JCM, Vol. 9, Pages 1329: Age-Related Macular Degeneration Staging by Color Fundus Photography vs. Multimodal Imaging—Epidemiological Implications (The Coimbra Eye Study—Report 6) Journal of Clinical Medicine doi: 10.3390/jcm9051329 Authors: Cláudia Farinha Maria Luz Cachulo Rita Coimbra Dalila Alves Sandrina Nunes Isabel Pires João Pedro Marques José Costa Amélia Martins Isa Sobral Patrícia Barreto Inês Laíns João Figueira Luisa Ribeiro José Cunha-Vaz...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1328: ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements Journal of Clinical Medicine doi: 10.3390/jcm9051328 Authors: Teresa M. Seccia Matteo Rigato Verdiana Ravarotto Lorenzo A. Calò Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors of the RhoA small GTPase and found to belong to the AGC family of serine/threonine kinases. They were shown to be downstream effectors of RhoA...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1330: Shape and Enhancement Analysis as a Useful Tool for the Presentation of Blood Hemodynamic Properties in the Area of Aortic Dissection Journal of Clinical Medicine doi: 10.3390/jcm9051330 Authors: Polanczyk Piechota-Polanczyk Stefanczyk Strzelecki The aim of this study was to create a mathematical approach for blood hemodynamic description with the use of brightness analysis. Medical data was collected from three male patients aged from 45 to 65 years...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1326: Clinical Characteristics and Disability Progression of Early- and Late-Onset Multiple Sclerosis Compared to Adult-Onset Multiple Sclerosis Journal of Clinical Medicine doi: 10.3390/jcm9051326 Authors: Omid Mirmosayyeb Serge Brand Mahdi Barzegar Alireza Afshari-Safavi Nasim Nehzat Vahid Shaygannejad Dena Sadeghi Bahmani Background: Compared to the adult onset of multiple sclerosis (AOMS), both early-onset (EOMS) and late-onset (LOMS) are much...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1325: A Proteomics-Based Analysis Reveals Predictive Biological Patterns in Fabry Disease Journal of Clinical Medicine doi: 10.3390/jcm9051325 Authors: Tebani Mauhin Abily-Donval Lesueur Berger Nadjar Berger Benveniste Lamari Laforêt Noel Marret Lidove Bekri Background: Fabry disease (FD) is an X-linked progressive lysosomal disease (LD) due to glycosphingolipid metabolism impairment. Currently, plasmatic globotriaosylsphingosine...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1322: Enhanced Visualization of Retinal Microvasculature in Optical Coherence Tomography Angiography Imaging via Deep Learning Journal of Clinical Medicine doi: 10.3390/jcm9051322 Authors: Shin Kadomoto Akihito Uji Yuki Muraoka Tadamichi Akagi Akitaka Tsujikawa Background: To investigate the effects of deep learning denoising on quantitative vascular measurements and the quality of optical coherence tomography angiography (OCTA) images. Methods: U-Net-based...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1319: Scoring System for Identification of “Survival Advantage” after Successful Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion Journal of Clinical Medicine doi: 10.3390/jcm9051319 Authors: Tatsuya Nakachi Shun Kohsaka Masahisa Yamane Toshiya Muramatsu Atsunori Okamura Yoshifumi Kashima Shunsuke Matsuno Masami Sakurada Yoshitane Seino Maoto Habara Background: Percutaneous coronary intervention (PCI) is widely...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1323: Serum Interleukin-6 and -8 as Predictors of Response to Vedolizumab in Inflammatory Bowel Diseases Journal of Clinical Medicine doi: 10.3390/jcm9051323 Authors: Bertani Caviglia Antonioli Pellicano Fagoonee Astegiano Saracco Bugianesi Blandizzi Costa Ribaldone Vedolizumab, a monoclonal antibody directed against integrin α4β7, is an effective treatment for inflammatory bowel diseases. However, a significant...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1321: Smoking and SARS-CoV-2 Disease (COVID-19): Dangerous Liaisons or Confusing Relationships? Journal of Clinical Medicine doi: 10.3390/jcm9051321 Authors: Giovanni Li Volti Massimo Caruso Riccardo Polosa We read with great interest the article by Brake SJ and colleagues [...]
