Related ArticlesAdult primary cervical rhabdomyosarcomas: A Multicentric cross-national case series. Int J Gynecol Cancer. 2020 01;30(1):21-28 Authors: Ricciardi E, Plett H, Sangiorgio V, Paderno M, Landoni F, Aletti G, Prader S, du Bois A, Harter P, Colombo N Abstract OBJECTIVES: Adult primary cervical rhabdomyosarcoma is a very rare disease and data regarding treatment are sparce. The goal of this study was to report on our experience with the management...
Thu Apr 30, 2020 13:10
Related ArticlesPrimary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma. Respir Res. 2019 Nov 21;20(1):262 Authors: Chen B, Chen X, Zhou P, Yang L, Ren J, Yang X, Li W Abstract BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare tumor and often misdiagnosed as squamous carcinoma. In the current study, clinical characteristics and outcome...
Thu Apr 30, 2020 13:10
Related ArticlesAnalysis of key clinical features for achieving complete remission in stage III and IV non-small cell lung cancer patients. Respir Res. 2019 Nov 21;20(1):263 Authors: Aoki T, Akiba T, Nishiyama J, Tajiri S, Hayama N, Takahashi G, Tanaka J, Sato M, Takiguchi H, Tomomatsu H, Tomomatsu K, Takihara T, Niimi K, Oguma T, Kohno M, Masuda R, Urano T, Itoh H, Kajiwara H, Nakamura N, Kunieda E, Matsumae M, Iwazaki M, Asano K Abstract BACKGROUND:...
Thu Apr 30, 2020 13:10
Related ArticlesPediatric Noncerebral Thromboembolism: Etiological Assessment and Outcome. Tunis Med. 2019 Mar;97(3):461-467 Authors: Mezghani F, Kazdaghli K, Fedhila F, Rhayem S, Jbebli E, Hadded S, Douira W, Toumi N, Khemiri M Abstract OBJECTIVE: To report clinical presentation and etiologic investigation findings during pediatric noncerebral thromboembolism. METHODS: Retrospective study of cases of vascular non cerebral thromboses admitted...
Thu Apr 30, 2020 13:10
Related ArticlesCandida tropicalis Thyroiditis Presenting With Thyroid Storm in a Pediatric Patient With Acute Lymphocytic Leukemia. Pediatr Infect Dis J. 2019 10;38(10):1051-1053 Authors: Niles D, Boguniewicz J, Shakeel O, Margolin J, Chelius D, Gupta M, Paul D, King KY, McNeil JC Abstract Suppurative thyroiditis is uncommon in the pediatric population and particularly rare to be caused by fungi. We present a case of Candida tropicalis thyroiditis...
Thu Apr 30, 2020 13:10
Related ArticlesTo Scan or Not to Scan-A Cross-Sectional Analysis of the Clinical Efficacy and Cost-Effectiveness of Audiometric Protocols for Magnetic Resonance Imaging Screening of Vestibular Schwannomas. Otol Neurotol. 2019 06;40(5S Suppl 1):S59-S66 Authors: Bhargava EK, Coyle P, Wong B, Masood A, Qayyum A Abstract INTRODUCTION: Vestibular schwannomas (VS) are a rare cause of asymmetrical hearing loss, and routine screening with magnetic resonance...
Thu Apr 30, 2020 13:10
Related ArticlesmiRNA deregulation targets specific pathways in leiomyosarcoma development: an in silico analysis. J Transl Med. 2019 05 14;17(1):153 Authors: Benna C, Rajendran S, Rastrelli M, Mocellin S Abstract BACKGROUND: MicroRNA (miRNA) mediate post-transcriptional gene repression and are involved in a variety of human diseases, including cancer. Soft tissue sarcomas are rare malignancies with a variety of histological subtypes which may occur...
Thu Apr 30, 2020 13:10
Related ArticlesEfficacy and safety of endoscopic resection for small submucosal tumors originating from the muscularis propria layer in the gastric fundus. Surg Endosc. 2019 08;33(8):2553-2561 Authors: Li B, Chen T, Qi ZP, Yao LQ, Xu MD, Shi Q, Cai SL, Sun D, Zhou PH, Zhong YS Abstract BACKGROUND: Gastric small submucosal tumors (SMTs) are becoming increasingly common. However, the fundus of stomach is regarded as a difficult area for endoscopic resection...
Thu Apr 30, 2020 13:10
Abstract Purpose The use of tyrosine kinase inhibitors (TKIs) in thyroid cancer patients is often limited by toxicities. Some have a long-term onset and potentially could impact patients’ survival. Among them, there is the nephrotoxicity, mainly represented by proteinuria. The aim of the study was to evaluate the prevalence of proteinuria in medullary thyroid cancer patients treated with cabozantinib, to examine whether it could be...
