Cells, Vol. 9, Pages 1122: Human Induced Pluripotent Stem Cell-Derived 3D-Neurospheres are Suitable for Neurotoxicity Screening Cells doi: 10.3390/cells9051122 Authors: Kobolak Teglasi Bellak Janstova Molnar Zana Bock Laszlo Dinnyes We present a hiPSC-based 3D in vitro system suitable to test neurotoxicity (NT). Human iPSCs-derived 3D neurospheres grown in 96-well plate format were characterized timewise for 6-weeks. Changes in complexity and homogeneity...
Fri May 01, 2020 03:00
Cells, Vol. 9, Pages 1121: Organoids of Human Endometrium: A Powerful In Vitro Model for the Endometrium–Embryo Cross-Talk at the Implantation Site Cells doi: 10.3390/cells9051121 Authors: Luddi Pavone Semplici Governini Criscuoli Paccagnini Gentile Morgante Leo Belmonte Zarovni Piomboni Embryo implantation has been defined as the “black box” of human reproduction. Most of the knowledge on mechanisms underlining this process...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1120: Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity Cells doi: 10.3390/cells9051120 Authors: Manisha Gupte Prachi Umbarkar Anand Prakash Singh Qinkun Zhang Sultan Tousif Hind Lal Obesity is an independent risk factor for cardiovascular diseases (CVD), including heart failure. Thus, there is an urgent need to understand the molecular mechanism...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1118: IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling Cells doi: 10.3390/cells9051118 Authors: Baptiste Dumétier Aymeric Zadoroznyj Laurence Dubrez Over the last decade, the E3-ubiquitine ligases from IAP (Inhibitor of Apoptosis) family have emerged as potent regulators of immune response. In immune cells, they control signaling pathways driving differentiation and inflammation in response to stimulation of tumor necrosis factor receptor (TNFR)...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1117: A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy Cells doi: 10.3390/cells9051117 Authors: Yusuke Matsuya Hisanori Fukunaga Motoko Omura Hiroyuki Date Boron neutron capture therapy (BNCT) is a type of radiation therapy for eradicating tumor cells through a 10B(n,α)7Li reaction in the presence of 10B in cancer cells. When delivering a high absorbed dose to cancer cells using BNCT,...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1116: Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants Cells doi: 10.3390/cells9051116 Authors: Arman Ali Ghodsinia J-Ann Marie T. Lego Reynaldo L. Garcia Phosphatidylinositol 3-kinase, catalytic subunit alpha (PIK3CA) is an oncogene often mutated in colorectal cancer (CRC). The contribution of PIK3CA mutations in acquired resistance to anti-epidermal growth factor receptor (EGFR) therapy is well documented,...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1115: Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease Cells doi: 10.3390/cells9051115 Authors: Giulia Lamonaca Mattia Volta The lack of effective disease-modifying strategies is the major unmet clinical need in Parkinson´s disease. Several experimental approaches have attempted to validate cellular targets and processes. Of these, autophagy has received considerable attention in...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1119: Co-Transplantation of Bone Marrow-MSCs and Myogenic Stem/Progenitor Cells from Adult Donors Improves Muscle Function of Patients with Duchenne Muscular Dystrophy Cells doi: 10.3390/cells9051119 Authors: Aleksandra Klimczak Agnieszka Zimna Agnieszka Malcher Urszula Kozlowska Katarzyna Futoma Jaroslaw Czarnota Pawel Kemnitz Anna Bryl Maciej Kurpisz Duchenne muscular dystrophy (DMD) is a genetic disorder associated with a progressive deficiency...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1112: Environmental Restrictions: A New Concept Governing HIV-1 Spread Emerging from Integrated Experimental-Computational Analysis of Tissue-Like 3D Cultures Cells doi: 10.3390/cells9051112 Authors: Samy Sid Ahmed Nils Bundgaard Frederik Graw Oliver T. Fackler HIV-1 can use cell-free and cell-associated transmission modes to infect new target cells, but how the virus spreads in the infected host remains to be determined. We recently established 3D collagen...