IJMS, Vol. 21, Pages 3226: Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21093226 Authors: Gabriela Lopes Martins Rita Carolina Figueiredo Duarte Marat A. Mukhamedyarov András Palotás Cláudia Natália Ferreira Helton José Reis Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn,...
Sat May 02, 2020 03:00
IJMS, Vol. 21, Pages 3227: Highly Expressed FOXF1 Inhibit Non-Small-Cell Lung Cancer Growth via Inducing Tumor Suppressor and G1-Phase Cell-Cycle Arrest International Journal of Molecular Sciences doi: 10.3390/ijms21093227 Authors: Wu Chan Dubey Wei Lu Chang Cheng Ou Deng Cancer pathogenesis results from genetic alteration-induced high or low transcriptional programs, which become highly dependent on regulators of gene expression. However, their role...
Sat May 02, 2020 03:00
IJMS, Vol. 21, Pages 3224: Bone Marrow Aspirate Concentrate: Its Uses in Osteoarthritis International Journal of Molecular Sciences doi: 10.3390/ijms21093224 Authors: Gi Beom Kim Min-Soo Seo Wook Tae Park Gun Woo Lee Human bone marrow (BM) is a kind of source of mesenchymal stem cells (MSCs) as well as growth factors and cytokines that may aid anti-inflammation and regeneration for various tissues, including cartilage and bone. However, since MSCs in BM usually occupy only a...
Sat May 02, 2020 03:00
IJMS, Vol. 21, Pages 3225: Detection of Podocin in Human Urine Sediment Samples by Charge Derivatization and LC-MS-MRM Method International Journal of Molecular Sciences doi: 10.3390/ijms21093225 Authors: Remigiusz Bąchor Dorota Gąszczyk Karolina Panek-Laszczyńska Andrzej Konieczny Wojciech Witkiewicz Piotr Stefanowicz Zbigniew Szewczuk Detection of podocytes in urine might serve as a useful diagnostic tool in both primary and secondary glomerular diseases. The utility...
Sat May 02, 2020 03:00
IJMS, Vol. 21, Pages 3223: Environmental Epigenetics and Genome Flexibility: Focus on 5-Hydroxymethylcytosine International Journal of Molecular Sciences doi: 10.3390/ijms21093223 Authors: Efimova Koltsova Krapivin Tikhonov Pendina Convincing evidence accumulated over the last decades demonstrates the crucial role of epigenetic modifications for mammalian genome regulation and its flexibility. DNA methylation and demethylation is a key mechanism of genome programming...
Sat May 02, 2020 03:00
IJMS, Vol. 21, Pages 3222: Diabetes and Hyperglycemia Affect Platelet GPIIIa Expression. Effects on Adhesion Potential of Blood Platelets from Diabetic Patients under In Vitro Flow Conditions International Journal of Molecular Sciences doi: 10.3390/ijms21093222 Authors: Przygodzki Luzak Kassassir Mnich Boncler Siewiera Kosmalski Szymanski Watala Blood platelets play a crucial role in the early stages of atherosclerosis development. The process is believed...
Sat May 02, 2020 03:00
IJMS, Vol. 21, Pages 3221: Cytokine and Growth Factor Delivery from Implanted Platelet-Rich Fibrin Enhances Rabbit Achilles Tendon Healing International Journal of Molecular Sciences doi: 10.3390/ijms21093221 Authors: Wong Huang Chen Lin Yeh Bai Tendons are hypocellular and hypovascular tissues, and thus, their natural healing capacity is low. In this study, we sought to evaluate the efficacy of platelet-rich fibrin (PRF) to serve as a bioactive scaffold in promoting...
Sat May 02, 2020 03:00
IJMS, Vol. 21, Pages 3220: The Impact of Transcription Factor Prospero Homeobox 1 on the Regulation of Thyroid Cancer Malignancy International Journal of Molecular Sciences doi: 10.3390/ijms21093220 Authors: Rudzińska Czarnocka Transcription factor Prospero homeobox 1 (PROX1) is continuously expressed in the lymphatic endothelial cells, playing an essential role in their differentiation. Many reports have shown that PROX1 is implicated in cancer development and acts as an oncoprotein...
Sat May 02, 2020 03:00
IJMS, Vol. 21, Pages 3219: Microglial and Astrocytic Function in Physiological and Pathological Conditions: Estrogenic Modulation International Journal of Molecular Sciences doi: 10.3390/ijms21093219 Authors: Crespo-Castrillo Arevalo There are sexual differences in the onset, prevalence, and outcome of numerous neurological diseases. Thus, in Alzheimer’s disease, multiple sclerosis, and major depression disorder, the incidence in women is higher than in men. In contrast,...
