Publication date: Available online 1 August 2020Source: Auris Nasus LarynxAuthor(s): Shogo Furuki, Hajime Sano, Takaomi Kurioka, Atsuko Ogiwara, Takahito Nakagawa, Rie Inoue, Sachie Umehara, Yuki Hara, Keiko Suzuki, Taku Yamashita
Sun Aug 02, 2020 15:58
Publication date: Available online 30 July 2020Source: Auris Nasus LarynxAuthor(s): Hiroshi Yamazaki, Takeshi Nakamura, Katsuhiro Hosono, Tomoya Yamaguchi, Yasuyuki Hiratsuka, Yoshihiro Hotta, Makio Takahashi
Fri Jul 31, 2020 13:46
Abstract 1. Combined radiation therapy and every‐3‐weeks high‐dose cisplatin has been often reported for head and neck cancer. However, this regimen can cause both severe acute complications and late complications. 2. The objective of this study is to evaluate the efficacy of combined weekly chemoradiation therapy using low‐dose platinum agent combined with radiation therapy. The 3‐ and 5‐year overall survival rates are comparable to those associated with combination high‐dose cisplatin and radiation...
Sat Aug 01, 2020 20:28
Abstract Aims 1. To systematically review the currently available evidence investigating the association between olfactory dysfunction (OD) and the novel coronavirus (COVID‐19). 2. To analyse the prevalence of OD in patients who have tested positive on Polymerase Chain Reaction (PCR) for COVID‐19. 2. To perform a meta‐analysis of patients presenting with olfactory dysfunction, during the pandemic, and to investigate the Positive Predictive Value for a COOVID‐19 positive result in this population....
Sat Aug 01, 2020 20:27
Abstract Objectives To demonstrate face and content validity of a home‐made simulation model as a training tool for front of neck access (FONA) procedures. Design This was a prospective evaluation study, in which experienced otolaryngologists and trainees were recruited to complete 3 tasks using our FONA model. Setting The study was completed during regular simulation training days and international conferences. Participants A total of 52 participants completed the questionnaire...
Sat Aug 01, 2020 19:15
Abstract Aims The accuracy of toluidine blue (TB) and chemiluminescence for diagnosing oral cancer and precancer was evaluated. Methods Two authors (working independently) comprehensively reviewed six databases (PubMed, Cochrane database, Embase, Web of Science, SCOPUS, and Google Scholar) from their dates of inception until March 2020. Oral mucosal disorder, as detected by TB, was compared with that detected by chemiluminescence. True‐positive, true‐negative, false‐positive, and false‐negative...
Sat Aug 01, 2020 17:45
Abstract Objective Radiotherapy (RT) for head and neck cancer (HNC) within 7 days of tooth extraction is contraindicated because it may increase the risk of osteoradionecrosis of the jaw (ORNJ). However, delayed RT could compromise survival in patients with HNC. By using a national health care database, we reviewed the contraindications and analysed other risk factors for ORNJ. Design A retrospective cohort study. Setting By using Taiwan’s National Health Insurance Research Database,...
Sat Aug 01, 2020 12:33
Abstract Background Tonsillectomy is one of the most common surgical procedures in children but indications and surgical practice change over time. Objectives We aimedto identify trends in tonsillectomy procedures in children, in particular the number of procedures performed, the age of child undergoing tonsillectomy and the type of hospital in which the surgery was performed. Design Review of Scottish Morbidity Records data (SMR01) which are routinelycollected after every day case...
Fri Jul 31, 2020 20:25
Abstract Large nasal septal perforations have higher extrusion rates with pre‐fabricated septal obturators. A prospective cohort study was conducted including patients with septal perforation who underwent custom‐made septal buttons and quality‐of‐life outcomes were measured. The mean total SNOT‐22 score improved after insertion of the prosthesis with highest change in perforation specific symptoms (crusting, bleeding, whistling). Accurate sizing and successful closure with 3‐D printing...
