Cancers, Vol. 12, Pages 1151: Cytoplasmic Increase in Hsp70 Protein: A Potential New Biomarker of Early Infiltration of Cutaneous Squamous Cell Carcinoma Arising from Actinic Keratosis Cancers doi: 10.3390/cancers12051151 Authors: Fernández-Guarino León Farré Morales Adrada Garde Navalon Olasolo Background: Cutaneous squamous skin cell carcinoma (SCC) is the second most frequent type of non-melanoma skin cancer and is the second leading cause of death by...
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Cancers, Vol. 12, Pages 1148: A Novel 4-Gene Score to Predict Survival, Distant Metastasis and Response to Neoadjuvant Therapy in Breast Cancer Cancers doi: 10.3390/cancers12051148 Authors: Oshi Katsuta Yan Ebos Rashid Matsuyama Endo Takabe We generated a 4-gene score with genes upregulated in LM2-4, a metastatic variant of MDA-MB-231 (DOK 4, HCCS, PGF, and SHCBP1) that was strongly associated with disease-free survival (DFS) in TCGA cohort (hazard ratio...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1147: Plasma-Derived Extracellular Vesicles Convey Protein Signatures that Reflect Pathophysiology in Lung and Pancreatic Adenocarcinomas Cancers doi: 10.3390/cancers12051147 Authors: Johannes F. Fahrmann Xiangying Mao Ehsan Irajizad Hiroyuki Katayama Michela Capello Ichidai Tanaka Taketo Kato Ignacio I. Wistuba Anirban Maitra Edwin J. Ostrin Samir M. Hanash Jody Vykoukal Using a combination of mass-spectrometry and aptamer array-based...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1146: Establishment and Validation of an Individualized Cell Cycle Process-Related Gene Signature to Predict Cancer-Specific Survival in Patients with Bladder Cancer Cancers doi: 10.3390/cancers12051146 Authors: Run Shi Xuanwen Bao Paul Rogowski Christian Schäfer Nina-Sophie Schmidt-Hegemann Kristian Unger Shun Lu Jing Sun Alexander Buchner Christian Stief Claus Belka Minglun Li More accurate models are essential to identify high-risk...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1145: Senescence and Cancer: Role of Nitric Oxide (NO) in SASP Cancers doi: 10.3390/cancers12051145 Authors: Nesrine Mabrouk Silvia Ghione Véronique Laurens Stéphanie Plenchette Ali Bettaieb Catherine Paul Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial....
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1143: Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells Cancers doi: 10.3390/cancers12051143 Authors: Sadeghi Arvidsson Merrien M.Wasik Görgens Smith Sander Wright Interactions between lymphoma cells and stromal cells play a key role in promoting tumor survival and development of drug resistance. We identified differences in key signaling pathways between the JeKo-1 and REC-1...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1144: Direct Oral Anticoagulants in Cancer Patients. Time for a Change in Paradigm Cancers doi: 10.3390/cancers12051144 Authors: Wojtukiewicz Skalij Tokajuk Politynska Wojtukiewicz Tucker Honn Thrombosis is a more common occurrence in cancer patients compared to the general population and is one of the main causes of death in these patients. Low molecular weight heparin (LMWH) has been the recognized standard treatment for more than a...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1140: SNAI1-Driven Sequential EMT Changes Attributed by Selective Chromatin Enrichment of RAD21 and GRHL2 Cancers doi: 10.3390/cancers12051140 Authors: Vignesh Sundararajan Ming Tan Tuan Zea Tan Qing You Pang Jieru Ye Vin Yee Chung Ruby Yun-Ju Huang Over two decades of research on cancer-associated epithelial-mesenchymal transition (EMT) led us to ascertain the occurrence of transitional intermediate states (collectively referred to as the EMT...