"Staying Home" - Early Changes in Patterns of Neurotrauma in New York City during the COVID-19 Pandemic. World Neurosurg. 2020 Jul 27;: Authors: Lara-Reyna J, Yaeger KA, Rossitto CP, Camara D, Wedderburn R, Ghatan S, Bederson JB, Margetis K Abstract OBJECTIVE: New York City is the epicenter of the novel coronavirus disease 2019 (COVID-19) pandemic in the United States. Traumatic brain injury accounts for a significant proportion of admissions...
Fri Jul 31, 2020 15:04
Rare Tumor-to-Tumor Metastases involving Lung Adenocarcinoma to Petroclival Meningiomas. World Neurosurg. 2020 Jul 27;: Authors: Mansour S, Luther E, Echeverry N, McCarthy D, Eichberg DG, Shah A, Matus A, Chen S, Gultekin SH, Ivan M, Morcos J Abstract BACKGROUND: and Importance: Lung carcinoma metastasizing to a skull base meningioma remains an extremely rare phenomenon with only 3 total reports in the literature. Furthermore, no documented...
Fri Jul 31, 2020 15:04
Deceptive Features on Surveillance Imaging of Intraneural Metastatic Deposits In Metastatic Renal Cell Cancer. World Neurosurg. 2020 Jul 27;: Authors: Houlihan LM, Ledingham C, O'Sullivan MG Abstract BACKGROUND: Spinal renal cell metastases are a common insidious pathological manifestation of the oncological process, but less common are intramedullary and intraneural spinal metastases. Differential diagnosis of such a pathology can be difficult...
Fri Jul 31, 2020 15:04
Postoperative MRI after surgery of brain metastases: Analysis of extent of resection and potential risk factors for incomplete resection. World Neurosurg. 2020 Jul 27;: Authors: Kiesel B, Prihoda R, Borkovec M, Mercea PA, Steindl A, Berghoff AS, Furtner J, Leitner J, Roetzer T, Preusser M, Roessler K, Widhalm G Abstract OBJECT: The extent of resection (EOR) constitutes a crucial factor for patient prognosis in surgery of brain metastases (BM)....
Fri Jul 31, 2020 15:04
Tuberculosis - The great mimicker: A case of traumatic drainage of cold abscess. World Neurosurg. 2020 Jul 27;: Authors: Rathod T, Sathe A, Marathe N, Mohanty SS Abstract BACKGROUND: The tuberculosis is characterised by cold abscess which classically lacks the usual signs and symptoms of inflammation. This case report highlights atypical presentation of tuberculous cold abscess in the form of appearance of massive swelling in back overnight...
Fri Jul 31, 2020 15:04
Robotic surgical approach to the mesial temporal region: A Preliminary 3D Cadaveric Study of Technical Feasibility. World Neurosurg. 2020 Jul 27;: Authors: Akbas A, Tugcu B, Eksi MS, Erkan B, Canbolat C, Pamir MN, Gungor A PMID: 32730970 [PubMed - as supplied by publisher]
Fri Jul 31, 2020 15:04
Granular cell astrocytoma - a diagnostic conundrum. World Neurosurg. 2020 Jul 27;: Authors: Dutta R, Chand Sharma M, Suri V, Sarkar C, Garg A, Srivastava A, Tandon V Abstract Granular cell astrocytoma (GCA) is an aggressive variant of astrocytoma characterised by predominantly round-to-polygonal cells with abundant eosinophilic granular cytoplasm. This tumor usually lack the morphological signatures of conventional astrocytoma and are devoid...
Fri Jul 31, 2020 15:04
Surgical treatment outcomes of patients with conus medullaris teratoma: a single-center experience of 39 patients. World Neurosurg. 2020 Jul 27;: Authors: Chen Y, Li Z, Chen X, Yin Y, Qiao G Abstract OBJECTIVE: Conus medullaris teratomas are extremely rare, and the current treatment experience is limited. The purpose of this study was to evaluate the clinical characteristics, radiological features, surgical outcomes and prognosis of the conus...
