Objective To assess the efficacy and safety of nabilone, a synthetic tetrahydrocannabinol analogue, as a treatment for non‐motor symptoms (NMS) in Parkinson´s Disease (PD). Methods This was a phase II placebo‐controlled, double‐blind, parallel‐group, enriched enrollment randomized withdrawal trial at the Medical University Innsbruck. A random sample of 47 PD patients with stable motor disease and disturbing NMS defined by a score of ≥4 points on the Movement Disorder Society‐Unified PD Rating...
Wed Aug 05, 2020 19:43
Publication date: Available online 5 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Marvin Darkwah Oppong, Leonie Droste, Daniela Pierscianek, Karsten H. Wrede, Laurèl Rauschenbach, Philipp Dammann, Annika Herten, Michael Forsting, Ulrich Sure, Ramazan Jabbarli
Thu Aug 06, 2020 20:18
Publication date: Available online 5 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Serkan Bayram, Alper Şükrü Kendirci, Şahin Karalar, Hacer Durmuş Tekçe, Fatma Yeşim Parman, Turgut Akgül, Hayati Durmaz
Thu Aug 06, 2020 20:18
Publication date: Available online 5 August 2020Source: Clinical Neurology and NeurosurgeryAuthor(s): Jun Zhang, Haili Wang, Yuping Li, Hengzhu Zhang, Lun Dong
Thu Aug 06, 2020 20:18
Publication date: April 2021Source: Current Opinion in Neurobiology, Volume 67Author(s): Shinichiro Tsutsumi, Akiko Hayashi-Takagi
Thu Aug 06, 2020 18:04
Abstract Focal dystonia, by definition, affects a specific body part; however, it may have a widespread neural substrate. We tested this hypothesis by examining the intrinsic behavior and the neuronal properties that are modulated by changes in the physiological behavior of their connections, i.e., feedback dependence, of the isolated pallidal neurons. During deep brain stimulation surgery in 12 patients with isolated cervical dystonia (without hand involvement), we measured spontaneous as well...
Wed Aug 05, 2020 22:54
Abstract Activation of the maternal immune system (MIA) during gestation is linked to neuropsychiatric diseases like schizophrenia. While many studies address behavioural aspects, less is known about underlying cellular mechanisms. In the following study, BALB/c mice received intraperitoneal injections of polyinosinic‐polycytidylic acid (Poly I:C) (20 µg/ml) or saline (0.9%) at gestation day (GD) 9.5 before hippocampal neurons were isolated and cultured from embryonic mice for further analysis....
Wed Aug 05, 2020 19:11
Abstract There are contralateral and less studied ipsilateral (i), indirect cortical descending projections to motoneurons (MNs). We compared ipsilateral cortical descending influences on MNs of wrist flexors by applying transcranial magnetic stimulation (TMS) over the right primary motor cortex at actively maintained flexion and extension wrist positions in uni- and bimanual tasks in right-handed participants (n = 23). The iTMS response includes a short latency (~ 25 ms) motor...
Thu Aug 06, 2020 03:00
Publication date: 1 October 2020Source: Journal of Neuroscience Methods, Volume 344Author(s):
Thu Aug 06, 2020 16:30
Publication date: Available online 5 August 2020Source: Journal of Neuroscience MethodsAuthor(s): Aboyeji Lukuman Oyewole, Kehinde Olumide Oyafemi, Kolade Samson Badmus, Janet Omotola Omoleye, Midrar Folahanmi Abubakar, Omolade Adeniyi-Raheem, Abdul-hameed Amedu, Dolapo Latifah Lawal, Aishat Oluwakemi Ijiyode, Ateeqah Oreoluwa Yussuf, Solomon Sunday Ishola, Fatimo Ajoke Sulaimon, Abdulmusawwir O. Alli-Oluwafuyi, Abdulrazaq Bidemi Nafiu, Olugbenga Akinola, Olayemi Joseph Olajide, Abdulbasit Amin,...
Thu Aug 06, 2020 16:30
Journal of Neurotrauma, Ahead of Print.
Wed Aug 05, 2020 10:00
Journal of Neurotrauma, Ahead of Print.