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1113: How Diffusion Impacts Cortical Protein Distribution in Yeasts Cells doi: 10.3390/cells9051113 Authors: Kyle D. Moran Daniel J. Lew Proteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achieve asymmetric distributions...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1114: Interleukin-6 Treatment Results in GLUT4 Translocation and AMPK Phosphorylation in Neuronal SH-SY5Y Cells Cells doi: 10.3390/cells9051114 Authors: Daniel M. Marko Gregory Foran Filip Vlavcheski David C. Baron Grant C. Hayward Bradley J. Baranowski Aleksander Necakov Evangelia Tsiani Rebecca E. K. MacPherson Interleukin-6 (IL-6) is a pleiotropic cytokine that can be released from the brain during prolonged exercise. In peripheral tissues,...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1110: Targeting GSK3 and Associated Signaling Pathways Involved in Cancer Cells doi: 10.3390/cells9051110 Authors: Przemysław Duda Shaw M. Akula Stephen L. Abrams Linda S. Steelman Alberto M. Martelli Lucio Cocco Stefano Ratti Saverio Candido Massimo Libra Giuseppe Montalto Melchiorre Cervello Agnieszka Gizak Dariusz Rakus James A. McCubrey Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although...
Thu Apr 30, 2020 03:00
Cells, Vol. 9, Pages 1111: Emerging Role of Exosomes in Diagnosis and Treatment of Infectious and Inflammatory Bowel Diseases Cells doi: 10.3390/cells9051111 Authors: Anaïs Larabi Nicolas Barnich Hang Thi Thu Nguyen To communicate with each other, cells release exosomes that transfer their composition, including lipids, proteins and nucleic acids, to neighboring cells, thus playing a role in various pathophysiological processes. During an infection with pathogenic bacteria, such...
Thu Apr 30, 2020 03:00
Chemosensors, Vol. 8, Pages 31: Synthesis of a 5-carboxy Indole-based Spiropyran Fluorophore: Thermal, Electrochemical, Photophysical and Bovine Serum Albumin Interaction Investigations Chemosensors doi: 10.3390/chemosensors8020031 Authors: Duarte Santos Araújo Cercena Brondani Zapp Gonçalves Rodembusch Dal-Bó In this study, we synthesized a spiropyran containing an electron-withdrawing carboxyl group in good yield by condensation of an aromatic aldehyde...
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Children, Vol. 7, Pages 42: Readiness to Change Among Adolescents with Chronic Pain and Their Parents: Is the German Version of the Pain Stages of Change Questionnaire a Useful Tool? Children doi: 10.3390/children7050042 Authors: Stahlschmidt Grothus Brown Zernikow Wager The Pain Stages of Change Questionnaire (PSOCQ) measures patients’ willingness to engage in active self-management of their pain. The present study aimed to create validated German short versions...
Sat May 02, 2020 03:00
Children, Vol. 7, Pages 41: Association between Active Travel to School and Depressive Symptoms among Early Adolescents Children doi: 10.3390/children7050041 Authors: Jiayi Gu Si-Tong Chen Background: Although much evidence has demonstrated the positive relationship of active school travel (AST) and physical health, little is known about the relationship of AST and mental health indicators among early adolescents, especially in Chinese populations. Thus, this study aimed to investigate...
Sat May 02, 2020 03:00
Children, Vol. 7, Pages 40: Health Locus of Control in Parents of Children with Leukemia and Associations with Their Life Perceptions and Depression Symptomatology Children doi: 10.3390/children7050040 Authors: Marta Tremolada Livia Taverna Sabrina Bonichini Maria Caterina Putti Marta Pillon Alessandra Biffi In childhood cancer, parents have an important role in the promotion of their children’s wellbeing and in their adoption of a locus of control style towards...