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1327: Endothelin-1 Serum Concentration is Lower in Children and Adolescents with High Myopia, a Preliminary Study Journal of Clinical Medicine doi: 10.3390/jcm9051327 Authors: Katarzyna Powierza Beata Żelazowska-Rutkowska Jolanta Sawicka-Powierza Bożena Mikołuć Beata Urban Wojciech Zaremba Bogdan Cylwik Alina Bakunowicz-Łazarczyk The aim of this study is to evaluate the levels of enothelin-1 (ET-1) in children and adolescents with high myopia and...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1317: Right Ventricular Free Wall Strain and Congestive Hepatopathy in Patients with Acute Worsening of Chronic Heart Failure: A CATSTAT-HF Echo Substudy Journal of Clinical Medicine doi: 10.3390/jcm9051317 Authors: Josip A. Borovac Duska Glavas Zora Susilovic Grabovac Daniela Supe Domic Lada Stanisic Domenico D’Amario Darko Duplancic Josko Bozic Right ventricular (RV) function is an important predictor of prognosis in patients with heart failure....
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1316: Relationships Between Short-Term Exposure to an Indoor Environment and Dry Eye (DE) Symptoms Journal of Clinical Medicine doi: 10.3390/jcm9051316 Authors: Maria A. Idarraga Juan S. Guerrero Samantha G. Mosle Frank Miralles Anat Galor Naresh Kumar Air composition influences Dry Eye (DE) symptoms as demonstrated by studies that have linked the outdoor environment to DE. However, there is insufficient data on the effect of short-term exposure to indoor...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1318: Gamma Knife Radiosurgery Followed by Flow-Reductive Embolization for Ruptured Arteriovenous Malformation Journal of Clinical Medicine doi: 10.3390/jcm9051318 Authors: Kim Park Park Jung Chang Chang Lee Chang : Background: Aggressive treatment to achieve complete obliteration of brain arteriovenous malformation (AVM) is necessary in patients with a recent history of hemorrhage. The major drawback of Gamma knife radiosurgery (GKRS)...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1320: Outcome Comparison between Low-Dose Rabbit Anti-Thymocyte Globulin and Basiliximab in Low-Risk Living Donor Kidney Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9051320 Authors: Kim Rhu Yoo Kim Lee Park The objective of this study was to compare outcomes between basiliximab and low-dose r-ATG in living donor kidney transplantation recipients with low immunological risk. Patients in the low-dose r-ATG group received 1.5 mg/kg...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1315: Long-Term Treatment Outcome of Progressive Mycobacterium Avium Complex Pulmonary Disease Journal of Clinical Medicine doi: 10.3390/jcm9051315 Authors: Fukushima Kitada Abe Yamamoto Matsuki Kagawa Oshitani Tsujino Yoshimura Miki Miki Kida Background: Multidrug therapy is essential for preventing respiratory failure in patients with highly progressive Mycobacterium avium complex pulmonary disease (MAC-PD). However, the...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1314: Optimal Control Theory for Personalized Therapeutic Regimens in Oncology: Background, History, Challenges, and Opportunities Journal of Clinical Medicine doi: 10.3390/jcm9051314 Authors: Jarrett Faghihi II Lima Virostko Biros Patt Yankeelov Optimal control theory is branch of mathematics that aims to optimize a solution to a dynamical system. While the concept of using optimal control theory to improve treatment regimens in oncology...