Tue Aug 04, 2020 10:00
Abstract Purpose Somatic mutations on H3 histone are currently considered a genetic hallmark for midline pediatric high-grade gliomas (HGGs). Yet, different tumor histologies have been occasionally described to carry these mutations. Since histone modifications can lead to major epigenetic changes with direct impact on prognosis and treatment, we thought to investigate the occurrence of H3F3A K27M and G34R/V mutations in a cohort of...
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Abstract Background Focal cortical dysplasia (FCD) is the most prevalent cause of intractable epilepsy in children. It was first described by Taylor et al. in 1971. In 2011, the International League against Epilepsy described an international consensus of classification for FCD. However, the exact mechanism causing this pathology remains unclear. The diagnosis and recognition of FCD increase with the advances in neuroradiology and electrophysiology....
Thu Aug 06, 2020 03:00
Abstract Purpose The purpose is to highlight the primary intracranial (meningeal-based) occurrence of Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET). Methods This report is a collation of clinicopathological features of eight cases of molecularly and clinicoradiologically confirmed primary (non-metastatic) intracranial (non-osseous) meningeal...
Thu Aug 06, 2020 03:00
Abstract Purpose To review the current genetic aspects of tuberous sclerosis complex. Methods Review of the literature. Results Tuberous sclerosis complex (TSC), a long known childhood-onset monogenic disorder, characterized by hamartoma formation affecting mainly...
Thu Aug 06, 2020 03:00
BACKGROUND AND PURPOSE:Management of contrast media allergies may lead to treatment delays in patients with acute ischemic stroke undergoing endovascular therapy. The optimal premedication strategy remains unclear. The aim of this report was to analyze our experience with emergent administration of premedication regimens before endovascular therapy.MATERIALS AND METHODS:We retrospectively reviewed prospective data for all patients undergoing endovascular therapy from 2012 to 2019 at an academic comprehensive...
Thu Aug 06, 2020 18:46
SUMMARY:Myalgia is a previously reported symptom in patients with COVID-19 infection; however, the presence of paraspinal myositis has not been previously reported. We report MR imaging findings of the spine obtained in a cohort of 9 patients with COVID-19 infection who presented to our hospital between March 3, 2020 and May 6, 2020. We found that 7 of 9 COVID-19 patients (78%) who underwent MR imaging of the spine had MR imaging evidence of paraspinal myositis, characterized by intramuscular edema...
Thu Aug 06, 2020 18:37
BACKGROUND AND PURPOSE:Although olfactory dysfunction is a common cranial nerve disorder, there are no simple objective morphometric criteria to assess olfactory dysfunction. The aim of this study was to evaluate the diagnostic performance of MR imaging morphometric parameters for detecting olfactory dysfunction.MATERIALS AND METHODS:This prospective study enrolled patients from those presenting with olfactory symptoms who underwent both an olfactory function test and MR imaging. Controls without...
Thu Aug 06, 2020 18:18
BACKGROUND AND PURPOSE:Hypophysitis is one of the well-known adverse effects of immune checkpoint inhibitors. Immune checkpoint inhibitor–induced hypophysitis frequently causes irreversible hypopituitarism, which requires long-term hormone replacement. Despite the high frequency and clinical significance, characteristic MR imaging findings of immune checkpoint inhibitor–induced hypophysitis have not been established. In the present study, we aimed to review and extract the MR imaging features of...
Thu Aug 06, 2020 18:06
BACKGROUND AND PURPOSE:Internal auditory canal diverticula are focal lucencies along the anterior-inferior aspect of the internal auditory canal fundus. Studies in adults report conflicting data on the etiology and clinical relevance of this finding. We would expect a pediatric study to help elucidate the significance of internal auditory canal diverticula. The primary goals of this study were to determine the temporal bone CT prevalence of diverticula among pediatric patients and to assess possible...
Thu Aug 06, 2020 18:01
BACKGROUND AND PURPOSE:It is unknown whether deceleration of brain atrophy is associated with disability improvement in patients with MS. Our aim was to investigate whether patients with MS with disability improvement develop less brain atrophy compared with those who progress in disability or remain stable.MATERIALS AND METHODS:We followed 980 patients with MS for a mean of 4.8 ± 2.4 years. Subjects were divided into 3 groups: progress in disability (n = 241, 24.6%), disability improvement (n =...