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1142: Integrative Analysis of Fecal Metagenomics and Metabolomics in Colorectal Cancer Cancers doi: 10.3390/cancers12051142 Authors: Clos-Garcia Garcia Alonso Iruarrizaga-Lejarreta D’Amato Crespo Iglesias Cubiella Bujanda Falcón-Pérez Although colorectal cancer (CRC) is the second leading cause of death in developed countries, current diagnostic tests for early disease stages are suboptimal. We have performed a combination...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1141: Molecular Signatures of JMJD10/MINA53 in Gastric Cancer Cancers doi: 10.3390/cancers12051141 Authors: Aziz Hong Jo Kim Kim Ashktorab Smoot Hur Yoo Cho The JMJD10 gene and its encoded protein MYC-induced nuclear antigen (MINA53) are associated with multiple cancers. Besides having both an oncogenic and tumor suppressor function, the intricate role of JMJD10 in cancer is complex as it depends on the cancer type. In particular,...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1139: Expanding the Spectrum of Adenoviral Vectors for Cancer Therapy Cancers doi: 10.3390/cancers12051139 Authors: Jian Gao Wenli Zhang Anja Ehrhardt Adenoviral vectors (AdVs) have attracted much attention in the fields of vaccine development and treatment for diseases such as genetic disorders and cancer. In this review, we discuss the utility of AdVs in cancer therapies. In recent years, AdVs were modified as oncolytic AdVs (OAs) that possess the characteristics...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1138: [18F]FDG-PET/CT Radiomics for Prediction of Bone Marrow Involvement in Mantle Cell Lymphoma: A Retrospective Study in 97 Patients Cancers doi: 10.3390/cancers12051138 Authors: Mayerhoefer Riedl Kumar Dogan Gibbs Weber Staber Castellanos Schöder Biopsy is the standard for assessment of bone marrow involvement in mantle cell lymphoma (MCL). We investigated whether [18F]FDG-PET radiomic texture features can improve prediction...
Sat May 02, 2020 03:00
Cancers, Vol. 12, Pages 1137: USP47 Promotes Tumorigenesis by Negative Regulation of p53 through Deubiquitinating Ribosomal Protein S2 Cancers doi: 10.3390/cancers12051137 Authors: Jinhong Cho Jinyoung Park Sang Chul Shin Mihue Jang Jae-Hong Kim Eunice EunKyeong Kim Eun Joo Song p53 is activated in response to cellular stresses such as DNA damage, oxidative stress, and especially ribosomal stress. Although the regulations of p53 by E3 ligase and deubiquitinating enzymes...
Fri May 01, 2020 03:00
Cancers, Vol. 12, Pages 1136: Increased Level of Long Non-Coding RNA MALAT1 is a Common Feature of Amoeboid Invasion Cancers doi: 10.3390/cancers12051136 Authors: Merta Gandalovičová Čermák Dibus Gutschner Diederichs Rösel Brábek The ability of cancer cells to adopt various migration modes (the plasticity of cancer cell invasiveness) is a substantive obstacle in the treatment of metastasis, yet still an incompletely understood process. We performed a comparison...
Fri May 01, 2020 03:00
Cancers, Vol. 12, Pages 1134: Inflammation-Based Scores Increase the Prognostic Value of Circulating Tumor Cells in Primary Breast Cancer Cancers doi: 10.3390/cancers12051134 Authors: Svetlana Miklikova Gabriel Minarik Tatiana Sedlackova Jana Plava Marina Cihova Silvia Jurisova Katarina Kalavska Marian Karaba Juraj Benca Bozena Smolkova Michal Mego A correlation between circulating tumor cells (CTCs) and monocytes in metastatic breast cancer (BC), where...
Fri May 01, 2020 03:00
Cancers, Vol. 12, Pages 1135: Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology Cancers doi: 10.3390/cancers12051135 Authors: Aoki Shoji Kashiro Takeuchi Shimizu Honda The comprehensive analysis of biological and clinical aspects of circulating tumor cells (CTCs) has attracted interest as a means of enabling non-invasive, real-time monitoring of cancer patients and enhancing our fundamental understanding of tumor metastasis. However,...