Fri Jul 31, 2020 20:24
Abstract Objective The neurocognitive associationsinpediatric obstructive sleep apnea (OSA) are well known; however, whether polysomnographic features can predict these associations is unknown. Therefore, the primary objective of this study was to compare common polysomnographic parameters in children with OSA in the presence and absence of neurocognitive dysfunction. Methods Polysomnography datafor children ages3‐6 yearswith mild‐moderate OSA who as defined by AHI between 5‐10 were analyzed...
Fri Jul 31, 2020 14:10
Abstract Objectives To evaluate the role of thrombin based hemostatic agent Surgiflo® (Ethicon, Somerville, USA) in improving the outcome of cricotracheal resection anastomosis. Design Randomized controlled clinical trial. Setting Otorhinolaryngology Department, Mansoura University Hospitals, Egypt. Participants This study included 55 patients with grade III and IV subglottic and/or cervical tracheal stenosis, who underwent cricotracheal resection anastomosis. Patients were...
Fri Jul 31, 2020 11:32
Abstract We read with interest the systematic review on the incidence of thyroid malignancy in patients undergoing thyroidectomy for hyperthyroidism.1 Varadharajan and Choudhury reported a malignancy rate of 8.5%, postulated potential underlying mechanisms and proposed routine preoperative imaging in these patients.
Fri Jul 31, 2020 11:32
Abstract The United Kingdom has been hit hard by the COVID‐19 pandemic with the highest death toll in Europe exceeding 40,000. London has been the epicentre of the UK outbreak, with more than 1600 positive recorded cases in our institution alone. Consequently, hospital specialities have had to adapt rapidly to the challenges COVID‐19 has posed.
Fri Jul 31, 2020 11:32
Abstract Objectives We aimed to audit current United Kingdom (UK) practice of Head and Neck Cancer (HNC) post‐treatment surveillance against national guidelines, and determine the outcomes of these practices in detecting recurrence. Design National cross‐sectional study of current HNC surveillance practice. Setting UK HNC outpatient departments. Participants HNC patients reviewed for post‐treatment surveillance. Main outcome measures Compliance with UK multidisciplinary...
Thu Jul 30, 2020 21:00
Condition: Healthy Chinese VolunteersInterventions: Drug: TG-1000; Drug: PlaceboSponsors: TaiGen Biotechnology Co., Ltd.; R&G Pharma Studies Co.,Ltd.Recruiting
Fri Jul 31, 2020 15:05
Abstract Purpose The proportion of elderly people aged ≥ 65 years is increasing worldwide. Although the reported prevalence of sinonasal disease can vary according to the diagnostic methods used, differences in allergic rhinitis prevalence in the elderly according to diagnostic method have not been reported. We thus aimed to evaluate allergic rhinitis prevalence in the elderly according to diagnostic criteria obtained from questionnaires,...
Sun Aug 02, 2020 03:00
In the original publication of the article, Fig. 1a was missing and caption of Fig. 1a was published as caption of Fig. 1b. The correct Fig. 1 and captions are provided below.
Sat Aug 01, 2020 03:00
Abstract Skin models mimicking features of psoriasis‐related inflammation are needed to support the development of new drugs in dermatology. Reconstructed skin models lack tissue complexity, including a fully competent skin barrier, and presence and/or diversity of immune cells. Here we describe InflammaSkin®, a novel human Th17‐driven ex vivo skin inflammation model. In this model, skin resident T cells are in situ activated by intradermal injection of anti‐CD3 and ‐CD28 antibodies and Th17 cells...
Sat Aug 01, 2020 12:19
Abstract Background Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with high mortality. Identifying patients at risk of distant metastasis assists with management and prognostication. We aimed to define the relationship between volume, survival, and risk of distant metastases. Methods A retrospective review of all patients with SNMM treated at a single institution over a 21‐year period was conducted. Tumor volume was calculated using cross‐sectional imaging and survival analysis...
Sat Aug 01, 2020 22:58
Clinical evaluation of an automated virtual surgical planning platform for mandibular reconstruction
Abstract Background Virtual surgical planning (VSP), via commercial services or developed in‐house, has been applied to facilitate head and neck reconstruction. We evaluate a custom, automated planning software. Methods Prospectively, VSP of 25 consecutive patients undergoing segmental mandibular reconstruction was performed. Postoperative CT was used to assess structural accuracy of VSP. Operative time, length of stay, and complication rate of the prospective cohort were compared with...
