IJMS, Vol. 21, Pages 5496: Physicochemical Evidence that Francisella FupA and FupB Proteins Are Porins International Journal of Molecular Sciences doi: 10.3390/ijms21155496 Authors: Claire Siebert Corinne Mercier Donald K. Martin Patricia Renesto Beatrice Schaack Responsible for tularemia, Francisella tularensis bacteria are highly infectious Gram-negative, category A bioterrorism agents. The molecular mechanisms for their virulence and resistance to antibiotics remain largely...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5501: Growing Old Too Early: Skeletal Muscle Single Fiber Biomechanics in Ageing R349P Desmin Knock-in Mice Using the MyoRobot Technology International Journal of Molecular Sciences doi: 10.3390/ijms21155501 Authors: Charlotte Pollmann Michael Haug Barbara Reischl Gerhard Prölß Thorsten Pöschel Stefan J Rupitsch Christoph S Clemen Rolf Schröder Oliver Friedrich Muscle biomechanics relies on active motor protein assembly and passive strain...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5492: Generation and Transcriptome Profiling of Slr1-d7 and Slr1-d8 Mutant Lines with a New Semi-Dominant Dwarf Allele of SLR1 Using the CRISPR/Cas9 System in Rice International Journal of Molecular Sciences doi: 10.3390/ijms21155492 Authors: Yu Jin Jung Jong Hee Kim Hyo Ju Lee Dong Hyun Kim Jihyeon Yu Sangsu Bae Yong-Gu Cho Kwon Kyoo Kang The rice SLR1 gene encodes the DELLA protein, and a loss-of-function mutation is dwarfed by inhibiting plant...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5494: Control of Innate Immunity by Sialic Acids in the Nervous Tissue International Journal of Molecular Sciences doi: 10.3390/ijms21155494 Authors: Huan Liao Christine Klaus Harald Neumann Sialic acids (Sias) are the most abundant terminal sugar residues of glycoproteins and glycolipids on the surface of mammalian cells. The nervous tissue is the organ with the highest expression level of Sias. The ‘sialylation’ of glycoconjugates is performed...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5495: Role of miR-96/EVI1/miR-449a Axis in the Nasopharyngeal Carcinoma Cell Migration and Tumor Sphere Formation International Journal of Molecular Sciences doi: 10.3390/ijms21155495 Authors: Lai-Sheung Chan Hong-Lok Lung Roger Kai-Cheong Ngan Anne Wing-Mui Lee Sai Wah Tsao Kwok-Wai Lo Michael Kahn Maria Li Lung Rotraud Wieser Nai-Ki Mak The Wnt signaling pathway is one of the major signaling pathways used by cancer stem cells (CSC). Ecotropic...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5491: The Impact of Small Extracellular Vesicles on Lymphoblast Trafficking across the Blood-Cerebrospinal Fluid Barrier In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21155491 Authors: Ulrike Erb Julia Hikel Svenja Meyer Hiroshi Ishikawa Thomas S. Worst Katja Nitschke Philipp Nuhn Stefan Porubsky Christel Weiss Horst Schroten Rüdiger Adam Michael Karremann Central nervous System (CNS) disease in pediatric acute...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5489: Proteomic Research in Peritoneal Dialysis International Journal of Molecular Sciences doi: 10.3390/ijms21155489 Authors: Mario Bonomini Francesc E. Borras Maribel Troya-Saborido Laura Carreras-Planella Lorenzo Di Liberato Arduino Arduini Peritoneal dialysis (PD) is an established home care, cost-effective renal replacement therapy (RRT), which offers several advantages over the most used dialysis modality, hemodialysis. Despite its potential...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5486: Crosstalk between Tumor and Stromal Cells in Pancreatic Ductal Adenocarcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21155486 Authors: Nadine Sperb Miltiadis Tsesmelis Thomas Wirth Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer. The poor prognosis calls for a more detailed understanding of disease biology in order to pave the way for the development of effective therapies. Typically, the pancreatic tumor is composed...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5488: Targeting on Gut Microbiota-Derived Metabolite Trimethylamine to Protect Adult Male Rat Offspring against Hypertension Programmed by Combined Maternal High-Fructose Intake and Dioxin Exposure International Journal of Molecular Sciences doi: 10.3390/ijms21155488 Authors: Chien-Ning Hsu Julie Y. H. Chan Hong-Ren Yu Wei-Chia Lee Kay L. H. Wu Guo-Ping Chang-Chien Sufan Lin Chih-Yao Hou You-Lin Tain Gut microbiota-dependent metabolites, in...