Fri May 01, 2020 03:00
Cancers, Vol. 12, Pages 1133: Multi-Gene Prognostic Signatures and Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy in ER-positive, HER2-negative Breast Cancer Patients Cancers doi: 10.3390/cancers12051133 Authors: Claudia Mazo Stephen Barron Catherine Mooney William M. Gallagher Determining which patients with early-stage breast cancer should receive chemotherapy is an important clinical issue. Chemotherapy has several adverse side effects, impacting...
Fri May 01, 2020 03:00
Cancers, Vol. 12, Pages 1132: Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies Cancers doi: 10.3390/cancers12051132 Authors: Graybill Davalos Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the treatment of tumors. PEFs increase the permeability of cell membranes, a phenomenon known as electroporation....
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1131: Multicenter Retrospective Analysis of Second-Line Therapy after Gemcitabine Plus Nab-Paclitaxel in Advanced Pancreatic Cancer Patients Cancers doi: 10.3390/cancers12051131 Authors: Valeria Merz Alessandro Cavaliere Carlo Messina Massimiliano Salati Camilla Zecchetto Simona Casalino Michele Milella Orazio Caffo Davide Melisi Pancreatic cancer is one of the most lethal solid tumors. In many European countries gemcitabine plus nab-paclitaxel...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1128: CUL4A, ERCC5, and ERCC1 as Predictive Factors for Trabectedin Efficacy in Advanced Soft Tissue Sarcomas (STS): A Spanish Group for Sarcoma Research (GEIS) Study Cancers doi: 10.3390/cancers12051128 Authors: David S. Moura Paloma Sanchez-Bustos Antonio Fernandez-Serra María Lopez-Alvarez José L. Mondaza-Hernandez Elena Blanco-Alcaina Angela Gavilan-Naranjo Paula Martinez-Delgado Serena Lacerenza Paloma Santos-Fernandez Irene Carrasco-Garcia...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1129: Chemotherapeutic Agents Sensitize Resistant Cancer Cells to the DR5-Specific Variant DR5-B more Efficiently than to TRAIL by Modulating the Surface Expression of Death and Decoy Receptors Cancers doi: 10.3390/cancers12051129 Authors: Аrtem А. Аrtykov Dmitry A. Belov Victoria O. Shipunova Daria B. Trushina Sergey M. Deyev Dmitry A. Dolgikh Mikhail P. Kirpichnikov Marine E. Gasparian TRAIL is considered a promising antitumor agent because...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1127: Metabolic Parameters Influence Brain Infarction and Outcome after Resection of Brain Metastases Cancers doi: 10.3390/cancers12051127 Authors: Nicole Lange Julia Urich Melanie Barz Kaywan Aftahy Arthur Wagner Lucia Albers Stefanie Bette Benedikt Wiestler Martin Bretschneider Bernhard Meyer Jens Gempt Perioperative infarction in brain tumor surgery occurs in about 30–80% of cases and is strongly associated with poor...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1130: Survival of Patients with Hepatocellular Carcinoma in Renal Insufficiency: Prognostic Role of Albumin-Bilirubin Grade Cancers doi: 10.3390/cancers12051130 Authors: Shu-Yein Ho Chia-Yang Hsu Po-Hong Liu Chih-Chieh Ko Yi-Hsiang Huang Chien-Wei Su Rheun-Chuan Lee Ming-Chih Hou Teh-Ia Huo Renal insufficiency (RI) is commonly seen in patients with hepatocellular carcinoma (HCC). The prognostic role of albumin-bilirubin (ALBI) grade in...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1125: Precision Medicine for NSCLC in the Era of Immunotherapy: New Biomarkers to Select the Most Suitable Treatment or the Most Suitable Patient Cancers doi: 10.3390/cancers12051125 Authors: Giovanni Rossi Alessandro Russo Marco Tagliamento Alessandro Tuzi Olga Nigro Giacomo Vallome Claudio Sini Massimiliano Grassi Maria Giovanna Dal Bello Simona Coco Luca Longo Lodovica Zullo Enrica Teresa Tanda Chiara Dellepiane Paolo Pronzato...