Thu Aug 06, 2020 17:34
BACKGROUND AND PURPOSE:Cellular uptake of the manganese ion, when administered as a contrast agent for MR imaging, can noninvasively highlight cellular activity and disease processes in both animals and humans. The purpose of this study was to explore the enhancement profile of manganese in patients with multiple sclerosis.MATERIALS AND METHODS:Mangafodipir is a manganese chelate that was clinically approved for MR imaging of liver lesions. We present a case series of 6 adults with multiple sclerosis...
Thu Aug 06, 2020 17:13
SUMMARY:Radiologically isolated syndrome refers to an entity in which white matter lesions fulfilling the criteria for multiple sclerosis occur in individuals without a history of a clinical demyelinating attack or alternative etiology. Since its introduction in 2009, the diagnostic criteria of radiologically isolated syndrome and its clinical relevance have been widely debated by neurologists and radiologists. The aim of the present study was to review the following: 1) historical evolution of radiologically...
Thu Aug 06, 2020 17:12
BACKGROUND AND PURPOSE:Clinical and imaging manifestations of idiopathic intracranial hypertension should prompt early diagnosis and treatment to avoid complications. Multiple diagnostic imaging criteria are reported to suggest the diagnosis of idiopathic intracranial hypertension with questionable sensitivity and/or specificity. Increased intracranial pressure results in dilation of the perineural cisternal spaces such as the optic nerve sheaths and the Meckel cave. It may also cause protrusion...
Thu Aug 06, 2020 16:35
RATIONALE: COPD is the most common non-infectious pulmonary disease among people living with HIV, independent of smoking. However, the cause for this enhanced susceptibility remains unclear, and the effects of HIV on pulmonary perfusion and ventilation are unknown. METHODS: We used PET-CT in 46 smokers and non-smokers, 23 of whom had documented HIV infection. Emphysema was assessed by CT and perfusion by nitrogen-13 (13NN) PET scans. After removal of image noise, vertical and axial gradients...
00:39
Rationale: In first-line treatment of Hodgkin lymphoma (HL) Deauville scores 1-3 define complete metabolic remission. Interim FDG-PET is also used for relapse treatment adaptation, however PET-response criteria are not validated for relapse treatment. Methods: We performed a pairwise comparative analysis of early treatment response to first-line and to second-line treatment in 127 patients with classical Hodgkin lymphoma who experienced relapse. Patients participated in the prospective, multicenter...
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With the ability to non-invasively image and monitor molecular processes within tumors, molecular imaging represents a fundamental tool for cancer scientists. In the current review, we describe emergent technologies for molecular imaging. We aim to provide the reader with an overview of the fundamental principles on which each imaging strategy is based, to introduce established and future applications, and to provide a rationale for selecting optical technologies for molecular imaging depending on...
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Increased mortality rates from infectious diseases is a growing public health concern. Successful management of acute bacterial infections requires early diagnosis and treatment, which are not always easy to achieve. Structural imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) are often applied to this problem. However, these methods generally rely on secondary inflammatory changes and are frequently not specific to infection. The use of nuclear medicine (NM)...
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In vivo biomarkers for pathology changes in Alzheimer’s disease (AD) performed by scintigraphic neuroimaging have been approved by the FDA (amyloid binding positron emission tomography (PET) agents) with additional agents, most notably targeting tau, currently under clinical investigation and likely to be submitted to the FDA for approval in the not too distant future. These agents, along with non-scintigraphic biomarkers from blood and cerebrospinal fluid (CSF) have provided an opportunity to investigate...
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The aim of this study was to evaluate the correlation between uptake of the positron emission tomography (PET) ligand 68Ga-NOTA-AE105 targeting the urokinase-type plasminogen activator receptor (uPAR) and Gleason score in patients undergoing prostate biopsy. Materials & Methods: Patients with clinical suspicion of prostate cancer (PCa) or previously diagnosed with PCa were prospectively enrolled in this phase II trial. A combined uPAR PET, multiparametric magnetic resonance imaging (mpMRI)...
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Publication date: October 2020Source: World Neurosurgery, Volume 142Author(s): Ali Akhaddar
Thu Aug 06, 2020 20:04
Publication date: October 2020Source: World Neurosurgery, Volume 142Author(s): Victor M. Lu, Lola B. Chambless
Thu Aug 06, 2020 20:04
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