Fri Jul 31, 2020 15:04
Diffuse Cerebral Vasospasm After Removal of a Posterior Fossa Hemangioblastoma in a 62-year-old Female. World Neurosurg. 2020 Jul 27;: Authors: Kinoshita Y, Sato K, Ito T, Nakamura H Abstract BACKGROUND: The development of diffuse cerebral vasospasm after the removal of a brain tumor is extremely rare. We report a case of cerebral vasospasm after the removal of a posterior fossa hemangioblastoma. CASE DESCRIPTION: A 62-year-old woman...
Fri Jul 31, 2020 15:04
A Case of Esophageal Perforation and Repair with a Supraclavicular Artery Island Fascial Flap 15 Years After Anterior Spine Surgery. World Neurosurg. 2020 Jul 27;: Authors: Gibson AW, Gobillot TA, Bass DI, Zakarevicius Z, Rizvi ZH, Ravanpay AC Abstract BACKGROUND: Esophageal perforation represents a rare but potentially life-threatening complication of an anterior cervical discectomy and fusion (ACDF). Delayed presentations of esophageal perforation...
Fri Jul 31, 2020 15:04
Asymptomatic Carrier Transmission of COVID-19 and The Multi-Point Aerosol Sampling to Assess Risks in OR During Pandemic Period. World Neurosurg. 2020 Jul 27;: Authors: Yang X, Chen F PMID: 32730965 [PubMed - as supplied by publisher]
Fri Jul 31, 2020 15:04
Modified translabyrinthine approach for massive petrous bone cholesteatoma removal and cochlear preservation by using latent spaces anterior to cochlea. World Neurosurg. 2020 Jul 27;: Authors: Gao Z, Tang WL, Qin ZJ, Zhao WD, Dai CF, Chi FL, Yuan YS Abstract OBJECTIVE: Microsurgery is the cornerstone for the treatment of petrous bone cholesteatoma (PBC). In majority of cases, radical removal of extensive PBC can only be achieved at the price...
Fri Jul 31, 2020 15:04
Re-rupture following flow diversion of a dissecting aneurysm of the vertebral artery: case report and review of the literature. World Neurosurg. 2020 Jul 27;: Authors: Pomeraniec IJ, Mastorakos P, Raper D, Park MS Abstract INTRODUCTION: Dissecting aneurysms of the posterior cerebral circulation can wield significant treatment challenges with devastating clinical outcomes. Despite an expanded therapeutic armamentarium, these vascular lesions...
Fri Jul 31, 2020 15:04
Revisiting the resolution of Chiari malformation in non-syndromic Craniosynostosis - A case of Posterior cranial vault reconstruction in secondary pan-suture synostosis. World Neurosurg. 2020 Jul 27;: Authors: Poggi J, Chen WS, Taylor HO, Sullivan S, Woo AS, Klinge PM PMID: 32730962 [PubMed - as supplied by publisher]
Fri Jul 31, 2020 15:04
Anticancer potential of AgNPs synthesized using Acinetobacter sp. and Curcuma aromatica against HeLa cell lines: A comparative study. J Trace Elem Med Biol. 2020 Jul 24;62:126630 Authors: Nadhe SB, Tawre MS, Agrawal S, Chopade BA, Sarkar D, Pardesi K Abstract BACKGROUND: Biogenic nanoparticles are gaining attention due to their low toxicity and numerous biomedical applications. Present study aimed to compare the potential anticancer activity...
Sun Aug 02, 2020 13:39
Molecular modeling and in vitro study on pyrocatechol as potential pharmacophore of CD151 inhibitor.
Molecular modeling and in vitro study on pyrocatechol as potential pharmacophore of CD151 inhibitor. J Mol Graph Model. 2020 Jul 22;100:107681 Authors: Akella M, Malla R Abstract CD151 has been recognized as a prognostic marker, the therapeutic target of breast cancers, but less explored for small molecule inhibitors due to lack of a validated model. The 3-D structure of CD151 large extracellular loop (LEL) was modeled using the LOMETS...