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1123: Identifying Therapies to Combat Epithelial Mesenchymal Plasticity-Associated Chemoresistance to Conventional Breast Cancer Therapies Using An shRNA Library Screen Cancers doi: 10.3390/cancers12051123 Authors: Sugandha Bhatia Tony Blick Cletus Pinto Mark Waltham James Monkman Ekaterina Ivanova Pamela M. Pollock Shivashankar H. Nagaraj Adrian P. Wiegmans Izhak Haviv Kaylene J. Simpson Erik W. Thompson Background: Breast cancer...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1126: Evaluation of Anti-Tumor Effects of Whole-Body Low-Dose Irradiation in Metastatic Mouse Models Cancers doi: 10.3390/cancers12051126 Authors: Kyung-Hee Song Seung-Youn Jung Jeong-In Park Jiyeon Ahn Jong-Kuk Park Sang-Gu Hwang Eun-Ho Kim Seon Young Nam Seungwoo Park Hunjoo Ha Jie-Young Song Low-dose irradiation (LDI) has recently been shown to have various beneficial effects on human health, such as on cellular metabolic activities,...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1120: The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review Cancers doi: 10.3390/cancers12051120 Authors: Frederik van Delft Hendrik Koffijberg Valesca Retèl Michel van den Heuvel Maarten IJzerman With the introduction of targeted therapies and immunotherapy, molecular diagnostics gained a more profound role in the management of non-small...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1122: The Role of lncRNAs TAPIR-1 and -2 as Diagnostic Markers and Potential Therapeutic Targets in Prostate Cancer Cancers doi: 10.3390/cancers12051122 Authors: Friedrich Wiedemann Reiche Puppel Pfeifer Zipfel Binder Köhl Müller Engeland Aigner Füssel Fröhner Peitzsch Dubrovska Rade Christ Schreiber Hackermüller Lehmann Toma Muders Sommer Baretton Wirth Horn In...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1121: Opportunities for Conventional and in Situ Cancer Vaccine Strategies and Combination with Immunotherapy for Gastrointestinal Cancers, A Review Cancers doi: 10.3390/cancers12051121 Authors: Rachid Bouzid Maikel Peppelenbosch Sonja I. Buschow Survival of gastrointestinal cancer remains dismal, especially for metastasized disease. For various cancers, especially melanoma and lung cancer, immunotherapy has been proven to confer survival benefits, but results...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1119: Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer Cancers doi: 10.3390/cancers12051119 Authors: Shamir Cassim Milica Vučetić Maša Ždralević Jacques Pouyssegur A defining hallmark of tumor phenotypes is uncontrolled cell proliferation, while fermentative glycolysis has long been considered as one of the major metabolic pathways that allows energy production and provides intermediates...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1124: Usefulness of Two Independent DNA and RNA Tissue-Based Multiplex Assays for the Routine Care of Advanced NSCLC Patients Cancers doi: 10.3390/cancers12051124 Authors: Elba Marin Cristina Teixido Elena Carmona-Rocha Roxana Reyes Ainara Arcocha Nuria Viñolas MªCarmen Rodríguez-Mues Carlos Cabrera Marcelo Sánchez Ivan Vollmer Sergi Castillo Silvia Muñoz Ivana G. Sullivan Adela Rodriguez Mireia Garcia Silvia Alos Pedro...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1118: Tetraploidy-Associated Genetic Heterogeneity Confers Chemo-Radiotherapy Resistance to Colorectal Cancer Cells Cancers doi: 10.3390/cancers12051118 Authors: Claudia Galofré Öykü Gönül Geyik Elena Asensio Darawalee Wangsa Daniela Hirsch Carolina Parra Jordi Saez Meritxell Mollà Zeynep Yüce Antoni Castells Thomas Ried Jordi Camps Tetraploidy, or whole-genome duplication, is a common phenomenon in cancer and preludes chromosome...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1128: Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex Cells doi: 10.3390/cells9051128 Authors: Solé Sastre Colomer-Molera Vallejo-Gracia Roig Pérez-Verdaguer Lillo Tamkun Felipe The voltage-gated potassium channel Kv1.3 plays a crucial role during the immune response. The channel forms oligomeric complexes by associating with several modulatory subunits. KCNE4, one of the five members of the KCNE family,...
