Biomedicines, Vol. 8, Pages 101: The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing Biomedicines doi: 10.3390/biomedicines8050101 Authors: Blair Z. Johnson Andrew W. Stevenson Cecilia M. Prêle Mark W. Fear Fiona M. Wood The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory...
Thu Apr 30, 2020 03:00
Biomedicines, Vol. 8, Pages 102: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with Oxaliplatin, Cisplatin, and Doxorubicin in Patients with Peritoneal Carcinomatosis: An Open-Label, Single-Arm, Phase II Clinical Trial Biomedicines doi: 10.3390/biomedicines8050102 Authors: Michele De Simone Marco Vaira Monica Argenziano Paola Berchialla Alberto Pisacane Armando Cinquegrana Roberta Cavalli Alice Borsano Manuela Robella Pressurized intraperitoneal aerosol...
Thu Apr 30, 2020 03:00
Biomolecules, Vol. 10, Pages 708: In Vitro Digestion of Grape Seed Oil Inhibits Phospholipid-Regulating Effects of Oxidized Lipids Biomolecules doi: 10.3390/biom10050708 Authors: Fruehwirth Zehentner Salim Sterneder Tiroch Lieder Zehl Somoza Pignitter The intake of dietary lipids is known to affect the composition of phospholipids in gastrointestinal cells, thereby influencing passive lipid absorption. However, dietary lipids rich in polyunsaturated...
Sat May 02, 2020 03:00
Biomolecules, Vol. 10, Pages 706: BAMBI and CHGA in Prion Diseases: Neuropathological Assessment and Potential Role as Disease Biomarkers Biomolecules doi: 10.3390/biom10050706 Authors: López-Pérez Bernal-Martín Hernaiz Llorens Betancor Otero Toivonen Zaragoza Zerr Badiola Bolea Martín-Burriel Prion diseases affect both animals and humans. Research in the natural animal model of the disease could help in the understanding of neuropathological...
Sat May 02, 2020 03:00
Biomolecules, Vol. 10, Pages 707: Novel Applications of Mesenchymal Stem Cell-derived Exosomes for Myocardial Infarction Therapeutics Biomolecules doi: 10.3390/biom10050707 Authors: Tan Floriano Nicastro Emanueli Catapano Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity globally, representing approximately a third of all deaths every year. The greater part of these cases is represented by myocardial infarction (MI), or heart attack as it...
Sat May 02, 2020 03:00
Biomolecules, Vol. 10, Pages 705: Endogenous Collagenases Regulate Osteoclast Fusion Biomolecules doi: 10.3390/biom10050705 Authors: Hyo Jeong Kim Youngkyun Lee The precise regulation of osteoclast differentiation and function is crucial for the maintenance of healthy bone. Despite several reports of collagenase expression in bone tissues, the precise isoform expression as well as the role in osteoclasts are still unclear. In the present report, the expression of matrix metalloprotease...
Fri May 01, 2020 03:00
Biomolecules, Vol. 10, Pages 703: Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy Biomolecules doi: 10.3390/biom10050703 Authors: Mercè Pallàs Santiago Vázquez Coral Sanfeliu Carles Galdeano Christian Griñán-Ferré Neuroinflammation is a crucial process associated with the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD). Several pieces of evidence suggest an active role of lipid...
Fri May 01, 2020 03:00
Biomolecules, Vol. 10, Pages 704: Autologous Splenocyte Reinfusion Improves Antibody-Mediated Immune Response to the 23-Valent Pneumococcal Polysaccharide-Based Vaccine in Splenectomized Mice Biomolecules doi: 10.3390/biom10050704 Authors: Shengwen Calvin Li Mustafa H. Kabeer Common clinical options, currently, for necessary splenectomy are vaccinations and antibiotic prophylaxis. However, despite these two adjuncts, there still occur numerous cases of overwhelming post-splenectomy...
Fri May 01, 2020 03:00
Biomolecules, Vol. 10, Pages 702: Oxidative Stress in DNA Repeat Expansion Disorders: A Focus on NRF2 Signaling Involvement Biomolecules doi: 10.3390/biom10050702 Authors: Piergiorgio La Rosa Sara Petrillo Enrico Silvio Bertini Fiorella Piemonte DNA repeat expansion disorders are a group of neuromuscular and neurodegenerative diseases that arise from the inheritance of long tracts of nucleotide repetitions, located in the regulatory region, introns, or inside the coding sequence...
Fri May 01, 2020 03:00
Biomolecules, Vol. 10, Pages 700: The Genoprotective Role of Naringin Biomolecules doi: 10.3390/biom10050700 Authors: Szczepaniak Ligaj Kobus-Cisowska Tichoniuk Dziedziński Przeor Szulc Since ancient times, fruits and edible plants have played a special role in the human diet for enhancing health and maintaining youthfulness. The aim of our work was to determine the interactions between naringin, a natural ingredient of grapefruits, and DNA using an electrochemical...
