Temporal trends in cardiovascular complications in people with or without type 2 diabetes: The Fremantle Diabetes Study. J Clin Endocrinol Metab. 2020 Apr 30;: Authors: Davis WA, Gregg EW, Davis TME Abstract CONTEXT: There is evidence that diabetes-related complications are declining but most data sources have limitations. OBJECTIVE: To characterize temporal changes in incidence rates (IRs) of chronic complications and mortality in well characterized,...
Fri May 01, 2020 13:35
From stem cell to immune effector: how adhesion, migration, and polarity shape T-cell and natural killer cell lymphocyte development in vitro and in vivo. Mol Biol Cell. 2020 May 01;31(10):981-991 Authors: Lee BJ, Mace EM Abstract Lymphocyte development is a complex and coordinated pathway originating from pluripotent stem cells during embryogenesis and continuing even as matured lymphocytes are primed and educated in adult tissue. Hematopoietic stem...
Fri May 01, 2020 13:24
Related ArticlesCentrosome-nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity. Mol Biol Cell. 2020 Apr 29;:mbcE20010047 Authors: Nunes V, Dantas M, Castro D, Vitiello E, Wang I, Carpi N, Balland M, Piel M, Aguiar P, Maiato H, Ferreira JG Abstract During the initial stages of cell division, the cytoskeleton is extensively reorganized so that a bipolar mitotic spindle can be correctly assembled. This...
Thu Apr 30, 2020 14:15
Related ArticlesFOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation. Mol Biol Cell. 2020 Apr 29;:mbcE19070413 Authors: Black M, Arumugam P, Shukla S, Pradhan A, Ustiyan V, Milewski D, Kalinichenko VV, Kalin TV Abstract Forkhead box M1 (FOXM1), a nuclear transcription factor which activates cell cycle regulatory genes, is highly expressed in a majority of human cancers. The function of FOXM1 independent...
Thu Apr 30, 2020 14:15
Related ArticlesDynamic heterogeneity and non-Gaussian statistics for ganglioside GM1s and acetylcholine receptors on live cell membrane. Mol Biol Cell. 2020 Apr 29;:mbcE19080473 Authors: He W, Su Y, Peng HB, Tong P Abstract We have carried out a comparative study of the lateral motion of ganglioside GM1, which is a glycosphingolipid residing on the outer leaflet of the plasma membrane, and acetylcholine receptor (AChR), which is a well-characterized...
Thu Apr 30, 2020 14:15
Related ArticlesThe Anterolateral Triangle: Implications for a Transnasal Prelacrimal Approach to the Floor of the Middle Cranial Fossa. Am J Rhinol Allergy. 2020 Apr 29;:1945892420922757 Authors: Li L, London NR, Prevedello DM, Carrau RL Abstract BACKGROUND: The anterolateral triangle enclosed by the foramen rotundum and foramen ovale constitutes part of the floor of the middle cranial fossa (MCF). OBJECTIVE: To assess the feasibility...
Fri May 01, 2020 13:18
Related ArticlesA Community-Based Study on the Prevalence of Olfactory Dysfunction. Am J Rhinol Allergy. 2020 Apr 28;:1945892420922771 Authors: Schlosser RJ, Desiato VM, Storck KA, Nguyen SA, Hill JB, Washington BJ, Noonan TE, Lamira J, Mulligan JK, Rowan NR, Yoo F, Matthews LJ, Dubno JR, Soler ZM Abstract BACKGROUND: Olfactory dysfunction (OD) is common, affecting an estimated 13 million adults in the United States. Prior studies may underestimate...
Thu Apr 30, 2020 14:31
Advances of droplet-based microfluidics in drug discovery. Expert Opin Drug Discov. 2020 Apr 30;:1-11 Authors: Wang Y, Chen Z, Bian F, Shang L, Zhu K, Zhao Y Abstract Introduction: Drug discovery through a large number of candidates with nearly unlimited possibilities is laborious, time-consuming, and incurs massive costs. It thus calls for fast and robust methods that allow for handling small amounts of reagents, automation, and high-throughput analysis....
Fri May 01, 2020 13:16
Related ArticlesThe emerging role of computational design in peptide macrocycle drug discovery. Expert Opin Drug Discov. 2020 Apr 28;:1-19 Authors: Mulligan VK Abstract Drug discovery is a laborious process with rising cost per new drug. Peptide macrocycles are promising therapeutics, though conformational flexibility can reduce target affinity and specificity. Recent computational advancements address this problem by enabling rational design of rigidly...