Sat Aug 01, 2020 22:55
Abstract This study aimed to ascertain the maximal exposure of the superior orbital fissure (SOF) afforded by combining endonasal and transorbital endoscopic approaches. Six cadaveric specimens (12 sides) were dissected using endonasal and transorbital endoscopic approaches to access the SOF. The order of the approaches was alternated in each specimen (eg, starting with an endonasal approach in one side followed by a transorbital exposure and reversing the order on the contralateral side). Maximal...
Sat Aug 01, 2020 22:41
Abstract Background The primary purpose was to evaluate the prognostic potential of diffusion imaging (DWI) and dynamic contrast enhanced magnetic resonance imaging (DCE‐MRI) in predicting distant metastases in squamous cell carcinoma of head and neck (HNSCC) patients. The secondary aim was to examine differences in DWI and DCE‐MRI‐derived parameters on the basis of human papilloma virus (HPV) status, differentiation grade, and nodal stage of HNSCC. Methods Fifty‐six patients underwent...
Sat Aug 01, 2020 22:28
Abstract Background Metastatic cutaneous squamous cell carcinoma (cSCC) carries a poor prognosis. Increased numbers of CD8+ cytotoxic T cells are associated with a favorable prognosis and programmed cell death receptor‐1 is a suppressor of the CD8+ cytotoxic T cell response. We aim to define their expression in metastatic cutaneous squamous cell carcinoma. Methods Cytotoxic T cell infiltrates and tumoral PD‐L1 expression in lymph node metastases from patients with cSCC of the head and neck...
Sat Aug 01, 2020 12:35
Abstract Background This study aimed to examine the prevalence, location, and severity of chronic internal, external, and combined head and neck lymphedema (HNL) in patients with head and neck (HNC) who were treated with definitive chemoradiotherapy (CRT) or postoperative radiotherapy (PORT). Methods Sixty‐two participants between 1 and 3 years post‐treatment were recruited. Internal HNL was rated with Patterson's Scale. External HNL was graded with the MD Anderson Cancer Center Lymphedema...
Fri Jul 31, 2020 14:14
Related Articles Explosion in hearing aid demands after Covid-19 outbreak curfew. Eur Arch Otorhinolaryngol. 2020 Aug 01;: Authors: Ertugrul S, Soylemez E PMID: 32737646 [PubMed - as supplied by publisher]
Sun Aug 02, 2020 13:59
Related Articles Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. Eur Arch Otorhinolaryngol. 2020 Jul 31;: Authors: Avilés-Jurado FX, Muñoz C, Meler C, Flores JC, Gumà J, Benaiges E, Mora J, Camacho M, León X, Vilaseca I, Terra X Abstract BACKGROUND: The identification of prognostic non-invasive biomarkers is a priority for cancer patients' care. Circulating microRNA (miRNAs) have been described in...
Sun Aug 02, 2020 13:59
Related Articles Laryngopharyngeal reflux as a potential cause of persistent local neck symptoms after total thyroidectomy. Eur Arch Otorhinolaryngol. 2020 Jul 31;: Authors: Cipolla C, Macaione I, Vieni S, Latteri M, Vullo A, Graceffa G, Fiorentino E Abstract PURPOSE: Local neck symptoms (LNS) may be related to goiter, but are also reported by patients suffering from laryngeal-pharyngeal reflux (LPR). The aim of this study was to investigate...
Sun Aug 02, 2020 13:59
Related Articles Effect of different blood groups on tympanometric findings and acoustic reflex thresholds. Eur Arch Otorhinolaryngol. 2020 Jul 31;: Authors: Prabhu P, Shaji SR, Vipinan KM, Ramanunny NV, Nagaraju B Abstract PURPOSE: The blood group can have an effect on the auditory system, and it is suggested that it could be an indicator of noise-induced hearing loss. There could be changes in the immittance findings, too, in adults having...