Thu Apr 30, 2020 03:00
Biomolecules, Vol. 10, Pages 701: Large-Scale Differential Gene Expression Transcriptomic Analysis Identifies a Metabolic Signature Shared by All Cancer Cells Biomolecules doi: 10.3390/biom10050701 Authors: Areej Abu Rmaileh Balakrishnan Solaimuthu Mayur Tanna Anees Khatib Michal Ben Yosef Arata Hayashi Michal Lichtenstein Yoav D. Shaul Cancer-dependent metabolic rewiring is often manifested by selective expression of enzymes essential for the transformed cells’...
Thu Apr 30, 2020 03:00
Biomolecules, Vol. 10, Pages 699: The Antitumor Agent Ansamitocin P-3 Binds to Cell Division Protein FtsZ in Actinosynnema pretiosum Biomolecules doi: 10.3390/biom10050699 Authors: Xinran Wang Rufan Wang Qianjin Kang Linquan Bai Ansamitocin P-3 (AP-3) is an important antitumor agent. The antitumor activity of AP-3 is a result of its affinity towards β-tubulin in eukaryotic cells. In this study, in order to improve AP-3 production, the reason for severe growth inhibition...
Thu Apr 30, 2020 03:00
Biomolecules, Vol. 10, Pages 696: Mitochondrial Functions, Energy Metabolism and Protein Glycosylation are Interconnected Processes Mediating Resistance to Bortezomib in Multiple Myeloma Cells Biomolecules doi: 10.3390/biom10050696 Authors: Daniele Tibullo Cesarina Giallongo Alessandra Romano Nunzio Vicario Alessandro Barbato Fabrizio Puglisi Rosalba Parenti Angela Amorini Miriam Wissam Saab Barbara Tavazzi Renata Mangione Maria Brundo Giacomo Lazzarino...
Thu Apr 30, 2020 03:00
Biomolecules, Vol. 10, Pages 697: Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition Biomolecules doi: 10.3390/biom10050697 Authors: Zuhra Augsburger Majtan Szabo Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (a cytotoxic molecule...
Thu Apr 30, 2020 03:00
Biomolecules, Vol. 10, Pages 698: Exomes of Ductal Luminal Breast Cancer Patients from Southwest Colombia: Gene Mutational Profile and Related Expression Alterations Biomolecules doi: 10.3390/biom10050698 Authors: Carolina Cortes-Urrea Fernando Bueno-Gutiérrez Melissa Solarte Miguel Guevara-Burbano Fabian Tobar-Tosse Patricia E. Vélez-Varela Juan Carlos Bonilla Guillermo Barreto Jaime Velasco-Medina Pedro A. Moreno Javier De Las Rivas Cancer is one of the...
Thu Apr 30, 2020 03:00
Biomolecules, Vol. 10, Pages 695: Differentiation of Murine C2C12 Myoblasts Strongly Reduces the Effects of Myostatin on Intracellular Signaling Biomolecules doi: 10.3390/biom10050695 Authors: Juulia H. Lautaoja Satu Pekkala Arja Pasternack Mika Laitinen Olli Ritvos Juha J. Hulmi Alongside in vivo models, a simpler and more mechanistic approach is required to study the effects of myostatin on skeletal muscle because myostatin is an important negative regulator of muscle...
Thu Apr 30, 2020 03:00
Biosensors, Vol. 10, Pages 47: An Array of MOX Sensors and ANNs to Assess Grated Parmigiano Reggiano Cheese Packs’ Compliance with CFPR Guidelines Biosensors doi: 10.3390/bios10050047 Authors: Abbatangelo Núñez-Carmona Sberveglieri Zappa Comini Sberveglieri Parmigiano Reggiano cheese is one of the most appreciated Italian foods on account of its high nutrient content and taste. Due to its high cost, these characteristics make this product subject to counterfeiting...
Sat May 02, 2020 03:00
Biosensors, Vol. 10, Pages 46: On the Electrochemical Detection of Alpha-Fetoprotein Using Aptamers: DNA Isothermal Amplification Strategies to Improve the Performance of Weak Aptamers Biosensors doi: 10.3390/bios10050046 Authors: Ramón Lorenzo-Gómez Daniel González-Robles Rebeca Miranda-Castro Noemí de-los-Santos-Álvarez María Jesús Lobo-Castañón Affinity characterization is essential to develop reliable aptamers for tumor biomarker detection. For alpha-fetoprotein (AFP),...
Thu Apr 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 278: Automatic Recognition of Personality Profiles Using EEG Functional Connectivity During Emotional Processing Brain Sciences doi: 10.3390/brainsci10050278 Authors: Klados Konstantinidi Dacosta-Aguayo Kostaridou Vinciarelli Zervakis Personality is the characteristic set of an individual’s behavioral and emotional patterns that evolve from biological and environmental factors. The recognition of personality profiles is crucial...