Sat May 02, 2020 03:00
IJMS, Vol. 21, Pages 3214: Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations International Journal of Molecular Sciences doi: 10.3390/ijms21093214 Authors: Lima Atkinson Bunney Katan Huang Selective FGFR inhibitors such as infigratinib (BGJ398) and erdafitinib (JNJ-42756493) have been evaluated in clinical trials for cancers with FGFR3 molecular alterations, particularly in urothelial carcinoma patients....
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3211: The Histological, Effectoromic, and Transcriptomic Analyses of Solanum pinnatisectum Reveal an Upregulation of Multiple NBS-LRR Genes Suppressing Phytophthora infestans Infection International Journal of Molecular Sciences doi: 10.3390/ijms21093211 Authors: Biao Gu Xiaoli Cao Xiaoli Zhou Zhaodan Chen Qinhu Wang Wei Liu Qin Chen Hua Zhao Utilization of disease resistance components from wild potatoes is a promising and sustainable approach...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3215: Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals—The FREIA Project International Journal of Molecular Sciences doi: 10.3390/ijms21093215 Authors: Majorie B.M. van Duursen Julie Boberg Sofie Christiansen Lisa Connolly Pauliina Damdimopoulou Panagiotis Filis Paul A. Fowler Bart M. Gadella Jan Holte Kersti Jääger Hanna K.L. Johansson Tianyi Li Séverine Mazaud-Guittot Anne-Simone Parent Andres Salumets...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3218: Pancreatic Cancer and Its Microenvironment—Recent Advances and Current Controversies International Journal of Molecular Sciences doi: 10.3390/ijms21093218 Authors: Stopa Kusiak Szopa Ferdek Jakubowska Pancreatic ductal adenocarcinoma (PDAC) causes annually well over 400,000 deaths world-wide and remains one of the major unresolved health problems. This exocrine pancreatic cancer originates from the mutated epithelial cells: acinar and ductal...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3217: The Functions of Mitochondrial 2′,3′-Cyclic Nucleotide-3′-Phosphodiesterase and Prospects for Its Future International Journal of Molecular Sciences doi: 10.3390/ijms21093217 Authors: Olga Yulia Vassilios 2′,3′-cyclic nucleotide-3′-phosphodiesterase (CNPase) is a myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2’,3’-cyclic nucleotides to 2’-nucleotides. However, its...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3212: New Insights into Molecular Links Between Microbiota and Gastrointestinal Cancers: A Literature Review International Journal of Molecular Sciences doi: 10.3390/ijms21093212 Authors: Yash Raj Rastogi Adesh K. Saini Vijay Kumar Thakur Reena V. Saini Despite decades of exhaustive research on cancer, questions about cancer initiation, development, recurrence, and metastasis have still not been completely answered. One of the reasons is the plethora of...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3216: Hybridization Chain Reactions Targeting the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) International Journal of Molecular Sciences doi: 10.3390/ijms21093216 Authors: Tzu-Heng Wu Chia-Chen Chang Ching-Hsu Yang Wei-Yin Lin Tan Joy Ee Chii-Wann Lin In this work, hybridization chain reactions (HCRs) toward Severe Acute Respiratory Syndrome Coronavirus 2 (SARS–CoV-2) nucleocapsid phosphoproteins gene loci and human RNase...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3213: High Expression of microRNA-143 is Associated with Favorable Tumor Immune Microenvironment and Better Survival in Estrogen Receptor Positive Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21093213 Authors: Yoshihisa Tokumaru Mariko Asaoka Masanori Oshi Eriko Katsuta Li Yan Sumana Narayanan Nobuhiko Sugito Nobuhisa Matsuhashi Manabu Futamura Yukihiro Akao Kazuhiro Yoshida Kazuaki Takabe microRNA-143(miR-143)...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3208: Effects of Strontium-Doped β-Tricalcium Scaffold on Longitudinal Nuclear Factor-Kappa Beta and Vascular Endothelial Growth Factor Receptor-2 Promoter Activities during Healing in a Murine Critical-Size Bone Defect Model International Journal of Molecular Sciences doi: 10.3390/ijms21093208 Authors: Mersedeh Tohidnezhad Yusuke Kubo Philipp Lichte Tobias Heigl Diana Roch Nazanin Barahmand Pour Christian Bergmann Tolga Taha Sönmez Jennifer Vanessa...