Sun Aug 02, 2020 13:59
Related Articles Microsurgical procedures during COVID-19 pandemic: the VITOM® 3D-HD exoscopic system as alternative to the operating microscope to properly use personal protective equipment (PPE). Eur Arch Otorhinolaryngol. 2020 Jul 29;: Authors: Carobbio ALC, Filauro M, Parrinello G, Missale F, Peretti G Abstract PURPOSE: In the field of microsurgery, the use of conventional operating microscope, adopted in several disciplines, is not suitable...
Fri Jul 31, 2020 14:40
Related Articles Longitudinal perioperative pain, neuromusculoskeletal complications and quality-of-life assessment in partial parotidectomy. Eur Arch Otorhinolaryngol. 2020 Jul 29;: Authors: Ozsoy-Unubol T, Bulgurcu S, Erkul BE Abstract AIM: The aim of this study was to evaluate the pain, neuromusculoskeletal complications, and quality of life (QoL) in patients who had undergone partial parotidectomy (PP) for benign parotid tumors. ...
Fri Jul 31, 2020 14:40
To identify and describe the dynamic features of velopharyngeal dysfunction (VPD) in patients with 22q11.2 deletion syndrome relative to patients with non-syndromic cleft palates.
Fri Jul 31, 2020 03:00
Melanoma is the most malignant form of skin cancer with high metastatic potential. Nuclear factor of activated T-cells (NFATs) are discovered as transcription factors that regulate the expression of proinflammatory cytokines and other genes during the immune response. Among five NFAT members, NFAT3 is exclusively not expressed in immune cells and its role in progression of different types of cancer remains controversial. Our previous study showed that NFAT3 was highly expressed in skin cancer compared...
Sat Aug 01, 2020 02:15
In this study, we sought to objectively determine the accuracy and comprehensibility of online material with regard to subungual melanoma, a nail disease that is rare within the general population, yet has high incidence in certain patient groups, and carries a poorer prognosis than other forms of cutaneous melanoma. Because improved prognosis relies on early diagnosis, the dissemination of accurate, understandable information is an important factor in patient education and health. Using a pro forma...
Sat Aug 01, 2020 02:15
Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanocyte and melanoma cell senescence is likely to come into play as a key factor affecting the course of tumorigenesis and responsiveness to therapy; little mechanistic information has been...
Sat Aug 01, 2020 02:15
The purpose of this study was to use the Surveillance, Epidemiology, and End Results database to identify the incidence rate and risk factors for suicide death in patients with skin malignant melanoma (MM) in the USA. We screened cases of skin MM in the SEER database. The balance of covariates between the two groups was examined by the χ2-test and Fisher’s exact test. Logistic regression was used to identify independent risk factors for committing suicide. A propensity 1: 2 matched analysis was applied...
Sat Aug 01, 2020 02:15
The results of local-regional advanced melanoma (stage III) management are still not satisfactory. Particularly, there is no personalized treatment in stage III melanoma patients due to the lack of useful classical pathological markers for prognostication of indolent or aggressive course of the disease. The aim of this study was to explore melanoma genomic landscape by means of the mutational profiling of 50 genes influencing carcinogenesis pathways in the randomly selected 93 kinase inhibitor-naïve...
Sat Aug 01, 2020 02:15
The treatment of cancer during pregnancy presents a unique challenge. Optimal treatments are often altered or even delayed to protect fetal growth and organogenesis. The landscape of cancer treatment has shifted dramatically over the past several years and treatment with checkpoint inhibitors, including anti-PD1 and anti-CTLA-4 agents has revolutionized treatment outcomes for patients across numerous tumor types. Until recently, little is known about the use of checkpoint inhibitor therapy during...
Sat Aug 01, 2020 02:15
Whole-body positron emission tomography/computed tomography (PET/CT) and brain magnetic resonance imaging (MRI) are commonly used to stage patients with palpable lymph node metastases from melanoma, but their role in patients with satellite and/or in-transit metastasis (S&ITM) is unclear. The aim of this study was to establish the diagnostic value of PET/CT and brain MRI in these patients, and to assess their influence on subsequent management decisions. In this prospective study, 25 melanoma...