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Abstract Objectives The prevalence of CAH in Egypt is reported to be ten times more than that of the worldwide prevalence. The study aimed at genetic screening of children diagnosed with 21-alpha hydroxylase deficiency congenital adrenal hyperplasia (21OHD-CAH). In addition, the study offers a rapid and easy guide for clinical reporting of common mutations for endocrinologists. ...
Fri May 01, 2020 03:00
Abstract Aim Over the last decades, the shift in age distribution towards older ages and the progressive ageing which has occurred in most populations have been paralleled by a global epidemic of obesity and its related metabolic disorders, primarily, type 2 diabetes (T2D). Dysfunction of the adipose tissue (AT) is widely recognized as a significant hallmark of the ageing process that, in turn, results in systemic metabolic alterations....
Fri May 01, 2020 03:00
Abstract Purpose We aimed to identify the phenotypic variability of IGF1R defects in a cohort of short children with normal GH secretion gathered through the last decade. Patients and methods Fifty children (25 girls) with short stature and a basal/stimulated growth hormone (GH) over 10 ng/ml having either a low birth weight or microcephaly were enrolled....
Thu Apr 30, 2020 03:00
Related ArticlesBiology of extracellular vesicles secreted from senescent cells as senescence-associated secretory phenotype factors. Geriatr Gerontol Int. 2020 May 01;: Authors: Misawa T, Tanaka Y, Okada R, Takahashi A Abstract The increase of the morbidity rate in age-related diseases, such as cancer, Alzheimer's disease, arteriosclerosis and pulmonary fibrosis, has become a profound social problem. Recent reports have pointed out that senescent...
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Related ArticlesmiR-29b and retinoic acid co-delivery: a promising tool to induce a synergistic antitumoral effect in non-small cell lung cancer cells. Drug Deliv Transl Res. 2020 May 02;: Authors: Magalhães M, Jorge J, Gonçalves AC, Sarmento-Ribeiro AB, Carvalho R, Figueiras A, Santos AC, Veiga F Abstract The high incidence, late diagnosis, and aggressive profile of lung cancer limit the treatment options, causing a reduced survival rate. Consequently,...
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Related ArticlesCholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts. J Biol Chem. 2020 May 01;: Authors: Kiatpakdee B, Sato K, Otsuka Y, Arashiki N, Chen Y, Tsumita T, Otsu W, Yamamoto A, Kawata R, Yamazaki J, Sugimoto Y, Takada K, Mohandas N, Inaba M Abstract TSPO2 (translocator protein 2) is a transmembrane protein specifically expressed in late erythroblasts and has been postulated...
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Related ArticlesSelenium nanoparticles (SeNPs) have potent antitumor activity against prostate cancer cells through the upregulation of miR-16. World J Surg Oncol. 2020 May 01;18(1):81 Authors: Liao G, Tang J, Wang D, Zuo H, Zhang Q, Liu Y, Xiong H Abstract OBJECTIVES: This research aimed to examine the antitumor mechanisms of selenium nanoparticles (SeNPs) specifically against prostate cancers. METHODS: The antitumor activities of SeNPs...
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Related ArticlesBacterial cell growth is arrested by violet and blue, but not yellow light excitation during fluorescence microscopy. BMC Mol Cell Biol. 2020 May 01;21(1):35 Authors: El Najjar N, van Teeseling MCF, Mayer B, Hermann S, Thanbichler M, Graumann PL Abstract BACKGROUND: Fluorescence microscopy is a powerful tool in cell biology, especially for the study of dynamic processes. Intensive irradiation of bacteria with UV, blue and violet light...
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Related ArticlesMiR-129-5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression. FASEB J. 2020 May 01;: Authors: He J, Ge Q, Lin Z, Shen W, Lin R, Wu J, Wang B, Lu Y, Chen L, Liu X, Zheng W, Zhang Y, Wang L, Wang K, Wang L, Zhuo W, Chen S Abstract MicroRNAs (miRNAs) play important roles in posttranscriptional regulation and may serve as targets for the diagnosis and treatment of cancers. Nevertheless,...
Sat May 02, 2020 13:51
Related ArticlesMorusin exerts anti-cancer activity in renal cell carcinoma by disturbing MAPK signaling pathways. Ann Transl Med. 2020 Mar;8(6):327 Authors: Yang C, Luo J, Luo X, Jia W, Fang Z, Yi S, Li L Abstract Background: Renal cell carcinoma (RCC) has gradually become a severe type of kidney malignant tumor, which warrants an urgent need for highly efficacious therapeutic agents. Morusin, a typical prenylated flavonoid, has been revealed to...