Fri May 01, 2020 03:00
Children, Vol. 7, Pages 39: Grief and Bereavement in Parents After the Death of a Child in Low- and Middle-Income Countries Children doi: 10.3390/children7050039 Authors: McNeil Namisango Hunt Powell Baker While great strides have been made in improving childhood mortality, millions of children die each year with significant health-related suffering. More than 98% of these children live in low- and middle-income countries (LMICs). Efforts have been made to increase...
Fri May 01, 2020 03:00
Climate, Vol. 8, Pages 61: Modeling of Atmospheric Carbon Dioxide (CO2) Concentrations as a Function of Fossil-Fuel and Land-Use Change CO2 Emissions Coupled with Oceanic and Terrestrial Sequestration Climate doi: 10.3390/cli8050061 Authors: O’Connor In this work, a semi-empirical relationship of carbon dioxide emissions with atmospheric CO2 concentrations has been developed that is capable of closely replicating observations from 1751 to 2018. The analysis was completed using data...
Sat May 02, 2020 03:00
Clocks & Sleep, Vol. 2, Pages 172-181: Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans Clocks & Sleep doi: 10.3390/clockssleep2020014 Authors: Danilenko Kobelev Yarosh Khazankin Brack Miroshnikova Aftanas The aim of the study was to investigate whether visual stimuli have the same potency to increase electroencephalography (EEG) delta wave power density during non-rapid eye movement (NREM)...
Thu Apr 30, 2020 03:00
Dentistry Journal, Vol. 8, Pages 39: Effects of Oral Commensal Streptococci on Porphyromonas gingivalis Invasion into Oral Epithelial Cells Dentistry Journal doi: 10.3390/dj8020039 Authors: Alyssa N. Hanel Hannah M. Herzog Michelle G. James Giancarlo A. Cuadra The objective of this study was to determine if the interaction between common oral commensal bacteria and oral epithelial cells would provide protective effects against the invasion of periodontopathogen Porphyromonas...
Sat May 02, 2020 03:00
Diagnostics, Vol. 10, Pages 277: Ultrasound Signs in the Diagnosis and Staging of Small Bowel Obstruction Diagnostics doi: 10.3390/diagnostics10050277 Authors: Tamburrini Serra Lugarà Mercogliano Liguori Toro Somma Mandato Guerra Sarti Carbone Tammaro Ferraro Abete Marano Ultrasound (US) is highly accurate in the diagnosis of small bowel obstruction (SBO). Because the indications for and timing of surgical intervention for SBO...
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Diagnostics, Vol. 10, Pages 276: Prediction of Antidepressant Treatment Outcome Using Event-Related Potential in Patients with Major Depressive Disorder Diagnostics doi: 10.3390/diagnostics10050276 Authors: Lee Baik Kim Kim Lee (1) Background: Prediction of treatment outcome has been one of the core objectives in clinical research of patients with major depressive disorder (MDD). This study explored the possibility of event-related potential (ERP) markers to predict...
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Diagnostics, Vol. 10, Pages 275: Immunohistochemical Features of Indoleamine 2,3-Dioxygenase (IDO) in Various Types of Lymphoma: A Single Center Experience Diagnostics doi: 10.3390/diagnostics10050275 Authors: Kim Park Son Lee Indolamine-2,3-dioxygenase (IDO) is an intracellular enzyme that catalyzes amino acid tryptophan to L-kynurenine. IDO is overexpressed in various cancers and several IDO inhibitors have been assessed in multiple clinical trials. If an IDO inhibitor...
Sat May 02, 2020 03:00
Diagnostics, Vol. 10, Pages 274: Acute Renal Failure/Acute Kidney Injury (AKI) Associated with Endovascular Procedures Diagnostics doi: 10.3390/diagnostics10050274 Authors: Krasinski Krasińska Olszewska Pawlaczyk AKI is one of the most common underdiagnosed postoperative complications that can occur after any type of surgery. Contrast-induced nephropathy (CIN) is still poorly defined and due a wide range of confounding individual variables, its risk is difficult to determine....