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5490: Roles Played by Biomarkers of Kidney Injury in Patients with Upper Urinary Tract Obstruction International Journal of Molecular Sciences doi: 10.3390/ijms21155490 Authors: Satoshi Washino Keiko Hosohata Tomoaki Miyagawa Partial or complete obstruction of the urinary tract is a common and challenging urological condition caused by a variety of conditions, including ureteral calculi, ureteral pelvic junction obstruction, ureteral stricture, and malignant...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5485: P38α MAPK Signaling—A Robust Therapeutic Target for Rab5-Mediated Neurodegenerative Disease International Journal of Molecular Sciences doi: 10.3390/ijms21155485 Authors: Ursula A. Germann John J. Alam Multifactorial pathologies, involving one or more aggregated protein(s) and neuroinflammation are common in major neurodegenerative diseases, such as Alzheimer’s disease and dementia with Lewy bodies. This complexity of multiple pathogenic drivers...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5487: Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis International Journal of Molecular Sciences doi: 10.3390/ijms21155487 Authors: Marisol Miranda-Galvis Yong Teng Hypoxia in locally advanced solid tumors develops due to uncontrollable cell proliferation, altered metabolism, and the severe structural and functional abnormality of the tumor vasculature, leading to an imbalance between oxygen supply and consumption...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5482: Corynebacterium glutamicum CrtR and Its Orthologs in Actinobacteria: Conserved Function and Application as Genetically Encoded Biosensor for Detection of Geranylgeranyl Pyrophosphate International Journal of Molecular Sciences doi: 10.3390/ijms21155482 Authors: Nadja A. Henke Sophie Austermeier Isabell L. Grothaus Susanne Götker Marcus Persicke Petra Peters-Wendisch Volker F. Wendisch Carotenoid biosynthesis in Corynebacteriumglutamicum is...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5484: Current Status and Future Perspectives of Checkpoint Inhibitor Immunotherapy for Prostate Cancer: A Comprehensive Review International Journal of Molecular Sciences doi: 10.3390/ijms21155484 Authors: Tae Jin Kim Kyo Chul Koo The clinical spectrum of prostate cancer (PCa) varies from castration-naive to metastatic castration-resistant disease. Despite the administration of androgen synthesis inhibitors and chemotherapy regimens for castration-resistant prostate...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5481: The Role of Protein Tyrosine Phosphatases in Inflammasome Activation International Journal of Molecular Sciences doi: 10.3390/ijms21155481 Authors: Marianne R. Spalinger Marlene Schwarzfischer Michael Scharl Inflammasomes are multi-protein complexes that mediate the activation and secretion of the inflammatory cytokines IL-1β and IL-18. More than half a decade ago, it has been shown that the inflammasome adaptor molecule, ASC requires tyrosine...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5483: Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome International Journal of Molecular Sciences doi: 10.3390/ijms21155483 Authors: Gabriela Gajek Anna S. Świerzko Maciej Cedzyński The Malpuech, Michels, Mingarelli, Carnevale (3MC) syndrome is a rare, autosomal recessive genetic- disorder associated with mutations in the MASP1/3, COLEC1,1 or COLEC10 genes. The number of 3MC patients with known mutations in these three...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5480: Benefits of Polydopamine as Particle/Matrix Interface in Polylactide/PD-BaSO4 Scaffolds International Journal of Molecular Sciences doi: 10.3390/ijms21155480 Authors: Naroa Sadaba Aitor Larrañaga Gemma Orpella-Aceret Ana F. Bettencourt Victor Martin Manus Biggs Isabel A. C. Ribeiro Jone M. Ugartemendia Jose-Ramon Sarasua Ester Zuza This work reports the versatility of polydopamine (PD) when applied as a particle coating in a composite...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5477: Does the Act of Copulation per se, without Considering Seminal Deposition, Change the Expression of Genes in the Porcine Female Genital Tract? International Journal of Molecular Sciences doi: 10.3390/ijms21155477 Authors: Manuel Alvarez-Rodriguez Cristina A. Martinez Dominic Wright Heriberto Rodriguez-Martinez Semen—through its specific sperm and seminal plasma (SP) constituents—induces changes of gene expression in the internal...