Sat May 02, 2020 13:51
Related ArticlesMicroRNA-520b targets interlukin-2 to regulate the growth, metastasis and drug sensitivity of liver cancer cells. Am J Transl Res. 2020;12(4):1267-1274 Authors: Sun W, Li W, Chen J, Teng Y, Ding X Abstract Liver cancer is ranked as the 5th major type of cancer and is responsible for significant number of human deaths across the world. Recent investigations have shown microRNAs (miRs) to be involved in diverse cellular processes. Additionally,...
Sat May 02, 2020 13:51
Related ArticlesDNA damage response signaling pathways and targets for radiotherapy sensitization in cancer. Signal Transduct Target Ther. 2020 May 01;5(1):60 Authors: Huang RX, Zhou PK Abstract Radiotherapy is one of the most common countermeasures for treating a wide range of tumors. However, the radioresistance of cancer cells is still a major limitation for radiotherapy applications. Efforts are continuously ongoing to explore sensitizing targets...
Sat May 02, 2020 13:51
Related ArticlesCompensation between Wnt-driven tumorigenesis and cellular responses to ribosome biogenesis inhibition in the murine intestinal epithelium. Cell Death Differ. 2020 Apr 30;: Authors: Raveux A, Stedman A, Coqueran S, Vandormael-Pournin S, Owens N, Romagnolo B, Cohen-Tannoudji M Abstract Ribosome biogenesis inhibition causes cell cycle arrest and apoptosis through the activation of tumor suppressor-dependent surveillance pathways. These...
Sat May 02, 2020 13:51
Related ArticlesAntiproliferative Effect of Bioaccessible Fractions of Four Brassicaceae Microgreens on Human Colon Cancer Cells Linked to Their Phytochemical Composition. Antioxidants (Basel). 2020 Apr 28;9(5): Authors: Fuente B, López-García G, Máñez V, Alegría A, Barberá R, Cilla A Abstract The antiproliferative effect of the bioaccessible fractions (BFs) of four hydroponic Brassicaceae microgreens (broccoli, kale, mustard and radish) was evaluated...
Sat May 02, 2020 13:51
Related ArticlesATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms. Cancers (Basel). 2020 Apr 28;12(5): Authors: Southgate HED, Chen L, Tweddle DA, Curtin NJ Abstract Background: High risk neuroblastoma (HR-NB) is one the most difficult childhood cancers to cure. These tumours frequently present with DNA damage response (DDR) defects including loss or mutation of key DDR genes, oncogene-induced...
Sat May 02, 2020 13:51
Related ArticlesDiethylstilbestrol exposure disrupts mouse oocyte meiotic maturation in vitro through affecting spindle assembly and chromosome alignment. Chemosphere. 2020 Jun;249:126182 Authors: Ding ZM, Hua LP, Ahmad MJ, Safdar M, Chen F, Wang YS, Zhang SX, Miao YL, Xiong JJ, Huo LJ Abstract An adverse tendency induced by the environmental estrogens in female reproductive health is one serious problem worldwide. Diethylstilbestrol (DES), as a synthetic...
Sat May 02, 2020 13:51
Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling. Biochem Pharmacol. 2020 Apr 27;:113999 Authors: Nasimian A, Farzaneh P, Tamanoi F, Zahra Bathaie S Abstract Different groups have reported the Crocin anticancer activity. We previously showed Crocin-induced apoptosis in rat model of breast and gastric cancers, through the increased Bax/Bcl-2...
Fri May 01, 2020 13:42
Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes. Mol Cell. 2020 Apr 22;: Authors: Xing M, Zhang F, Liao H, Chen S, Che L, Wang X, Bao Z, Ji F, Chen G, Zhang H, Li W, Chen Z, Liu Y, Hickson ID, Shen H, Ying S Abstract Nonrandom DNA segregation (NDS) is a mitotic event in which sister chromatids carrying the oldest DNA strands are inherited exclusively by one of the two daughter cells. Although this phenomenon...
Fri May 01, 2020 13:42
BET bromodomain containing epigenetic reader proteins regulate vascular smooth muscle cell proliferation and neointima formation. Cardiovasc Res. 2020 Apr 30;: Authors: Dutzmann J, Haertle M, Daniel JM, Kloss F, Musmann RJ, Kalies K, Knöpp K, Pilowski C, Sirisko M, Sieweke JT, Bauersachs J, Sedding DG, Gegel S Abstract AIMS: Recent studies revealed that the bromodomain and extraterminal (BET) epigenetic reader proteins resemble key regulators in...
Fri May 01, 2020 13:42
Flow Cytometry Definition of Rat Mammary Epithelial Cell Populations and Their Distinct Radiation Responses. Radiat Res. 2020 Apr 30;: Authors: Kudo KI, Takabatake M, Nagata K, Nishimura Y, Daino K, Iizuka D, Nishimura M, Suzuki K, Kakinuma S, Imaoka T Abstract Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as...