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1310: Effect of Dysmetabolisms and Comorbidities on the Efficacy and Safety of Biological Therapy in Chronic Inflammatory Joint Diseases Journal of Clinical Medicine doi: 10.3390/jcm9051310 Authors: Laura Cometi Cosimo Bruni Nicolò Chiti Lorenzo Tofani Francesca Nacci Francesca Bartoli Silvia Bellando-Randone Daniela Melchiorre Ginevra Fiori Serena Guiducci Marco Matucci-Cerinic In the present study we evaluated how systemic arterial hypertension...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1312: The Effect of a Multicomponent Dual-Task Exercise on Cortical Thickness in Older Adults with Cognitive Decline: A Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9051312 Authors: Seongryu Bae Kenji Harada Sangyoon Lee Kazuhiro Harada Keitaro Makino Ippei Chiba Hyuntae Park Hiroyuki Shimada The aim of this study was to examine cortical thickness changes associated with a multicomponent exercise intervention combining...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1311: Challenges to the Application of Integrated, Personalized Care for Patients with COPD—A Vision for the Role of Clinical Information Journal of Clinical Medicine doi: 10.3390/jcm9051311 Authors: Vanfleteren Hul Kulbacka-Ortiz Andersson Ullman Ingvar Chronic Obstructive Pulmonary Disease (COPD) is a complex disease defined by airflow limitation and characterized by a spectrum of treatable and untreatable pulmonary and extra-pulmonary disease...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1313: Diagnostic Utility and Pathogenic Role of Circulating MicroRNAs in Vasospastic Angina Journal of Clinical Medicine doi: 10.3390/jcm9051313 Authors: Chan Soon Park Inho Kim Gyu Chul Oh Jung-Kyu Han Han-Mo Yang Kyung Woo Park Hyun-Jai Cho Hyun-Jae Kang Bon-Kwon Koo Woo-Young Chung Seil Oh Hae-Young Lee We investigated the diagnostic value and pathophysiological role of circulating microRNA (miR) in vasospastic angina (VA). We enrolled...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1309: Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis Journal of Clinical Medicine doi: 10.3390/jcm9051309 Authors: Anna Zubrzycka Marek Zubrzycki Ewelina Perdas Maria Zubrzycka Endometriosis is a chronic gynecological disease, affecting up to 10% of reproductive-age women. The exact cause of the disease is unknown; however, it is a heritable condition affected by multiple genetic, epigenetic, and environmental factors. Previous...
Sat May 02, 2020 03:00
JCM, Vol. 9, Pages 1303: Shortening of Overall Orthodontic Treatment Duration with Low-Intensity Pulsed Ultrasound (LIPUS) Journal of Clinical Medicine doi: 10.3390/jcm9051303 Authors: Harmanpreet Kaur Tarek El-Bialy The aim of this retrospective clinical study was to determine if there is a reduction in the overall treatment duration in orthodontic patients using low-intensity pulsed ultrasound (LIPUS) and Invisalign SmartTrack® clear aligners. Data were collected from the...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1304: Prediction of Motor Recovery in Patients with Basal Ganglia Hemorrhage Using Diffusion Tensor Imaging Journal of Clinical Medicine doi: 10.3390/jcm9051304 Authors: Yu-Sun Min Kyung Eun Jang Eunhee Park Ae-Ryoung Kim Min-Gu Kang Youn-Soo Cheong Ju-Hyun Kim Seung-Hwan Jung Jaechan Park Tae-Du Jung Predicting prognosis in patients with basal ganglia hemorrhage is difficult. This study aimed to investigate the usefulness of diffusion tensor...