Fri May 01, 2020 03:00
Fri May 01, 2020 03:00
Fri May 01, 2020 03:00
Fri May 01, 2020 03:00
Nature Communications, Published online: 30 April 2020; doi:10.1038/s41467-020-15977-4A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.
Thu Apr 30, 2020 03:00
Nature Communications, Published online: 30 April 2020; doi:10.1038/s41467-020-15859-9River avulsions are dramatic events that can cause the loss of many human lives. The authors here investigate how river avulsion style changes with river morphology, and how these changes impact flooding and stratigraphy.
Thu Apr 30, 2020 03:00
Nature Communications, Published online: 30 April 2020; doi:10.1038/s41467-020-15739-2Biosphere productivity is an important component of the CO2 cycle, but how it has varied over past glacial-interglacial cycles is not well known. Here, the authors present new data that shows that global biosphere productivity was 10 to 30% higher during Termination V compared to younger deglaciations.
Thu Apr 30, 2020 03:00
Nature Communications, Published online: 30 April 2020; doi:10.1038/s41467-020-15903-8The response to DNA damage-stalled RNA polymerase II leads to the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. Here, the authors reveal the complex assembly mechanism of the TCR complex in human cells.
Thu Apr 30, 2020 03:00
Nature Communications, Published online: 30 April 2020; doi:10.1038/s41467-020-15953-yPrecise patterning of lipid-stabilised aqueous droplets is a key challenge in building synthetic tissue designs. Here, the authors show how the interactions between pairs of droplets direct the packing of droplets within 3D-printed networks, enabling the formation of synthetic tissues with high-resolution features.
Thu Apr 30, 2020 03:00
Nature Communications, Published online: 30 April 2020; doi:10.1038/s41467-020-15765-0Single-cell RNA-seq can reveal accurate and precise cell types and states. Here the authors present an scRNA-seq platform, Paired-seq, which uses differential flow resistance to achieve 95% cell utilisation efficiency for improved cell-free RNA removal and gene detection.
Thu Apr 30, 2020 03:00
Nature Communications, Published online: 30 April 2020; doi:10.1038/s41467-020-15845-1Altering cellular responses to double-strand breaks in DNA could rebalance CRISPRediting outcomes. Here, the authors use a pooled CRISPR screen to identify inhibition of CDC7 as a strategy to improve HDR outcomes.
Thu Apr 30, 2020 03:00
Nature Communications, Published online: 30 April 2020; doi:10.1038/s41467-020-15779-8The genome of the malaria parasite Plasmodium falciparum contains a record of past evolutionary forces. Here, using 2537 parasite sequences from the Democratic Republic of the Congo, the authors demonstrate how drug pressure and human movement have shaped the present-day parasite population.
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Related ArticlesTapia's syndrome as an uncommon complication after cervical spine surgery with tracheostomy: a case report and literature review. Spine Deform. 2020 Apr 29;: Authors: Mega C, Ricci A, Giannone S, Facchini F, Gasbarrini A Abstract PURPOSE: The aim of the present work is to present a rare case of Tapia's syndrome (hypoglossal and recurrent laryngeal nerve apraxia) following cervical spine surgery with tracheostomy. METHODS: Clinical...
Fri May 01, 2020 13:48
Related ArticlesLong term phonatory function following acoustic neuroma surgery: a cohort study. Acta Otolaryngol. 2020 Apr 29;:1-5 Authors: Abbas-Kayano RT, Solla D, Rabelo NN, Gomes M, Cabrera H, Teixeira MJ, Figueiredo EG Abstract Background: Acoustic neuroma (AN) is a well-recognized cause of neurological morbidity, peripheral facial paralysis being one of the most prevalent. Phonatory dysfunction in the late post-operative term has not been properly...
Thu Apr 30, 2020 15:02
Related ArticlesIdiopathic Ulcerative Laryngitis: A National Survey of Academic Laryngologists. J Voice. 2020 Apr 25;: Authors: Kim C, Badash I, Gao WZ, O'Dell K, Johns MM Abstract OBJECTIVES: Idiopathic ulcerative laryngitis (IUL) is a rare disorder characterized by ulceration in the mid-membranous portions of the vocal folds. The etiology and optimal management of this condition are poorly understood. We aimed to survey laryngologists on their experiences...
Thu Apr 30, 2020 15:02
Publication date: Available online 1 May 2020Source: Journal of Surgical EducationAuthor(s): Ola Ahmed, Thomas Noel Walsh
Fri May 01, 2020 13:38
Predictors of drug survival of biologic therapies in psoriasis patients. J Dermatolog Treat. 2020 Apr 30;:1-17 Authors: Zorlu O, Bülbül Başkan E, Yazici S, Sığırlı D, Budak F, Sarıcaoğlu H, Aydoğan K Abstract Introduction: We aimed to investigate the clinical, immunological, and genetic factors affecting the response to anti-TNFα (tumor necrosis factor-α) and interleukin-12/23 therapies and drug survivals.Methods: A total of 180 patients were divided...
Fri May 01, 2020 13:36
Related ArticlesEffectiveness of cyclosporine A in patients with moderate to severe plaque psoriasis in a real-life clinical setting in Italy: the TRANSITION study. J Dermatolog Treat. 2020 Apr 30;:1-7 Authors: Marsili F, Travaglini M, Stinco G, Manzoni R, Tiberio R, Prignano F, Mazzotta A, Cannavò SP, Cuccia A, Germino M, Bongiorno MR, Persechino S, Florio T, Pettinato M, Tabanelli M, Sarkar R, Aloisi E, Bartezaghi M, Orsenigo R Abstract Background:...
Fri May 01, 2020 13:36
Related ArticlesDisease activity and treatment efficacy using patient-level Psoriasis Area and Severity Index scores from tildrakizumab phase 3 clinical trials. J Dermatolog Treat. 2020 Apr 30;:1-10 Authors: Gordon KB, Reich K, Crowley JJ, Korman NJ, Murphy FT, Poulin Y, Spelman L, Yamauchi PS, Mendelsohn AM, Parno J, Rozzo SJ, Ellis CN Abstract Background: It is unclear whether primary efficacy outcomes in plaque psoriasis clinical trials represent...
Fri May 01, 2020 13:36
Related ArticlesDupilumab provides rapid and sustained improvement in SCORAD outcomes in adults with moderate-to-severe atopic dermatitis: combined results of four randomized phase 3 trials. J Dermatolog Treat. 2020 Apr 29;:1-34 Authors: Barbarot S, Wollenberg A, Silverberg JI, Deleuran M, Pellacani G, Armario-Hita JC, Chen Z, Shumel B, Eckert L, Gadkari A, Lu Y, Rossi AB Abstract Background: Dupilumab, a first-in-class therapy targeting the two key...
Thu Apr 30, 2020 14:31
Related ArticlesThe Danger of Neglecting Melanoma during the COVID-19 Pandemic. J Dermatolog Treat. 2020 Apr 29;:1-8 Authors: Gomolin T, Cline A, Handler MZ Abstract Due to the COVID-19 pandemic, planned medical and surgical activities are being postponed. For the dermatology community, this interruption to the healthcare system can lead to delays in the diagnosis and treatment of melanoma. Neglecting melanoma during this crisis can result in increased...
Thu Apr 30, 2020 14:31
Related ArticlesMedicare and Medicaid Spending Trends for Immunomodulators Prescribed for Dermatologic Conditions. J Dermatolog Treat. 2020 Apr 29;:1-13 Authors: Price KN, Atluri SSS, Hsiao JL, Shi VY Abstract Immunomodulators are the most expensive prescription medications used in dermatology for chronic skin conditions. Each year, rising costs for immunomodulators pose significant financial burdens on patients and the healthcare system as a whole....
Thu Apr 30, 2020 14:31
Related ArticlesOptimizing doxepin therapy in dermatology: Introducing blood level monitoring and genotype testing. J Dermatolog Treat. 2020 Apr 29;:1-30 Authors: Myers B, Reddy V, Chan S, Thibodeaux Q, Brownstone N, Koo J Abstract Doxepin, a tricyclic antidepressant, is the most efficacious antipruritic available to dermatologists, however its use is often suboptimal because of significant interindividual variability in doxepin plasma levels and clinical...
Thu Apr 30, 2020 14:31
Related ArticlesMolluscum contagiosum in paediatric patients: to treat or not to treat? Could a personalised Imiquimod regimen be the answer to the dilemma? J Dermatolog Treat. 2020 Apr 29;:1-27 Authors: Gualdi G, Pascalucci C, Panarese F, Prignano F, Giuliani F, Verga E, Amerio P, Verdolini R Abstract AbstractsBackground: Although molluscum contagiosum virus (MCV) infection is a common disease widespread among children and young adults, there is no...
Thu Apr 30, 2020 14:31
Related ArticlesDermoscopy-guided Mohs micrographic surgery in post-laser basal cell carcinomas: Is dermoscopy helpful for demarcation of the surgical margin? J Dermatolog Treat. 2020 Apr 29;:1-12 Authors: Shin K, Kim HJ, Ko HC, Kim BS, Kim MB, Kim HS Abstract Background: Mohs micrographic surgery (MMS) in cases where the tumor margin is poorly defined to the naked eye can lead to the need to take an increased number of Mohs stages.Objective: To evaluate...
Thu Apr 30, 2020 14:31
Related ArticlesEfficacy and Safety of Active Vitamin D Supplementation in Chronic Spontaneous Urticaria Patients. J Dermatolog Treat. 2020 Apr 29;:1-22 Authors: Ahmed Mohamed A, Hussein MS, Salah EM, Eldemery A, Darwish MM, Ghaith DM, Attala RA, El Borolossy R Abstract Background: Chronic spontaneous urticaria (CSU) is a common skin disorder affecting negatively patients' lives. Vitamin D deficiency has been reported to be associated to many allergic...
Thu Apr 30, 2020 14:31
The role of living donor liver transplantation for acute liver failure. Int J Surg. 2020 Apr 27;: Authors: Ogura Y, Kabacam G, Singhal A, Moon DB Abstract Acute liver failure (ALF) is a life-threatening illness that occurs in the absence of pre-existing liver disease. When symptoms seriously progress under continuous supportive medical care, liver transplantation becomes the only therapeutic strategy. However, the available sources of organs for...
Fri May 01, 2020 13:35
Hypothermic machine perfusion in liver transplantation. Int J Surg. 2020 Apr 27;: Authors: Karangwa S, Panayotova G, Dutkowski P, Porte RJ, Guarrera JV, Schlegel A Abstract Dynamic preservation strategies are a promising option to improve graft quality before transplantation, and to extend preservation time for either logistic or treatment reasons. In contrast to normothermic oxygenated perfusion, which intends to mimic physiological conditions in...
Fri May 01, 2020 13:35
A 10-step guide to convert a surgical unit into a COVID-19 unit during the COVID-19 pandemic. Int J Surg. 2020 Apr 27;: Authors: Mari GM, Crippa J, Casciaro F, Maggioni D PMID: 32353555 [PubMed - as supplied by publisher]
Fri May 01, 2020 13:35
ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure. J Clin Endocrinol Metab. 2020 Apr 30;: Authors: Leung JH, Bayomy OF, Bonyhay I, Celli J, White J, Freeman R, Adler GK Abstract CONTEXT: Hypoglycemia attenuates cardiovascular homeostatic autonomic control. This attenuation, known as the cardiovascular component of hypoglycemia associated autonomic failure (HAAF) is characterized most...
Fri May 01, 2020 13:35
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