kim J, Song C, Pahwa M, Ge CB, Arrandale VH, McLeod CB, Peters CE, Lavoué J, Davies HW, Nicol AM, Demers PA Abstract Exposure to occupational carcinogens is often overlooked as a contributor to the burden of cancer. To estimate the proportion of cancer cases attributable to occupational exposure in Canada...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the future burden of cancer attributable to infections in Canada. Prev Med. 2019 05;122:118-127 Authors: Volesky KD, El-Zein M, Franco EL, Brenner DR, Friedenreich CM, Ruan Y, ComPARe Study Team Abstract More than 7000 incident cancers diagnosed in Canada in 2015 were attributable to infections. The future infection-associated cancer burden can be lowered by reducing the prevalence of major cancer-causing infections; hepatitis...
Fri May 01, 2020 13:53
Related ArticlesEstimates of the current and future burden of lung cancer attributable to residential radon exposure in Canada. Prev Med. 2019 05;122:100-108 Authors: Gogna P, Narain TA, O'Sullivan DE, Villeneuve PJ, Demers PA, Hystad P, Brenner DR, Friedenreich CM, King WD, ComPARe Study Team Abstract Radon is widely recognized as a human carcinogen and findings from epidemiologic studies support a causal association between residential radon exposure...
Fri May 01, 2020 13:53
Related ArticlesHepatocellular carcinoma up-regulated long non-coding RNA: a putative marker in multiple sclerosis. Metab Brain Dis. 2019 08;34(4):1201-1205 Authors: Sayad A, Taheri M, Arsang-Jang S, Glassy MC, Ghafouri-Fard S Abstract Highly up-regulated in liver cancer (HULC) is a cancer-associated long non-coding RNA (lncRNA) which may regulate expression of other genes by working as a competing RNA for microRNAs. In the current study, we assessed...
Fri May 01, 2020 13:53
Related ArticlesCould India be the origin of next COVID-19 like epidemic? Sci Total Environ. 2020 Apr 22;728:138918 Authors: Minhas S Abstract The COVID-19 global pandemic is not even over yet but it has already taught us a lot of lessons - the hard way. The vast majority of the global community has blamed the Chinese Illegal wildlife markets for the origin of this pandemic. Through careful scientific analysis, I have explained in this article that we...
Thu Apr 30, 2020 14:31
Related ArticlesThe central role of provider training in implementing resource-stratified guidelines for palliative care in low-income and middle-income countries: Lessons from the Jamaica Cancer Care and Research Institute in the Caribbean and Universidad Católica in Latin America. Cancer. 2020 May 15;126 Suppl 10:2448-2457 Authors: Stoltenberg M, Spence D, Daubman BR, Greaves N, Edwards R, Bromfield B, Perez-Cruz PE, Krakauer EL, Argentieri MA, Shields AE Abstract...
Thu Apr 30, 2020 14:31
Related ArticlesThe role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment. Expert Opin Investig Drugs. 2020 Apr 29;: Authors: Buckens OJ, El Hassouni B, Giovannetti E, Peters GJ Abstract Introduction: Erythropoietin-producing human hepatocellular (Eph) receptors are among the largest family of tyrosine kinases that are divided into two classes: EphA and EphB receptors. Over the past two decades, their role in cancer...
Thu Apr 30, 2020 14:31
Related ArticlesPrevalence of Neisseria gonorrhoeae and Trichomonas vaginalis in Portuguese women of childbearing age. J Obstet Gynaecol. 2020 Apr 29;:1-5 Authors: Silva J, Cerqueira F, Teixeira AL, Campainha R, Amorim J, Medeiros R Abstract The purpose of this study was to evaluate the prevalence of Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) in Portuguese women of childbearing age. Cervicovaginal self-collected samples of 680 childbearing-age...
Thu Apr 30, 2020 14:31
Related ArticlesThe prognostic and predictive role of 21-gene recurrence scores in hormone receptor-positive early-stage breast cancer. J Surg Oncol. 2020 Apr 28;: Authors: Ahmed S, Pati S, Le D, Haider K, Iqbal N Abstract Over the past two decades, gene expression profiling of breast cancer has emerged as an important tool in early-stage breast cancer management. The approach provides important information on underlying biological mechanisms, breast...
Thu Apr 30, 2020 13:38
Related ArticlesCognitive complaints by hematopoietic cell transplantation recipients and change in neuropsychological performance over time. Support Care Cancer. 2020 Apr 28;: Authors: LaLonde L, Votruba K, Kentor R, Gatza E, Choi SW, Hoodin F Abstract PURPOSE: Hematopoietic stem cell transplant (HSCT) recipients are at risk for cognitive decline. Cross-sectional studies show patients' complaints of cognitive decline do not correlate well with concurrently...
Thu Apr 30, 2020 13:38
Related ArticlesAn Observational Study of Team Management Approach for CapeOX Therapy in Patients with Advanced and Recurrent Colorectal Cancer: SMILE Study (The Study of Metastatic colorectal cancer to investigate the Impact of Learning Effect). J Anus Rectum Colon. 2020;4(2):79-84 Authors: Matsuoka H, Ogata Y, Nakamura M, Shibata Y, Munemoto Y, Bando H, Nishijima K, Okuda H, Terada I, Shiroiwa T, Kishimoto J, Maeda K Abstract Objectives: In recent...