Sun Aug 02, 2020 13:39
Discovery of Novel c-Mesenchymal-Epithelia transition factor and histone deacetylase dual inhibitors. Eur J Med Chem. 2020 Jul 22;204:112651 Authors: Hu H, Chen F, Dong Y, Li M, Xu S, Qin M, Gong P Abstract Clinically, a single agent that simultaneously inhibits multiple targets has been widely used in cancer treatment to overcome complicated dose design and anti-cancer resistance. Inspired by the synergistic effects between c-Met and...
Sun Aug 02, 2020 13:39
Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β. Exp Cell Res. 2020 Jul 29;:112203 Authors: Marques L, Johnson AA, Stolzing A Abstract Cellular senescence is defined by irreversible cell-cycle arrest and is an evolutionarily conserved hallmark of aging. In this study, we generate senescent microglial cells via exposure to the...
Sun Aug 02, 2020 13:39
Related Articles Developmental regulation of edited CYb and COIII mitochondrial mRNAs is achieved by distinct mechanisms in Trypanosoma brucei. Nucleic Acids Res. 2020 Aug 01;: Authors: Smith JT, Doleželová E, Tylec B, Bard JE, Chen R, Sun Y, Zíková A, Read LK Abstract Trypanosoma brucei is a parasitic protozoan that undergoes a complex life cycle involving insect and mammalian hosts that present dramatically different nutritional environments....
Sun Aug 02, 2020 13:39
Related Articles Effect of methoxy stilbenes-analogs of resveratrol-on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells. Mol Cell Biochem. 2020 Jul 31;: Authors: Zielińska-Przyjemska M, Kaczmarek M, Krajka-Kuźniak V, Wierzchowski M, Baer-Dubowska W Abstract The present study aimed to evaluate the cytotoxicity and its mechanism of five synthetic methoxy stilbenes, namely 3,4,4'-trimethoxy, 3,4,2'-trimethoxy,...
Sun Aug 02, 2020 13:39
Design, synthesis, biological evaluation and molecular docking of new uracil analogs-1,2,4-oxadiazole hybrids as potential anticancer agents. Bioorg Med Chem Lett. 2020 Jul 28;:127438 Authors: El Mansouri AE, Oubella A, Maatallah M, Youssef AitItto M, MohamedZahouily, Morjani H, Lazrek HB Abstract A new series of uracil analogues-1,2,4-oxadiazole hybrid derivatives were synthesized by a new, simple, and efficient method using for the first...
Sat Aug 01, 2020 13:03
Combinatorial therapy of Thymoquinone and Emodin synergistically enhances apoptosis, attenuates cell migration and reduces stemness efficiently in breast cancer. Biochim Biophys Acta Gen Subj. 2020 Jul 28;:129695 Authors: Bhattacharjee M, Upadhyay P, Sarker S, Basu A, Das S, Ghosh A, Ghosh S, Adhikary A Abstract BACKGROUND: Breast cancer intimidates the contemporary medical advances, attempting to revolutionize cancer therapeutics. While patients...
Sat Aug 01, 2020 13:03
Related Articles Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on Breast Cancer Cells. Front Immunol. 2020;11:1171 Authors: Murugaiah V, Agostinis C, Varghese PM, Belmonte B, Vieni S, Alaql FA, Alrokayan SH, Khan HA, Kaur A, Roberts T, Madan T, Bulla R, Kishore U Abstract Human surfactant protein D (SP-D) belongs to the family of collectins...