Sat Aug 01, 2020 02:15
The aim was to evaluate changes in skin melanoma incidence and mortality at a population level in central Italy over the past two decades. Skin melanoma incidence rate from 1994 to 2014, were retrieved from the Umbrian Cancer Registry (about 900 000 inhabitants). Changes from 1994–1999 to 2010–2014 in tumour and patient characteristics – sex, age (0–44, 45–64, ≥ 65 years), site (head and neck, trunk, limbs), morphology (superficial spreading, nodular, other), thickness (≤ 1, 1–2, 2–4, > 4) and...
Sat Aug 01, 2020 02:15
Management of PD-1 blockade resistance in metastatic melanoma (MM) remains challenging. Immunotherapy or chemotherapy alone provides limited benefit in this setting. Chemo-immunotherapy (CIT) has demonstrated favorable efficacy and safety profiles in lung cancer. Our pre-clinical study showed that in MM patients who have failed PD-1 blockade, the addition of chemotherapy increases CX3CR1+ therapy-responsive CD8+ T-cells with enhanced anti-tumor activity, resulting in improved clinical response. Here,...
Sat Aug 01, 2020 02:15
Response to talimogene laherparepvec (T-Vec) is difficult to assess as pigmented macrophages that have ingested melanoma cells (‘melanophages’) persist after injection, mimicking melanoma. We used quantitative immunofluorescence (qIF) to (1) distinguish melanophages from melanoma in biopsies from two patients treated with T-Vec and (2) evaluate the tumor microenvironment pretreatment and posttreatment. Tissues were stained with 4’,6-diamidino-2-phenylindole, cluster of differentiation (CD) 3, CD8,...
Sat Aug 01, 2020 02:15
To evaluate factors affecting the utilization of immunotherapy and to stratify results based on the approval of ipilimumab in 2011 and PD-1 inhibitors in 2014, an analysis of available data from the National Cancer Database (NCDB) was performed. Stage IV melanoma patients were identified. Effects of immunotherapy on overall survival (OS) were assessed using Kaplan–Meier curves and Cox proportional hazards model. A total of 19 233 patients were analyzed and 1998 received immunotherapy. Between 2011...
Sat Aug 01, 2020 02:15
Despite being benign tumors, hibernomas show intense fluorine-18-fluorodeoxyglucose uptake, as they are derived from brown fat, which is frequently seen as hypermetabolic fatty areas on PET/CT. We present the case of a patient with cutaneous melanoma, diagnosed with a cervical hibernoma mimicking a metastatic lymph node at fluorine-18-fluorodeoxyglucose PET/CT. Being aware of the metabolic behavior and radiologic appearance of this entity may prevent reporting false-positive lesions, especially in...
Sat Aug 01, 2020 02:15
Up-to-date melanoma relative survival (RS) estimates and trend analysis facilitate close monitoring of melanoma patients’ prognosis. This study aimed to provide recent 5-year and 10-year RS from melanoma, stratified by prognostic factors, and identify latest survival trends. Data from 12 German cancer registries were analysed. We included patients with primary cutaneous malignant melanoma (ICD-10: C43.X) diagnosed in 1997–2013 who were at least 15 years old. Five-year and 10-year RS were estimated...
Sat Aug 01, 2020 02:15
We observed several cases of hypotension associated with high-dose dacarbazine. We conducted a retrospective observational analysis of all patients treated with high-dose dacarbazine from January 2018 to August 2019 in Oscar Lambret Center, Lille, France. In our study, a total of 23 patients in outpatient care were analyzed, they underwent 57 treatment cycles. We observed 8 episodes of hypotension in 7 of the 23 consecutive treated patients (30.4%). We discuss herein several hypotheses explaining...