Sat May 02, 2020 03:00
Cells, Vol. 9, Pages 1127: Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis–From Research to Clinical Practice Cells doi: 10.3390/cells9051127 Authors: Wysocki Olesińska Paradowska-Gorycka Rheumatoid arthritis (RA) is an autoimmune disease with an unclear pathogenic mechanism. However, it has been proven that the key underlying risk factor is a genetic predisposition. Association studies of the HLA-DRB1 gene clearly indicate its importance in...
Sat May 02, 2020 03:00
Cells, Vol. 9, Pages 1126: The Cellular Protein CAD is Recruited into Ebola Virus Inclusion Bodies by the Nucleoprotein NP to Facilitate Genome Replication and Transcription Cells doi: 10.3390/cells9051126 Authors: Janine Brandt Lisa Wendt Bianca S. Bodmer Thomas C. Mettenleiter Thomas Hoenen Ebola virus (EBOV) is a zoonotic pathogen causing severe hemorrhagic fevers in humans and non-human primates with high case fatality rates. In recent years, the number and extent of...
Fri May 01, 2020 03:00
Cells, Vol. 9, Pages 1125: The Impact of Mutations in the HvCPD and HvBRI1 Genes on the Physicochemical Properties of the Membranes from Barley Acclimated to Low/High Temperatures Cells doi: 10.3390/cells9051125 Authors: Elżbieta Rudolphi-Szydło Iwona Sadura Maria Filek Damian Gruszka Anna Janeczko (1) Background: The study characterized barley mutants with brassinosteroid (BR) biosynthesis and signaling disturbances in terms of the physicochemical/structural properties of...
Fri May 01, 2020 03:00
Cells, Vol. 9, Pages 1124: Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy Cells doi: 10.3390/cells9051124 Authors: Lin Ho Huang Wu Lee Huang Wang Yang Chiang. Impairment of the ubiquitin-proteasome-system (UPS) and autophagy causing cytoplasmic aggregation of ubiquitin andp62 have been implicated in the pathogenesis of most neurodegenerative disorders, yet, they have not been fully elucidated in leukodystrophies....
Fri May 01, 2020 03:00
Cells, Vol. 9, Pages 1123: CDDO-Me Inhibits Microglial Activation and Monocyte Infiltration by Abrogating NFκB- and p38 MAPK-Mediated Signaling Pathways Following Status Epilepticus Cells doi: 10.3390/cells9051123 Authors: Ji-Eun Kim Hana Park Ji-Eun Lee Tae-Cheon Kang Following status epilepticus (SE, a prolonged seizure activity), microglial activation, and monocyte infiltration result in the inflammatory responses in the brain that is involved in the epileptogenesis. Therefore,...
Fri May 01, 2020 03:00
Cells, Vol. 9, Pages 1122: Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres are Suitable for Neurotoxicity Screening Cells doi: 10.3390/cells9051122 Authors: Kobolak Teglasi Bellak Janstova Molnar Zana Bock Laszlo Dinnyes We present a hiPSC-based 3D in vitro system suitable to test neurotoxicity (NT). Human iPSCs-derived 3D neurospheres grown in 96-well plate format were characterized timewise for 6-weeks. Changes in complexity and homogeneity...
Fri May 01, 2020 03:00
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