IJMS, Vol. 21, Pages 5650: In Vitro Comparison of Passive and Active Clinical Proton Beams International Journal of Molecular Sciences doi: 10.3390/ijms21165650 Authors: Anna Michaelidesová Jana Vachelová Jana Klementová Tomáš Urban Kateřina Pachnerová Brabcová Stanislav Kaczor Martin Falk Iva Falková Daniel Depeš Vladimír Vondráček Marie Davídková Nowadays, the irradiation methodology in proton therapy is switching from the use of passively scattered beams...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5652: Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in a Murine Model of Urosepsis International Journal of Molecular Sciences doi: 10.3390/ijms21165652 Authors: Mette G. Christensen Nanna Johnsen Marianne Skals Aimi D. M. Hamilton Peter Rubak Anne-Mette Hvas Helle Praetorius Urosepsis is a potentially life-threatening, systemic reaction to uropathogenic bacteria entering the bloodstream...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5648: MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators International Journal of Molecular Sciences doi: 10.3390/ijms21165648 Authors: Karen Aughton Helen Kalirai Sarah E. Coupland Uveal melanoma (UM) is a rare tumour of the eye, characterised by a high propensity to metastasise in half of all patients, most frequently to the liver. Although there are effective treatment options for the primary tumour, once metastasis...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5647: Hypoxia Alters the Expression of CC Chemokines and CC Chemokine Receptors in a Tumor–A Literature Review International Journal of Molecular Sciences doi: 10.3390/ijms21165647 Authors: Jan Korbecki Klaudyna Kojder Katarzyna Barczak Donata Simińska Izabela Gutowska Dariusz Chlubek Irena Baranowska-Bosiacka Hypoxia, i.e., oxygen deficiency condition, is one of the most important factors promoting the growth of tumors. Since its effect on the...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5646: Proteotoxicity and Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21165646 Authors: Clara Ruz Jose Luis Alcantud Francisco Vives Montero Raquel Duran Sara Bandres-Ciga Neurodegenerative diseases are a major burden for our society, affecting millions of people worldwide. A main goal of past and current research is to enhance our understanding of the mechanisms underlying proteotoxicity, a common theme among...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5645: Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms21165645 Authors: Joseph Wai-Hin Leung Kwok-Kuen Cheung Shirley Pui-Ching Ngai Hector Wing-Hong Tsang Benson Wui-Man Lau Neurogenesis is the process by which functional new neurons are generated from the neural stem cells (NSCs) or neural progenitor cells (NPCs). Increasing...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5642: Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities International Journal of Molecular Sciences doi: 10.3390/ijms21165642 Authors: Mariarosaria Boccellino Stefania D’Angelo The prevalence of obesity has steadily increased worldwide over the past three decades. The conventional approaches to prevent or treat this syndrome and its associated complications include a balanced diet, an increase energy expenditure, and lifestyle...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5649: Appraising the Genetic Architecture of Kernel Traits in Hexaploid Wheat Using GWAS International Journal of Molecular Sciences doi: 10.3390/ijms21165649 Authors: Ali Muhammad Weicheng Hu Zhaoyang Li Jianguo Li Guosheng Xie Jibin Wang Lingqiang Wang Kernel morphology is one of the major yield traits of wheat, the genetic architecture of which is always important in crop breeding. In this study, we performed a genome-wide association study (GWAS)...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5643: PTEN Is Required for The Anti-Epileptic Effects of AMPA Receptor Antagonists in Chronic Epileptic Rats International Journal of Molecular Sciences doi: 10.3390/ijms21165643 Authors: Ji-Eun Kim Hana Park Ji-Eun Lee Tae-Hyun Kim Tae-Cheon Kang α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is one of the ligand-gated ion channels for glutamate, which is an important player in the generation and spread of seizures. The...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5638: Assay Systems for Profiling Deubiquitinating Activity International Journal of Molecular Sciences doi: 10.3390/ijms21165638 Authors: Jinhong Cho Jinyoung Park Eunice EunKyeong Kim Eun Joo Song Deubiquitinating enzymes regulate various cellular processes, particularly protein degradation, localization, and protein–protein interactions. The dysregulation of deubiquitinating enzyme (DUB) activity has been linked to several diseases; however,...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5644: Adaptive Immune Response against Hepatitis C Virus International Journal of Molecular Sciences doi: 10.3390/ijms21165644 Authors: Janine Kemming Robert Thimme Christoph Neumann-Haefelin A functional adaptive immune response is the major determinant for clearance of hepatitis C virus (HCV) infection. However, in the majority of patients, this response fails and persistent infection evolves. Here, we dissect the HCV-specific key players of adaptive immunity,...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5641: The Role of Semaphorins in Metabolic Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21165641 Authors: Qiongyu Lu Li Zhu Semaphorins are a family originally identified as axonal guidance molecules. They are also involved in tumor growth, angiogenesis, immune regulation, as well as other biological and pathological processes. Recent studies have shown that semaphorins play a role in metabolic diseases including obesity, adipose inflammation,...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5639: Adjustment of Photosynthetic and Antioxidant Activities to Water Deficit Is Crucial in the Drought Tolerance of Lolium multiflorum/Festuca arundinacea Introgression Forms International Journal of Molecular Sciences doi: 10.3390/ijms21165639 Authors: Katarzyna Lechowicz Izabela Pawłowicz Dawid Perlikowski Magdalena Arasimowicz-Jelonek Sara Blicharz Aleksandra Skirycz Adam Augustyniak Robert Malinowski Marcin Rapacz Arkadiusz Kosmala ...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5640: Proteome-Wide Analyses Provide New Insights into the Compatible Interaction of Rice with the Root-Knot Nematode Meloidogyne graminicola International Journal of Molecular Sciences doi: 10.3390/ijms21165640 Authors: Chao Xiang Xiaoping Yang Deliang Peng Houxiang Kang Maoyan Liu Wei Li Wenkun Huang Shiming Liu The root-knot nematode Meloidogyne graminicola is an important pathogen in rice, causing huge yield losses annually worldwide. Details...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5636: Plant Cell and Organism Development International Journal of Molecular Sciences doi: 10.3390/ijms21165636 Authors: Robert Hasterok Alexander Betekhtin Plants represent a unique and fascinating group of living organisms [...]
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5635: Biomarkers of Physical Frailty and Sarcopenia: Coming up to the Place? International Journal of Molecular Sciences doi: 10.3390/ijms21165635 Authors: Anna Picca Riccardo Calvani Matteo Cesari Francesco Landi Roberto Bernabei Hélio José Coelho-Júnior Emanuele Marzetti Physical frailty and sarcopenia (PF&S) recapitulates all the hallmarks of aging and has become a focus in geroscience. Factors spanning muscle-specific processes (e.g.,...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5637: Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923 International Journal of Molecular Sciences doi: 10.3390/ijms21165637 Authors: Veronica Esposito Francesca Esposito Antonietta Pepe Isabel Gomez Monterrey Enzo Tramontano Luciano Mayol Antonella Virgilio Aldo Galeone In this paper, we report studies concerning four variants of the G-quadruplex forming anti-HIV-integrase aptamer T30923,...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5633: The Chloroplast RNA Binding Protein CP31A Has a Preference for mRNAs Encoding the Subunits of the Chloroplast NAD(P)H Dehydrogenase Complex and Is Required for Their Accumulation International Journal of Molecular Sciences doi: 10.3390/ijms21165633 Authors: Benjamin Lenzen Thilo Rühle Marie-Kristin Lehniger Ayako Okuzaki Mathias Labs Jose M. Muino Uwe Ohler Dario Leister Christian Schmitz-Linneweber Chloroplast RNA processing requires...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5632: All d-Lysine Analogues of the Antimicrobial Peptide HPA3NT3-A2 Increased Serum Stability and without Drug Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21165632 Authors: Jong-Kook Lee Yoonkyung Park Novel antibiotic drugs are urgently needed because of the increase in drug-resistant bacteria. The use of antimicrobial peptides has been suggested to replace antibiotics as they have strong antimicrobial activity and can be extracted...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5631: Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance International Journal of Molecular Sciences doi: 10.3390/ijms21165631 Authors: Silvia Valtorta Daniela Salvatore Paolo Rainone Sara Belloli Gloria Bertoli Rosa Maria Moresco This review highlights the importance and the complexity of tumour biology and microenvironment in the progression...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5634: Lower Exposure to Busulfan Allows for Stable Engraftment of Donor Hematopoietic Stem Cells in Children with Mucopolysaccharidosis Type I: A Case Report of Four Patients International Journal of Molecular Sciences doi: 10.3390/ijms21165634 Authors: Praveen Shukla Christopher C. Dvorak Janel Long-Boyle Sandhya Kharbanda Busulfan is an alkylating agent routinely used in conditioning regimens prior to allogeneic hematopoietic cell transplantation (HCT)...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5629: Highly Sensitive and Specific Molecular Test for Mutations in the Diagnosis of Thyroid Nodules: A Prospective Study of BRAF-Prevalent Population International Journal of Molecular Sciences doi: 10.3390/ijms21165629 Authors: Yoon Young Cho So Young Park Jung Hee Shin Young Lyun Oh Jun-Ho Choe Jung-Han Kim Jee Soo Kim Hyun Sook Yim Yoo-Li Kim Chang-Seok Ki Tae Hyuk Kim Jae Hoon Chung Sun Wook Kim Molecular testing offers more...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5630: Platelets and Defective N-Glycosylation International Journal of Molecular Sciences doi: 10.3390/ijms21165630 Authors: Elmina Mammadova-Bach Jaak Jaeken Thomas Gudermann Attila Braun N-glycans are covalently linked to an asparagine residue in a simple acceptor sequence of proteins, called a sequon. This modification is important for protein folding, enhancing thermodynamic stability, and decreasing abnormal protein aggregation within the endoplasmic...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5626: Biomarkers of Gemtuzumab Ozogamicin Response for Acute Myeloid Leukemia Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21165626 Authors: Laurène Fenwarth Elise Fournier Meyling Cheok Thomas Boyer Fanny Gonzales Sylvie Castaigne Nicolas Boissel Juliette Lambert Hervé Dombret Claude Preudhomme Nicolas Duployez Gemtuzumab ozogamicin (GO, Mylotarg®) consists of a humanized CD33-targeted antibody-drug...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5628: Structural Isomerism and Enhanced Lipophilicity of Pyrithione Ligands of Organoruthenium(II) Complexes Increase Inhibition on AChE and BuChE International Journal of Molecular Sciences doi: 10.3390/ijms21165628 Authors: Jerneja Kladnik Samuel Ristovski Jakob Kljun Andrea Defant Ines Mancini Kristina Sepčić Iztok Turel The increasing number of Alzheimer’s disease (AD) cases requires the development of new improved drug candidates,...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5627: Effects of Maternal Chewing on Prenatal Stress-Induced Cognitive Impairments in the Offspring via Multiple Molecular Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21165627 Authors: Qian Zhou Ayumi Suzuki Mitsuo Iinuma Ke-Yong Wang Kin-ya Kubo Kagaku Azuma We aimed to investigate the effects of maternal chewing on prenatal stress-induced cognitive impairments in the offspring and to explore the molecular pathways of maternal...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5625: Aromatase Inhibitors—Induced Musculoskeletal Disorders: Current Knowledge on Clinical and Molecular Aspects International Journal of Molecular Sciences doi: 10.3390/ijms21165625 Authors: Sara Tenti Pierpaolo Correale Sara Cheleschi Antonella Fioravanti Luigi Pirtoli Aromatase inhibitors (AIs) have radically changed the prognosis of hormone receptor positive breast cancer (BC) in post-menopausal women, and are a mainstay of the adjuvant therapy for...
Thu Aug 06, 2020 03:00
IJMS, Vol. 21, Pages 5622: Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects International Journal of Molecular Sciences doi: 10.3390/ijms21165622 Authors: Salman Ahmed Haroon Khan Michael Aschner Hamed Mirzae Esra Küpeli Akkol Raffaele Capasso Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment...
Thu Aug 06, 2020 03:00
JCDD, Vol. 7, Pages 29: The Importance of Telomere Shortening for Atherosclerosis and Mortality Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7030029 Authors: Wolfgang Herrmann Markus Herrmann Telomeres are the protective end caps of chromosomes and shorten with every cell division. Short telomeres are associated with older age and adverse lifestyle factors. Leucocyte telomere length (LTL) has been proposed as a biomarker of biological age. The shortening of LTL...
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2555: The Effect of Diabetes on Prognosis Following Myocardial Infarction Treated with Primary Angioplasty and Potent Antiplatelet Therapy Journal of Clinical Medicine doi: 10.3390/jcm9082555 Authors: Stanislav Simek Zuzana Motovska Ota Hlinomaz Petr Kala Milan Hromadka Jiri Knot Ivo Varvarovsky Jaroslav Dusek Richard Rokyta Frantisek Tousek Michal Svoboda Alexandra Vodzinska Jan Mrozek Jiri Jarkovsky and on behalf of the PRAGUE‐18...
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2553: Traumatic Events in Dual Disorders: Prevalence and Clinical Characteristics
JCM, Vol. 9, Pages 2553: Traumatic Events in Dual Disorders: Prevalence and Clinical Characteristics Journal of Clinical Medicine doi: 10.3390/jcm9082553 Authors: Laura Blanco Albert Sió Bridget Hogg Ricard Esteve Joaquim Radua Aleix Solanes Itxaso Gardoki-Souto Rosa Sauras Adriana Farré Claudio Castillo Alicia Valiente-Gómez Víctor Pérez Marta Torrens Benedikt L. Amann Ana Moreno-Alcázar Psychological trauma has been identified in substance...
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2554: Phase Angle as an Indicator of Sarcopenia, Malnutrition, and Cachexia in Inpatients with Cardiovascular Diseases Journal of Clinical Medicine doi: 10.3390/jcm9082554 Authors: Hirose Nakajima Nozawa Katayanagi Ishizaka Mizushima Matsumoto Nishikawa Toyama Takahashi Arakawa Yasuda Haruyama Yazawa Yamaguchi Toyoda Shibasaki Mizushima Fukuda Inoue Malnutrition is associated with sarcopenia,...
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2551: Load-Bearing Detection with Insole-Force Sensors Provides New Treatment Insights in Fragility Fractures of the Pelvis Journal of Clinical Medicine doi: 10.3390/jcm9082551 Authors: Daniel Pfeufer Christopher A. Becker Leon Faust Alexander M. Keppler Marissa Stagg Christian Kammerlander Wolfgang Böcker Carl Neuerburg Background: Due to an aging society, more and more surgeons are confronted with fragility fractures of the pelvis (FFPs). The...
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2549: Diagnostic and Clinical Impact of 18F-FDG PET/CT in Staging and Restaging Soft-Tissue Sarcomas of the Extremities and Trunk: Mono-Institutional Retrospective Study of a Sarcoma Referral Center Journal of Clinical Medicine doi: 10.3390/jcm9082549 Authors: Alessio Annovazzi Sandra Rea Carmine Zoccali Rosa Sciuto Jacopo Baldi Vincenzo Anelli Maria G. Petrongari Edoardo Pescarmona Roberto Biagini Virginia Ferraresi Background: Soft-tissue...
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2552: Endometrial Carcinomas with Intestinal-Type Metaplasia/Differentiation: Does Mismatch Repair System Defects Matter? Case Report and Systematic Review of the Literature Journal of Clinical Medicine doi: 10.3390/jcm9082552 Authors: Laura Ardighieri Andrea Palicelli Federico Ferrari Mattia Bugatti Emma Drera Enrico Sartori Franco Odicino Background: Intestinal metaplasia/differentiation in primary endometrial carcinomas is an uncommon phenomenon,...
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2550: Influenza D Virus: The Most Discreet (for the Moment?) of the Influenza Viruses Journal of Clinical Medicine doi: 10.3390/jcm9082550 Authors: Alessandra Falchi The review of Kumari et al [...]
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2548: The Role of Imaging Techniques to Define a Peri-Prosthetic Hip and Knee Joint Infection: Multidisciplinary Consensus Statements Journal of Clinical Medicine doi: 10.3390/jcm9082548 Authors: Carlo Luca Romanò Nicola Petrosillo Giuseppe Argento Luca Maria Sconfienza Giorgio Treglia Abass Alavi Andor W.J.M. Glaudemans Olivier Gheysens Alex Maes Chiara Lauri Christopher J. Palestro Alberto Signore Diagnosing a peri-prosthetic joint...
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2547: Stable Clinical Course of Chronic Obstructive Pulmonary Disease Patients in the Era of Double Bronchodilator Therapy: A Single Referral Center Experience Journal of Clinical Medicine doi: 10.3390/jcm9082547 Authors: Sun Hye Shin Noeul Kang Juhee Cho Yeonseok Choi Hyun Kyu Cho Hye Sook Choi Hojoong Kim Jun Hyeok Lim Hye Yun Park Despite clinical benefits of long-acting muscarinic antagonist (LAMA)/long-acting beta2-agonist (LABA) double...
Thu Aug 06, 2020 03:00
JCM, Vol. 9, Pages 2546: Relationship between Tube Parameters and Corneal Endothelial Cell Damage after Ahmed Glaucoma Valve Implantation: A Comparative Study Journal of Clinical Medicine doi: 10.3390/jcm9082546 Authors: Han Min Lee Kyoung Nam Kim Kee Sup Park Nam Ho Lee Sung Bok Lee Chang-Sik Kim Purpose: We compared the clinical factors, including anterior chamber tube parameters, in patients with and without corneal endothelial cell damage after Ahmed glaucoma valve...
Thu Aug 06, 2020 03:00
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