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Brain Sciences, Vol. 10, Pages 276: Effects of Combined Transcranial Direct Current Stimulation with Cognitive Training in Girls with Rett Syndrome Brain Sciences doi: 10.3390/brainsci10050276 Authors: Rosa Angela Fabio Antonio Gangemi Martina Semino Aglaia Vignoli Maria Paola Canevini Alberto Priori Gabriella Di Rosa Tindara Caprì Background: Transcranial Direct Current Stimulation (tDCS) combined with traditional rehabilitative techniques has not been widely applied...
Sat May 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 277: Bioenergy Crisis in Coronavirus Diseases? Brain Sciences doi: 10.3390/brainsci10050277 Authors: Dutta Das Kondziella Stachowiak Coronavirus disease (COVID-19) has been declared as a pandemic by the World Health Organization (WHO).[...]
Sat May 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 275: Transcriptome Analysis of Alcohol Drinking in Non-Dependent and Dependent Mice Following Repeated Cycles of Forced Swim Stress Exposure Brain Sciences doi: 10.3390/brainsci10050275 Authors: Sean P. Farris Gayatri R. Tiwari Olga Ponomareva Marcelo F. Lopez R. Dayne Mayfield Howard C. Becker Chronic stress is a known contributing factor to the development of drug and alcohol addiction. Animal models have previously shown that repeated...
Sat May 02, 2020 03:00
Brain Sciences, Vol. 10, Pages 273: Cadence Modulation in Walking and Running: Pacing Steps or Strides? Brain Sciences doi: 10.3390/brainsci10050273 Authors: Anouk Nijs Melvyn Roerdink Peter J. Beek A change in cadence during walking or running might be indicated for a variety of reasons, among which mobility improvement and injury prevention. In a within-subject study design, we examined whether walking or running cadences are modulated best by means of step-based or stride-based...
Fri May 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 274: Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014 Brain Sciences doi: 10.3390/brainsci10050274 Authors: Chiarotti Venerosi The prevalence of Autism Spectrum Disorder (ASD) has increased dramatically in recent decades, supporting the claim of an autism epidemic. Systematic monitoring of ASD allows estimating prevalence and identifying potential sources of variation over time and geographical areas....
Fri May 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 271: Postnatal Ethanol-Induced Neurodegeneration Involves CB1R-Mediated β-Catenin Degradation in Neonatal Mice Brain Sciences doi: 10.3390/brainsci10050271 Authors: Shivakumar Subbanna Balapal S. Basavarajappa Alcohol consumption by pregnant women may produce neurological abnormalities that affect cognitive processes in children and are together defined as fetal alcohol spectrum disorders (FASDs). However, the molecular underpinnings are still poorly...
Fri May 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 272: Atypical Electrophysiological Indices of Eyes-Open and Eyes-Closed Resting-State in Children and Adolescents with ADHD and Autism Brain Sciences doi: 10.3390/brainsci10050272 Authors: Alessio Bellato Iti Arora Puja Kochhar Chris Hollis Madeleine J. Groom Investigating electrophysiological measures during resting-state might be useful to investigate brain functioning and responsivity in individuals under diagnostic assessment for attention...
Fri May 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 269: Clinical Predictors of 3- and 6-Month Outcome for Mild Traumatic Brain Injury Patients with a Negative Head CT Scan in the Emergency Department: A TRACK-TBI Pilot Study Brain Sciences doi: 10.3390/brainsci10050269 Authors: Debbie Madhok John Yue Xiaoying Sun Catherine Suen Nathan Coss Sonia Jain Geoffrey Manley the TRACK-TBI Investigators A considerable subset of mild traumatic brain injury (mTBI) patients fail to return to baseline...
Fri May 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 270: 7,8-Dihydroxyflavone Enhances Cue-Conditioned Alcohol Reinstatement in Rats Brain Sciences doi: 10.3390/brainsci10050270 Authors: Samuel J. Hogarth Elvan Djouma Maarten van den Buuse Alcohol use disorder (AUD) is a detrimental disease that develops through chronic ethanol exposure. Reduced brain-derived neurotrophic factor (BDNF) expression has been associated with AUD and alcohol addiction, however the effects of activation of BDNF signalling...
Fri May 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 266: Effect of Rehabilitation with Extremely Low Frequency Electromagnetic Field on Molecular Mechanism of Apoptosis in Post-Stroke Patients Brain Sciences doi: 10.3390/brainsci10050266 Authors: Natalia Cichon Ewelina Synowiec Elzbieta Miller Tomasz Sliwinski Michal Ceremuga Joanna Saluk-Bijak Michal Bijak Apoptosis in acute stroke is associated with a negative prognosis and is correlated with the severity of the neurological deficit....