Sat Aug 01, 2020 02:15
Publication date: Available online 1 August 2020Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Robert T. Sataloff, Karen M. Kost
Sun Aug 02, 2020 18:31
Introduction: Endoscopic stapes surgery is a technically demanding procedure that is increasing in popularity. Surgical outcomes and complication rates have been demonstrated to be comparable to traditional microscopic techniques. The surgical outcomes for patients undergoing stapes surgery performed by the Sydney Endoscopic Ear Surgery Research Group are presented. Study Design: Retrospective review from prospectively gathered database. Setting: Tertiary referral centers....
Mon Jul 27, 2020 03:00
Objective: To determine the efficacy of various treatment modalities used for acute noise-induced hearing loss (aNIHL) from acute acoustic trauma (AAT) via a systematic review and meta-analysis. Data Sources: PubMed, Cochrane, and Scopus databases. Study Selection: The scientific literature was searched up to October 2018 for articles evaluating hearing outcomes after treatment of aNIHL. Data Extraction: The following were extracted: Oxford level of evidence, number...
Mon Jul 27, 2020 03:00
Objective: To determine the feasibility of a patient-specific, three-dimensionally (3D)-printed reconstruction plate for repair of lateral skull base defects. Study Design: Prospective case series and cadaveric study. Setting: A university-based, tertiary care hospital. Patients: Three patients with lateral skull base defects and five cadavers. Main Outcome Measure(s): Caliper gauge fit testing was performed in the cadaver temporal bones to determine the fit...
Mon Jul 27, 2020 03:00
Objective: To assess the benefits of bimodal listening (i.e., addition of contralateral hearing aid) for cochlear implant (CI) users on real-world tasks involving high-talker variability speech materials, environmental sounds, and self-reported quality of life (quality of hearing) in listeners’ own best-aided conditions. Study Design: Cross-sectional study between groups. Setting: Outpatient hearing clinic. Patients: Fifty experienced adult CI users divided into groups...
Mon Jul 27, 2020 03:00
Objective(s): To assess the incidence of central nervous system abnormalities in pediatric subjects with sensorineural hearing loss (SNHL). Methods: One hundred forty-three pediatric subjects evaluated for SNHL at a single academic center from 2007 to 2014 were included and divided into eight diagnosis groups based on etiology of SNHL. One hundred forty-three age- and gender-matched control subjects with no known brain-related pathology or history of hearing loss were included as healthy...
Mon Jul 27, 2020 03:00
Objective: We sought to examine the intra- and interobserver variability in measuring the cochlear duct length (CDL) from magnetic resonance imaging (MRI) images versus computed tomography (CT) images using an otological surgical planning software that uses measurements of the basal turn diameter and cochlear width to estimate the CDL. Patients: Twenty-one adult cochlear implant patients with preoperative MRI and CT images. Intervention: Three fellowship-trained neurotologists...
Mon Jul 27, 2020 03:00
When Opposites Attract: Pediatric Cochlear Implantation in the Setting of Cerebrospinal Fluid Shunts
Objective: The Food and Drug Administration (FDA) has recently raised concern regarding the safety of cochlear implantation in the setting of programmable cerebrospinal fluid shunts. The purpose of this study was to evaluate the outcomes and complications of cochlear implantation in children who have a cerebrospinal fluid shunt. Study Design: Retrospective chart review. Setting: Tertiary academic referral center. Patients: Twenty pediatric subjects with a cerebrospinal...
Mon Jul 27, 2020 03:00
Objective: Temporal bone osteoradionecrosis (TBORN) is a rare, chronic complication of head and neck radiation. Initial treatment consists of conservative management, with surgical resection of necrotic bone indicated for cases of severe, symptomatic, or progressive disease. Pentoxifylline-tocopherol (PENTO) has demonstrated usefulness for osteoradionecrosis of other head and neck subsites. Herein, we report five TBORN cases utilizing this protocol. Study Design: Retrospective case...
Mon Jul 27, 2020 03:00
Hypothesis: The presence and distribution of ionized calcium binding adaptor 1 and CD68 macrophages in the human cochlea is altered in cochlear implantation (CI) compared with the normative or nonimplanted cochlea. Background: It has been hypothesized that CI induces an immunological response in macrophages leading to implant failure or reduced hearing. Macrophages are resident immune cells in human cochlea and have been shown to phagocytize implant material. In animal models, macrophage...