Thu Apr 30, 2020 14:56
Related ArticlesIs high performance computing a requirement for novel drug discovery and how will this impact academic efforts? Expert Opin Drug Discov. 2020 Apr 29;:1-5 Authors: Puertas-Martín S, Banegas-Luna AJ, Paredes-Ramos M, Redondo JL, Ortigosa PM, Brovarets' OO, Pérez-Sánchez H PMID: 32345062 [PubMed - as supplied by publisher]
Thu Apr 30, 2020 14:56
Related ArticlesSignificance of Cytokeratin-1 Single-Nucleotide Polymorphism and Protein Level in Susceptibility to Vocal Leukoplakia and Laryngeal Squamous Cell Carcinoma. ORL J Otorhinolaryngol Relat Spec. 2019;81(2-3):121-129 Authors: Yang Y, Zhou J, Wu H Abstract OBJECTIVE: To investigate the association between the cytokeratin (CK)-1 single-nucleotide polymorphism (SNP), the protein level of CK-1 and the risk of vocal leukoplakia and laryngeal...
Fri May 01, 2020 13:16
Fri May 01, 2020 11:54
Fri May 01, 2020 11:48
Thu Apr 30, 2020 17:20
Objective Whether bridging therapy (intravenous thrombolysis [IVT] followed by endovascular treatment) is superior to IVT alone in minor stroke with large vessel occlusion (LVO) is unknown. Methods Multicentric retrospective observational study including, in intention‐to‐treat, consecutive IVT‐treated minor strokes (NIHSS≤5) with LVO, with or without additional mechanical thrombectomy. Propensity‐score (inverse probability of treatment weighting) was used to reduce baseline between‐groups...
Wed Apr 29, 2020 20:55
"Tailored" approach to selected recurrent cranio-cervical chordomas: experience and lessons learned.
"Tailored" approach to selected recurrent cranio-cervical chordomas: experience and lessons learned. Rhinology. 2020 Apr 30;: Authors: Dallan I, de Notaris M, Verstegen M, Fiacchini G, Cambi C, Seccia V, Caniglia M, van Furth W Abstract BACKGROUND: Among chordoma patients, recurrent cases are by far more complex to be managed, and cranio-cervical junction (CCJ) localizations represent a particular challenge due to the complexity of the anatomical region...
Fri May 01, 2020 13:12
Sniffing out the evidence; It's now time for public health bodies recognize the link between COVID-19 and smell and taste disturbance. Rhinology. 2020 Apr 30;: Authors: Lechien JR, Hopkins C, Saussez S Abstract Since the outbreak of the pandemic, anecdotal observations have been accumulating rapidly that sudden anosmia and dysgeusia are peculiar symptoms associated with the COVID-19 infection. Prof C. Hopkins, as President of British Rhinological Society,...
Fri May 01, 2020 13:12
Getting in Touch with Mechanical Pain Mechanisms. Trends Neurosci. 2020 May;43(5):311-325 Authors: Hill RZ, Bautista DM Abstract The peripheral somatosensory system bestows mammals with a diverse repertoire of sensory modalities: gentle touch, mechanical pain, itch, thermosensation, and proprioception. The cells and molecules that transduce many of these stimuli have already been characterized. But how somatosensory neurons transduce acutely painful...
Fri May 01, 2020 13:12
Related ArticlesDistinct Function of Estrogen Receptors in the Rodent Anterior Cingulate Cortex in Pain-related Aversion. Anesthesiology. 2020 Apr 24;: Authors: Zang KK, Xiao X, Chen LQ, Yang Y, Cao QL, Tang YL, Lv SS, Cao H, Zhang L, Zhang YQ Abstract BACKGROUND: Brain-derived estrogen is implicated in pain-related aversion; however, which estrogen receptors mediate this effect remains unclear. This study hypothesized that the different estrogen receptors...
Thu Apr 30, 2020 14:26
Abstract Altered sleep neurophysiology has consistently been reported in adult patients with schizophrenia. Converging evidence suggests that childhood onset schizophrenia (COS), a rare but severe form of schizophrenia, is continuous with adult onset schizophrenia. The aim of the current study was to characterize sleep neurophysiology in COS. An overnight sleep electroencephalogram (EEG) was recorded in 17 children and adolescents with COS (16 years ± 6.6) and 17 age and gender‐matched controls....