Sat May 02, 2020 03:00
Diagnostics, Vol. 10, Pages 273: Single Nucleotide and Copy-Number Variants in IL4 and IL13 Are Not Associated with Asthma Susceptibility or Inflammatory Markers: A Case-Control Study in a Mexican-Mestizo Population Diagnostics doi: 10.3390/diagnostics10050273 Authors: Enrique Ambrocio-Ortiz Gustavo Galicia-Negrete Gloria Pérez-Rubio Areli J. Escobar-Morales Edgar Abarca-Rojano Alma D. Del Angel-Pablo Manuel D. J. Castillejos-López Ramcés Falfán-Valencia Background:...
Thu Apr 30, 2020 03:00
Diagnostics, Vol. 10, Pages 272: Paper-Based Detection Device for Alzheimer’s Disease—Detecting β-amyloid Peptides (1–42) in Human Plasma Diagnostics doi: 10.3390/diagnostics10050272 Authors: Wei-Hsuan Sung Jung-Tung Hung Yu-Jen Lu Chao-Min Cheng The diagnosis of Alzheimer’s disease (AD) is frequently missed or delayed in clinical practice. To remedy this situation, we developed a screening, paper-based (P-ELISA) platform to detect β-amyloid peptide 1–42...
Thu Apr 30, 2020 03:00
Diagnostics, Vol. 10, Pages 271: The Effects of Early Bispectral Index to Predict Poor Neurological Function in Cardiac Arrest Patients: A Systematic Review and Meta-Analysis Diagnostics doi: 10.3390/diagnostics10050271 Authors: Chun-Yu Chang Chien-Sheng Chen Yung-Jiun Chien Po-Chen Lin Meng-Yu Wu The diagnostic performance of the bispectral index (BIS) to early predict neurological outcomes in patients achieving return of spontaneous circulation (ROSC) after cardiac arrest...
Thu Apr 30, 2020 03:00
Diagnostics, Vol. 10, Pages 270: Left Supraclavicular Lymph Node Metastasis from Ovarian Cancer Associated with Papillary Thyroid Microcarcinoma, a Confusing Pathology-Essential Role of Functional Imaging Diagnostics doi: 10.3390/diagnostics10050270 Authors: Doina Piciu Alexandru Meșter Calin Căinap Elena Bărbuș Dragos-Stefan Morariu Andra Piciu The revolution of imaging in medicine leads to new standards of care, mostly in specialties like oncology, neurology, or endocrinology....
Thu Apr 30, 2020 03:00
Diagnostics, Vol. 10, Pages 269: Male Breast Cancer: Results of the Application of Multigene Panel Testing to an Italian Cohort of Patients Diagnostics doi: 10.3390/diagnostics10050269 Authors: Gianluca Tedaldi Michela Tebaldi Valentina Zampiga Ilaria Cangini Francesca Pirini Elisa Ferracci Rita Danesi Valentina Arcangeli Mila Ravegnani Giovanni Martinelli Fabio Falcini Paola Ulivi Daniele Calistri Male breast cancer (MBC) is a rare tumor, accounting...
Thu Apr 30, 2020 03:00
Diseases, Vol. 8, Pages 11: Uropathogenic Escherichia coli Biofilm-Forming Capabilities are not Predictable from Clinical Details or from Colonial Morphology Diseases doi: 10.3390/diseases8020011 Authors: Shane Whelan Mary Claire O’Grady Dan Corcoran Karen Finn Brigid Lucey Antibiotic resistance is increasing to an extent where efficacy is not guaranteed when treating infection. Biofilm formation has been shown to complicate treatment, whereby the formation of biofilm is...
Thu Apr 30, 2020 03:00
Diversity, Vol. 12, Pages 177: Factors Affecting the Detection of an Imperiled and Cryptic Species Diversity doi: 10.3390/d12050177 Authors: Crawford Dreslik Baker Phillips Peterman Population surveying and monitoring are important for identifying conservation needs and tracking trends in populations, communities, and ecosystems over time and laying the groundwork for conservation management and policy decisions. If species or populations go undetected because of inadequate...