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5478: Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior International Journal of Molecular Sciences doi: 10.3390/ijms21155478 Authors: Valentina S. Rumanova Monika Okuliarova Michal Zeman The disruption of circadian rhythms by environmental conditions can induce alterations in body homeostasis, from behavior to metabolism. The light:dark cycle is the most reliable environmental agent, which entrains...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5479: Mesocellular Silica Foams (MCFs) with Tunable Pore Size as a Support for Lysozyme Immobilization: Adsorption Equilibrium and Kinetics, Biocomposite Properties International Journal of Molecular Sciences doi: 10.3390/ijms21155479 Authors: Agnieszka Chrzanowska Anna Derylo-Marczewska Malgorzata Wasilewska The effect of the porous structure of mesocellular silica foams (MCFs) on the lysozyme (LYS) adsorption capacity, as well as the rate, was studied to...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5475: SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms21155475 Authors: Manuela Pennisi Giuseppe Lanza Luca Falzone Francesco Fisicaro Raffaele Ferri Rita Bella Increasing evidence suggests that Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-CoV-2) can also invade the central nervous system (CNS). However, findings available on its neurological manifestations...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5474: Mechanosensitivity Is a Characteristic Feature of Cultured Suburothelial Interstitial Cells of the Human Bladder International Journal of Molecular Sciences doi: 10.3390/ijms21155474 Authors: Jochen Neuhaus Andreas Gonsior Sheng Cheng Jens-Uwe Stolzenburg Frank Peter Berger Bladder dysfunction is characterized by urgency, frequency (pollakisuria, nocturia), and dysuria and may lead to urinary incontinence. Most of these symptoms can be attributed...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5476: A Structural Model for Bax∆2-Mediated Activation of Caspase 8-Dependent Apoptosis International Journal of Molecular Sciences doi: 10.3390/ijms21155476 Authors: Bing Xie Qi Yao Jialing Xiang David D.L. Minh Bax∆2 is a pro-apoptotic anti-tumor protein in the Bax family. While most of the Bax family causes cell death by targeting mitochondria, Bax∆2 forms cytosolic aggregates and activates caspase 8-dependent cell death. We previously showed that the...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5472: Sialylated Immunoglobulins for the Treatment of Immuno-Inflammatory Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21155472 Authors: Yuliya V. Markina Elena V. Gerasimova Alexander M. Markin Victor Y. Glanz Wei-Kai Wu Igor A. Sobenin Alexander N. Orekhov Immunoglobulins are the potent effector proteins of the humoral immune response. In the course of evolution, immunoglobulins have formed extremely diverse types of molecular...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5471: Approaches and Technologies in Male Fertility Preservation International Journal of Molecular Sciences doi: 10.3390/ijms21155471 Authors: Huleihel Lunenfeld Male fertility preservation is required when treatment with an aggressive chemo-/-radiotherapy, which may lead to irreversible sterility. Due to new and efficient protocols of cancer treatments, surviving rates are more than 80%. Thus, these patients are looking forward to family life and fathering...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5473: Calsequestrin Deletion Facilitates Hippocampal Synaptic Plasticity and Spatial Learning in Post-Natal Development International Journal of Molecular Sciences doi: 10.3390/ijms21155473 Authors: Ambrogini Lattanzi Palma Ciacci Savelli Galati Gioacchini Pietrangelo Vallorani Protasi Cuppini : Experimental evidence highlights the involvement of the endoplasmic reticulum (ER)-mediated Ca2+ signals in modulating synaptic plasticity...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5469: Cold Press Pomegranate Seed Oil Attenuates Dietary-Obesity Induced Hepatic Steatosis and Fibrosis through Antioxidant and Mitochondrial Pathways in Obese Mice International Journal of Molecular Sciences doi: 10.3390/ijms21155469 Authors: Marco Raffaele Maria Licari Sherif Amin Ragin Alex Hsin-hsueh Shen Shailendra P. Singh Luca Vanella Rita Rezzani Francesca Bonomini Stephen J. Peterson David E. Stec Nader G. Abraham Aim: Obesity...