Sat Aug 01, 2020 13:03
Related Articles Dual Repressive Function by Cip1, a Budding Yeast Analog of p21, in Cell-Cycle START Regulation. Front Microbiol. 2020;11:1623 Authors: Li P, Liu X, Hao Z, Jia Y, Zhao X, Xie D, Dong J, Zeng F Abstract Cip1, a newly identified yeast analog of p21, is a Cln3-CDK inhibitor that negatively regulates cell-cycle START. However, its function remains poorly understood. In this study, we found that deletion of CLN3 did not result...
Sat Aug 01, 2020 13:03
Related Articles Systems Analysis of Insulin and IGF1 Receptors Networks in Breast Cancer Cells Identifies Commonalities and Divergences in Expression Patterns. Front Endocrinol (Lausanne). 2020;11:435 Authors: Sarfstein R, Yeheskel A, Sinai-Livne T, Pasmanik-Chor M, Werner H Abstract Insulin and insulin-like growth factor-1 (IGF1), acting respectively via the insulin (INSR) and IGF1 (IGF1R) receptors, play key developmental and metabolic...
Sat Aug 01, 2020 13:03
Related Articles Protein Arginine Methyltransferase 5 as a Therapeutic Target for KRAS Mutated Colorectal Cancer. Cancers (Basel). 2020 Jul 28;12(8): Authors: Shifteh D, Sapir T, Pahmer M, Haimowitz A, Goel S, Maitra R Abstract Nearly 45% of colorectal cancer (CRC) patients harbor a mutation in their KRAS gene for which, despite many years of research, there are still no targeted therapies available. Protein Arginine Methyltransferase 5...
Sat Aug 01, 2020 13:03
Related Articles Anti-Proliferative Effect of Statins Is Mediated by DNMT1 Inhibition and p21 Expression in OSCC Cells. Cancers (Basel). 2020 Jul 28;12(8): Authors: Dongoran RA, Wang KH, Lin TJ, Yuan TC, Liu CH Abstract Statins, also known as HMG-CoA reductase inhibitors, are a class of cholesterol-lowering drugs and their anti-cancer effects have been studied in different types of malignant diseases. In the present study, we investigated...
Sat Aug 01, 2020 13:03
Chemopreventive mechanism of action by oxidative stress and toxicity induced surface decorated selenium nanoparticles. J Trace Elem Med Biol. 2020 May 22;62:126549 Authors: Menon S, Shanmugam VK Abstract BACKGROUND: Scientists are working on creating novel materials that can help in the treatment of diverse cancer-related diseases having trademark highlights like the target siting, specificity, improved therapeutic index of radiotherapy...
Fri Jul 31, 2020 13:23
The effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanisms. PLoS One. 2020;15(7):e0236395 Authors: Cui J, Qu Z, Harata-Lee Y, Shen H, Aung TN, Wang W, Kortschak RD, Adelson DL Abstract Traditional Chinese Medicine (TCM) preparations are often extracts of single or multiple herbs containing hundreds of compounds, and hence it has been difficult to study their mechanisms of action....
Fri Jul 31, 2020 13:23
Related Articles NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest. Nucleic Acids Res. 2020 Jul 30;: Authors: Sun X, Wang Y, Ji K, Liu Y, Kong Y, Nie S, Li N, Hao J, Xie Y, Xu C, Du L, Liu Q Abstract Nuclear factor erythroid 2-related factor 2 (NRF2) is a well-characterized transcription factor that protects cells against oxidative and electrophilic stresses. Emerging evidence has suggested that NRF2...
Fri Jul 31, 2020 13:23
Related Articles Combination of Detoxified Pneumolysin Derivative ΔA146Ply and Berbamine as a Treatment Approach for Breast Cancer. Mol Ther Oncolytics. 2020 Sep 25;18:247-261 Authors: Zhang H, Zhu T, Fu R, Peng Y, Jing P, Xu W, Wang H, Li S, Shu Z, Yin Y, Zhang X Abstract Increasing evidence demonstrates that microorganisms and their products can modulate host responses to cancer therapies and contribute to tumor shrinkage via various...