Fri May 01, 2020 13:42
Ergosterol peroxide from Pleurotus ferulae inhibits gastrointestinal tumor cell growth through induction of apoptosis via reactive oxygen species and endoplasmic reticulum stress. Food Funct. 2020 Apr 30;: Authors: Yang Y, Luo X, Yasheng M, Zhao J, Li J, Li J Abstract Ergosterol peroxide was purified from Pleurotus ferulae by silica gel chromatography, Sephadex LH-20 chromatography and recrystallization and named PFEP, which was identified by ESI-MS...
Fri May 01, 2020 13:42
Kinesin-7 CENP-E regulates chromosome alignment and genome stability of spermatogenic cells. Cell Death Discov. 2020;6:25 Authors: She ZY, Yu KW, Zhong N, Xiao Y, Wei YL, Lin Y, Li YL, Lu MH Abstract Kinesin-7 CENP-E is an essential kinetochore motor required for chromosome alignment and congression. However, the specific functions of CENP-E in the spermatogenic cells during spermatogenesis remain unknown. In this study, we find that CENP-E proteins...
Fri May 01, 2020 13:42
Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin. Chin Med. 2020;15:37 Authors: Ma Q, Liao H, Xu L, Li Q, Zou J, Sun R, Xiao D, Liu C, Pu W, Cheng J, Zhou X, Huang G, Yao L, Zhong X, Guo X Abstract Background: Dihydroartemisinin (DHA), a derivate of artemisinin, is an effective antimalarial agent. DHA has been shown to exert anticancer activities to numerous cancer cells in the past few years, while the...
Fri May 01, 2020 13:42
Value of long non-coding RNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy. World J Gastroenterol. 2020 Apr 21;26(15):1775-1791 Authors: Li ZY, Li HF, Zhang YY, Zhang XL, Wang B, Liu JT Abstract BACKGROUND: Esophageal cancer is a common digestive tract tumor that is generally treated with radiotherapy. Poor responses to radiotherapy in most patients generally result in local radiotherapy failure, so it is essential...
Fri May 01, 2020 13:42
Related ArticlesSerine 319 phosphorylation is necessary and sufficient to induce a Cx37 conformation that leads to arrested cell cycling. J Cell Sci. 2020 Apr 29;: Authors: Taylor SZ, Jacobsen NL, Pontifex TK, Langlais P, Burt JM Abstract Connexin 37 (Cx37) expression profoundly suppresses proliferation of rat insulinoma (Rin) cells in a manner dependent on gap junction channel (GJCh) functionality and the presence and phosphorylation status of its...
Fri May 01, 2020 13:42
Related ArticlesPartitioned Extracts of Bauhinia championii Induce G0/G1 Phase Arrest and Apoptosis in Human Colon Cancer Cells. Am J Chin Med. 2020 Apr 29;:1-18 Authors: Chen YF, Lee AS, Chen WY, Lin CH, Kuo CL, Chung JG Abstract Bauhinia championii (Benth.) is one of the commonly used herbs in Taiwan. The stem of this plant has been used to treat epigastria pain and rheumatoid arthritis. However, the antitumor activities of this herb have never...
Fri May 01, 2020 13:42
Related ArticlesAnti-Obesity Effects of Tanshinone I from Salvia miltiorrhiza Bunge in Mice Fed a High-Fat Diet through Inhibition of Early Adipogenesis. Nutrients. 2020 Apr 27;12(5): Authors: Jung DY, Kim JH, Jung MH Abstract Tanshinone I (Tan I) is a diterpenoid isolated from Salvia miltiorrhiza Bunge and exhibits antitumor effects in several cancers. However, the anti-obesity properties of Tan I remain unexplored. Here, we evaluated the anti-obesity...
Fri May 01, 2020 13:42
Related ArticlesEffect of Angelica gigas Nakai Ethanol Extract and Decursin on Human Pancreatic Cancer Cells. Molecules. 2020 Apr 27;25(9): Authors: Kweon B, Han YH, Kee JY, Mun JG, Jeon HD, Yoon DH, Choi BM, Hong SH Abstract Pancreatic cancer (PC) is one of the most severe cancers, and its incidence and mortality rates have steadily increased in the past decade. In this study, we demonstrate the effect of Angelica gigas Nakai extract on pancreatic...
Fri May 01, 2020 13:42
Related ArticlesSprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle. EBioMedicine. 2019 Dec;50:166-177 Authors: Qiu B, Chen T, Sun R, Liu Z, Zhang X, Li Z, Xu Y, Zhang Z Abstract BACKGROUND: Perihilar cholangiocarcinoma (PHCC) is the most common subtype of cholangiocarcinoma(CCA). We previously investigated the expression pattern of Sprouty(SPRY) in intrahepatic...
Fri May 01, 2020 13:42
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