Thu Apr 30, 2020 11:08
Publication date: May 2020Source: Sleep Medicine, Volume 69Author(s):
Fri May 01, 2020 12:52
Publication date: Available online 30 April 2020Source: Sleep MedicineAuthor(s): Marcos García, Juan A. Cabrera, Alex Bataller, Javier Vila, Pedro Mayoral
Fri May 01, 2020 12:52
Publication date: Available online 30 April 2020Source: Sleep MedicineAuthor(s): Nour Eissa, Quais Mujawar, Tareq Abdul-Salam, Sahar Zohni, Wael El-Matary
Thu Apr 30, 2020 16:02
Publication date: Available online 29 April 2020Source: Sleep MedicineAuthor(s): Jianwen Wang, Xuan Zhang, Shellie R. Simons, Jiwei Sun, Di Shao, Fenglin Cao
Thu Apr 30, 2020 16:02
Publication date: Available online 29 April 2020Source: Sleep MedicineAuthor(s): Robert Göder, Sarah Bares, Charlotte Vogel, Heidi Böttcher, Henning Johannes Drews, Julia Lechinger, Kamila Jauch-Chara, Sara Weinhold
Thu Apr 30, 2020 16:02
Abstract The Fitness Versus Body Fat Hypothesis argues that cardiorespiratory fitness (CRF) plays a more important role in cardiovascular health than adiposity. It remains poorly understood whether CRF or adiposity accounts for a greater amount of variation in measures of brain health. We examined the contribution of CRF, adiposity, and their interaction with hippocampal structure. This study included 124 sedentary adults (M = 44.34) with overweight/obesity (Body Mass Index mean = 32.43). FMRIB’s...
Thu Apr 30, 2020 18:25
Abstract Background The clinical presentation of European patients with mild‐to‐moderate Covid‐19 infection is still unknown. Objective To study the clinical presentation of Covid‐19 in Europe. Methods Patients with positive diagnosis of Covid‐19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analyzing the relationship between outcomes. Results 1,420 patients...
Thu Apr 30, 2020 15:29
Abstract Background Cardiac troponin T (cTnT) and I (cTnI) concentrations provide strong prognostic information in anticoagulated patients with atrial fibrillation (AF). Whether the associations between cardiac troponin concentrations and mortality and morbidity differs by sex is not known. Objectives To assess whether men and women have different concentrations and prognostic value of cTnT and cTnI measurements in anticoagulated patients with AF. Methods cTnT and cTnI concentrations...
Thu Apr 30, 2020 11:19
Abstract Severe acute respiratory syndrome coronavirus (SARS‐CoV)‐2, a novel coronavirus from the same family as SARS‐CoV and Middle East respiratory syndrome coronavirus, has spread worldwide leading the World Health Organization to declare a pandemic. The disease caused by SARS‐CoV‐2, coronavirus disease 2019 (COVID‐19), presents flu‐like symptoms which can become serious in high‐risk individuals. Here we provide an overview of the known clinical features of and treatment options for...
Wed Apr 29, 2020 22:45
Abstract Studies developing and applying organoid technology have greatly increased in volume and visibility over the past decade. Organoids are three‐dimensional structures that are established from pluripotent stem cells (PSCs) or adult tissue stem cells (ASCs). They consist of organ‐specific cell types that self‐organize through cell sorting and spatially restricted lineage commitment to generate architectural and functional characteristics of the tissue of interest. The field of respiratory...
Wed Apr 29, 2020 17:49
Abstract The disproportionate obesity in African‐American (AA) women has a physiologic basis, and can be explained by the interactive effects of insulin secretion, insulin clearance, insulin sensitivity, and the glycemic load of the diet. This review will present data supporting a physiologic basis for obesity propensity in obesity‐prone AA women that resides in their unique metabolic/endocrine phenotype: high beta‐cell responsiveness, low hepatic insulin extraction, and relatively high...
Wed Apr 29, 2020 16:29
Publication date: Available online 30 April 2020Source: Journal of VoiceAuthor(s): Adam D. Rubin, Juliana Codino, Anya Costeloe, Michael M. Johns, Austin Collum, Pasquale Bottalico
Fri May 01, 2020 12:19
Publication date: Available online 30 April 2020Source: Journal of VoiceAuthor(s): Marco Guzman, Christian Castro, Karol Acevedo, Camilo Moran, Victor Espinoza, Camilo Quezada
Fri May 01, 2020 12:19
Publication date: Available online 30 April 2020Source: Journal of VoiceAuthor(s): Chloe Santa Maria, Chih-Kwang Sung, Brandon J. Baird, Elizabeth Erickson-DiRenzo
Fri May 01, 2020 12:19
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