Mon Jul 27, 2020 03:00
Objective: Intratympanic (IT) steroid injections are often used for the treatment of inner ear pathologies, including sudden sensorineural hearing loss. IT steroids are also commonly used in conjunction with or in case of systemic steroid therapy failure. They are viable options for patients who cannot endure side effects or are at high risk of complications from systemic therapy. The duration of treatment, strength, and type of steroid, and number of IT injections are important factors that...
Mon Jul 27, 2020 03:00
Objectives: In 2012 the first active bone conduction implant was introduced, but did not fit into the mastoids of some adults and many children. Thus, a geometry change of the transducer was proposed (BCI 602). In this study, we aimed to determine whether these changes improved the mastoid cavity fit of the implant in children and young adults. Design: We retrospectively analyzed computed tomography scans of 151 mastoids from 81 children and adolescents (age range, 5 mo to 20 yr) and...
Mon Jul 27, 2020 03:00
Background: Waardenburg syndrome (WS) is a rare disorder characterized by varying combinations of sensorineural hearing loss and abnormal pigmentation of the hair and skin. WS is classified into four subtypes (WS1–WS4) based on additional symptoms. Dystopia canthorum is a hallmark of WS type 1. There are two genes linked to WS type 1, including PAX3 and EDNRB. Objective: This study aimed to investigate the genetic etiology of WS type 1 in a pair of twins from China with profound hearing...
Mon Jul 27, 2020 03:00
Objective: Sleep apnea has been associated with dizziness, but the clinical characteristics of this dizziness have not been fully described. This study evaluated clinical descriptions of dizziness, vestibular diagnoses, and the response to treatment of dizzy patients with sleep apnea. Patients: All subjects had a new diagnosis of sleep apnea with a confirmatory pulse oximetry or polysomnogram and received treatment for sleep apnea through our center. Fifty-two patients met these criteria,...
Mon Jul 27, 2020 03:00
Objectives and Main Outcome Measures: To determine the prevalence of sensorineural hearing loss (SNHL) attributable to sickle cell disease (SCD) in the global adult population and to identify factors contributing to its severity. Study Design: Systematic Review and Meta-analysis. Methods: We performed a comprehensive literature search for scientific articles in PubMed, Scopus, CINAHL, Web of Science, and the Cochrane Library that reported the incidence of hearing loss in populations...
Mon Jul 27, 2020 03:00
Publication date: Available online 1 August 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Manuel Penton, Silvia Schibeci Oraa, Ashraf Abdelhemid, Caitlin Otto, Margaret R. Hammerschlag
Sun Aug 02, 2020 18:20
ABSTRACT BackgroundDistal nasolacrimal duct stenosis is usually treated by head and neck surgeons with transnasal endoscopic dacryocystorhinostomy (DCR). The presented clinical study discusses advantages and drawbacks of a robot‐assisted endoscope positioning system, which allows for hands‐free visualization of the surgical field.Material and MethodsTwo patients were treated by surgical DCR. The endoscopic positioning system (Medineering®, Munich, Germany) features a mechatronic holding arm with...
Fri Jul 31, 2020 13:11
Abstract BackgroundSemi‐active robot‐assisted total hip arthroplasty (THA) has two options to measure the leg length discrepancy (LLD) and combined offset (CO), the “enhanced” femoral workflow and the so‐called “express” simplified workflow. The purpose of this study was to determine the precision and accuracy of intraoperative LLD and CO measurement with express workflow robotic THA.MethodsBetween February 2018 and December 2019, 30 patients underwent an express workflow robot‐assisted primary...
Fri Jul 31, 2020 13:08
Objectives/Hypothesis Menopause adversely affecs power and endurance of the limb muscles. However, despite clinical observations that menopause corresponds to negative changes of the voice, the direct effects of estrogen deprivation on the thyroarytenoid muscles are unknown. The purpose of this study was to investigate the effects of estrogen deprivation via ovariectomy on three neuromuscular parameters of the thyroarytenoid muscles using a rat model. Study Design Animal model. Methods...