Thu Apr 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 264: Improving the Ability to Write Persuasive Texts in a Boy with Autism Spectrum Disorder: Outcomes of an Intervention Brain Sciences doi: 10.3390/brainsci10050264 Authors: Sergio Melogno Maria Antonietta Pinto Andrea Ruzza Teresa Gloria Scalisi In this paper, we describe an intervention implemented to assist a 13.2-year-old boy with Autism Spectrum Disorder, G, without intellectual disability, aimed at improving his ability to compose persuasive...
Thu Apr 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 267: Neuromodulation for Intractable Pain Brain Sciences doi: 10.3390/brainsci10050267 Authors: Green Aziz Over 7% of the Western population suffer from intractable pain and despite pharmacotherapy, [...]
Thu Apr 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 265: Anxiety and Risk of Vascular Dementia in an Elderly Community Sample: The Role of Sex Brain Sciences doi: 10.3390/brainsci10050265 Authors: Javier Santabárbara Beatriz Villagrasa Raúl Lopez-Anton Concepción De la Cámara Patricia Gracia-García Antonio Lobo Background: To assess the association between anxiety and risk of vascular dementia (VaD), as well as potential sex differences, in a community-based cohort. Methods: A random sample...
Thu Apr 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 268: The Source of Palm Orientation Errors in the Signing of Children with ASD: Imitative, Motoric, or Both? Brain Sciences doi: 10.3390/brainsci10050268 Authors: Shield Igel Randall Meier Palm orientation reversal errors (e.g., producing the ‘bye-bye’ gesture with palm facing inward rather than outward as is customary in American culture) have been documented in the signing of deaf and hearing children with autism spectrum...
Thu Apr 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 263: Effects of Mini-Basketball Training Program on Executive Functions and Core Symptoms among Preschool Children with Autism Spectrum Disorders Brain Sciences doi: 10.3390/brainsci10050263 Authors: Jin-Gui Wang Ke-Long Cai Zhi-Mei Liu Fabian Herold Liye Zou Li-Na Zhu Xuan Xiong Ai-Guo Chen This study examined the effects of a 12-week mini-basketball training program (MBTP) on executive functions and core symptoms among preschoolers...
Thu Apr 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 262: Dopamine Receptor DRD2 Gene rs1076560, Personality Traits and Anxiety in the Polysubstance Use Disorder Brain Sciences doi: 10.3390/brainsci10050262 Authors: Aleksandra Suchanecka Jolanta Chmielowiec Krzysztof Chmielowiec Jolanta Masiak Olimpia Sipak-Szmigiel Mariusz Sznabowicz Wojciech Czarny Monika Michałowska-Sawczyn Grzegorz Trybek Anna Grzywacz Development of an addiction is conditioned by many factors. The dopaminergic...
Thu Apr 30, 2020 03:00
Brain Sciences, Vol. 10, Pages 261: Processing of Rhythm in Speech and Music in Adult Dyslexia Brain Sciences doi: 10.3390/brainsci10050261 Authors: Natalie Boll-Avetisyan Anjali Bhatara Barbara Höhle Recent studies have suggested that musical rhythm perception ability can affect the phonological system. The most prevalent causal account for developmental dyslexia is the phonological deficit hypothesis. As rhythm is a subpart of phonology, we hypothesized that reading deficits...
Thu Apr 30, 2020 03:00
Cancers, Vol. 12, Pages 1150: In Vitro Organotypic Systems to Model Tumor Microenvironment in Human Papillomavirus (HPV)-Related Cancers Cancers doi: 10.3390/cancers12051150 Authors: Vincenza De Gregorio Francesco Urciuolo Paolo Antonio Netti Giorgia Imparato Despite the well-known role of chronic human papillomavirus (HPV) infections in causing tumors (i.e., all cervical cancers and other human malignancies from the mucosal squamous epithelia, including anogenital and oropharyngeal...
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Cancers, Vol. 12, Pages 1149: Leveraging Advances in Artificial Intelligence to Improve the Quality and Timing of Palliative Care Cancers doi: 10.3390/cancers12051149 Authors: Paul Windisch Caroline Hertler David Blum Daniel Zwahlen Robert Förster In recent years, research on artificial intelligence (AI) in medicine has seen great advances, especially with regards to the detection of diseases [...]
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Cancers, Vol. 12, Pages 1151: Cytoplasmic Increase in Hsp70 Protein: A Potential New Biomarker of Early Infiltration of Cutaneous Squamous Cell Carcinoma Arising from Actinic Keratosis Cancers doi: 10.3390/cancers12051151 Authors: Fernández-Guarino León Farré Morales Adrada Garde Navalon Olasolo Background: Cutaneous squamous skin cell carcinoma (SCC) is the second most frequent type of non-melanoma skin cancer and is the second leading cause of death by...
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