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1308: Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis Journal of Clinical Medicine doi: 10.3390/jcm9051308 Authors: Ewa M. Koźma Kornelia Kuźnik-Trocha Katarzyna Winsz-Szczotka Grzegorz Wisowski Paweł Olczyk Katarzyna Komosińska-Vassev Mariusz Kasperczyk Krystyna Olczyk Acute pancreatitis (AP) manifests itself either as a mild, self-limiting inflammation...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1307: Prognostic Value of Tumor Size in Resected Stage IIIA-N2 Non-Small-Cell Lung Cancer Journal of Clinical Medicine doi: 10.3390/jcm9051307 Authors: Chih-Yu Chen Bing-Ru Wu Chia-Hung Chen Wen-Chien Cheng Wei-Chun Chen Wei-Chih Liao Chih-Yi Chen Te-Chun Hsia Chih-Yen Tu The eighth edition of the American Joint Committee on Cancer (AJCC) staging system for lung cancer was introduced in 2017 and included major revisions, especially of stage...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1305: Association of Salivary Human Papillomavirus Infection and Oral and Oropharyngeal Cancer: A Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9051305 Authors: Óscar Rapado-González Cristina Martínez-Reglero Ángel Salgado-Barreira Almudena Rodríguez-Fernández Santiago Aguín-Losada Luis León-Mateos Laura Muinelo-Romay Rafael López-López María Mercedes Suarez-Cunqueiro Background. Human papillomavirus (HPV) infection has been recognized...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1306: Elevated Levels of Monocyte Chemotactic Protein-1 in the Follicular Fluid Reveals Different Populations among Women with Severe Endometriosis Journal of Clinical Medicine doi: 10.3390/jcm9051306 Authors: Pierre-Emmanuel Bouet Juan-Manuel Chao de la Barca Lisa Boucret Philippe Descamps Guillaume Legendre Hady El Hachem Simon Blanchard Pascale Jeannin Pascal Reynier Pascale May-Panloup To determine if a modification of the cytokine profile...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1301: Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Gastric Mesenchymal Tumors Journal of Clinical Medicine doi: 10.3390/jcm9051301 Authors: Masaya Iwamuro Koji Miyahara Chihiro Sakaguchi Ryuta Takenaka Sayo Kobayashi Hirokazu Mouri Shigetomi Tanaka Tatsuya Toyokawa Shouichi Tanaka Mamoru Nishimura Kenji Yamauchi Takehiro Tanaka Hiroyuki Okada There have been no comparative studies investigating the results...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1302: The Effect of an Abnormal BMI on Orthopaedic Trauma Patients: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9051302 Authors: Florence Kinder Peter V. Giannoudis Tim Boddice Anthony Howard Aims: The aim of this systemic review is to identify the complications that arise in operating on orthopaedic trauma patients with an abnormal body mass index (BMI). Materials and Methods: Systematic literature search using a combination...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1300: Role of Reconstructive Microsurgery in Tubal Infertility in Young Women Journal of Clinical Medicine doi: 10.3390/jcm9051300 Authors: Sorin Barac Lucian Petru Jiga Andreea Rata Ioan Sas Roxana Ramona Onofrei Mihai Ionac Aim: Here, we retrospectively analyzed the success rate of reconstructive microsurgery for tubal infertility (RMTI) as a “first-line” approach to achieving tubal reversal and pregnancy after tubal infertility....