Thu Apr 30, 2020 13:38
Related ArticlesThe Impact of a Communication Skills Workshop on Doctors' Behavior Over Time. Adv Med Educ Pract. 2020;11:289-294 Authors: Bylund CL, Adams KA, Sinha T, Afana A, Yassin MA, El Geziry A, Nauman A, Al-Romaihi S, Anand A Abstract Purpose: Communication skills education is still relatively new in some non-Western countries. Further, most evaluation research on communication skills education examines only short-term results. In our communication...
Thu Apr 30, 2020 13:38
Related ArticlesHaploidentical hematopoietic stem cell transplantation in aplastic anemia: a systematic review and meta-analysis of clinical outcome on behalf of the severe aplastic anemia working party of the European group for blood and marrow transplantation (SAAWP of EBMT). Bone Marrow Transplant. 2020 Apr 28;: Authors: ElGohary G, El Fakih R, de Latour R, Risitano A, Marsh J, Schrezenmeier H, Gluckman E, Höchsmann B, Pierri F, Halkes C, Alzahrani H, De la Fuente...
Thu Apr 30, 2020 13:38
Related ArticlesOncobiosis and Microbial Metabolite Signaling in Pancreatic Adenocarcinoma. Cancers (Basel). 2020 Apr 25;12(5): Authors: Kiss B, Mikó E, Sebő É, Toth J, Ujlaki G, Szabó J, Uray K, Bai P, Árkosy P Abstract Pancreatic adenocarcinoma is one of the most lethal cancers in both men and women, with a median five-year survival of around 5%. Therefore, pancreatic adenocarcinoma represents an unmet medical need. Neoplastic diseases, such as pancreatic...
Thu Apr 30, 2020 13:38
The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids-From Bench to Bedside.
Related ArticlesThe Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids-From Bench to Bedside. Int J Mol Sci. 2020 Apr 24;21(8): Authors: Ciebiera M, Włodarczyk M, Zgliczyński S, Łoziński T, Walczak K, Czekierdowski A Abstract Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. Their prevalence usually is estimated at 30-40%, but may reach up to 70-80% in predisposed groups of women. UFs may cause...
Thu Apr 30, 2020 13:38
Related ArticlesClinical factors and biomarkers predict outcome in patients with immune-mediated thrombotic thrombocytopenic purpura. Haematologica. 2019 01;104(1):166-175 Authors: Staley EM, Cao W, Pham HP, Kim CH, Kocher NK, Zheng L, Gangaraju R, Lorenz RG, Williams LA, Marques MB, Zheng XL Abstract Immune-mediated thrombotic thrombocytopenic purpura is characterized by severe thrombocytopenia and microangiopathic hemolytic anemia. It is primarily...
Thu Apr 30, 2020 13:38
Related ArticlesEffectiveness of Online Cancer Education for Nurses and Allied Health Professionals; a Systematic Review Using Kirkpatrick Evaluation Framework. J Cancer Educ. 2019 04;34(2):339-356 Authors: Campbell K, Taylor V, Douglas S Abstract Embedding online learning within higher education can provide engaging, cost-effective, interactive and flexible education. By evaluating the impact, outcomes and pedagogical influence of online cancer and...
Thu Apr 30, 2020 13:38
Related ArticlesHemodynamics and tissue biomechanics of the thoracic aorta with a trileaflet aortic valve at different phases of valve opening. Int J Numer Method Biomed Eng. 2020 May 02;: Authors: Sundström E, Jonnagiri R, Gutmark-Little I, Gutmark E, Critser P, Taylor MD, Tretter JT Abstract In a normal cardiac cycle, the trileaflet aortic valve opening is progressive, which correlates with the phasic blood flow. Therefore, we aimed to determine...
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Related ArticlesLifetime health care costs of oropharyngeal cancer for commercially insured patients in the United States. Head Neck. 2020 May 02;: Authors: Wu CF, Lairson DR, Dahlstrom KR, Fokom Domgue J, Fu S, Sturgis EM, Chan W Abstract BACKGROUND: Incidence of oropharyngeal cancer (OPC) is expected to increase but its health care cost is unknown. The purpose for this study was to estimate the phase-specific lifetime health care costs of OPC for...
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Related ArticlesHead and neck survivorship care in the times of the SARS-CoV-2 pandemic. Head Neck. 2020 May 01;: Authors: Huang VW, Imam SA, Nguyen SA Abstract With the arrival of the coronavirus disease (SARS-CoV-2) in the United States, care practice paradigms have drastically changed. Data from China suggest that the new virus poses additional risks as case fatality of patients with cancer was higher at 5.6% compared to 2.3% of the general population....
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Related ArticlesTracheostomy during COVID-19 pandemic - a novel approach. Head Neck. 2020 May 01;: Authors: Chow VLY, Chan JYW, Ho VWY, Pang SSY, Lee GCC, Wong MMK, Lo ASH, Lui F, Poon CCM, Wong STS Abstract BACKGROUND: This study describes a novel approach in reducing SARS-CoV-2 transmission during tracheostomy. METHODS: Five patients underwent tracheostomy between April 1, 2020 and April 17, 2020. A clear and sterile plastic drape was...
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Related ArticlesEndoscopic Skull Base and Transoral Surgery During the COVID-19 Pandemic: Minimizing Droplet Spread with a Negative-Pressure Otolaryngology Viral Isolation Drape (NOVID). Head Neck. 2020 May 01;: Authors: David AP, Jiam NT, Reither JM, Gurrola JG, Aghi M, El-Sayed IH Abstract BACKGROUND: The COVID-19 pandemic has raised concern of transmission of infectious organisms through aerosols formation in endonasal and transoral surgery. ...
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