Sat Aug 01, 2020 19:04
Objective Evaluate patterns and predictors of spread to the neck in pediatric metastatic differentiated thyroid carcinoma (DTC). Methods Patients <18 years old undergoing thyroidectomy by a single surgeon from January 2015 to December 2019 were included. Neck sublevels were removed separately according to AJCC boundaries. Clinical outcomes included nerve injury, hypocalcemia, hematoma, and residual tumor. Results Forty‐eight children underwent thyroid surgery. Thirty (63%) were for...
Sat Aug 01, 2020 18:54
Objectives Many patients complain about olfactory fluctuation (OF), which is a symptom commonly attributed to sinonasal disease. Data‐based evidence for its association with sinonasal disease is scarce. The aim of the study is to identify explanatory variables associated with OF and to analyze its predictive value regarding sinonasal disease. Study design We performed a retrospective study based on patients with olfactory dysfunction. Methods We analyzed data from 482 patients attending...
Sat Aug 01, 2020 18:24
Objectives/Hypothesis Results from a prospective trial demonstrated better speech recognition for cochlear implant (CI) recipients implanted with a long lateral wall electrode array compared to subjects with a short array after 1 year of listening experience. As short array recipients may require an extended adaptation period, this study investigated whether differences in speech recognition continued through 4 years of CI use. Study Design Long‐term follow‐up of a prospective randomized trial....
Sat Aug 01, 2020 18:14
Objectives/Hypothesis To evaluate the efficacy and safety of a slow‐release form of bepotastine salicylate (HL151, Belion CR) in patients with perennial allergic rhinitis (PAR). Study Design Double‐blind, placebo‐controlled multicenter comparative study. Methods Two hundred seventy‐two PAR patients (aged 19–65 years) were studied to determine the efficacy and safety of HL151 (20 mg once daily administration) relative to those of a placebo in terms of improvements in total and nasal symptom...
Fri Jul 31, 2020 22:29
Objectives To evaluate laryngopharyngeal sensation at specific subsites using a novel adaptation of a buckling force aesthesiometer for delivery of calibrated tactile stimuli. Study Design Cross‐sectional. Methods Twenty‐two healthy adults (12 men, 10 women) were tested for responses to tactile forces, using 30‐mm 6‐0, 5‐0, and 4‐0 nylon monofilaments to map sensation of the aryepiglottic (AE) fold, lateral pyriform sinus (PS), and medial PS bilaterally. The outcome measures were the...
Fri Jul 31, 2020 21:59
Fri Jul 31, 2020 11:59
Objectives To determine the representation of women in leadership positions within otolaryngology societies and to compare their academic rank and research productivity to men. Methods The leadership positions of all U.S. otolaryngology societies were compiled. The Medicare Physician Compare database was used to obtain gender and medical school graduation year for all otolaryngologists. An online search was used to determine board member's academic faculty rank. The Scopus database was used...
Thu Jul 30, 2020 21:03
Objectives This study aimed to evaluate the efficacy of chemoradiotherapy (CRT) for patients with advanced cancer of the external auditory canal (EAC) by analyzing the outcome of the patients. Methods This is a multi‐institutional retrospective survey, and we reviewed the medical records of the subjects. A total of 181 patients with tumor (T)3 or T4 tumor in 17 institutions were enrolled. Further analysis was performed for 74 patients who underwent CRT under curative intent. Results Overall...
Thu Jul 30, 2020 20:59
Objectives Pre‐operative airway evaluation is essential to decrease the proportion of possible mortality and morbidity due to difficult airway (DA). The study aimed to evaluate the accuracy of pre‐operative ultrasonographic airway assessment (UAA) and indirect laryngoscopy (IL) in predicting DA. Study Design Prospective obsevational study. Methods Preoperative clinical examination (body mass index [BMI], mallampati classification [MP], thyromental distance, sternomental distance, neck...
Thu Jul 30, 2020 20:49
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