Fri Jul 31, 2020 03:00
IJMS, Vol. 21, Pages 5470: VAS3947 Induces UPR-Mediated Apoptosis through Cysteine Thiol Alkylation in AML Cell Lines International Journal of Molecular Sciences doi: 10.3390/ijms21155470 Authors: Maya El Dor Hassan Dakik Marion Polomski Eloi Haudebourg Marie Brachet Fabrice Gouilleux Gildas Prié Kazem Zibara Frédéric Mazurier Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) involvement has been established in the oncogenic cell signaling of...
Fri Jul 31, 2020 03:00
JCDD, Vol. 7, Pages 28: Triglycerides to High-Density Lipoprotein Cholesterol Ratio Predicts Chronic Renal Disease in Patients without Diabetes Mellitus (STELLA Study) Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7030028 Authors: Vaia D. Raikou Despina Kyriaki Sotiris Gavriil Background: The triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been included in the potential indices for atherosclerosis in chronic kidney disease (CKD)....
Sat Aug 01, 2020 03:00
JCM, Vol. 9, Pages 2486: The Relationship between Cognitive and Emotional Factors and Healthcare and Medication Use in People Experiencing Pain: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9082486 Authors: Eva Huysmans Lynn Leemans David Beckwée Jo Nijs Kelly Ickmans Maarten Moens Lisa Goudman Ronald Buyl Koen Putman Iris Coppieters Pain conditions are among the leading causes of global disability, impacting on global healthcare utilization...
03:00
JCM, Vol. 9, Pages 2485: Living-Donor Uterus Transplantation: Pre-, Intra-, and Postoperative Parameters Relevant to Surgical Success, Pregnancy, and Obstetrics with Live Births Journal of Clinical Medicine doi: 10.3390/jcm9082485 Authors: Sara Yvonne Brucker Thomas Strowitzki Florin-Andrei Taran Katharina Rall Dorit Schöller Markus Hoopmann Melanie Henes Martina Guthoff Nils Heyne Stephan Zipfel Norbert Schäffeler Hans Bösmüller Falko Fend Peter Rosenberger...
03:00
JCM, Vol. 9, Pages 2484: The Role of Oral Microbiota in Intra-Oral Halitosis Journal of Clinical Medicine doi: 10.3390/jcm9082484 Authors: Katarzyna Hampelska Marcelina Maria Jaworska Zuzanna Łucja Babalska Tomasz M. Karpiński Halitosis is a common ailment concerning 15% to 60% of the human population. Halitosis can be divided into extra-oral halitosis (EOH) and intra-oral halitosis (IOH). The IOH is formed by volatile compounds, which are produced mainly by anaerobic bacteria....