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3210: Enhanced Integrin Activation of PLD2-Deficient Platelets Accelerates Inflammation after Myocardial Infarction International Journal of Molecular Sciences doi: 10.3390/ijms21093210 Authors: Aglaia Maria Klose Meike Klier Simone Gorressen Margitta Elvers Background: Phospholipase (PL)D1 is crucial for integrin αIIbβ3 activation of platelets in arterial thrombosis and TNF-α-mediated inflammation and TGF-β-mediated...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3209: Long-Range and Directional Allostery of Actin Filaments Plays Important Roles in Various Cellular Activities International Journal of Molecular Sciences doi: 10.3390/ijms21093209 Authors: Kiyotaka Tokuraku Masahiro Kuragano Taro Q. P. Uyeda A wide variety of uniquely localized actin-binding proteins (ABPs) are involved in various cellular activities, such as cytokinesis, migration, adhesion, morphogenesis, and intracellular transport. In a micrometer-scale...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3207: Post-Translational Modifications of Transcription Factors Harnessing the Etiology and Pathophysiology in Colonic Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21093207 Authors: Chao-Yuan Hsu Shin-Huei Fu Ming-Wei Chien Yu-Wen Liu Shyi-Jou Chen Huey-Kang Sytwu Defects in mucosal immune balance can lead to colonic diseases such as inflammatory bowel diseases and colorectal cancer. With the advancement of understanding for...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3206: Advances in Enzymatic Synthesis of D-Amino Acids International Journal of Molecular Sciences doi: 10.3390/ijms21093206 Authors: Loredano Pollegioni Elena Rosini Gianluca Molla In nature, the D-enantiomers of amino acids (D-AAs) are not used for protein synthesis and during evolution acquired specific and relevant physiological functions in different organisms. This is the reason for the surge in interest and investigations on these “unnatural”...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3205: Mechanisms of Wheat Allergenicity in Mice: Comparison of Adjuvant-Free vs. Alum-Adjuvant Models International Journal of Molecular Sciences doi: 10.3390/ijms21093205 Authors: Yining Jin Haoran Gao Rick Jorgensen Jillian Salloum Dan Ioan Jian Perry K.W. Ng Venugopal Gangur Wheat protein is considered a major type of food allergen in many countries including the USA. The mechanisms of allergenicity of wheat proteins are not well understood at...
Fri May 01, 2020 03:00
IJMS, Vol. 21, Pages 3204: Ultraviolet Irradiation Enhances the Microbicidal Activity of Silver Nanoparticles by Hydroxyl Radicals International Journal of Molecular Sciences doi: 10.3390/ijms21093204 Authors: Nakamura Ando Sato Ishihara It is known that silver has microbicidal qualities; even at a low concentration, silver is active against many kinds of bacteria. Silver nanoparticles (AgNPs) have been extensively studied for a wide range of applications. Alternately, the...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3203: Synergy between Photodynamic Therapy and Dactinomycin Chemotherapy in 2D and 3D Ovarian Cancer Cell Cultures International Journal of Molecular Sciences doi: 10.3390/ijms21093203 Authors: Hadi Yaghini MacRobert Loizidou In this study we explored the efficacy of combining low dose photodynamic therapy using a porphyrin photosensitiser and dactinomycin, a commonly used chemotherapeutic agent. The studies were carried out on compressed collagen 3D...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3202: Burst, Short, and Sustained Vitamin D3 Applications Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21093202 Authors: Cindy Kelder Jolanda M.A. Hogervorst Daniël Wismeijer Cornelis J. Kleverlaan Teun J. de Vries Astrid D. Bakker Incorporation of 1,25(OH)2 vitamin D3 (vitD3) into tissue-engineered scaffolds could aid the healing of critical-sized bone defects....
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3201: The Sophisticated Transcriptional Response Governed by Transposable Elements in Human Health and Disease International Journal of Molecular Sciences doi: 10.3390/ijms21093201 Authors: Marasca Gasparotto Polimeni Vadalà Ranzani Bodega : Transposable elements (TEs), which cover ~45% of the human genome, although firstly considered as “selfish” DNA, are nowadays recognized as driving forces in eukaryotic genome evolution....
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3198: Synthetic Retinoid Seletinoid G Improves Skin Barrier Function through Wound Healing and Collagen Realignment in Human Skin Equivalents International Journal of Molecular Sciences doi: 10.3390/ijms21093198 Authors: Lee Ahn Bae Min Park Jung Kim Hong Park Lee The outer epidermal skin is a primary barrier that protects the body from extrinsic factors, such as ultraviolet (UV) radiation, chemicals and pollutants. The complete...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3200: The Novel ncRNA OsiR Positively Regulates Expression of katE2 and Is Required for Oxidative Stress Tolerance in Deinococcus radiodurans International Journal of Molecular Sciences doi: 10.3390/ijms21093200 Authors: Gao Chen Tian Yan Zhan Zhou Zhang Lin Chen Deinococcus radiodurans is a polyextremophilic bacterium well known for its extreme resistance to irradiation, oxidative stress, and other damaging conditions. Many small...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3196: Short Exposure to Ethanol Diminishes Caspase-1 and ASC Activation in Human HepG2 Cells In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21093196 Authors: Hörauf Kany Janicova Xu Vrdoljak Sturm Dunay Martin Relja This paper discusses how the assembly of pro-caspase-1 and apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC) in macromolecular protein complexes, inflammasomes,...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3197: Development of a Radiofluorinated Adenosine A2B Receptor Antagonist as Potential Ligand for PET Imaging International Journal of Molecular Sciences doi: 10.3390/ijms21093197 Authors: Lindemann Moldovan Hinz Deuther-Conrad Gündel Dukic-Stefanovic Toussaint Teodoro Juhl Steinbach Brust Müller Wenzel The adenosine A2B receptor has been proposed as a novel therapeutic target in cancer, as its expression is drastically...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3199: The Role of Sclerostin in Bone and Ectopic Calcification International Journal of Molecular Sciences doi: 10.3390/ijms21093199 Authors: Maré D’Haese Verhulst Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it leads to an increased bone resorption and decreased bone formation. Serum sclerostin levels are known to be increased...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3194: Transcriptomic Changes Related to Cellular Processes with Particular Emphasis on Cell Activation in Lysosomal Storage Diseases from the Group of Mucopolysaccharidoses International Journal of Molecular Sciences doi: 10.3390/ijms21093194 Authors: Estera Rintz Lidia Gaffke Magdalena Podlacha Joanna Brokowska Zuzanna Cyske Grzegorz Węgrzyn Karolina Pierzynowska Although mucopolysaccharidoses (MPS), inherited metabolic diseases from the group...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3195: Limited Proteolysis of Cyclooxygenase-2 Enhances Cell Proliferation International Journal of Molecular Sciences doi: 10.3390/ijms21093195 Authors: Saadi Sood Dromi Srouji Hatoum Tal Barki-Harrington Accumulating evidence suggests that the cyclooxygenase-2 (COX-2) enzyme has additional catalytic-independent functions. Here we show that COX-2 appears to be cleaved in mouse and human tumors, which led us to hypothesize that COX-2 proteolysis...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3191: Mitochondrial Dysfunction and Calcium Dysregulation in Leigh Syndrome Induced Pluripotent Stem Cell Derived Neurons International Journal of Molecular Sciences doi: 10.3390/ijms21093191 Authors: Teresa Galera-Monge Francisco Zurita-Díaz Isaac Canals Marita Grønning Hansen Laura Rufián-Vázquez Johannes K. Ehinger Eskil Elmér Miguel A. Martin Rafael Garesse Henrik Ahlenius M. Esther Gallardo Leigh syndrome (LS) is the most frequent...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3192: Developments of Riboswitches and Toehold Switches for Molecular Detection—Biosensing and Molecular Diagnostics International Journal of Molecular Sciences doi: 10.3390/ijms21093192 Authors: Tin Hoang Trung Chau Dung Hoang Anh Mai Diep Ngoc Pham Hoa Thi Quynh Le Eun Yeol Lee Riboswitches and toehold switches are considered to have potential for implementation in various fields, i.e., biosensing, metabolic engineering, and molecular diagnostics. The...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3190: Characterization of ABC Transporters in EpiAirway™, a Cellular Model of Normal Human Bronchial Epithelium International Journal of Molecular Sciences doi: 10.3390/ijms21093190 Authors: Bianca Maria Rotoli Amelia Barilli Rossana Visigalli Francesca Ferrari Caterina Frati Costanza Annamaria Lagrasta Maria Di Lascia Benedetta Riccardi Paola Puccini Valeria Dall’Asta The ATP-binding cassette (ABC) transporters P-glycoprotein (MDR1/ABCB1),...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3188: Mechanisms of ATII-to-ATI Cell Differentiation during Lung Regeneration International Journal of Molecular Sciences doi: 10.3390/ijms21093188 Authors: Mohit Aspal Rachel L. Zemans The alveolar epithelium consists of (ATI) and type II (ATII) cells. ATI cells cover the majority of the alveolar surface due to their thin, elongated shape and are largely responsible for barrier function and gas exchange. During lung injury, ATI cells are susceptible to injury,...
Thu Apr 30, 2020 03:00
IJMS, Vol. 21, Pages 3189: Dietary AhR Ligands Regulate AhRR Expression in Intestinal Immune Cells and Intestinal Microbiota Composition International Journal of Molecular Sciences doi: 10.3390/ijms21093189 Authors: Oliver Schanz Rieka Chijiiwa Sevgi Can Cengiz Yasmin Majlesain Heike Weighardt Haruko Takeyama Irmgard Förster A diet rich in vegetables and fruit is generally considered healthy because of a high content of phytochemicals, vitamins, and fiber. The phytochemical...
Thu Apr 30, 2020 03:00
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