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1299: Antibiotic Resistance and Therapy for H. pylori Infection in Immigrant Patients Treated in Italy Journal of Clinical Medicine doi: 10.3390/jcm9051299 Authors: Giulia Fiorini Ilaria Maria Saracino Angelo Zullo Matteo Pavoni Laura Saccomanno Tiziana Lazzarotto Rossana Cavallo Guido Antonelli Berardino Vaira Background: Helicobacter pylori (H. pylori) infection is the leading cause of both peptic ulcers and gastric tumors, including low-grade...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1297: Time from Symptom Onset to Hospitalisation of Coronavirus Disease 2019 (COVID-19) Cases: Implications for the Proportion of Transmissions from Infectors with Few Symptoms Journal of Clinical Medicine doi: 10.3390/jcm9051297 Authors: Robin N. Thompson Francesca A. Lovell-Read Uri Obolski Interventions targeting symptomatic hosts and their contacts were successful in bringing the 2003 SARS pandemic under control. In contrast, the COVID-19 pandemic has been...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1298: Predicting Total Knee Replacement from Symptomology and Radiographic Structural Change Using Artificial Neural Networks—Data from the Osteoarthritis Initiative (OAI) Journal of Clinical Medicine doi: 10.3390/jcm9051298 Authors: Stephan Heisinger Wolfgang Hitzl Gerhard M. Hobusch Reinhard Windhager Sebastian Cotofana The aim of the study was to longitudinally investigate symptomatic and structural factors prior to total knee replacement (TKR) surgery...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1296: What Determines Spontaneous Physical Activity in Patients with Parkinson’s Disease? Journal of Clinical Medicine doi: 10.3390/jcm9051296 Authors: Agnieszka Gorzkowska Joanna Cholewa Andrzej Małecki Aleksandra Klimkowicz-Mrowiec Jarosław Cholewa Physical activity (PA) is a factor that may have an influence on the symptoms of Parkinson’s disease (PD). The aim of this study was to identify the potential determinants of spontaneous PA in a PD...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1295: Association of Specific Comorbidities with Monosodium Urate Crystal Deposition in Urate-Lowering Therapy-Naive Gout Patients: A Cross-Sectional Dual-Energy Computed Tomography Study Journal of Clinical Medicine doi: 10.3390/jcm9051295 Authors: Tristan Pascart André Ramon Sébastien Ottaviani Julie Legrand Vincent Ducoulombier Eric Houvenagel Laurène Norberciak Pascal Richette Fabio Becce Paul Ornetti Jean-François Budzik (1) Background:...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1294: Inhibition of Protein-tyrosine Phosphatase PTP1B and LMPTP Promotes Palmitate/Oleate-challenged HepG2 Cell Survival by Reducing Lipoapoptosis, Improving Mitochondrial Dynamics and Mitigating Oxidative and Endoplasmic Reticulum Stress Journal of Clinical Medicine doi: 10.3390/jcm9051294 Authors: Lynda Bourebaba Jacek Łyczko Michalina Alicka Nabila Bourebaba Antoni Szumny Andrzej M. Fal Krzysztof Marycz Objectives: Non-alcoholic fatty liver disease...
Fri May 01, 2020 03:00
JCM, Vol. 9, Pages 1293: Plasma Hyperosmolality Prolongs QTc Interval and Increases Risk for Atrial Fibrillation in Traumatic Brain Injury Patients Journal of Clinical Medicine doi: 10.3390/jcm9051293 Authors: Dabrowski Siwicka-Gieroba Robba Badenes Bialy Iwaniuk Schlegel Jaroszynski Introduction: Hyperosmotic therapy with mannitol is frequently used for treatment cerebral edema, and 320 mOsm/kg H2O has been recommended as a high limit for therapeutic plasma...
Thu Apr 30, 2020 03:00
JCM, Vol. 9, Pages 1292: Insular Cell Integrity Markers Linked to Weight Concern in Anorexia Nervosa—An MR-Spectroscopy Study Journal of Clinical Medicine doi: 10.3390/jcm9051292 Authors: Maier Nickel Perlov Kukies Zeeck Elst Endres Spieler Holovics Hartmann Dacko Lange Joos Objective: An insular involvement in the pathogenesis of anorexia nervosa (AN) has been suggested in many structural and functional neuroimaging studies. This magnetic...
Thu Apr 30, 2020 03:00
JCM, Vol. 9, Pages 1291: Visual Feedback and Postural Control in Multiple Sclerosis Journal of Clinical Medicine doi: 10.3390/jcm9051291 Authors: Inojosa Schriefer Trentzsch Klöditz Ziemssen As people with multiple sclerosis (pwMS) manifest heterogeneous demyelinating lesions that could affect somatosensory or vestibular ways, visual stimulus as feedback could be especially relevant to achieve postural control. This has clinical importance for the development of preventive...
Thu Apr 30, 2020 03:00
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