Sun Aug 02, 2020 03:00
JCM, Vol. 9, Pages 2483: Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis Journal of Clinical Medicine doi: 10.3390/jcm9082483 Authors: Natalia Mena-Vázquez Marta Rojas-Gimenez Francisco Gabriel Jimenez Nuñez Sara Manrique-Arija José Rioja Patricia Ruiz-Limón Inmaculada Ureña Manuel Castro-Cabezas Pedro Valdivielso Antonio Fernández-Nebro Objective: To describe postprandial lipemia in patients...
Sun Aug 02, 2020 03:00
JCM, Vol. 9, Pages 2481: Detection of BRAFV600E in Liquid Biopsy from Patients with Papillary Thyroid Cancer Is Associated with Tumor Aggressiveness and Response to Therapy Journal of Clinical Medicine doi: 10.3390/jcm9082481 Authors: Jensen Thakur Patel Mendonca-Torres Costello Gomes-Lima Walter Wartofsky Burman Bikas Ylli Vasko Klubo-Gwiezdzinska The detection of rare mutational targets in plasma (liquid biopsy) has emerged as a promising...
Sun Aug 02, 2020 03:00
JCM, Vol. 9, Pages 2482: The Subgingival Microbiome in Patients with Down Syndrome and Periodontitis
JCM, Vol. 9, Pages 2482: The Subgingival Microbiome in Patients with Down Syndrome and Periodontitis Journal of Clinical Medicine doi: 10.3390/jcm9082482 Authors: Nóvoa Sánchez Blanco Limeres Cuenca Marín Sanz Herrera Diz Objective: To describe the subgingival microbiome of individuals with Down syndrome (DS). Methods: We conducted a cross-sectional observational study that obtained bacterial DNA samples from 50 patients with DS, 25 with periodontitis...
Sun Aug 02, 2020 03:00
JCM, Vol. 9, Pages 2480: Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9082480 Authors: Veronica Papa Luisa Marracino Francesca Fortini Paola Rizzo Gianluca Campo Mauro Vaccarezza Francesco Vieceli Dalla Sega Some random mutations can confer a selective advantage to a hematopoietic stem cell. As a result, mutated hematopoietic stem cells can give rise to a significant proportion...
Sun Aug 02, 2020 03:00
JCM, Vol. 9, Pages 2479: Effects of COMT Genotypes on Working Memory Performance in Fibromyalgia Patients Journal of Clinical Medicine doi: 10.3390/jcm9082479 Authors: David Ferrera Francisco Gómez-Esquer Irene Peláez Paloma Barjola Roberto Fernandes-Magalhaes Alberto Carpio María E. De Lahoz Gema Díaz-Gil Francisco Mercado Growing research has reported the presence of a clear impairment of working memory functioning in fibromyalgia. Although different genetic...
Sat Aug 01, 2020 03:00
JCM, Vol. 9, Pages 2477: Neuroimaging-Based Scalp Acupuncture Locations for Dementia Journal of Clinical Medicine doi: 10.3390/jcm9082477 Authors: Jin Cao Yiting Huang Nathaniel Meshberg Sierra A. Hodges Jian Kong Scalp acupuncture is a modality of acupuncture in which acupuncture needles are inserted into a certain layer of the scalp in order to affect the function of corresponding areas of the cerebral cortex and relieve symptoms. Clinical studies have demonstrated the...
Sat Aug 01, 2020 03:00
JCM, Vol. 9, Pages 2476: Chronic Kidney Disease and Its Impact on a Prothrombotic State in Patients with Atrial Fibrillation Journal of Clinical Medicine doi: 10.3390/jcm9082476 Authors: Paweł T. Matusik Zbigniew Heleniak Elżbieta Papuga-Szela Krzysztof Plens Jacek Lelakowski Anetta Undas It is unclear whether chronic kidney disease (CKD) increases thromboembolism in atrial fibrillation (AF). We conducted a retrospective cross-sectional analysis of 502 non-anticoagulated...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου