IJMS, Vol. 21, Pages 3187: Season Affects Yield and Metabolic Profiles of Rice (Oryza sativa) under High Night Temperature Stress in the Field International Journal of Molecular Sciences doi: 10.3390/ijms21093187 Authors: Schaarschmidt Lawas Glaubitz Li Erban Kopka Jagadish Hincha Zuther Rice (Oryza sativa) is the main food source for more than 3.5 billion people in the world. Global climate change is having a strong negative effect on rice production....
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3193: Tubulin Folding Cofactor TBCB is a Target of the Salmonella Effector Protein SseK1 International Journal of Molecular Sciences doi: 10.3390/ijms21093193 Authors: Juan Luis Araujo-Garrido Fernando Baisón-Olmo Joaquín Bernal-Bayard Francisco Romero Francisco Ramos-Morales Salmonella enterica serovar Typhimurium is a human and animal pathogen that uses type III secretion system effectors to manipulate the host cell and fulfill infection. SseK1 is a...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3186: Shared Genomic and Proteomic Contribution of Amyloid and Tau Protein Characteristic of Alzheimer’s Disease to Brain Ischemia International Journal of Molecular Sciences doi: 10.3390/ijms21093186 Authors: Ryszard Pluta Marzena Ułamek-Kozioł Sławomir Januszewski Stanisław J. Czuczwar Post-ischemic brain damage is associated with the deposition of folding proteins such as the amyloid and tau protein in the intra- and extracellular spaces of brain tissue....
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3184: Neonatal Clonazepam Administration Induced Long-Lasting Changes in GABAA and GABAB Receptors International Journal of Molecular Sciences doi: 10.3390/ijms21093184 Authors: Hana Kubová Zdeňka Bendová Simona Moravcová Dominika Pačesová Luisa Rocha Pavel Mareš Benzodiazepines (BZDs) are widely used in patients of all ages. Unlike adults, neonatal animals treated with BZDs exhibit a variety of behavioral deficits later in life; however, the mechanisms...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3185: Correction: Lin, K.-H., et al. Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis. Int. J. Mol. Sci., 2019, 20, 4986 International Journal of Molecular Sciences doi: 10.3390/ijms21093185 Authors: Yu-Chin Liu Chau-Ting Yeh Kwang-Huei Lin The authors wish to make the following corrections to this paper [...]
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3183: Adipose Tissue Modification through Feeding Strategies and Their Implication on Adipogenesis and Adipose Tissue Metabolism in Ruminants International Journal of Molecular Sciences doi: 10.3390/ijms21093183 Authors: Olaia Urrutia José Antonio Mendizabal Leopoldo Alfonso Beatriz Soret Kizkitza Insausti Ana Arana Dietary recommendations by health authorities have been advising of the importance of diminishing saturated fatty acids (SFA) consumption...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3173: The Expression and Function of CD300 Molecules in the Main Players of Allergic Responses: Mast Cells, Basophils and Eosinophils International Journal of Molecular Sciences doi: 10.3390/ijms21093173 Authors: Joana Vitallé Iñigo Terrén Ane Orrantia Agurtzane Bilbao Pedro M. Gamboa Francisco Borrego Olatz Zenarruzabeitia Allergy is the host immune response against non-infectious substances called allergens. The prevalence of allergic diseases...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3180: Whole Genome DNA Methylation Analysis of Active Pulmonary Tuberculosis Disease Identifies Novel Epigenotypes: PARP9/miR-505/RASGRP4/GNG12 Gene Methylation and Clinical Phenotypes International Journal of Molecular Sciences doi: 10.3390/ijms21093180 Authors: Yung-Che Chen Chang-Chun Hsiao Ting-Wen Chen Chao-Chien Wu Tung-Ying Chao Sum-Yee Leung Hock-Liew Eng Chiu-Ping Lee Ting-Ya Wang Meng-Chih Lin We hypothesized that DNA methylation...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3171: DRUGPATH: The Drug Gene Pathway Meta-Database International Journal of Molecular Sciences doi: 10.3390/ijms21093171 Authors: Rajeev Jaundoo Travis J. A. Craddock The complexity of modern-day diseases often requires drug treatment therapies consisting of multiple pharmaceutical interventions, which can lead to adverse drug reactions for patients. A priori prediction of these reactions would not only improve the quality of life for patients but also save both...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3179: SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms21093179 Authors: Young-Sheng Chang Bo-Han Ko Jyh-Cherng Ju Hsin-Hou Chang Su-Hua Huang Cheng-Wen Lin Severe acute respiratory syndrome–associated coronavirus (SARS-CoV) initiates the cytokine/chemokine storm-mediated lung injury....
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3181: Current Synthesis and Systematic Review of Main Effects of Calf Blood Deproteinized Medicine (Actovegin®) in Ischemic Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21093181 Authors: Florentina Carmen Firan Aurelia Romila Gelu Onose Background: Stroke is one of the largest problems and clinical-social challenges within neurology and, in general, pathology. Here, we briefly reviewed the main pathophysiological mechanisms of ischemic...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3182: Functional Mechanisms of Mitochondrial Respiratory Chain Supercomplex Assembly Factors and Their Involvement in Muscle Quality International Journal of Molecular Sciences doi: 10.3390/ijms21093182 Authors: Kotaro Azuma Kazuhiro Ikeda Satoshi Inoue Impairment of skeletal muscle function causes disabilities in elderly people. Therefore, in an aged society, prevention and treatment of sarcopenia are important for expanding healthy life expectancy. In addition...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3178: Novel Phenothiazine-Bridged Porphyrin-(Hetero)aryl dyads: Synthesis, Optical Properties, In Vitro Cytotoxicity and Staining of Human Ovarian Tumor Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21093178 Authors: Eva Molnar Emese Gal Luiza Gaina Castelia Cristea Eva Fischer-Fodor Maria Perde-Schrepler Patriciu Achimas-Cadariu Monica Focsan Luminita Silaghi-Dumitrescu We report here the synthetic procedure applied...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3176: Exploring the Enzymatic and Antibacterial Activities of Novel Mycobacteriophage Lysin B Enzymes International Journal of Molecular Sciences doi: 10.3390/ijms21093176 Authors: Adel Abouhmad Ahmed H. Korany Carl Grey Tarek Dishisha Rajni Hatti-Kaul Mycobacteriophages possess different sets of lytic enzymes for disruption of the complex cell envelope of the mycobacteria host cells and release of the viral progeny. Lysin B (LysB) enzymes are mycolylarabinogalactan...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3177: Estradiol-Induced Epigenetically Mediated Mechanisms and Regulation of Gene Expression International Journal of Molecular Sciences doi: 10.3390/ijms21093177 Authors: Tamás Kovács Edina Szabó-Meleg István M. Ábrahám Gonadal hormone 17β-estradiol (E2) and its receptors are key regulators of gene transcription by binding to estrogen responsive elements in the genome. Besides the classical genomic action, E2 regulates gene transcription via the modification...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3174: Two Festuca Species—F. arundinacea and F. glaucescens—Differ in the Molecular Response to Drought, While Their Physiological Response Is Similar International Journal of Molecular Sciences doi: 10.3390/ijms21093174 Authors: Katarzyna Lechowicz Izabela Pawłowicz Dawid Perlikowski Magdalena Arasimowicz-Jelonek Joanna Majka Adam Augustyniak Marcin Rapacz Arkadiusz Kosmala Impact of photosynthetic and antioxidant capacities on drought tolerance...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3172: The Role of Chemokines and Chemokine Receptors in Diabetic Nephropathy International Journal of Molecular Sciences doi: 10.3390/ijms21093172 Authors: Ting-Ting Chang Jaw-Wen Chen Kidney function decline is one of the complications of diabetes mellitus and may be indicated as diabetic nephropathy (DN). DN is a chronic inflammatory disease featuring proteinuria and a decreasing glomerular filtration rate. Despite several therapeutic options being currently...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3175: Fractalkine Regulates HEC-1A/JEG-3 Interaction by Influencing the Expression of Implantation-Related Genes in an In Vitro Co-Culture Model International Journal of Molecular Sciences doi: 10.3390/ijms21093175 Authors: Ramóna Pap Gergely Montskó Gergely Jánosa Katalin Sipos Gábor L. Kovács Edina Pandur Embryo implantation is a complex process regulated by a network of biological molecules. Recently, it has been described that fractalkine (CX3CL1,...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3169: A Single Amino Acid Change in Nramp6 from Sedum Alfredii Hance Affects Cadmium Accumulation International Journal of Molecular Sciences doi: 10.3390/ijms21093169 Authors: Zhuchou Lu Shuangshuang Chen Xiaojiao Han Jin Zhang Guirong Qiao Yugen Jiang Renying Zhuo Wenmin Qiu SaNramp6 in Sedum alfredii encodes a membrane-localized metal transporter. We isolated the SaNramp6h allele from the hyperaccumulating ecotype (HE) of S. alfredii. When...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3170: Autographivirinae Bacteriophage Arno 160 Infects Pectobacterium carotovorum via Depolymerization of the Bacterial O-Polysaccharide International Journal of Molecular Sciences doi: 10.3390/ijms21093170 Authors: Mikhail M. Shneider Anna A. Lukianova Peter V. Evseev Anna M. Shpirt Marsel R. Kabilov Anna D. Tokmakova Kirill K. Miroshnikov Ekaterina A. Obraztsova Olga A. Baturina Alexander S. Shashkov Alexander N. Ignatov Yuriy A. Knirel...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3167: Ischemic Heart Disease and Heart Failure: Role of Coronary Ion Channels International Journal of Molecular Sciences doi: 10.3390/ijms21093167 Authors: Paolo Severino Andrea D’Amato Mariateresa Pucci Fabio Infusino Lucia Ilaria Birtolo Marco Valerio Mariani Carlo Lavalle Viviana Maestrini Massimo Mancone Francesco Fedele Heart failure is a complex syndrome responsible for high rates of death and hospitalization. Ischemic heart disease...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3168: Influence of Cannabinoid Receptor Deficiency on Parameters Involved in Blood Glucose Regulation in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21093168 Authors: Juliane Zibolka Anja Wolf Lisa Rieger Candy Rothgänger Anne Jörns Beat Lutz Andreas Zimmer Faramarz Dehghani Ivonne Bazwinsky-Wutschke Cannabinoids are known to influence hormone secretion of pancreatic islets via G protein‑coupled cannabinoid receptor type...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3165: Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21093165 Authors: Thuy Trang Nguyen Qui Thanh Hoai Ta Thi Kim Oanh Nguyen Thi Thuy Dung Nguyen Vo Van Giau The exact connection between Alzheimer’s disease (AD) and type 2 diabetes is still in debate. However, poorly controlled blood sugar may increase the risk of developing Alzheimer’s. This relationship...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3166: Convolutional Neural Network Can Recognize Drug Resistance of Single Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms21093166 Authors: Kiminori Yanagisawa Masayasu Toratani Ayumu Asai Masamitsu Konno Hirohiko Niioka Tsunekazu Mizushima Taroh Satoh Jun Miyake Kazuhiko Ogawa Andrea Vecchione Yuichiro Doki Hidetoshi Eguchi Hideshi Ishii It is known that single or isolated tumor cells enter cancer patients’...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3164: Leukamenin E Induces K8/18 Phosphorylation and Blocks the Assembly of Keratin Filament Networks Through ERK Activation International Journal of Molecular Sciences doi: 10.3390/ijms21093164 Authors: Bo Xia Hui Zhang Minghui Yang Shilong Du Jingxin Wei Lan Ding Leukamenin E is a natural ent-kaurane diterpenoid isolated from Isodon racemosa (Hemsl) Hara that has been found to be a novel and potential keratin filament inhibitor, but its underlying...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3163: Roles of Progesterone, Testosterone and Their Nuclear Receptors in Central Nervous System Myelination and Remyelination International Journal of Molecular Sciences doi: 10.3390/ijms21093163 Authors: Abdel Mouman Ghoumari Charly Abi Ghanem Narimène Asbelaoui Michael Schumacher Rashad Hussain Progesterone and testosterone, beyond their roles as sex hormones, are neuroactive steroids, playing crucial regulatory functions within the nervous system....
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3161: Sildenafil Reduces Expression and Release of IL-6 and IL-8 Induced by Reactive Oxygen Species in Systemic Sclerosis Fibroblasts International Journal of Molecular Sciences doi: 10.3390/ijms21093161 Authors: Luigi Di Luigi Paolo Sgrò Guglielmo Duranti Stefania Sabatini Daniela Caporossi Francesco Del Galdo Ivan Dimauro Cristina Antinozzi Oxidative stress linked to vascular damage plays an important role in the pathogenesis of systemic sclerosis...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3158: Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals International Journal of Molecular Sciences doi: 10.3390/ijms21093158 Authors: Tian Qin Samantha Prins Geert Jan Groeneveld Gerard Van Westen Helga E. de Vries Yin Cheong Wong Luc J.M. Bischoff Elizabeth C.M. de Lange To diagnose and treat early-stage (preclinical) Alzheimer’s...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3162: Investigating Programmed Cell Death and Tumor Invasion in a Three-Dimensional (3D) Microfluidic Model of Glioblastoma International Journal of Molecular Sciences doi: 10.3390/ijms21093162 Authors: Ehsan Samiei Amir Seyfoori Brian Toyota Saeid Ghavami Mohsen Akbari Glioblastoma multiforme (GBM) is a rapidly progressive and deadly form of brain tumor with a median survival rate of ~15 months. GBMs are hard to treat and significantly affect the patient's...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3159: Fullerene Negative Ions: Formation and Catalysis International Journal of Molecular Sciences doi: 10.3390/ijms21093159 Authors: Zineb Felfli Kelvin Suggs Nantambu Nicholas Alfred Z. Msezane We first explore negative-ion formation in fullerenes C44 to C136 through low-energy electron elastic scattering total cross sections calculations using our Regge-pole methodology. Then, the formed negative ions C44ˉ to C136ˉ are used to investigate the catalysis...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3157: Repurposing Tyrosine Kinase Inhibitors to Overcome Multidrug Resistance in Cancer: A Focus on Transporters and Lysosomal Sequestration International Journal of Molecular Sciences doi: 10.3390/ijms21093157 Authors: Maria Krchniakova Jan Skoda Jakub Neradil Petr Chlapek Renata Veselska Tyrosine kinase inhibitors (TKIs) are being increasingly used to treat various malignancies. Although they were designed to target aberrant tyrosine kinases, they are...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3156: Molecular Markers Associated with Agro-Physiological Traits under Terminal Drought Conditions in Bread Wheat International Journal of Molecular Sciences doi: 10.3390/ijms21093156 Authors: Sajid Shokat Deepmala Sehgal Prashant Vikram Fulai Liu Sukhwinder Singh Terminal drought stress poses a big challenge to sustain wheat grain production in rain-fed environments. This study aimed to utilize the genetically diverse pre-breeding lines for identification...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3160: Isolation and Characterization of Two Klebsiella pneumoniae Phages Encoding Divergent Depolymerases International Journal of Molecular Sciences doi: 10.3390/ijms21093160 Authors: Pilar Domingo-Calap Beatriz Beamud Lucas Mora-Quilis Fernando González-Candelas Rafael Sanjuán The emergence of multidrug-resistant bacteria is a major global health concern. The search for new therapies has brought bacteriophages into the spotlight, and new phages are...
Thu Apr 30, 2020 03:00
IJNS, Vol. 6, Pages 36: Assessing the Performance of Dried-Blood-Spot DNA Extraction Methods in Next Generation Sequencing International Journal of Neonatal Screening doi: 10.3390/ijns6020036 Authors: Miyono M. Hendrix Carla D. Cuthbert Suzanne K. Cordovado An increasing number of newborn screening laboratories in the United States and abroad are moving towards incorporating next-generation sequencing technology, or NGS, into routine screening, particularly for cystic fibrosis....
Thu Apr 30, 2020 03:00
IJNS, Vol. 6, Pages 35: Implementing Statewide Newborn Screening for New Disorders: U.S. Program Experiences International Journal of Neonatal Screening doi: 10.3390/ijns6020035 Authors: Kellar-Guenther McKasson Hale Singh Sontag Ojodu Data were collected from 39 newborn screening (NBS) programs to provide insight into the time and factors required for implementing statewide screening for Pompe, Mucopolysaccharidosis type I (MPS I), adrenoleukodystrophy (ALD), and...
Thu Apr 30, 2020 03:00
JCM, Vol. 9, Pages 1333: Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients Journal of Clinical Medicine doi: 10.3390/jcm9051333 Authors: Ulrich Jehn Katharina Schütte-Nütgen Ute Henke Joachim Bautz Hermann Pavenstädt Barbara Suwelack Stefan Reuter Growth differentiation factor-15 (GDF15) is associated with inflammatory conditions, chronic kidney disease, cardiovascular disease and mortality. There is very limited data on GDF15 after...
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JCM, Vol. 9, Pages 1332: Eating Disorders, Heredity and Environmental Activation: Getting Epigenetic Concepts into Practice Journal of Clinical Medicine doi: 10.3390/jcm9051332 Authors: Howard Steiger Linda Booij Epigenetic mechanisms are believed to link environmental exposures to alterations in gene expression, and in so doing, to provide a physical substrate for the activation of hereditary potentials by life experiences. In keeping with this idea, accumulating data suggest that...
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JCM, Vol. 9, Pages 1331: Characteristics of Circulating CD4+ T Cell Subsets in Patients with Mycobacterium avium Complex Pulmonary Disease Journal of Clinical Medicine doi: 10.3390/jcm9051331 Authors: Han Ko Shin Jhun Although prevalence of Mycobacterium avium complex pulmonary disease (MAC-PD) is increasing, limited data are available regarding vulnerability to Mycobacterium avium complex (MAC) infections. To understand the pathobiology of interaction between MAC and host-immunity,...
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JCM, Vol. 9, Pages 1324: The Influence of Bariatric Surgery on Pregnancy and Perinatal Outcomes—A Case-Control Study Journal of Clinical Medicine doi: 10.3390/jcm9051324 Authors: Anna Różańska-Walędziak Maciej Walędziak Paweł Bartnik Joanna Kacperczyk-Bartnik Michał Janik Piotr Kowalewski Andrzej Kwiatkowski Krzysztof Czajkowski Introduction: Obesity in pregnant women increases the incidence of pregnancy-induced comorbidities and the rate of operative deliveries....
Sat May 02, 2020 03:00
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