Fri May 01, 2020 03:00
Diversity, Vol. 12, Pages 176: Vulnerable Forests of the Pink Sea Fan Eunicella verrucosa in the Mediterranean Sea Diversity doi: 10.3390/d12050176 Authors: Giovanni Chimienti The pink sea fan Eunicella verrucosa (Cnidaria, Anthozoa, Alcyonacea) can form coral forests at mesophotic depths in the Mediterranean Sea. Despite the recognized importance of these habitats, they have been scantly studied and their distribution is mostly unknown. This study reports the new finding of E. verrucosa...
Thu Apr 30, 2020 03:00
Diversity, Vol. 12, Pages 175: Potential of DNA Intercalating Alkaloids and Other Plant Secondary Metabolites against SARS-CoV-2 Causing COVID-19 Diversity doi: 10.3390/d12050175 Authors: Michael Wink Many plants produce secondary metabolites (PSMs) with antiviral activities. Among the antiviral PSMs, lipophilic terpenoids in essential oils can disturb the lipid envelope of viruses. Phenols and polyphenols (flavonoids, rosmarinic acid and tannins) attack viral proteins present in the...
Thu Apr 30, 2020 03:00
Environments, Vol. 7, Pages 35: Assessing Energy-Based CO2 Emission and Workers’ Health Risks at the Shipbreaking Industries in Bangladesh Environments doi: 10.3390/environments7050035 Authors: Nandita Mitra Shihab Ahmad Shahriar Nurunnaher Lovely Md Shohel Khan Aweng Eh Rak S. P. Kar Md Abdul Khaleque Mohamad Faiz Mohd Amin Imrul Kayes Mohammed Abdus Salam The study represents the estimation of energy-based CO2 emission and the health risks of workers involved...
Thu Apr 30, 2020 03:00
Foods, Vol. 9, Pages 565: Isolation, Gastroprotective Effects and Untargeted Metabolomics Analysis of Lycium Minutifolium J. Remy (Solanaceae) Foods doi: 10.3390/foods9050565 Authors: Stephanie Rodriguez Mariano Walter Pertino Chantal Arcos Luana Reichert Javier Echeverria Mario Simirgiotis Jorge Borquez Alberto Cornejo Carlos Areche Beatriz Sepulveda Lycium minutifolium J. Remy (Solanaceae) is commonly used as an infusion in traditional medicine to treat stomach...
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Foods, Vol. 9, Pages 563: The Effect of an Evaluative Label on Consumer Perception of Cheeses in Hungary Foods doi: 10.3390/foods9050563 Authors: Szakály Soós Balsa-Budai Kovács Kontor Traditional strategies (such as education, economic incentives or prohibitions) targeted at altering dietary habits only influence health-conscious consumers. Less health-conscious consumers are less capable of self-regulatory behavior, therefore they are more likely to be influenced through...
Sat May 02, 2020 03:00
Foods, Vol. 9, Pages 562: New Edible Packaging Material with Function in Shelf Life Extension: Applications for the Meat and Cheese Industries Foods doi: 10.3390/foods9050562 Authors: Roxana Gheorghita (Puscaselu) Sonia Amariei Liliana Norocel Gheorghe Gutt Nowadays, biopolymer films have gained notoriety among the packaging materials. Some studies clearly test their effectiveness for certain periods of time, with applicability in the food industry. This research has been carried...
Sat May 02, 2020 03:00
Foods, Vol. 9, Pages 564: A New Insight on Cardoon: Exploring New Uses besides Cheese Making with a View to Zero Waste Foods doi: 10.3390/foods9050564 Authors: Barbosa Andrade Vilarinho Castanheira Fernando Loizzo Silva Cardoon, Cynara cardunculus L., is a perennial plant whose flowers are used as vegetal rennet in cheese making. Cardoon is native from the Mediterranean area and is commonly used in the preparation of salads and soup dishes. Nowadays, cardoon...
Sat May 02, 2020 03:00
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