Fri Jul 31, 2020 13:23
Related Articles Quercetin Suppresses Proliferation of Liver Cancer Cell Lines In Vitro. Anticancer Res. 2020 Aug;40(8):4695-4700 Authors: Hisaka T, Sakai H, Sato T, Goto Y, Nomura Y, Fukutomi S, Fujita F, Mizobe T, Nakashima O, Tanigawa M, Naito Y, Akiba J, Ogasawara S, Nakashima K, Akagi Y, Okuda K, Yano H Abstract BACKGROUND/AIM: We investigated the anti-proliferative effect of quercetin on liver cancer cell lines. MATERIALS...
Fri Jul 31, 2020 13:23
Related Articles Biology of Glioblastoma Multiforme-Exploration of Mitotic Catastrophe as a Potential Treatment Modality. Int J Mol Sci. 2020 Jul 27;21(15): Authors: Vitovcova B, Skarkova V, Rudolf K, Rudolf E Abstract Glioblastoma multiforme (GBM) represents approximately 60% of all brain tumors in adults. This malignancy shows a high biological and genetic heterogeneity associated with exceptional aggressiveness, leading to a poor survival...
Fri Jul 31, 2020 13:23
Related Articles Can We Use Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Levels to Predict Acute Kidney Injury in Neonate and Infants Undergoing Cardiac Surgery? Not Yet…. Pediatr Crit Care Med. 2020 06;21(6):593-594 Authors: Couloures KG, Marsenic O PMID: 32483026 [PubMed - indexed for MEDLINE]
Fri Jul 31, 2020 13:23
Multimorbidity and psychotropic polypharmacy among participants with autism spectrum disorder with intellectual disability. Psychiatry Res. 2020 Jul 22;292:113321 Authors: Espadas C, Ballester P, Londoño AC, Almenara S, Aguilar V, Belda C, Pérez E, Peiró AM Abstract Nowadays, adults with autism spectrum disorder (ASD) experience several comorbidities whose treatment implies a wide range of psychotropic prescriptions. This study aimed to evaluate...
Sun Aug 02, 2020 15:40
Cues for seizure timing. Epilepsia. 2020 Aug 01;: Authors: Rao VR, G Leguia M, Tcheng TK, Baud MO Abstract The cyclical organization of seizures in epilepsy has been described since antiquity. However, historical explanations for seizure cycles-based on celestial, hormonal, and environmental factors-have only recently become testable with the advent of chronic electroencephalography (cEEG) and modern statistical techniques. Here, factors purported...
Sun Aug 02, 2020 15:40
Related Articles Drug-drug and drug-food interactions in an infant with early-onset SCN2A epilepsy treated with carbamazepine, phenytoin and a ketogenic diet. Br J Clin Pharmacol. 2020 Jul 31;: Authors: Welzel T, Ziesenitz VC, Weber P, Datta AN, van den Anker JN, Gotta V Abstract Sodium channel alpha two subunit (SCN2A) mutations cause difficult-to-treat early-onset epilepsy. Effective treatment includes high-dose phenytoin or carbamazepine...
Sun Aug 02, 2020 15:40
Related Articles Reliability and availability of granger causality density in localization of Rolandic focus in BECTS. Brain Imaging Behav. 2020 Jul 31;: Authors: Dai XJ, Yang Y, Wang N, Tao W, Fan J, Wang Y Abstract A new method, called granger causality density (GCD), could reflect the directed information flow of the epileptiform activity, which is much closely match with excitatory and inhibitory imbalance theory of epilepsy. Here, we investigated...
Sun Aug 02, 2020 15:40
Related Articles The ethics of neurologically complicated pregnancies. Handb Clin Neurol. 2020;171:227-242 Authors: Smok D, Prager KM Abstract Bioethical conflicts in pregnancy are distinguished from those in other areas of medicine due to competing interests between mother and fetus because of their shared biology. Historically, prior to the advent of fetal therapy and advances in medical technology, the maternal-fetal complex was considered...
Sun Aug 02, 2020 15:40
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